Personal information

Keywords

Depression, Inflammation, Inflammasome, Cytokines, Stress

Countries

Japan

Activities

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Employment (4)

Tottori University Faculty of Medicine: Yonago, Tottori, JP

2016-04-01 to present | Associate Professor (Department of Neuropsychiatry)
Employment
Source: Self-asserted source
Masaaki Iwata

Tottori University Faculty of Medicine: Yonago, Tottori, JP

2012-10-01 to 2014-03-31 | Assistant Professor (Department of Neuropsychiatry)
Employment
Source: Self-asserted source
Masaaki Iwata

Yale University School of Medicine: New Haven, CT, US

2009-09-01 to 2012-09-30 | Postdoctral Fellow (Departments of Psychiatry and Pharmacology)
Employment
Source: Self-asserted source
Masaaki Iwata

Tottori University Faculty of Mecidine: Yonago, Tottori, JP

2000-04-01 to 2009-08-31 (Department of Neuropsychiatry)
Employment
Source: Self-asserted source
Masaaki Iwata

Education and qualifications (2)

Tottori University Faculty of Medicine: Yonago, Tottori, JP

2002-04-01 to 2006-03-31 | Ph.D. (Department of Nrueopsychiatry)
Education
Source: Self-asserted source
Masaaki Iwata

Tottori University Faculty of Medicine: Yonago, Tottori, JP

1994-04-01 to 2000-03-23 | M.D.
Education
Source: Self-asserted source
Masaaki Iwata

Funding (3)

Development of novel therapeutic drugs for mental disorders targeting inhibition of activation of NLRP3

Source: Self-asserted source
Masaaki Iwata via DimensionsWizard

The development of understanding and new treatments of the mechanisms by which stress-induced depression through the inflammation in the brain

Source: Self-asserted source
Masaaki Iwata via DimensionsWizard

Psychological stress activates the inflammasome via release of ATP and stimulation of the P2X7 receptor

Source: Self-asserted source
Masaaki Iwata via DimensionsWizard

Works (36)

The genome‐wide DNA methylation profiles among neurosurgery patients with and without post‐operative delirium

Psychiatry and Clinical Neurosciences
2023-01 | Journal article
DOI: 10.1111/pcn.13495
Contributors: Takehiko Yamanashi; Kaitlyn J. Crutchley; Nadia E. Wahba; Takaaki Nagao; Pedro S. Marra; Cade C. Akers; Eleanor J. Sullivan; Masaaki Iwata; Mathew A Howard, III; Hyunkeun R. Cho et al.
Source: check_circle
Crossref

Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity

2022-10-24 | Preprint
DOI: 10.1101/2022.10.22.513357
Contributors: Pedro S. Marra; Takehiko Yamanashi; Kaitlyn J. Crutchley; Nadia E. Wahba; Zoe-Ella M. Anderson; Manisha Modukuri; Gloria Chang; Tammy Tran; Masaaki Iwata; Ryan Cho et al.
Source: check_circle
Crossref

Stress increases blood beta‐hydroxybutyrate levels and prefrontal cortex NLRP3 activity jointly in a rodent model

Neuropsychopharmacology Reports
2021-06 | Journal article
DOI: 10.1002/npr2.12164
Contributors: Tsuyoshi Nishiguchi; Masaaki Iwata; Naofumi Kajitani; Akihiko Miura; Ryoichi Matsuo; Shumei Murakami; Yumeto Nakada; Shenghong Pu; Yuki Shimizu; Tatsuya Tsubakino et al.
Source: check_circle
Crossref

Discontinuation of antidepressants after remission with antidepressant medication in major depressive disorder: a systematic review and meta-analysis

Molecular Psychiatry
2021-01 | Journal article
DOI: 10.1038/s41380-020-0843-0
Contributors: Masaki Kato; Hikaru Hori; Takeshi Inoue; Junichi Iga; Masaaki Iwata; Takahiko Inagaki; Kiyomi Shinohara; Hissei Imai; Atsunobu Murata; Kazuo Mishima et al.
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Crossref

New Cutoff Scores for Delirium Screening Tools to Predict Patient Mortality

Journal of the American Geriatrics Society
2021-01 | Journal article
DOI: 10.1111/jgs.16815
Contributors: Takehiko Yamanashi; Masaaki Iwata; Kaitlyn J. Crutchley; Eleanor J. Sullivan; Johnny R. Malicoat; Zoe‐Ella M. Anderson; Pedro S. Marra; Gloria Chang; Koichi Kaneko; Eri Shinozaki et al.
Source: check_circle
Crossref

Non‐24‐hour sleep‐wake disorder successfully treated with the combination of ramelteon and suvorexant in a case of autism spectrum disorder

Neuropsychopharmacology Reports
2020-12 | Journal article
DOI: 10.1002/npr2.12142
Contributors: Masaaki Iwata; Koichi Kaneko
Source: check_circle
Crossref

Monoaminergic balances predict non-depression-like phenotype in Learned Helplessness Paradigm

Neuroscience
2020-08 | Journal article
DOI: 10.1016/j.neuroscience.2020.03.033
Contributors: Katsumasa Muneoka; Yasunori Oda; Masaaki Iwata; Masaomi Iyo; Kenji Hashimoto; Yukihiko Shirayama
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Crossref

Prefrontal cortex infusion of beta‐hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, produces antidepressant‐like effects in a rodent model of depression

Neuropsychopharmacology Reports
2020-06 | Journal article
DOI: 10.1002/npr2.12099
Contributors: Naofumi Kajitani; Masaaki Iwata; Akihiko Miura; Kyohei Tsunetomi; Takehiko Yamanashi; Ryoichi Matsuo; Tsuyoshi Nishiguchi; Saki Fukuda; Mayu Nagata; Midori Shibushita et al.
Source: check_circle
Crossref

Association between social functioning and prefrontal cortex function during a verbal fluency task in schizophrenia: A near‐infrared spectroscopic study

Psychiatry and Clinical Neurosciences
2017-11 | Journal article
DOI: 10.1111/pcn.12548
Contributors: Masashi Itakura; Shenghong Pu; Hiroaki Ohdachi; Hiroshi Matsumura; Katsutoshi Yokoyama; Izumi Nagata; Masaaki Iwata; Koichi Kaneko
Source: check_circle
Crossref

Beta-hydroxybutyrate, an endogenic NLRP3 inflammasome inhibitor, attenuates stress-induced behavioral and inflammatory responses

Scientific Reports
2017-08-09 | Journal article
DOI: 10.1038/s41598-017-08055-1
Contributors: Takehiko Yamanashi; Masaaki Iwata; Naho Kamiya; Kyohei Tsunetomi; Naofumi Kajitani; Nodoka Wada; Takahiro Iitsuka; Takahira Yamauchi; Akihiko Miura; Shenghong Pu et al.
Source: check_circle
Crossref

Association of fronto-temporal function with cognitive ability in schizophrenia

Scientific Reports
2017-02 | Journal article
DOI: 10.1038/srep42858
Contributors: Shenghong Pu; Kazuyuki Nakagome; Masashi Itakura; Masaaki Iwata; Izumi Nagata; Koichi Kaneko
Source: Self-asserted source
Masaaki Iwata via Crossref Metadata Search

Learned helplessness activates hippocampal microglia in rats: A potential target for the antidepressant imipramine

Pharmacology Biochemistry and Behavior
2016-11 | Journal article
DOI: 10.1016/j.pbb.2016.10.005
Contributors: Masaaki Iwata; Hisahito Ishida; Koichi Kaneko; Yukihiko Shirayama
Source: Self-asserted source
Masaaki Iwata via Crossref Metadata Search

Associations between depressive symptoms and fronto-temporal activities during a verbal fluency task in patients with schizophrenia

Scientific Reports
2016-07 | Journal article
DOI: 10.1038/srep30685
Contributors: Shenghong Pu; Kazuyuki Nakagome; Akihiko Miura; Masaaki Iwata; Izumi Nagata; Koichi Kaneko
Source: Self-asserted source
Masaaki Iwata via Crossref Metadata Search

Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor

Biological Psychiatry
2016-07 | Journal article
DOI: 10.1016/j.biopsych.2015.11.026
Contributors: Masaaki Iwata; Kristie T. Ota; Xiao-Yuan Li; Fumika Sakaue; Nanxin Li; Sophie Dutheil; Mounira Banasr; Vanja Duric; Takehiko Yamanashi; Koichi Kaneko et al.
Source: Self-asserted source
Masaaki Iwata via Crossref Metadata Search

Integrating neuroimmune systems in the neurobiology of depression

Nature Reviews Neuroscience
2016-06-09 | Journal article
DOI: 10.1038/nrn.2016.69
Contributors: Eric S. Wohleb; Tina Franklin; Masaaki Iwata; Ronald S. Duman
Source: Self-asserted source
Masaaki Iwata via Crossref Metadata Search

The association between cognitive deficits and prefrontal hemodynamic responses during performance of working memory task in patients with schizophrenia

Schizophrenia Research
2016-04 | Journal article
DOI: 10.1016/j.schres.2016.01.045
Contributors: Shenghong Pu; Kazuyuki Nakagome; Masashi Itakura; Masaaki Iwata; Izumi Nagata; Koichi Kaneko
Source: Self-asserted source
Masaaki Iwata via Crossref Metadata Search

Social cognition and prefrontal hemodynamic responses during a working memory task in schizophrenia

Scientific Reports
2016-03-01 | Journal article
DOI: 10.1038/srep22500
Contributors: Shenghong Pu; Kazuyuki Nakagome; Takeshi Yamada; Masashi Itakura; Takehiko Yamanashi; Sayaka Yamada; Mieko Masai; Akihiko Miura; Takahira Yamauchi; Takahiro Satake et al.
Source: Self-asserted source
Masaaki Iwata via Crossref Metadata Search

Self-reported social functioning and prefrontal hemodynamic responses during a cognitive task in schizophrenia

Psychiatry Research: Neuroimaging
2015-10 | Journal article
DOI: 10.1016/j.pscychresns.2015.09.008
Contributors: Shenghong Pu; Kazuyuki Nakagome; Masashi Itakura; Takehiko Yamanashi; Takuya Sugie; Akehiko Miura; Takahiro Satake; Masaaki Iwata; Izumi Nagata; Koichi Kaneko
Source: Self-asserted source
Masaaki Iwata via Crossref Metadata Search

Child ego state is associated with high prevalence of repeated hospitalizations in patients with heart failure

ESC Heart Failure
2015-09 | Journal article
DOI: 10.1002/ehf2.12060
Contributors: Kiyotaka Yanagihara; Yoshiharu Kinugasa; Kinya Shirota; Yoshiaki Inoue; Hiroshige Ishii; Fumiyo Tsunoda; Masaaki Iwata; Shinobu Sugihara; Shinya Takeda; Masayuki Hirai et al.
Source: Self-asserted source
Masaaki Iwata via Crossref Metadata Search

Suicidal ideation is associated with reduced prefrontal activation during a verbal fluency task in patients with major depressive disorder

Journal of Affective Disorders
2015-08 | Journal article
DOI: 10.1016/j.jad.2015.04.010
Contributors: Shenghong Pu; Kazuyuki Nakagome; Takeshi Yamada; Katsutoshi Yokoyama; Hiroshi Matsumura; Sayaka Yamada; Takuya Sugie; Akihiko Miura; Hideaki Mitani; Masaaki Iwata et al.
Source: Self-asserted source
Masaaki Iwata via Crossref Metadata Search

REDD1 is essential for stress-induced synaptic loss and depressive behavior

Nature Medicine
2014-04 | Journal article
DOI: 10.1038/nm.3513
Contributors: Kristie T Ota; Rong-Jian Liu; Bhavya Voleti; Jaime G Maldonado-Aviles; Vanja Duric; Masaaki Iwata; Sophie Dutheil; Catharine Duman; Steve Boikess; David A Lewis et al.
Source: Self-asserted source
Masaaki Iwata via Crossref Metadata Search

The inflammasome: Pathways linking psychological stress, depression, and systemic illnesses

Brain, Behavior, and Immunity
2013-07 | Journal article
DOI: 10.1016/j.bbi.2012.12.008
Contributors: Masaaki Iwata; Kristie T. Ota; Ronald S. Duman
Source: Self-asserted source
Masaaki Iwata via Crossref Metadata Search

Neural Activation by Milnacipran and Memory Extinction

Journal of Behavioral and Brain Science
2012 | Journal article
DOI: 10.4236/jbbs.2012.22016
Contributors: Hisahito Ishida; Masaaki Iwata; Yukihiko Shirayama; Katsumasa Muneoka
Source: Self-asserted source
Masaaki Iwata via Crossref Metadata Search

Depressive state due to isolated adrenocorticotropic hormone deficiency underlies school refusal

Psychiatry and Clinical Neurosciences
2012-03 | Journal article
DOI: 10.1111/j.1440-1819.2012.02322.x
Contributors: Masaaki Iwata; Gen-i Hazama; Kazuyuki Nakagome
Source: Self-asserted source
Masaaki Iwata via Crossref Metadata Search

VPA improves the tolerance for the stress in learned helplessness rats

Neuroscience Research
2011-09 | Journal article
DOI: 10.1016/j.neures.2011.07.1323
Contributors: Hokuto Kobayashi; Masaaki Iwata; Hideaki Mitani; Takeshi Yamada; Kazuyuki Nakagome; Koichi Kaneko
Source: Self-asserted source
Masaaki Iwata via Crossref Metadata Search

Hippocampal astrocytes are necessary for antidepressant treatment of learned helplessness rats

Hippocampus
2010 | Journal article
DOI: 10.1002/hipo.20803
Contributors: Masaaki Iwata; Yukihiko Shirayama; Hisahito Ishida; Gen-i. Hazama; Kazuyuki Nakagome
Source: Self-asserted source
Masaaki Iwata via Crossref Metadata Search

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

Science
2010-08 | Journal article
DOI: 10.1126/science.1190287
Contributors: N. Li; B. Lee; R.-J. Liu; M. Banasr; J. M. Dwyer; M. Iwata; X.-Y. Li; G. Aghajanian; R. S. Duman
Source: Self-asserted source
Masaaki Iwata via Crossref Metadata Search

Altered levels of synapsin I, dopamine transporter, dynorphin A, and neuropeptide Y in the nucleus accumbens and striatum at post-puberty in rats treated neonatally with pregnenolone or DHEA

International Journal of Developmental Neuroscience
2009-10 | Journal article
DOI: 10.1016/j.ijdevneu.2009.06.005
Contributors: Katsumasa Muneoka; Masaaki Iwata; Yukihiko Shirayama
Source: Self-asserted source
Masaaki Iwata via Crossref Metadata Search

Infusion of neuropeptide Y into CA3 region of hippocampus produces antidepressant-like effect via Y1 receptor

Hippocampus
2007 | Journal article
DOI: 10.1002/hipo.20264
Contributors: Hisahito Ishida; Yukihiko Shirayama; Masaaki Iwata; Seiji Katayama; Ayaka Yamamoto; Ryuzou Kawahara; Kazuyuki Nakagome
Source: Self-asserted source
Masaaki Iwata via Crossref Metadata Search

Dopamine transporter density and behavioral response to methylphenidate in a hyperlocomotor rat model

Congenital Anomalies
2006-09 | Journal article
DOI: 10.1111/j.1741-4520.2006.00119.x
Contributors: Katsumasa Muneoka; Makiko Kuwagata; Masaaki Iwata; Yukihiko Shirayama; Tetsuo Ogawa; Morikuni Takigawa
Source: Self-asserted source
Masaaki Iwata via Crossref Metadata Search

Hippocampal synapsin I, growth-associated protein-43, and microtubule-associated protein-2 immunoreactivity in learned helplessness rats and antidepressant-treated rats

Neuroscience
2006-01 | Journal article
DOI: 10.1016/j.neuroscience.2006.04.060
Contributors: M. Iwata; Y. Shirayama; H. Ishida; R. Kawahara
Source: Self-asserted source
Masaaki Iwata via Crossref Metadata Search

A study of a dendritic marker, microtubule-associated protein 2 (MAP-2), in rats neonatally treated neurosteroids, pregnenolone and dehydroepiandrosterone (DHEA)

Neuroscience Letters
2005-10 | Journal article
DOI: 10.1016/j.neulet.2005.06.004
Contributors: Masaaki Iwata; Katsumasa T. Muneoka; Yukihiko Shirayama; Ayaka Yamamoto; Ryuzou Kawahara
Source: Self-asserted source
Masaaki Iwata via Crossref Metadata Search

Effects of acute administration of methamphetamine on Narp mRNA in rat brain

Addiction Biology
2005-09 | Journal article
DOI: 10.1080/13556219599222621
Contributors: Makoto Fukumoto; Masaaki Iwata; Chiko Shinbori; Gen-i Hazama; Yukihiko Shirayama; Ryuzou Kawahara
Source: Self-asserted source
Masaaki Iwata via Crossref Metadata Search

Subchronic treatment with imipramine ameliorates the decreased number in neuropeptide Y-positive cells in the hippocampus of learned helplessness rats

Brain Research
2005-06 | Journal article
DOI: 10.1016/j.brainres.2005.04.007
Contributors: Hisahito Ishida; Yukihiko Shirayama; Masaaki Iwata; Ryuzou Kawahara
Source: Self-asserted source
Masaaki Iwata via Crossref Metadata Search

Pregnenolone and dehydroepiandrosterone administration in neonatal rats alters the immunoreactivity of hippocampal synapsin I, neuropeptide Y and glial fibrillary acidic protein at post-puberty

Neuroscience
2005-01 | Journal article
DOI: 10.1016/j.neuroscience.2005.01.051
Contributors: Y. Shirayama; K.T. Muneoka; M. Iwata; H. Ishida; G. Hazama; R. Kawahara
Source: Self-asserted source
Masaaki Iwata via Crossref Metadata Search

Stress increases dynorphin immunoreactivity in limbic brain regions and dynorphin antagonism produces antidepressant-like effects

Journal of Neurochemistry
2004-09 | Journal article
DOI: 10.1111/j.1471-4159.2004.02589.x
Contributors: Yukihiko Shirayama; Hisahito Ishida; Masaaki Iwata; Gen-i Hazama; Ryuzou Kawahara; Ronald S. Duman
Source: Self-asserted source
Masaaki Iwata via Crossref Metadata Search
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