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Employment (1)

Janssen-Cilag s.r.o., a Johnson & Johnson company: Prague, CZ

Senior Principal Scientist (Manufacturing and Applied Statistics)
Employment
Source: Self-asserted source
Martin Otava

Education and qualifications (3)

Hasselt University: Hasselt, BE

PhD
Education
Source: Self-asserted source
Martin Otava

Hasselt University: Hasselt, BE

MSc
Education
Source: Self-asserted source
Martin Otava

Charles University: Prague, CZ

Mgr.
Education
Source: Self-asserted source
Martin Otava

Works (28)

Split‐plot experiments with replicated runs in pharmaceutical synthesis

Quality and Reliability Engineering International
2025-03 | Journal article
DOI: 10.1002/qre.3676
Contributors: Martin Otava; Kalliopi Mylona
Source: check_circle
Crossref

The impact of glidant addition on the loss-in-weight feeding of active pharmaceutical ingredients

International Journal of Pharmaceutics
2025-02 | Journal article
DOI: 10.1016/j.ijpharm.2025.125243
Contributors: Tom Verbeek; Alexander De Man; Melissa Debacker; Bram Bekaert; Bernd Van Snick; Martin Otava; Chris Vervaet; Valérie Vanhoorne
Source: check_circle
Crossref

The impact of glidants on the rheological properties of active pharmaceutical ingredients: A study of conventional and alternative flow enhancers

International Journal of Pharmaceutics
2025-02 | Journal article
DOI: 10.1016/j.ijpharm.2024.125121
Contributors: Tom Verbeek; Alexander De Man; Bernd Van Snick; Martin Otava; Chris Vervaet; Valérie Vanhoorne
Source: check_circle
Crossref

Dissolution Testing Strategies for Large Sample Sizes and Applications in Continuous Manufacturing

Dissolution Technologies
2024-08 | Journal article
DOI: 10.14227/dt310324p128
Part of ISSN: 1521-298X
Contributors: Martin Otava; Sylvaine Jacquart; Stan Altan
Source: Self-asserted source
Martin Otava

A comparative study of dry and wet top-down milling approaches for the preparation of microparticle suspensions

Powder Technology
2023-10 | Journal article
DOI: 10.1016/j.powtec.2023.118829
Part of ISSN: 0032-5910
Contributors: Fidel Méndez Cañellas; Noor Al-Rifai; Luis Padrela; Lidia Tajber; Tatsiana Khamiakova; Martin Otava; Robert Geertman
Source: Self-asserted source
Martin Otava

Process Analytical Technology, continuous manufacturing, and the development of a surrogate model for dissolution: a pharmaceutical manufacturing statistical engineering case study

Quality Engineering
2023-10-02 | Journal article
DOI: 10.1080/08982112.2023.2196556
Part of ISSN: 0898-2112
Part of ISSN: 1532-4222
Contributors: Stan Altan; Hans Coppenolle; Lynne Hare; Sarah Nielsen; Martin Otava
Source: Self-asserted source
Martin Otava

Bayesian model averaging in longitudinal studies using Bayesian variable selection methods

Communications in Statistics - Simulation and Computation
2023-06-03 | Journal article
DOI: 10.1080/03610918.2021.1914088
Part of ISSN: 0361-0918
Part of ISSN: 1532-4141
Contributors: Belay B Yimer; Martin Otava; Teshome Degefa; Delenasaw Yewhalaw; Ziv Shkedy
Source: Self-asserted source
Martin Otava

Survey and Recommendations on the Use of<i>P</i>-Values Driving Decisions in Nonclinical Pharmaceutical Applications

Statistics in Biopharmaceutical Research
2023-04-03 | Journal article
DOI: 10.1080/19466315.2022.2038258
Part of ISSN: 1946-6315
Contributors: Stan Altan; Dhammika Amaratunga; Javier Cabrera; Jeonifer Garren; Helena Geys; John Kolassa; David LeBlond; Dingzhou Li; Jason Liao; Jia Liu et al.
Source: Self-asserted source
Martin Otava

Predictive In-Vitro Dissolution for Real-Time Release Test (RTRT) for Continuous Manufacturing Process on Drug Product

Continuous Pharmaceutical Processing and Process Analytical Technology
2022-12-26 | Book chapter
Part of DOI: 10.1201/9781003149835
Part of ISBN: 9781003149835
Contributors: Zhenqui Shi; Stan Altan; Dwaine Banton; Sarah Nielsen; Martin Otava; Aaron Garrett; Matthew Walworth
Source: Self-asserted source
Martin Otava

A Bayesian Approach to Multivariate Conditional Regression Surrogate Modeling with Application to Real Time Release Testing

Case Studies in Bayesian Methods for Biopharmaceutical CMC
2022-10-26 | Book chapter
DOI: 10.1201/9781003255093-9
Part of ISBN: 9781003255093
Contributors: Stan Altan; Dwaine Banton; Hans Coppenolle; Martin Kovarik; Christian Schmid; Martin Otava
Source: Self-asserted source
Martin Otava

Confidence intervals for point‐of‐stabilization of content uniformity

Pharmaceutical Statistics
2022-09 | Journal article
DOI: 10.1002/pst.2207
Contributors: Zdeněk Hlávka; Petr Míchal; Martin Otava
Source: check_circle
Crossref

Communicating statistical conclusions of experiments to scientists

Quality and Reliability Engineering International
2020-12 | Journal article
DOI: 10.1002/qre.2697
Contributors: Martin Otava; Kalliopi Mylona
Source: check_circle
Crossref
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Sampling Considerations in Continuous Manufacturing

Pharmaceuitcal Engineering
2019 | Magazine article
Contributors: Plinio A. De los Santos; Jeffrey Hofer; Eric Jayjock; Timothy T. Kramer; Kevin R. Lief; Martin Otava
Source: Self-asserted source
Martin Otava

Development of a Human iPSC Cardiomyocyte-Based Scoring System for Cardiac Hazard Identification in Early Drug Safety De-risking

Stem Cell Reports
2018 | Journal article
DOI: 10.1016/j.stemcr.2018.11.007
Part of ISSN: 2213-6711
Contributors: Ivan Kopljar; Hua Rong Lu; Karel Van Ammel; Martin Otava; Fetene Tekle; Ard Teisman; David J. Gallacher
Source: Self-asserted source
Martin Otava via Crossref Metadata Search

Základní principy navrhování experimentů

Pokroky matematiky, fyziky a astronomie
2018 | Journal article
Source: Self-asserted source
Martin Otava

Objective interpretation of calcium transient screening data on hiPS-derived cardiomyocytes using a novel hazard prediction system

Journal of Pharmacological and Toxicological Methods
2018-09 | Journal article
DOI: 10.1016/j.vascn.2018.01.535
Part of ISSN: 1056-8719
Contributors: Ivan Kopljar; Hua Rong Lu; Karel Van Ammel; Martin Otava; Fetene Tekle; Ard Teisman; David J. Gallacher
Source: Self-asserted source
Martin Otava via Crossref Metadata Search

biclustGUI Shiny App

Applied Biclustering Methods for Big and High-Dimensional Data Using R
2017 | Book chapter
Part of ISBN: 978-1-4822-0823-8
Contributors: Ewoud De Troyer; Rudradev Sengupta; Martin Otava; Jitao David Zhang; Sebastian Kaiser; Aedin Culhane; Daniel Gusenleitner; Pierre Gestraud; Gabor Csardi; Sepp Hochreiter et al.
Source: Self-asserted source
Martin Otava

IsoGeneGUI: Multiple Approaches for Dose-Response Analysis of Microarray Data Using R

The R Journal
2017 | Journal article
DOI: 10.32614/rj-2017-002
Part of ISSN: 2073-4859
Contributors: Martin Otava; Rudradev Sengupta; Ziv Shkedy; Dan Lin; Setia Pramana; Tobias Verbeke; Philippe Haldermans; Ludwig,A. Hothorn; Daniel Gerhard; Rebecca,M. Kuiper et al.
Source: Self-asserted source
Martin Otava via Crossref Metadata Search

Pattern Discovery in High-Dimensional Problems

Applied biclustering methods for big and high dimensional data using R
2017 | Book chapter
Part of ISBN: 9781482208238
Contributors: Martin Otava; Geert R. Verheyen; Ziv Shkedy; Willem Talloen; Adetayo Kasim
Source: Self-asserted source
Martin Otava

Stručný průvodce statistickými intervaly

Pokroky matematiky, fyziky a astronomie
2017 | Journal article
Source: Self-asserted source
Martin Otava

The BiclustGUI Package

Applied biclustering methods for big and high dimensional data using R
2017 | Book chapter
Part of ISBN: 978-1-4822-0823-8
Contributors: Ewoud De Troyer; Martin Otava; Jitao David Zhang; Setia Pramana; Tatsiana Khamiakova; Sebastian Kaiser; Martin Sill; Aedin Culhane; Daniel Gusenleitner; Pierre Gestraud et al.
Source: Self-asserted source
Martin Otava

Identification of the minimum effective dose for normally distributed data using a Bayesian variable selection approach

Journal of Biopharmaceutical Statistics
2017-03 | Journal article
DOI: 10.1080/10543406.2017.1295247
Part of ISSN: 1054-3406
Contributors: Martin Otava; Ziv Shkedy; Ludwig A. Hothorn; Willem Talloen; Daniel Gerhard; Adetayo Kasim
Source: Self-asserted source
Martin Otava via Crossref Metadata Search

Multinomial additive hazard model to assess the disability burden using cross-sectional data

Biometrical Journal
2017-03 | Journal article
DOI: 10.1002/bimj.201600157
Part of ISSN: 0323-3847
Contributors: Renata T. C. Yokota; Herman Van Oyen; Caspar W. N. Looman; Wilma J. Nusselder; Martin Otava; Yimer Wasihun Kifle; Geert Molenberghs
Source: Self-asserted source
Martin Otava via Crossref Metadata Search

Identification of in vitro and in vivo disconnects using transcriptomic data

BMC Genomics
2015-08 | Journal article
DOI: 10.1186/s12864-015-1726-7
Part of ISSN: 1471-2164
Contributors: Martin Otava; Ziv Shkedy; Willem Talloen; Geert R Verheyen; Adetayo Kasim
Source: Self-asserted source
Martin Otava via Crossref Metadata Search

Prediction of gene expression in human using rat in vivo gene expression in Japanese Toxicogenomics Project

Systems Biomedicine
2014-10 | Journal article
DOI: 10.4161/sysb.29412
Part of ISSN: 2162-8130
Contributors: Martin Otava; Ziv Shkedy; Adetayo Kasim
Source: Self-asserted source
Martin Otava via Crossref Metadata Search

Dose–Response Modeling Under Simple Order Restrictions Using Bayesian Variable Selection Methods

Statistics in Biopharmaceutical Research
2014-07-03 | Journal article
DOI: 10.1080/19466315.2013.855472
Part of ISSN: 1946-6315
Source: Self-asserted source
Martin Otava

δ-Clustering of Monotone Profiles

Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R
2012-07-04 | Other
DOI: 10.1007/978-3-642-24007-2_9
Contributors: Adetayo Kasim; Suzy Van Sanden; Martin Otava; Sepp Hochreiter; Djork-Arné Clevert; Willem Talloen; Dan Lin
Source: Self-asserted source
Martin Otava via Crossref Metadata Search

Longitudinal trends with Improvement in Quality of Life after TVT, TVT O and Burch Colposuspension Procedures

Medical Science Monitor
2011 | Journal article
DOI: 10.12659/msm.881389
Part of ISSN: 1234-1010
Source: Self-asserted source
Martin Otava
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