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Loop profile: 978213
SciProfiles: 1780311

Biography

Histopathological comparison of eyes from patients with autosomal recessive retinitis pigmentosa caused by novel EYS mutations. Bonilha VL, Rayborn ME, Bell BA, Marino MJ, Pauer GJ, Beight CD, Chiang J, Traboulsi EI, Hollyfield JG, Hagstrom SA. Graefes Arch Clin Exp Ophthalmol. 2015 Feb;253(2):295-305. PMID: 25491159
Retinal Histopathology in Eyes from a Patient with Stargardt disease caused by Compound Heterozygous ABCA4 Mutations. Bonilha VL, Rayborn ME, Bell BA, Marino MJ, Fishman GA, Hollyfield JG. Ophthalmic Genet. 2014 Sep 29:1-11. PMID: 25265374
Oxidative stress regulation by DJ-1 in the retinal pigment epithelium. Bonilha VL, Rayborn ME, Yang X, Xie C, Cai H.
Adv Exp Med Biol. 2014;801:649-54. PMID: 24664754
Retinal pigment epithelium (RPE) cytoskeleton in vivo and in vitro. Bonilha VL. Exp Eye Res. 2014 Sep;126:38-45. PMID: 24090540
DJ-1-dependent regulation of oxidative stress in the retinal pigment epithelium (RPE). Shadrach KG, Rayborn ME, Hollyfield JG, Bonilha VL. PLoS One. 2013 Jul 2;8(7):e67983. PMID: 23844142
Retinal deimination and PAD2 levels in retinas from donors with age-related macular degeneration (AMD). Bonilha VL, Shadrach KG, Rayborn ME, Li Y, Pauer GJ, Hagstrom SA, Bhattacharya SK, Hollyfield JG. Exp Eye Res. 2013 Jun;111:71-8. PMID: 23562679
CD40 induces anti-Toxoplasma gondii activity in nonhematopoietic cells dependent on autophagy proteins. Van Grol J, Muniz-Feliciano L, Portillo JA, Bonilha VL, Subauste CS. Infect Immun. 2013 Jun;81(6):2002-11. PMID: 23509150
Age-related changes in the retinal pigment epithelium (RPE). Gu X, Neric NJ, Crabb JS, Crabb JW, Bhattacharya SK, Rayborn ME, Hollyfield JG, Bonilha VL. PLoS One. 2012;7(6):e38673. PMID: 22701690
Imaging human postmortem eyes with SLO and OCT. Bagheri N, Bell BA, Bonilha VL, Hollyfield JG. Adv Exp Med Biol. 2012;723:479-88. PMID: 22183367
Histopathology and functional correlations in a patient with a mutation in RPE65, the gene for retinol isomerase. Bonilha VL, Rayborn ME, Li Y, Grossman GH, Berson EL, Hollyfield JG. Invest Ophthalmol Vis Sci. 2011 Oct 28;52(11):8381-92. PMID: 21931134
Retinal pathology of a patient with Goldmann-Favre syndrome. Bonilha VL, Fishman GA, Rayborn ME, Hollyfield JG. Ophthalmic Genet. 2009 Dec;30(4):172-80. PMID: 19852574
Choroideremia: analysis of the retina from a female symptomatic carrier. Bonilha VL, Trzupek KM, Li Y, Francis PJ, Hollyfield JG, Rayborn ME, Smaoui N, Weleber RG. Ophthalmic Genet. 2008 Sep;29(3):99-110. PMID: 18766988
Age and disease-related structural changes in the retinal pigment epithelium. Bonilha VL. Clin Ophthalmol. 2008 Jun;2(2):413-24. PMID: 19668732
Retinal pigment epithelium lipofuscin proteomics. Ng KP, Gugiu B, Renganathan K, Davies MW, Gu X, Crabb JS, Kim SR, Rózanowska MB, Bonilha VL, Rayborn ME, Salomon RG, Sparrow JR, Boulton ME, Hollyfield JG, Crabb JW. Mol Cell Proteomics. 2008 Jul;7(7):1397-405. doi: 10.1074/mcp.M700525-MCP200. Epub 2008 Apr 24. PMID: 18436525
Age-related reduction in retinal deimination levels in the F344BN rat.
Bhattacharya SK, Sinicrope B, Rayborn ME, Hollyfield JG, Bonilha VL. Aging Cell. 2008 Jun;7(3):441-4. PMID: 18248664
Oxidative damage-induced inflammation initiates age-related macular degeneration. Hollyfield JG, Bonilha VL, Rayborn ME, Yang X, Shadrach KG, Lu L, Ufret RL, Salomon RG, Perez VL. Nat Med. 2008 Feb;14(2):194-8. PMID: 18223656
Semenogelins in the human retina: Differences in distribution and content between AMD and normal donor tissues.
Bonilha VL, Rayborn ME, Shadrach KG, Li Y, Lundwall A, Malm J, Hollyfield JG. Exp Eye Res. 2008 Jan;86(1):150-6. PMID: 18036592
The retinal pigment epithelium apical microvilli and retinal function. Bonilha VL, Rayborn ME, Bhattacharya SK, Gu X, Crabb JS, Crabb JW, Hollyfield JG. Adv Exp Med Biol. 2006;572:519-24. PMID: 17249618
CRALBP ligand and protein interactions. Wu Z, Bhattacharya SK, Jin Z, Bonilha VL, Liu T, Nawrot M, Teller DC, Saari JC, Crabb JW. Adv Exp Med Biol. 2006;572:477-83. PMID: 17249612
Proteomics implicates peptidyl arginine deiminase 2 and optic nerve citrullination in glaucoma pathogenesis.
Bhattacharya SK, Crabb JS, Bonilha VL, Gu X, Takahara H, Crabb JW. Invest Ophthalmol Vis Sci. 2006 Jun;47(6):2508-14. PMID: 16723463
Glucose utilization by the retinal pigment epithelium: evidence for rapid uptake and storage in glycogen, followed by glycogen utilization. Senanayake Pd, Calabro A, Hu JG, Bonilha VL, Darr A, Bok D, Hollyfield JG. Exp Eye Res. 2006 Aug;83(2):235-46. PMID: 16690055
Focus on molecules: ezrin. Bonilha VL. Exp Eye Res. 2007 Apr;84(4):613-4. PMID: 16616740
Characterization of semenogelin proteins in the human retina. Bonilha VL, Rayborn ME, Shadrach K, Lundwall A, Malm J, Bhattacharya SK, Crabb JW, Hollyfield JG. Exp Eye Res. 2006 Jul;83(1):120-7. PMID: 16545373
Microvilli defects in retinas of ezrin knockout mice. Bonilha VL, Rayborn ME, Saotome I, McClatchey AI, Hollyfield JG.
Exp Eye Res. 2006 Apr;82(4):720-9. PMID: 16289046

Activities

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Funding (2)

Geographic Atrophy: Changes in the RPE and inflammatory cell populations in the region of expanding lesions.

Grant
BrightFocus Foundation (Md., Md., US)
GRANT_NUMBER:

M2016079
Source: Self-asserted source
Vera Bonilha
grade
Preferred source (of 2)‎

RPE, aging and age-related macular degeneration: the role of oxidative stress

Grant
National Institutes of Health (Md., Md., US)
GRANT_NUMBER:

EY027750
Source: Self-asserted source
Vera Bonilha

Works (11)

Modeling aging and retinal degeneration with mitochondrial DNA mutation burden

Aging Cell
2024-11 | Journal article
DOI: 10.1111/acel.14282
Contributors: John Sturgis; Rupesh Singh; Quinn R. Caron; Ivy S. Samuels; Thomas Micheal Shiju; Aditi Mukkara; Paul Freedman; Vera L. Bonilha
Source: check_circle
Crossref

NR2E3 loss disrupts photoreceptor cell maturation and fate in human organoid models of retinal development

Journal of Clinical Investigation
2024-06-03 | Journal article
DOI: 10.1172/JCI173892
Contributors: Nathaniel K. Mullin; Laura R. Bohrer; Andrew P. Voigt; Lola P. Lozano; Allison T. Wright; Vera L. Bonilha; Robert F. Mullins; Edwin M. Stone; Budd A. Tucker
Source: check_circle
Crossref

Regulated cell death pathways in the sodium iodate model: Insights and implications for AMD

Experimental Eye Research
2024-01 | Journal article
DOI: 10.1016/j.exer.2023.109728
Contributors: Mala Upadhyay; Vera L. Bonilha
Source: check_circle
Crossref

Modeling aging and retinal degeneration with mitochondrial DNA mutation burden

2023-12-01 | Preprint
DOI: 10.1101/2023.11.30.569464
Contributors: John Sturgis; Rupesh Singh; Quinn Caron; Ivy S. Samuels; Thomas Micheal Shiju; Aditi Mukkara; Paul Freedman; Vera L. Bonilha
Source: check_circle
Crossref

CDCP1 regulates retinal pigmented epithelial barrier integrity for the development of experimental autoimmune uveitis

JCI Insight
2022-09-22 | Journal article
DOI: 10.1172/jci.insight.157038
Contributors: Lingjun Zhang; Nozha Borjini; Yu Lun; Sweta Parab; Gospel Asonye; Rupesh Singh; Brent A. Bell; Vera L. Bonilha; Andrei Ivanov; David A. Fox et al.
Source: check_circle
Crossref

Oxidation of DJ-1 Cysteines in Retinal Pigment Epithelium Function

International Journal of Molecular Sciences
2022-09-01 | Journal article
DOI: 10.3390/ijms23179938
Contributors: Sanghamitra Bhattacharyya; Johnathon Sturgis; Arvydas Maminishkis; Sheldon S. Miller; Vera L. Bonilha
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Evidence of complement dysregulation in outer retina of Stargardt disease donor eyes

Redox Biology
2020-10 | Journal article
DOI: 10.1016/j.redox.2020.101787
Contributors: Jane Hu; Gayle J. Pauer; Stephanie A. Hagstrom; Dean Bok; Meghan J. DeBenedictis; Vera L. Bonilha; Joe G. Hollyfield; Roxana A. Radu
Source: check_circle
Crossref

Oxidative stress in the retina and retinal pigment epithelium (RPE): Role of aging, and DJ-1

Redox Biology
2020-10 | Journal article
DOI: 10.1016/j.redox.2020.101623
Contributors: Mala Upadhyay; Caroline Milliner; Brent A. Bell; Vera L. Bonilha
Source: check_circle
Crossref

Data from: Oxidative stress in the retina and retinal pigment epithelium (RPE): role of aging, and DJ-1

Dryad
2020-08-20 | Dataset
DOI: 10.5061/dryad.xpnvx0kb6
Contributors: Vera Bonilha; Mala Upadhya; Caroline Milliner; Brent Bell
Source: check_circle
DataCite

Retinal angiotensin II and angiotensin-(1-7) response to hyperglycemia and an intervention with captopril

Journal of the Renin-Angiotensin-Aldosterone System
2018-07 | Journal article
DOI: 10.1177/1470320318789323
Contributors: Preenie deS Senanayake; Vera L Bonilha; John W Peterson; Yoshiro Yamada; Sadashiva S Karnik; Firouz Daneshgari; K Bridget Brosnihan; Joe G Hollyfield
Source: check_circle
Crossref

The BALB/c mouse: Effect of standard vivarium lighting on retinal pathology during aging

Experimental Eye Research
2015-06 | Journal article
DOI: 10.1016/j.exer.2015.04.009
Contributors: Brent A. Bell; Charles Kaul; Vera L. Bonilha; Mary E. Rayborn; Karen Shadrach; Joe G. Hollyfield
Source: check_circle
Crossref

Peer review (9 reviews for 8 publications/grants)

Review activity for Current eye research (1)
Review activity for Experimental Eye Research. (2)
Review activity for Eye and vision. (1)
Review activity for Free radical biology & medicine. (1)
Review activity for Life science alliance. (1)
Review activity for Nature communications (1)
Review activity for Photochemical & photobiological sciences. (1)
Review activity for PloS one. (1)
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