Personal information

learning and memory, neurodevelopmental disorders, mouse, hippocampus, cerebellum, social recognition memory

Activities

Employment (1)

Seoul National University College of Medicine: Seoul, KR

2016-09-01 to present | Professor (Department of Physiology, Department of Biomedical Sciences)
Employment
Source: Self-asserted source
Yong-Seok Lee

Education and qualifications (1)

Seoul National University: Seoul, KR

2000-03-01 to 2006-02-28 | Ph.D. (Interdisciplinary program in genetic engineering)
Education
Source: Self-asserted source
Yong-Seok Lee

Works (50 of 121)

Items per page:
Page 1 of 3

Hippocampal-cortical interactions in the consolidation of social memory

2024-10-12 | Preprint
Contributors: Gaeun Park; Min Seok Kim; Young-Beom Lee; Soonho Shin; Doyun Lee; Sang Jeong Kim; Yong-Seok Lee
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Crossref

Cerebellar systems consolidation driven by the temporal dynamics of Purkinje cell excitability

2024-07-25 | Preprint
Contributors: Jewoo Seo; Yong Gyu Kim; Yong-Seok Lee; Sang Jeong Kim
Source: check_circle
Crossref

Acquisition phase-specific contribution of climbing fiber transmission to cerebellum-dependent motor memory

2024-05-23 | Preprint
Contributors: Jewoo Seo; Seung Ha Kim; Jaegeon Lee; Min Seok Kim; Yong-Seok Lee; Sang Jeong Kim
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Crossref

Acquisition phase-specific contribution of climbing fiber transmission to cerebellum-dependent motor memory

2024-05-23 | Preprint
Contributors: Jewoo Seo; Seung Ha Kim; Jaegeon Lee; Min Seok Kim; Yong-Seok Lee; Sang Jeong Kim
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Crossref

SHP2 regulates GluA2 tyrosine phosphorylation required for AMPA receptor endocytosis and mGluR-LTD

Proceedings of the National Academy of Sciences
2024-04-30 | Journal article
Contributors: Sanghyeon Lee; Jungho Kim; Hyun-Hee Ryu; Hanbyul Jang; DoEun Lee; Seungha Lee; Jae-man Song; Yong-Seok Lee; Young Ho Suh
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Crossref

Intrinsic plasticity of Purkinje cell serves homeostatic regulation of fear memory

Molecular Psychiatry
2024-02 | Journal article
Contributors: Jaegeon Lee; Seung Ha Kim; Dong Cheol Jang; Mirae Jang; Myeong Seong Bak; Hyun Geun Shim; Yong-Seok Lee; Sang Jeong Kim
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Acquisition phase-specific contribution of climbing fiber transmission to cerebellum-dependent motor memory

2024-01-08 | Preprint
Contributors: Jewoo Seo; Seung Ha Kim; Jaegeon Lee; Min Seok Kim; Yong-Seok Lee; Sang Jeong Kim
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Crossref

Cntnap2-dependent molecular networks in autism spectrum disorder revealed through an integrative multi-omics analysis

Molecular Psychiatry
2023 | Journal article
EID:

2-s2.0-85140004388

Part of ISSN: 14765578 13594184
Contributors: Jang, W.E.; Park, J.H.; Park, G.; Bang, G.; Na, C.H.; Kim, J.Y.; Kim, K.-Y.; Kim, K.P.; Shin, C.Y.; An, J.-Y. et al.
Source: Self-asserted source
Yong-Seok Lee via Scopus - Elsevier

Dysregulation of the Wnt/β-catenin signaling pathway via Rnf146 upregulation in a VPA-induced mouse model of autism spectrum disorder

Experimental and Molecular Medicine
2023 | Journal article
EID:

2-s2.0-85166216335

Part of ISSN: 20926413 12263613
Contributors: Park, G.; Jang, W.E.; Kim, S.; Gonzales, E.L.; Ji, J.; Choi, S.; Kim, Y.; Park, J.H.; Mohammad, H.B.; Bang, G. et al.
Source: Self-asserted source
Yong-Seok Lee via Scopus - Elsevier

Effects of 20-hydroxyecdysone on UVB-induced photoaging in hairless mice

Biomedicine and Pharmacotherapy
2023 | Journal article
EID:

2-s2.0-85162839160

Part of ISSN: 19506007 07533322
Contributors: Lim, H.-S.; Yoon, K.; Lee, D.H.; Lee, Y.-S.; Chung, J.H.; Park, G.
Source: Self-asserted source
Yong-Seok Lee via Scopus - Elsevier

Self-aggregating Tau Fragments Recapitulate Pathologic Phenotypes and Neurotoxicity of Alzheimer's Disease in Mice

ChemRxiv
2023 | Other
EID:

2-s2.0-85152231007

Part of ISSN: 25732293
Contributors: Le, L.T.H.L.; Lee, J.; Im, D.; Park, S.; Hwang, K.-D.; Lee, J.H.; Jiang, Y.; Lee, Y.-S.; Suh, Y.H.; Kim, H.I. et al.
Source: Self-asserted source
Yong-Seok Lee via Scopus - Elsevier

Self-Aggregating Tau Fragments Recapitulate Pathologic Phenotypes and Neurotoxicity of Alzheimer's Disease in Mice

Advanced Science
2023 | Journal article
EID:

2-s2.0-85168329588

Part of ISSN: 21983844
Contributors: Le, L.T.H.L.; Lee, J.; Im, D.; Park, S.; Hwang, K.-D.; Lee, J.H.; Jiang, Y.; Lee, Y.-S.; Suh, Y.H.; Kim, H.I. et al.
Source: Self-asserted source
Yong-Seok Lee via Scopus - Elsevier

Cerebellar nuclei neurons projecting to the lateral parabrachial nucleus modulate classical fear conditioning

Cell Reports
2023-04 | Journal article
Contributors: Kyoung-Doo Hwang; Jinhee Baek; Hyun-Hee Ryu; Jaegeon Lee; Hyun Geun Shim; Sun Yong Kim; Sang Jeong Kim; Yong-Seok Lee
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Cerebellar Circuits for Classical Fear Conditioning

Frontiers in Cellular Neuroscience
2022 | Journal article
EID:

2-s2.0-85128471532

Part of ISSN: 16625102
Contributors: Hwang, K.-D.; Kim, S.J.; Lee, Y.-S.
Source: Self-asserted source
Yong-Seok Lee via Scopus - Elsevier

Chronic skin ultraviolet irradiation induces transcriptomic changes associated with microglial dysfunction in the hippocampus

Molecular Brain
2022 | Journal article
EID:

2-s2.0-85144536547

Part of ISSN: 17566606
Contributors: Yoon, K.-N.; Kim, Y.; Cui, Y.; Ji, J.; Park, G.; Chung, J.H.; Lee, Y.-S.; An, J.-Y.; Lee, D.H.
Source: Self-asserted source
Yong-Seok Lee via Scopus - Elsevier

Early stage ultraviolet irradiation damage to skin collagen can be suppressed by HPA axis control via controlled CYP11B

Biomedicine and Pharmacotherapy
2022 | Journal article
EID:

2-s2.0-85138354267

Part of ISSN: 19506007 07533322
Contributors: Lim, H.-S.; Lee, S.H.; Seo, H.; Lee, H.-H.; Yoon, K.; Kim, Y.-U.; Park, M.-K.; Chung, J.H.; Lee, Y.-S.; Lee, D.H. et al.
Source: Self-asserted source
Yong-Seok Lee via Scopus - Elsevier

Gradual decorrelation of CA3 ensembles associated with contextual discrimination learning is impaired by Kv1.2 insufficiency

Hippocampus
2022 | Journal article
EID:

2-s2.0-85122009618

Part of ISSN: 10981063 10509631
Contributors: Eom, K.; Lee, H.R.; Hyun, J.H.; An, H.; Lee, Y.-S.; Ho, W.-K.; Lee, S.-H.
Source: Self-asserted source
Yong-Seok Lee via Scopus - Elsevier

Novel measures of Morris water maze performance that use vector field maps to assess accuracy, uncertainty, and intention of navigational searches

Hippocampus
2022 | Journal article
EID:

2-s2.0-85122727642

Part of ISSN: 10981063 10509631
Contributors: Meenakshi, P.K.; Mehrotra, D.; Nruthyathi, N.; Almeida-Filho, D.; Lee, Y.-S.; Silva, A.; Balaji, J.
Source: Self-asserted source
Yong-Seok Lee via Scopus - Elsevier

Decreased in vivo glutamate/GABA ratio correlates with the social behavior deficit in a mouse model of autism spectrum disorder

Molecular Brain
2022-12 | Journal article
Contributors: Gaeun Park; Se Jin Jeon; In Ok Ko; Ji Hwan Park; Kyo Chul Lee; Min-Sik Kim; Chan Young Shin; Hyeonjin Kim; Yong-Seok Lee
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Cerebellar Bergmann Glia Integrating Noxious Information Modulate Nocifensive Behaviors

2022-05-19 | Preprint
Contributors: Seung Ha Kim; Jaegeon Lee; Seung-Eon Roh; Mirae Jang; Soobin Kim; Ji Hwan Lee; Jewoo Seo; Jae Yoon Hwang; Yong-Seok Lee; Eiji Shigetomi et al.
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Association between ARID2 and RAS-MAPK pathway in intellectual disability and short stature

Journal of Medical Genetics
2021 | Journal article
EID:

2-s2.0-85096305029

Part of ISSN: 14686244 00222593
Contributors: Kang, E.; Kang, M.; Ju, Y.; Lee, S.-J.; Lee, Y.-S.; Woo, D.-C.; Sung, Y.H.; Baek, I.-J.; Shim, W.H.; Son, W.-C. et al.
Source: Self-asserted source
Yong-Seok Lee via Scopus - Elsevier

Chronic ultraviolet irradiation to the skin dysregulates adrenal medulla and dopamine metabolism in vivo

Antioxidants
2021 | Journal article
EID:

2-s2.0-85107202829

Part of ISSN: 20763921
Contributors: Lim, H.-S.; Yoon, K.-N.; Chung, J.H.; Lee, Y.-S.; Lee, D.H.; Park, G.
Source: Self-asserted source
Yong-Seok Lee via Scopus - Elsevier

Dysfunction of NMDA receptors in neuronal models of an autism spectrum disorder patient with a DSCAM mutation and in Dscam-knockout mice

Molecular Psychiatry
2021 | Journal article
EID:

2-s2.0-85110498867

Part of ISSN: 14765578 13594184
Contributors: Lim, C.-S.; Kim, M.J.; Choi, J.E.; Islam, M.A.; Lee, Y.-K.; Xiong, Y.; Shim, K.-W.; Yang, J.-E.; Lee, R.U.; Lee, J. et al.
Source: Self-asserted source
Yong-Seok Lee via Scopus - Elsevier

Kdm3b haploinsufficiency impairs the consolidation of cerebellum-dependent motor memory in mice

Molecular Brain
2021 | Journal article
EID:

2-s2.0-85108989702

Part of ISSN: 17566606
Contributors: Kim, Y.G.; Bak, M.S.; Kim, A.; Kim, Y.; Chae, Y.-C.; Kim, Y.L.; Chun, Y.-S.; An, J.-Y.; Seo, S.-B.; Kim, S.J. et al.
Source: Self-asserted source
Yong-Seok Lee via Scopus - Elsevier

Novel measures of Morris water maze performance that use vector field maps to assess accuracy, uncertainty, and intention of navigational searches

bioRxiv
2021 | Other
EID:

2-s2.0-85112667909

Part of ISSN: 26928205
Contributors: Meenakshi, P.; Mehrotra, D.; Nruthyathi, N.; Almeida-Filho, D.; Lee, Y.-S.; Silva, A.J.; Balaji, J.
Source: Self-asserted source
Yong-Seok Lee via Scopus - Elsevier

Social isolation impairs the prefrontal-nucleus accumbens circuit subserving social recognition in mice

Cell Reports
2021-05 | Journal article
Contributors: Gaeun Park; Changhyeon Ryu; Soobin Kim; Se Jin Jeong; Ja Wook Koo; Yong-Seok Lee; Sang Jeong Kim
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Ablation of STAT3 in Purkinje cells reorganizes cerebellar synaptic plasticity in long-term fear memory network

eLife
2021-01-18 | Journal article
Contributors: Jeong-Kyu Han; Sun-Ho Kwon; Yong Gyu Kim; Jaeyong Choi; Jong-Il Kim; Yong-Seok Lee; Sang-Kyu Ye; Sang Jeong Kim
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Ablation of STAT3 in Purkinje cells reorganizes cerebellar synaptic plasticity in long-term fear memory network

bioRxiv
2020 | Other
EID:

2-s2.0-85098896683

Part of ISSN: 26928205
Contributors: Han, J.-K.; Kwon, S.-H.; Kim, Y.G.; Choi, J.; Kim, J.-I.; Lee, Y.-S.; Ye, S.-K.; Kim, S.J.
Source: Self-asserted source
Yong-Seok Lee via Scopus - Elsevier

Autophagy pathway upregulation in a human iPSC-derived neuronal model of Cohen syndrome with VPS13B missense mutations

Molecular Brain
2020 | Journal article
EID:

2-s2.0-85084328913

Part of ISSN: 17566606
Contributors: Lee, Y.-K.; Lee, S.-K.; Choi, S.; Huh, Y.H.; Kwak, J.-H.; Lee, Y.-S.; Jang, D.-J.; Lee, J.-H.; Lee, K.; Kaang, B.-K. et al.
Source: Self-asserted source
Yong-Seok Lee via Scopus - Elsevier

Cohen syndrome patient ipsc-derived neurospheres and forebrain-like glutamatergic neurons reveal reduced proliferation of neural progenitor cells and altered expression of synapse genes

Journal of Clinical Medicine
2020 | Journal article
EID:

2-s2.0-85110486494

Part of ISSN: 20770383
Contributors: Lee, Y.-K.; Hwang, S.-K.; Lee, S.-K.; Yang, J.-E.; Kwak, J.-H.; Seo, H.; Ahn, H.; Lee, Y.-S.; Kim, J.; Lim, C.-S. et al.
Source: Self-asserted source
Yong-Seok Lee via Scopus - Elsevier

Connecting the dots between SHP2 and glutamate receptors

Korean Journal of Physiology and Pharmacology
2020 | Journal article
EID:

2-s2.0-85088493776

Part of ISSN: 20933827 12264512
Contributors: Ryu, H.-H.; Kim, S.Y.; Lee, Y.-S.
Source: Self-asserted source
Yong-Seok Lee via Scopus - Elsevier

Identification of a novel Shank2 transcriptional variant in Shank2 knockout mouse model of autism spectrum disorder

Molecular Brain
2020 | Journal article
EID:

2-s2.0-85083071553

Part of ISSN: 17566606
Contributors: Lee, Y.-S.; Yu, N.-K.; Chun, J.; Yang, J.-E.; Lim, C.-S.; Kim, H.; Park, G.; Lee, J.-A.; Lee, K.; Kaang, B.-K. et al.
Source: Self-asserted source
Yong-Seok Lee via Scopus - Elsevier

Kv1.2 contributes to pattern separation by regulating the hippocampal CA3 neuronal ensemble size

bioRxiv
2020 | Other
EID:

2-s2.0-85098838333

Part of ISSN: 26928205
Contributors: Eom, K.; Lee, H.R.; Hyun, J.H.; Ryu, H.-H.; Lee, Y.-S.; Lee, I.; Ho, W.-K.; Lee, S.-H.
Source: Self-asserted source
Yong-Seok Lee via Scopus - Elsevier

Neuron type-specific expression of a mutant KRAS impairs hippocampal-dependent learning and memory

Scientific Reports
2020 | Journal article
EID:

2-s2.0-85093094532

Part of ISSN: 20452322
Contributors: Ryu, H.-H.; Kang, M.; Hwang, K.-D.; Jang, H.B.; Kim, S.J.; Lee, Y.-S.
Source: Self-asserted source
Yong-Seok Lee via Scopus - Elsevier

Persistent Activity of Metabotropic Glutamate Receptor 5 in the Periaqueductal Gray Constrains Emergence of Chronic Neuropathic Pain

Current Biology
2020 | Journal article
EID:

2-s2.0-85092140544

Part of ISSN: 18790445 09609822
Contributors: Chung, G.; Shim, H.G.; Kim, C.Y.; Ryu, H.-H.; Jang, D.C.; Kim, S.H.; Lee, J.; Kim, C.-E.; Kim, Y.K.; Lee, Y.-S. et al.
Source: Self-asserted source
Yong-Seok Lee via Scopus - Elsevier

Quantitative Proteomics Reveals Distinct Molecular Signatures of Different Cerebellum-Dependent Learning Paradigms

Journal of Proteome Research
2020 | Journal article
EID:

2-s2.0-85084190435

Part of ISSN: 15353907 15353893
Contributors: Kim, Y.G.; Woo, J.; Park, J.; Kim, S.; Lee, Y.-S.; Kim, Y.; Kim, S.J.
Source: Self-asserted source
Yong-Seok Lee via Scopus - Elsevier

Reduced chronic restraint stress in mice overexpressing hyperactive proteasomes in the forebrain

Molecular Brain
2020 | Journal article
EID:

2-s2.0-85077785849

Part of ISSN: 17566606
Contributors: Kim, J.H.; Kim, A.; Yun, Y.; Park, S.; Lee, J.H.; Lee, Y.-S.; Lee, M.J.
Source: Self-asserted source
Yong-Seok Lee via Scopus - Elsevier

Rho guanine nucleotide exchange factor 4 (Arhgef4) deficiency enhances spatial and object recognition memory

Experimental Neurobiology
2020 | Journal article
EID:

2-s2.0-85097455886

Part of ISSN: 20938144 12262560
Contributors: Yoo, K.-S.; Lee, K.; Lee, Y.-S.; Oh, W.-J.; Kim, H.K.
Source: Self-asserted source
Yong-Seok Lee via Scopus - Elsevier

Social isolation impairs the prefrontal-nucleus accumbens circuit subserving social recognition in mice

2020-10-09 | Preprint
Contributors: Gaeun Park; Changhyeon Ryu; Soobin Kim; Yong-Seok Lee; Sang Jeong Kim
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Excitatory neuron–specific SHP2-ERK signaling network regulates synaptic plasticity and memory

Science Signaling
2019 | Journal article
EID:

2-s2.0-85062597374

Part of ISSN: 19379145 19450877
Contributors: Ryu, H.-H.; Kim, T.; Kim, J.-W.; Kang, M.; Park, P.; Kim, Y.G.; Kim, H.; Ha, J.; Choi, J.E.; Lee, J. et al.
Source: Self-asserted source
Yong-Seok Lee via Scopus - Elsevier

Spatial learning and motor deficits in vacuolar protein sorting-associated protein 13b (Vps13b) mutant mouse

Experimental Neurobiology
2019 | Journal article
EID:

2-s2.0-85073350291

Part of ISSN: 20938144 12262560
Contributors: Kim, M.J.; Lee, R.U.; Oh, J.; Choi, J.E.; Kim, H.; Lee, K.; Hwang, S.-K.; Lee, J.-H.; Lee, J.-A.; Kaang, B.-K. et al.
Source: Self-asserted source
Yong-Seok Lee via Scopus - Elsevier

Enriched expression of NF1 in inhibitory neurons in both mouse and human brain

Molecular Brain
2019-12 | Journal article
Contributors: Hyun-Hee Ryu; Minkyung Kang; Jinsil Park; Sung-Hye Park; Yong-Seok Lee
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The impact of RASopathy-associated mutations on CNS development in mice and humans

Molecular Brain
2019-12 | Journal article
Contributors: Minkyung Kang; Yong-Seok Lee
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Adenomatous polyposis coli-stimulated GEF 1 (Asef1) is a negative regulator of excitatory synaptic function

Journal of Neurochemistry
2018 | Journal article
EID:

2-s2.0-85056770281

Part of ISSN: 14714159 00223042
Contributors: Oh, J.-Y.; Lim, C.-S.; Yoo, K.-S.; Park, H.; Park, Y.S.; Kim, E.-G.; Lee, Y.-S.; Kaang, B.-K.; Kim, H.K.
Source: Self-asserted source
Yong-Seok Lee via Scopus - Elsevier

Erratum: Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASM (Neuron (2018) 100(1) (167–182.e9), (S0896627318307839) (10.1016/j.neuron.2018.09.010))

Neuron
2018 | Journal article
EID:

2-s2.0-85055620933

Part of ISSN: 10974199 08966273
Contributors: Park, M.H.; Lee, J.Y.; Park, K.H.; Jung, I.K.; Kim, K.-T.; Lee, Y.-S.; Ryu, H.-H.; Jeong, Y.; Kang, M.; Schwaninger, M. et al.
Source: Self-asserted source
Yong-Seok Lee via Scopus - Elsevier

Remote memory and cortical synaptic plasticity require neuronal CCCTC-binding factor (CTCF)

Journal of Neuroscience
2018 | Journal article
EID:

2-s2.0-85050796912

Part of ISSN: 15292401 02706474
Contributors: Kim, S.; Yu, N.-K.; Shim, K.-W.; Kim, J.-I.; Kim, H.; Han, D.H.; Choi, J.E.; Lee, S.-W.; Choi, D.I.; Kim, M.W. et al.
Source: Self-asserted source
Yong-Seok Lee via Scopus - Elsevier

The emerging concept of intrinsic plasticity: Activity-dependent modulation of intrinsic excitability in cerebellar Purkinje cells and motor learning

Experimental Neurobiology
2018 | Journal article
EID:

2-s2.0-85050071907

Part of ISSN: 20938144 12262560
Contributors: Shim, H.G.; Lee, Y.-S.; Kim, S.J.
Source: Self-asserted source
Yong-Seok Lee via Scopus - Elsevier

Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASM

Neuron
2018 | Journal article
EID:

2-s2.0-85054143700

Part of ISSN: 10974199 08966273
Contributors: Park, M.H.; Lee, J.Y.; Park, K.H.; Jung, I.K.; Kim, K.-T.; Lee, Y.-S.; Ryu, H.-H.; Jeong, Y.; Kang, M.; Schwaninger, M. et al.
Source: Self-asserted source
Yong-Seok Lee via Scopus - Elsevier

Enhancing inhibitory synaptic function reverses spatial memory deficits in Shank2 mutant mice

Neuropharmacology
2017 | Journal article
EID:

2-s2.0-84994187846

Part of ISSN: 18737064 00283908
Contributors: Lim, C.-S.; Kim, H.; Yu, N.-K.; Kang, S.J.; Kim, T.; Ko, H.-G.; Lee, J.; Yang, J.-E.; Ryu, H.-H.; Park, T. et al.
Source: Self-asserted source
Yong-Seok Lee via Scopus - Elsevier

Noonan syndrome-associated SHP2 mutation differentially modulates the expression of postsynaptic receptors according to developmental maturation

Neuroscience Letters
2017 | Journal article
EID:

2-s2.0-85017463593

Part of ISSN: 18727972 03043940
Contributors: Oh, J.-Y.; Rhee, S.; Silva, A.J.; Lee, Y.-S.; Kim, H.K.
Source: Self-asserted source
Yong-Seok Lee via Scopus - Elsevier
Items per page:
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Peer review (56 reviews for 6 publications/grants)

Review activity for Experimental and molecular medicine (10)
Review activity for Molecular brain (39)
Review activity for Nature communications (2)
Review activity for Neurobiology of disease. (1)
Review activity for Neuropsychopharmacology. (2)
Review activity for The journal of neuroscience : (2)