Personal information

Activities

Employment (4)

University of Glasgow: Glasgow, Glasgow, GB

2018-09-01 to present | Professor of Cell Signalling (Institute of Cancer Sciences)
Employment
Source: Self-asserted source
Gareth Inman

CRUK Beatson Institute: Glasgow, Glasgow, GB

2018-09-01 to present | Director of Research Strategy
Employment
Source: Self-asserted source
Gareth Inman

University of Dundee: Dundee, Dundee, GB

2010-03-01 to 2018-08-31 | Professor of Cell Signalling (School of Medicine)
Employment
Source: Self-asserted source
Gareth Inman

Beatson Institute for Cancer Research: Glasgow, Glasgow, GB

2003-01-09 to 2010-09-30 | Junior Group Leader
Employment
Source: Self-asserted source
Gareth Inman

Education and qualifications (1)

University of London: London, London, GB

1990-01-10 to 1995-03-01 | PhD (Imperial College (Ludwig Institute for Cancer Research))
Qualification
Source: Self-asserted source
Gareth Inman

Professional activities (1)

University of Dundee: Dundee, Dundee, GB

2018-09-01 to present | Honorary Professor
Invited position
Source: Self-asserted source
Gareth Inman

Funding (5)

Characterisation of C1ORF106 a novel mediator of TGFbeta driven tumour promotion

2014-08-01 to 2016-12-31 | Grant
Worldwide Cancer Research (St Andrews, GB)
GRANT_NUMBER:

WCR-14-1156

Source: Self-asserted source
Gareth Inman via DimensionsWizard

Crosstalk between oncogenic BRAF and TGF-ß signalling during tumourigenesis

2011-08-01 to 2014-07-31 | Grant
Worldwide Cancer Research (St Andrews, GB)
GRANT_NUMBER:

WCR-11-0788

Source: Self-asserted source
Gareth Inman via DimensionsWizard

Mechanisms of transforming growth factor-beta signalling in growth control, apoptosis and tumour progression

2004-03-01 to 2009-02-28 | Grant
Cancer Research UK (London, GB)
GRANT_NUMBER:

CRUK-A4184

Source: Self-asserted source
Gareth Inman via DimensionsWizard

Mechanisms of Tranforming Growth Factor-Beta Signalling in Growth Control, Apoptosis and Tumour Progression

2003-10-01 to 2009-09-30 | Grant
Worldwide Cancer Research (St Andrews, GB)
GRANT_NUMBER:

WCR-03-0900

Source: Self-asserted source
Gareth Inman via DimensionsWizard

TGF - beta signalling pathways and cancer

Grant
Cancer Research UK (London, GB)
GRANT_NUMBER:

CRUK-A4252

Source: Self-asserted source
Gareth Inman via DimensionsWizard

Works (50 of 58)

Items per page:
Page 1 of 2

<i>C1orf106</i> (<i>INAVA</i>) Is a SMAD3-Dependent TGF-β Target Gene That Promotes Clonogenicity and Correlates with Poor Prognosis in Breast Cancer

Cells
2024-09 | Journal article | Author
Contributors: Lauren S. Strathearn; Lindsay Claire Spender; Christina Schoenherr; Susan Mason; Ruairidh Edwards; Karen Blyth; Gareth Inman
Source: check_circle
Multidisciplinary Digital Publishing Institute

Clinicopathological Determinants of Recurrence Risk and Survival in Mucinous Ovarian Carcinoma

Cancers
2021-11 | Journal article | Author
Contributors: Robert L Hollis; Lorna J. Stillie; Samantha Hopkins; Clare Bartos; Michael churchman; Tzyvia Rye; Fiona Nussey; Scott Fegan; Rachel Nirsimloo; Gareth Inman et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

A Unique Panel of Patient-Derived Cutaneous Squamous Cell Carcinoma Cell Lines Provides a Preclinical Pathway for Therapeutic Testing.

International journal of molecular sciences
2019-07 | Journal article
Contributors: Hassan S; Purdie KJ; Wang J; Harwood CA; Proby CM; Pourreyron C; Mladkova N; Nagano A; Dhayade S; Athineos D et al.
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

Azathioprine: friend or foe?

The British journal of dermatology
2019-05 | Journal article
Contributors: Leigh IM; Proby CM; Inman GJ; Harwood CA
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

Preclinical Evaluation of AZ12601011 and AZ12799734, Inhibitors of Transforming Growth Factor β Superfamily Type 1 Receptors.

Molecular pharmacology
2018-11 | Journal article
Contributors: Spender LC; Ferguson GJ; Hughes GD; Davies BR; Goldberg FW; Herrera B; Taylor RG; Strathearn LS; Sansom OJ; Barry ST et al.
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

Differential expression of secreted factors SOSTDC1 and ADAMTS8 cause pro-fibrotic changes in linear morphoea fibroblasts.

The British journal of dermatology
2018-10 | Journal article
Contributors: Badshah II; Brown S; Weibel L; Rose A; Way B; Sebire N; Inman G; Harper J; Kinsler V; O'Shaughnessy R
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature.

Nature communications
2018-09 | Journal article
Contributors: Inman GJ; Wang J; Nagano A; Alexandrov LB; Purdie KJ; Taylor RG; Sherwood V; Thomson J; Hogan S; Spender LC et al.
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

The Role of Human Papillomaviruses and Polyomaviruses in BRAF-Inhibitor Induced Cutaneous Squamous Cell Carcinoma and Benign Squamoproliferative Lesions.

Frontiers in Microbiology
2018-08 | Journal article
Contributors: Purdie KJ; Proby CM; Rizvi H; Griffin H; Doorbar J; Sommerlad M; Feltkamp MC; der Meijden EV; Inman GJ; South AP et al.
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma.

Oncotarget
2018-02 | Journal article
Contributors: Rose AM; Spender LC; Stephen C; Mitchell A; Rickaby W; Bray S; Evans AT; Dayal J; Purdie KJ; Harwood CA et al.
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development.

Scientific reports
2017-08 | Journal article
Contributors: Phillips TJ; Scott H; Menassa DA; Bignell AL; Sood A; Morton JS; Akagi T; Azuma K; Rogers MF; Gilmore CE et al.
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis.

Cell death and differentiation
2017-06 | Journal article
Contributors: Cammareri P; Vincent DF; Hodder MC; Ridgway RA; Murgia C; Nobis M; Campbell AD; Varga J; Huels DJ; Subramani C et al.
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

Targeting BRAF-mutant tumours with TGFBR1 inhibitors.

Aging
2017-01 | Journal article
Contributors: Spender LC; Inman GJ
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling.

Nature communications
2017-01 | Journal article
Contributors: Hurst LA; Dunmore BJ; Long L; Crosby A; Al-Lamki R; Deighton J; Southwood M; Yang X; Nikolic MZ; Herrera B et al.
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

Fatal attractions? Correlations of CXCL12-CXCR4-CXCR7 expression with disease progression in melanoma and Kaposi sarcoma.

The British journal of dermatology
2016-12 | Journal article
Contributors: Spender LC; Inman GJ
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

Mutational activation of BRAF confers sensitivity to transforming growth factor beta inhibitors in human cancer cells.

Oncotarget
2016-12 | Journal article
Contributors: Spender LC; Ferguson GJ; Liu S; Cui C; Girotti MR; Sibbet G; Higgs EB; Shuttleworth MK; Hamilton T; Lorigan P et al.
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

Loss of TGF-β signaling drives cSCC from skin stem cells - More evidence.

Cell cycle (Georgetown, Tex.)
2016-11 | Journal article
Contributors: Rose AM; Sansom OJ; Inman GJ
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma.

Nature communications
2016-08 | Journal article
Contributors: Cammareri P; Rose AM; Vincent DF; Wang J; Nagano A; Libertini S; Ridgway RA; Athineos D; Coates PJ; McHugh A et al.
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

Exosome-mediated transfer from the tumor microenvironment increases TGFβ signaling in squamous cell carcinoma.

American journal of translational research
2016-05 | Journal article
Contributors: Languino LR; Singh A; Prisco M; Inman GJ; Luginbuhl A; Curry JM; South AP
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

The Promise of Genomics and the Development of Targeted Therapies for Cutaneous Squamous Cell Carcinoma.

Acta dermato-venereologica
2016-01 | Journal article
Contributors: Harwood CA; Proby CM; Inman GJ; Leigh IM
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

E3 ubiquitin ligase HOIP attenuates apoptotic cell death induced by cisplatin.

Cancer research
2014-03 | Journal article
Contributors: MacKay C; Carroll E; Ibrahim AFM; Garg A; Inman GJ; Hay RT; Alpi AF
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

Developments in Burkitt's lymphoma: novel cooperations in oncogenic MYC signaling.

Cancer management and research
2014-01 | Journal article
Contributors: Spender LC; Inman GJ
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

BMP9 is a proliferative and survival factor for human hepatocellular carcinoma cells.

PloS one
2013-07 | Journal article
Contributors: Herrera B; García-Álvaro M; Cruz S; Walsh P; Fernández M; Roncero C; Fabregat I; Sánchez A; Inman GJ
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

A complex secretory program orchestrated by the inflammasome controls paracrine senescence.

Nature cell biology
2013-06 | Journal article
Contributors: Acosta JC; Banito A; Wuestefeld T; Georgilis A; Janich P; Morton JP; Athineos D; Kang TW; Lasitschka F; Andrulis M et al.
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

Methylated tissue factor pathway inhibitor 2 (TFPI2) DNA in serum is a biomarker of metastatic melanoma.

The Journal of investigative dermatology
2013-02 | Journal article
Contributors: Lo Nigro C; Wang H; McHugh A; Lattanzio L; Matin R; Harwood C; Syed N; Hatzimichael E; Briasoulis E; Merlano M et al.
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

Exogenous heparin binds and inhibits bone morphogenetic protein 6 biological activity.

International orthopaedics
2013-01 | Journal article
Contributors: Brkljacic J; Pauk M; Erjavec I; Cipcic A; Grgurevic L; Zadro R; Inman GJ; Vukicevic S
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

Transforming growth factor-β directly induces p53-up-regulated modulator of apoptosis (PUMA) during the rapid induction of apoptosis in myc-driven B-cell lymphomas.

The Journal of biological chemistry
2012-12 | Journal article
Contributors: Spender LC; Carter MJ; O'Brien DI; Clark LJ; Yu J; Michalak EM; Happo L; Cragg MS; Inman GJ
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

Crosstalk between p53 and TGF-β Signalling.

Journal of signal transduction
2012-03 | Journal article
Contributors: Elston R; Inman GJ
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

NT5E (CD73) is epigenetically regulated in malignant melanoma and associated with metastatic site specificity.

British journal of cancer
2012-03 | Journal article
Contributors: Wang H; Lee S; Nigro CL; Lattanzio L; Merlano M; Monteverde M; Matin R; Purdie K; Mladkova N; Bergamaschi D et al.
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

Phosphoinositide 3-kinase/AKT/mTORC1/2 signaling determines sensitivity of Burkitt's lymphoma cells to BH3 mimetics.

Molecular cancer research : MCR
2012-01 | Journal article
Contributors: Spender LC; Inman GJ
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

Inhibition of germinal centre apoptotic programmes by epstein-barr virus.

Advances in hematology
2011-10 | Journal article
Contributors: Spender LC; Inman GJ
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

Switching TGFβ from a tumor suppressor to a tumor promoter.

Current opinion in genetics & development
2011-01 | Journal article
Contributors: Inman GJ
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

Differing contributions of LIMK and ROCK to TGFβ-induced transcription, motility and invasion.

European journal of cell biology
2010-11 | Journal article
Contributors: Morin P; Wickman G; Munro J; Inman GJ; Olson MF
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

Regulation of cell proliferation and apoptosis in neuroblastoma cells by ccp1, a FGF2 downstream gene.

BMC cancer
2010-11 | Journal article
Contributors: Pellicano F; Thomson RE; Inman GJ; Iwata T
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter.

The Journal of clinical investigation
2010-07 | Journal article
Contributors: Hannigan A; Smith P; Kalna G; Lo Nigro C; Orange C; O'Brien DI; Shah R; Syed N; Spender LC; Herrera B et al.
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

Autocrine bone morphogenetic protein-9 signals through activin receptor-like kinase-2/Smad1/Smad4 to promote ovarian cancer cell proliferation.

Cancer research
2009-12 | Journal article
Contributors: Herrera B; van Dinther M; Ten Dijke P; Inman GJ
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

Targeting the BCL-2 family in malignancies of germinal centre origin.

Expert opinion on therapeutic targets
2009-12 | Journal article
Contributors: Spender LC; Inman GJ
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

A rapid and sensitive bioassay for the simultaneous measurement of multiple bone morphogenetic proteins. Identification and quantification of BMP4, BMP6 and BMP9 in bovine and human serum.

BMC cell biology
2009-03 | Journal article
Contributors: Herrera B; Inman GJ
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

TGF-beta induces apoptosis in human B cells by transcriptional regulation of BIK and BCL-XL.

Cell death and differentiation
2009-01 | Journal article
Contributors: Spender LC; O'Brien DI; Simpson D; Dutt D; Gregory CD; Allday MJ; Clark LJ; Inman GJ
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

TGF-beta-mediated activation of RhoA signalling is required for efficient (V12)HaRas and (V600E)BRAF transformation.

Oncogene
2008-12 | Journal article
Contributors: Fleming YM; Ferguson GJ; Spender LC; Larsson J; Karlsson S; Ozanne BW; Grosse R; Inman GJ
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

TGF-beta induces growth arrest in Burkitt lymphoma cells via transcriptional repression of E2F-1.

The Journal of biological chemistry
2008-11 | Journal article
Contributors: Spender LC; Inman GJ
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

NCAM is at the heart of reciprocal regulation of E-cadherin- and integrin-mediated adhesions via signaling modulation.

Developmental cell
2008-10 | Journal article
Contributors: Frame MC; Inman GJ
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

TSC22 in mammary gland development and breast cancer.

Breast cancer research : BCR
2008-05 | Journal article
Contributors: Huser C; Heath V; Pringle M; Bell A; Crighton D; Ryan K; Inman G; Stein T; Gusterson B
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

Linking Smads and transcriptional activation.

The Biochemical journal
2005-02 | Journal article
Contributors: Inman GJ
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

Stoichiometry of active smad-transcription factor complexes on DNA.

The Journal of biological chemistry
2002-10 | Journal article
Contributors: Inman GJ; Hill CS
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity.

Molecular cell
2002-08 | Journal article
Contributors: Inman GJ; Nicolás FJ; Hill CS
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7.

Molecular pharmacology
2002-07 | Journal article
Contributors: Inman GJ; Nicolás FJ; Callahan JF; Harling JD; Gaster LM; Reith AD; Laping NJ; Hill CS
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

A novel Xenopus Smad-interacting forkhead transcription factor (XFast-3) cooperates with XFast-1 in regulating gastrulation movements.

Development (Cambridge, England)
2002-06 | Journal article
Contributors: Howell M; Inman GJ; Hill CS
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif.

The EMBO journal
2002-01 | Journal article
Contributors: Randall RA; Germain S; Inman GJ; Bates PA; Hill CS
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

Activators of the Epstein-Barr virus lytic program concomitantly induce apoptosis, but lytic gene expression protects from cell death.

Journal of virology
2001-03 | Journal article
Contributors: Inman GJ; Binné UK; Parker GA; Farrell PJ; Allday MJ
Source: Self-asserted source
Gareth Inman via Europe PubMed Central

Apoptosis induced by TGF-beta 1 in Burkitt's lymphoma cells is caspase 8 dependent but is death receptor independent.

Journal of immunology (Baltimore, Md. : 1950)
2000-09 | Journal article
Contributors: Inman GJ; Allday MJ
Source: Self-asserted source
Gareth Inman via Europe PubMed Central
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Peer review (4 reviews for 2 publications/grants)

Review activity for Advanced science. (1)
Review activity for Nature communications (3)