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Endocrinology Web profile

Keywords

Cholesterol, Diabetes, Alzheimer's disease, Cognitive Decline, Metabolism

Countries

United States

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Employment (3)

University of Virginia Health System: Charlottesville, US

2024-07-01 to present | Associate Professor (Medicine and Neuroscience)
Employment
Source: Self-asserted source
Heather Ferris

UVA Health: Charlottesville, VA, US

2017-05 to 2025-06-30 | Assistant Professor (Medicine and Neuroscience)
Employment
Source: Self-asserted source
Heather Ferris

Joslin Diabetes Center: Boston, MA, US

2012-08 to 2017-04 | Research Associate and Staff Physician (Integrative Physiology and Metabolism)
Employment
Source: Self-asserted source
Heather Ferris

Education and qualifications (5)

Beth Israel Deaconess Medical Center: Boston, MA, US

2009-07 to 2012-06 | Fellow (Endocrinology and Metabolism)
Education
Source: Self-asserted source
Heather Ferris

University of Pittsburgh Medical Center: Pittsburgh, PA, US

2006-07 to 2009-06 | Residency (Internal Medicine)
Education
Source: Self-asserted source
Heather Ferris

University of Virginia Health System: Charlottesville, VA, US

1998-09 to 2006-05 | MD (School of Medicine)
Education
Source: Self-asserted source
Heather Ferris

University of Virginia: Charlottesville, VA, US

1998-06 to 2005 | PhD (Molecular Physiology and Biological Physics)
Education
Source: Self-asserted source
Heather Ferris

College of Charleston: Charleston, SC, US

1994-09 to 1998-05 | BS- Biochemistry, BA- Chemistry (Chemistry)
Education
Source: Self-asserted source
Heather Ferris

Funding (4)

Mevalonate Pathway Regulation of Astrocyte ApoE

2022-12-15 to 2027-11-30 | Grant
National Institute on Aging (Baltimore, US)
URL: https://app.dimensions.ai/details/grant/grant.13057652
GRANT_NUMBER: R01AG080773
Source: Self-asserted source
Heather Ferris via DimensionsWizard

Cholesterol Metabolites as Regulators of Nicastrin

2022-09-01 to 2024-08-31 | Grant
National Institute on Aging (Baltimore, US)
URL: https://app.dimensions.ai/details/grant/grant.12966787
GRANT_NUMBER: R56AG077637
Source: Self-asserted source
Heather Ferris via DimensionsWizard

The brain cholesterol interactome

2021-02-01 to 2023-01-31 | Grant
National Institute on Aging (Baltimore, US)
URL: https://app.dimensions.ai/details/grant/grant.9560447
GRANT_NUMBER: R03AG070428
Source: Self-asserted source
Heather Ferris via DimensionsWizard

Insulin and SREBP-2 in brain cholesterol regulation

2012-09-21 to 2017-06-30 | Grant
National Institute of Diabetes and Digestive and Kidney Diseases (n/a, US)
URL: https://grants.uberresearch.com/100000062/K08DK097293/Insulin-and-SREBP-2-in-brain-cholesterol-regulation
GRANT_NUMBER: grant.K08DK097293
Source: Self-asserted source
Heather Ferris via DimensionsWizard

Works (37)

Regulation of glial ApoE secretion by the mevalonate pathway is independent of ApoE isoform

Journal of Alzheimer’s Disease
2025-02-24 | Journal article
DOI: 10.1177/13872877251317732
Contributors: Joshua L Milstein; Joshua A Kulas; Aria Kamal; An B Lo; Heather A Ferris
Source: check_circle
Crossref

Mechanical activation of TWIK-related potassium channel by nanoscopic movement and rapid second messenger signaling

2023-12-19 | Preprint
DOI: 10.7554/eLife.89465.2
Contributors: E. Nicholas Petersen; Mahmud Arif Pavel; Samuel S. Hansen; Manasa Gudheti; Hao Wang; Zixuan Yuan; Keith R. Murphy; William W. Ja; Heather A Ferris; Erik M. Jorgensen et al.
Source: check_circle
Crossref

Mechanical activation of TWIK-related potassium channel by nanoscopic movement and rapid second messenger signaling

2023-12-19 | Preprint
DOI: 10.7554/eLife.89465
Contributors: E. Nicholas Petersen; Mahmud Arif Pavel; Samuel S. Hansen; Manasa Gudheti; Hao Wang; Zixuan Yuan; Keith R. Murphy; William W. Ja; Heather A Ferris; Erik M. Jorgensen et al.
Source: check_circle
Crossref

Incidental Diagnosis of Williams Syndrome in an Adult With Recurrent Hypercalcemia

JCEM Case Reports
2023-12-15 | Journal article
DOI: 10.1210/jcemcr/luad164
Contributors: Seth Tersteeg; Vladimer Bakhutashvili; Margaret Crook; Heather A Ferris
Source: check_circle
Crossref

Mechanical activation of TWIK-related potassium channel by nanoscopic movement and rapid second messenger signaling

2023-07-27 | Preprint
DOI: 10.7554/eLife.89465.1
Contributors: E. Nicholas Petersen; Mahmud Arif Pavel; Samuel S. Hansen; Manasa Gudheti; Hao Wang; Zixuan Yuan; Keith R. Murphy; William W. Ja; Heather A Ferris; Erik M. Jorgensen et al.
Source: check_circle
Crossref

Inceptor as a regulator of brain insulin sensitivity

Scientific Reports
2023-07-18 | Journal article
DOI: 10.1038/s41598-023-36248-4
Contributors: Lisa A. Post; Joshua A. Kulas; Joshua L. Milstein; Sarah V. L. Sebastian; Seyyedmohsen Hosseini-Barkooie; Max E. Stevenson; George S. Bloom; Heather A. Ferris
Source: check_circle
Crossref

Altered circadian behavior and light sensing in mouse models of Alzheimer’s disease

2023-05-03 | Preprint
DOI: 10.1101/2023.05.02.539086
Contributors: Thaddeus K. Weigel; Cherry L. Guo; Ali D. Güler; Heather A. Ferris
Source: check_circle
Crossref

Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes

Chemical Science
2021 | Journal article
DOI: 10.1039/D0SC06623K
Contributors: Tao Huang; Seyyedmohsen Hosseinibarkooie; Adam L. Borne; Mitchell E. Granade; Jeffrey W. Brulet; Thurl E. Harris; Heather A. Ferris; Ku-Lung Hsu
Source: check_circle
Crossref

Neutrophil Enzyme Myeloperoxidase Modulates Neuronal Response in a Model of Subarachnoid Hemorrhage by Venous Injury

Stroke
2021-10 | Journal article
DOI: 10.1161/STROKEAHA.120.033513
Contributors: Aminata P. Coulibaly; Pinar Pezuk; Paul Varghese; William Gartman; Danielle Triebwasser; Joshua A. Kulas; Lei Liu; Mariam Syed; Petr Tvrdik; Heather Ferris et al.
Source: check_circle
Crossref

Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol

Proceedings of the National Academy of Sciences
2021-08-17 | Journal article
DOI: 10.1073/pnas.2102191118
Contributors: Hao Wang; Joshua A. Kulas; Chao Wang; David M. Holtzman; Heather A. Ferris; Scott B. Hansen
Source: check_circle
Crossref

SOD1 Mediates Lysosome-to-Mitochondria Communication and its Dysregulation by Amyloid-β Oligomers

2021-06 | Preprint
DOI: 10.1101/2021.06.14.448281
PPR: PPR357530
Contributors: Norambuena A; Sun X; Wallrabe H; Cao R; Sun N; Pardo E; Shivange N; Wang DB; Post LA; Ferris HA et al.
Source: Self-asserted source
Heather Ferris via Europe PubMed Central

The brain as an insulin-sensitive metabolic organ.

Molecular metabolism
2021-04 | Journal article
DOI: 10.1016/j.molmet.2021.101234
PMID: 33845179
PMC: PMC8513144
Contributors: Milstein JL; Ferris HA
Source: Self-asserted source
Heather Ferris via Europe PubMed Central

Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol

2020-06-18 | Preprint
DOI: 10.1101/2020.06.18.159632
Contributors: Hao Wang; Joshua A. Kulas; Heather A. Ferris; Scott B. Hansen
Source: check_circle
Crossref

Insulin resistance and impaired lipid metabolism as a potential link between diabetes and Alzheimer's disease

Drug Development Research
2020-04 | Journal article
DOI: 10.1002/ddr.21643
Contributors: Joshua A. Kulas; Thaddeus K. Weigel; Heather A. Ferris
Source: check_circle
Crossref

Oxidized cholesterol species as signaling molecules in the brain: diabetes and Alzheimer’s disease

Neuronal Signaling
2019-12-20 | Journal article
DOI: 10.1042/NS20190068
Contributors: Thaddeus K. Weigel; Joshua A. Kulas; Heather A. Ferris
Source: check_circle
Crossref

Mechanical activation of TWIK-related potassium channel by nanoscopic movement and rapid second messenger signaling

2019-09-05 | Preprint
DOI: 10.1101/758896
Contributors: E. Nicholas Petersen; Mahmud Arif Pavel; Samuel S. Hansen; Manasa Gudheti; Hao Wang; Zixuan Yuan; Keith R. Murphy; William W. Ja; Heather A Ferris; Erik M. Jorgensen et al.
Source: check_circle
Crossref

The neutrophil enzyme myeloperoxidase directly modulates neuronal response after subarachnoid hemorrhage, a sterile injury model

2019-05-03 | Other
DOI: 10.1101/627638
Contributors: Aminata P. Coulibaly; Pinar Pezuk; Paul Varghese; William Gartman; Danielle Triebwasser; Joshua A. Kulas; Lei Liu; Mariam Syed; Petr Tvrdik; Heather Ferris et al.
Source: check_circle
Crossref

Insulin regulates astrocyte gliotransmission and modulates behavior.

The Journal of clinical investigation
2018-04 | Journal article
DOI: 10.1172/jci99366
PMID: 29664737
Contributors: Cai W; Xue C; Sakaguchi M; Konishi M; Shirazian A; Ferris HA; Li M; Yu R; Kleinridders A; Pothos EN et al.
Source: Self-asserted source
Heather Ferris via Europe PubMed Central
grade
Preferred source (of 2)‎

Regional differences in brain glucose metabolism determined by imaging mass spectrometry.

Molecular metabolism
2018-04 | Journal article
DOI: 10.1016/j.molmet.2018.03.013
PMID: 29681509
Contributors: Kleinridders A; Ferris HA; Reyzer ML; Rath M; Soto M; Manier ML; Spraggins J; Yang Z; Stanton RC; Caprioli RM et al.
Source: Self-asserted source
Heather Ferris via Europe PubMed Central
grade
Preferred source (of 2)‎

Time for an End to Juice in the Special Supplemental Nutrition Program for Women, Infants, and Children

JAMA Pediatrics
2017-06-01 | Journal article
DOI: 10.1001/jamapediatrics.2017.0134
Part of ISSN: 2168-6203
Contributors: Heather A. Ferris; Elvira Isganaitis; Florence Brown
Source: Self-asserted source
Heather Ferris via Crossref Metadata Search

Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism.

Proceedings of the National Academy of Sciences of the United States of America
2017-01 | Journal article
DOI: 10.1073/pnas.1620506114
PMID: 28096339
PMC: PMC5293102
Source: Self-asserted source
Heather Ferris via Europe PubMed Central

Unraveling the Paradox of Selective Insulin Resistance in the Liver: the Brain-Liver Connection.

Diabetes
2016-06 | Journal article
DOI: 10.2337/dbi16-0010
PMID: 27222392
PMC: PMC4878421
Source: Self-asserted source
Heather Ferris via Europe PubMed Central

Effect of Cholesterol Reduction on Receptor Signaling in Neurons

Journal of Biological Chemistry
2015-09 | Journal article
DOI: 10.1074/jbc.m115.664367
Part of ISSN: 0021-9258
Contributors: Kenji Fukui; Heather A. Ferris; C. Ronald Kahn
Source: Self-asserted source
Heather Ferris via Crossref Metadata Search

Insulin action in brain regulates systemic metabolism and brain function.

Diabetes
2014-07 | Journal article
DOI: 10.2337/db14-0568
PMID: 24931034
PMC: PMC4066341
Source: Self-asserted source
Heather Ferris via Europe PubMed Central

Reduction of the cholesterol sensor SCAP in the brains of mice causes impaired synaptic transmission and altered cognitive function.

PLoS biology
2013 | Journal article
DOI: 10.1371/journal.pbio.1001532
PMID: 23585733
PMC: PMC3621654
Source: Self-asserted source
Heather Ferris via Europe PubMed Central

Mechanical circulatory support in advanced heart failure #205, 2nd ed.

Journal of palliative medicine
2013-08 | Journal article
DOI: 10.1089/jpm.2013.9489
PMID: 23767951
PMC: PMC3727522
Source: Self-asserted source
Heather Ferris via Europe PubMed Central

Therapeutic Implications of Diffuse Hepatic Uptake Following I-131 Therapy for Differentiated Thyroid Cancer

Endocrine Practice
2013-03 | Journal article
DOI: 10.4158/ep12077.or
Part of ISSN: 1530-891X
Contributors: Heather Ferris; Gethin Williams; J. Parker; Jeffrey Garber
Source: Self-asserted source
Heather Ferris via Crossref Metadata Search

New mechanisms of glucocorticoid-induced insulin resistance: make no bones about it

Journal of Clinical Investigation
2012-10 | Journal article
DOI: 10.1172/jci66180
Part of ISSN: 0021-9738
Contributors: Heather A. Ferris; C. Ronald Kahn
Source: Self-asserted source
Heather Ferris via Crossref Metadata Search

Destination Ventricular Assist Devices for Heart Failure #205

Journal of Palliative Medicine
2009-10 | Journal article
DOI: 10.1089/jpm.2009.9952
Part of ISSN: 1096-6218
Contributors: Heather Ferris; Susan Hunt
Source: Self-asserted source
Heather Ferris via Crossref Metadata Search

Luteinizing hormone beta promoter stimulation by adenylyl cyclase and cooperation with gonadotropin-releasing hormone 1 in transgenic mice and LBetaT2 Cells.

Biology of reproduction
2007-12 | Journal article
DOI: 10.1095/biolreprod.107.064139
PMID: 17699734
Source: Self-asserted source
Heather Ferris via Europe PubMed Central

Mechanisms for Pulsatile Regulation of the Gonadotropin Subunit Genes by GNRH11

Biology of Reproduction
2006-06-01 | Journal article
DOI: 10.1095/biolreprod.105.049049
Part of ISSN: 0006-3363
Contributors: Heather A. Ferris; Margaret A. Shupnik
Source: Self-asserted source
Heather Ferris via Crossref Metadata Search

Small nuclear RING finger protein stimulates the rat luteinizing hormone-beta promoter by interacting with Sp1 and steroidogenic factor-1 and protects from androgen suppression.

Molecular Endocrinology
2004-05 | Journal article
DOI: 10.1210/me.2003-0221
PMID: 14988433
Source: Self-asserted source
Heather Ferris via Europe PubMed Central

The calcium component of gonadotropin-releasing hormone-stimulated luteinizing hormone subunit gene transcription is mediated by calcium/calmodulin-dependent protein kinase type II.

Endocrinology
2003-06 | Journal article
DOI: 10.1210/en.2002-0013
PMID: 12746302
Source: Self-asserted source
Heather Ferris via Europe PubMed Central

Cholecystokinin activates PYK2/CAKbeta by a phospholipase C-dependent mechanism and its association with the mitogen-activated protein kinase signaling pathway in pancreatic acinar cells.

The Journal of biological chemistry
1999-10 | Journal article
DOI: 10.1074/jbc.274.44.31261
PMID: 10531323
Source: Self-asserted source
Heather Ferris via Europe PubMed Central

CCKA receptor activation stimulates p130(Cas) tyrosine phosphorylation, translocation, and association with Crk in rat pancreatic acinar cells.

Biochemistry
1999-02 | Journal article
DOI: 10.1021/bi981903w
PMID: 9931015
Source: Self-asserted source
Heather Ferris via Europe PubMed Central

Location and Characterization of the Human GRP Receptor Expressed by Gastrointestinal Epithelial Cells

Peptides
1997 | Journal article
DOI: 10.1016/s0196-9781(97)00127-7
Part of ISSN: 0196-9781
Contributors: Heather A. Ferris; Robert E. Carroll; Donald L. Lorimer; Richard V. Benya
Source: Self-asserted source
Heather Ferris via Crossref Metadata Search

Constitutive activation of the gastrin-releasing peptide receptor expressed by the nonmalignant human colon epithelial cell line NCM460.

Journal of Clinical Investigation
1997-11 | Journal article
DOI: 10.1172/jci119795
PMID: 9366567
PMC: PMC508453
Source: Self-asserted source
Heather Ferris via Europe PubMed Central

Peer review (14 reviews for 7 publications/grants)

Review activity for Acta diabetologica. (1)
Review activity for Cell metabolism. (1)
Review activity for Endocrinology (8)
Review activity for Journal of endocrinological investigation. (1)
Review activity for Journal of the Endocrine Society. (1)
Review activity for Molecular neurodegeneration (1)
Review activity for Translational psychiatry. (1)
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