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Loop profile: 278355

Keywords

Chaperones, Cancer, Yeast, Hsp70, Hsp90, Proteomics, DNA damage response, Cell signaling, Phopshorylation

Countries

United States

Activities

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Employment (2)

University of North Carolina at Charlotte: Charlotte, North Carolina, US

2021-07-01 to present | Associate Professor (Biological Sciences)
Employment
Source: Self-asserted source
Andrew Truman

University of North Carolina at Charlotte: Charlotte, NC, US

2015-08-01 to 2021-06-30 | Assistant Professor (Biological Sciences)
Employment
Source: Self-asserted source
Andrew Truman

Professional activities (1)

Faculty Opinions: London, GB

2020-04-22 to 2022-07-19 | Faculty Member
Invited position
Source: check_circle
Faculty Opinions

Funding (3)

Understanding the reciprocal regulation between Hsp70 and the DNA damage response

2020-12-03 to 2024-11-30 | Grant
National Institute of General Medical Sciences (Bethesda, US)
URL: https://app.dimensions.ai/details/grant/grant.9519709
GRANT_NUMBER: R01GM139885
Source: Self-asserted source
Andrew Truman via DimensionsWizard

Understanding ER chaperone-mediated RNR regulation

2020-09-01 to 2023-08-31 | Grant
National Institute of General Medical Sciences (Bethesda, US)
URL: https://app.dimensions.ai/details/grant/grant.9393880
GRANT_NUMBER: R15GM139059
Source: Self-asserted source
Andrew Truman via DimensionsWizard

Regulation of Hsp70-Mediated Cyclin D1 Destruction in Breast Cancer

2017-04-01 to 2020-03-31 | Grant
National Cancer Institute (Rockville, US)
URL: https://app.dimensions.ai/details/grant/grant.6618597
GRANT_NUMBER: R15CA208773
Source: Self-asserted source
Andrew Truman via DimensionsWizard

Works (50 of 55)

Items per page:
Page 1 of 2

Targeting biomolecular condensates: The rise of engineered chaperones

Cell Chemical Biology
2025-03 | Journal article
DOI: 10.1016/j.chembiol.2025.02.005
Contributors: Yevheniia Bushman; Duhita A. Mirikar; Andrew.W. Truman
Source: check_circle
Crossref

Acetylation of the yeast Hsp40 chaperone protein Ydj1 fine-tunes proteostasis and translational fidelity

PLOS Genetics
2024-12-09 | Journal article
DOI: 10.1371/journal.pgen.1011338
Contributors: Siddhi Omkar; Guang-Chao Chen; Megan M. Mitchem; Joel R. Hoskins; Courtney Shrader; Jake T. Kline; Nitika; Luca Fornelli; Sue Wickner; Andrew W. Truman
Source: check_circle
Crossref

Structural transitions modulate the chaperone activities of Grp94

Trends in Biochemical Sciences
2024-09 | Journal article
DOI: 10.1016/j.tibs.2024.06.007
Contributors: Duhita Mirikar; Yevheniia Bushman; Andrew W. Truman
Source: check_circle
Crossref

Acetylation of the yeast Hsp40 chaperone protein Ydj1 fine-tunes proteostasis and translational fidelity

2024-06-14 | Preprint
DOI: 10.1101/2024.06.13.598777
Contributors: Siddhi Omkar; Courtney Shrader; Joel R. Hoskins; Jake T. Kline; Megan M. Mitchem; Luca Fornelli; Sue Wickner; Andrew W. Truman
Source: check_circle
Crossref

Understanding chaperone specificity: evidence for a ‘client code’

Trends in Biochemical Sciences
2023-08 | Journal article
DOI: 10.1016/j.tibs.2023.05.008
Contributors: Siddhi Omkar; Ainella Rysbayeva; Andrew W. Truman
Source: check_circle
Crossref

Proteomic analysis defines the interactome of telomerase in the protozoan parasite,Trypanosoma brucei

2022-11-28 | Preprint
DOI: 10.1101/2022.11.27.518122
Contributors: Justin A. Davis; Andres V. Reyes; Nitika; Arpita Saha; Donald J. Wolfgeher; Shou-Ling Xu; Andrew W. Truman; Bibo Li; Kausik Chakrabarti
Source: check_circle
Crossref

Comprehensive characterization of the Hsp70 interactome reveals novel client proteins and interactions mediated by posttranslational modifications.

PLoS biology
2022-10-21 | Journal article | Author
DOI: 10.1371/journal.pbio.3001839
PMID: 36269765
PMC: PMC9629621
Contributors: Nitika; Zheng B; Ruan L; Kline JT; Omkar S; Sikora J; Texeira Torres M; Wang Y; Takakuwa JE; Huguet R et al.
Source: Self-asserted source
Andrew Truman

Feeling the heat: how chaperones deal with biomolecular condensates

Trends in Biochemical Sciences
2022-09 | Journal article
DOI: 10.1016/j.tibs.2022.04.008
Contributors: Siddhi Omkar; Andrew W. Truman
Source: check_circle
Crossref

The APE2 Exonuclease Is a Client of the Hsp70–Hsp90 Axis in Yeast and Mammalian Cells

Biomolecules
2022-06-21 | Journal article
DOI: 10.3390/biom12070864
Contributors: Siddhi Omkar; Tasaduq H. Wani; Bo Zheng; Megan M. Mitchem; Andrew W. Truman
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

The C-terminal domain of Hsp70 is responsible for paralog-specific regulation of ribonucleotide reductase

PLOS Genetics
2022-04-13 | Journal article
DOI: 10.1371/journal.pgen.1010079
Contributors: Laura E. Knighton; Patricija van Oosten-Hawle; Nitika; Siddhi Omkar; Andrew W. Truman
Source: check_circle
Crossref

Chemogenomic and bioinformatic profiling of ERdj paralogs underpins their unique roles in cancer

Cell Stress and Chaperones
2022-03 | Journal article
DOI: 10.1007/s12192-022-01256-2
Contributors: Laura E. Knighton; Nitika; Tasaduq H. Wani; Andrew W. Truman
Source: check_circle
Crossref

The C-terminal domain of Hsp70 is responsible for paralog-specific regulation of ribonucleotide reductase

2022-02-08 | Preprint
DOI: 10.1101/2022.02.08.479504
Contributors: Laura E. Knighton; Nitika; Siddhi Omkar; Andrew. W. Truman
Source: check_circle
Crossref

First Virtual International Congress on Cellular and Organismal Stress Responses, November 5-6, 2020.

Cell stress & chaperones
2021-02-09 | Journal article
DOI: 10.1007/s12192-021-01192-7
PMID: 33559835
PMC: PMC7871303
Source: Self-asserted source
Andrew Truman

Dealing with difficult clients via personalized chaperone inhibitors

Journal of Biological Chemistry
2021-01 | Journal article
DOI: 10.1016/j.jbc.2020.100211
Contributors: Andrew W. Truman
Source: check_circle
Crossref

Decrypting the chaperone code

Journal of Biological Chemistry
2021-01 | Journal article
DOI: 10.1016/j.jbc.2021.100293
Contributors: Andrew W. Truman; Dimitra Bourboulia; Mehdi Mollapour
Source: check_circle
Crossref

Post-translational modifications of Hsp70 family proteins: Expanding the chaperone code

Journal of Biological Chemistry
2020-07-31 | Journal article
DOI: 10.1074/jbc.REV120.011666
Contributors: Nitika; Corey M. Porter; Andrew W. Truman; Matthias C. Truttmann
Source: check_circle
Crossref

The intracellular DNA sensors cGAS and IFI16 do not mediate effective antiviral immune responses to HSV-1 in human microglial cells.

Journal of neurovirology
2020-06-02 | Journal article
DOI: 10.1007/s13365-020-00852-1
PMID: 32488842
Source: Self-asserted source
Andrew Truman

Host expression system modulates recombinant Hsp70 activity through post-translational modifications.

The FEBS journal
2020-03-06 | Journal article
DOI: 10.1111/febs.15279
PMID: 32144867
Source: Self-asserted source
Andrew Truman
grade
Preferred source (of 2)‎

Rapid deacetylation of yeast Hsp70 mediates the cellular response to heat stress

Scientific Reports
2019-11-07 | Journal article
DOI: 10.1038/s41598-019-52545-3
Contributors: Linan Xu; Nitika; Naushaba Hasin; Daragh D. Cuskelly; Donald Wolfgeher; Sean Doyle; Paul Moynagh; Sarah Perrett; Gary W. Jones; Andrew W. Truman
Source: check_circle
Crossref

Chemogenomic screening Identifies the Hsp70 Co-chaperone HDJ2 as a Hub for Anticancer Drug Resistance

2019-10-28 | Other
DOI: 10.1101/818427
Contributors: Nitika; Jacob S. Blackman; Laura E. Knighton; Jade E. Takakuwa; Stuart K. Calderwood; Andrew W. Truman
Source: check_circle
Crossref

Not quite the SSAme: unique roles for the yeast cytosolic Hsp70s

Current Genetics
2019-10-24 | Journal article
DOI: 10.1007/s00294-019-00978-8
Contributors: Sarah K. Lotz; Laura E. Knighton; Nitika; Gary W. Jones; Andrew W. Truman
Source: check_circle
Crossref

Dynamic remodeling of the interactomes of Nematostella vectensis Hsp70 isoforms under heat shock.

Journal of proteomics
2019-06-21 | Journal article
DOI: 10.1016/j.jprot.2019.103416
PMID: 31233900
Source: Self-asserted source
Andrew Truman

Mevalonate pathway activity as a determinant of radiation sensitivity in head and neck cancer.

Molecular oncology
2019-06-21 | Journal article
DOI: 10.1002/1878-0261.12535
PMID: 31225926
Source: Self-asserted source
Andrew Truman
grade
Preferred source (of 2)‎

Novel insights into molecular chaperone regulation of ribonucleotide reductase

Current Genetics
2019-04-05 | Journal article
DOI: 10.1007/s00294-018-0916-7
Contributors: Laura E. Knighton; Lena E. Delgado; Andrew W. Truman
Source: check_circle
Crossref

The Hsp70 co-chaperone Ydj1/HDJ2 regulates ribonucleotide reductase activity

PLOS Genetics
2018-11-19 | Journal article
DOI: 10.1371/journal.pgen.1007462
Contributors: Isaac T. Sluder; Gregory P. Copenhaver; Nitika; Laura E. Knighton; Andrew W. Truman
Source: check_circle
Crossref

Characterizing functional differences in sea anemone Hsp70 isoforms using budding yeast

Cell Stress and Chaperones
2018-09 | Journal article
DOI: 10.1007/s12192-018-0900-7
Contributors: Shawn J. Waller; Laura E. Knighton; Lenora M. Crabtree; Abigail L. Perkins; Adam M. Reitzel; Andrew W. Truman
Source: check_circle
Crossref

Genetic analysis of Hsp70 phosphorylation sites reveals a role in Candida albicans cell and colony morphogenesis

2018-09 | Journal article
DOI: 10.1016/j.bbapap.2018.09.001
Part of ISSN: 1570-9639
Source: Self-asserted source
Andrew Truman

Endogenous epitope tagging of heat shock protein 70 isoform Hsc70 using CRISPR/Cas9

Cell Stress and Chaperones
2018-05 | Journal article
DOI: 10.1007/s12192-017-0845-2
Contributors: Nitika; Andrew W. Truman
Source: check_circle
Crossref

Cracking the Chaperone Code: Cellular Roles for Hsp70 Phosphorylation.

Trends in biochemical sciences
2017-11-05 | Journal article
DOI: 10.1016/j.tibs.2017.10.002
PMID: 29102083
PMC: PMC5701876
Source: Self-asserted source
Andrew Truman

Phosphorylation and Ubiquitination Regulate Protein Phosphatase 5 Activity and Its Prosurvival Role in Kidney Cancer.

Cell reports
2017-11-01 | Journal article
DOI: 10.1016/j.celrep.2017.10.074
PMID: 29141220
PMC: PMC5699234
Source: Self-asserted source
Andrew Truman

Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors.

Cell reports
2016-01-21 | Journal article
DOI: 10.1016/j.celrep.2015.12.084
PMID: 26804907
PMC: PMC4887101
Source: Self-asserted source
Andrew Truman

c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells

Cell reports
2015 | Journal article
Source: Self-asserted source
Andrew Truman

Quantitative proteomics of the yeast Hsp70/Hsp90 interactomes during DNA damage reveal chaperone-dependent regulation of ribonucleotide reductase

Journal of proteomics
2015 | Journal article
Source: Self-asserted source
Andrew Truman

The dynamic interactome of human Aha1 upon Y223 phosphorylation.

Data in Brief
2015-11-06 | Journal article
DOI: 10.1016/j.dib.2015.10.028
PMID: 26693507
PMC: PMC4659802
Source: Self-asserted source
Andrew Truman

Cdc37 engages in stable, S14A mutation-reinforced association with the most atypical member of the yeast kinome, Cdk-activating kinase (Cak1)

Cell Stress and Chaperones
2014 | Journal article
Source: Self-asserted source
Andrew Truman

The quantitative changes in the yeast Hsp70 and Hsp90 interactomes upon DNA damage.

Data in Brief
2014-11-07 | Journal article
DOI: 10.1016/j.dib.2014.10.006
PMID: 26217697
PMC: PMC4459869
Source: Self-asserted source
Andrew Truman

DNA resection proteins Sgs1 and Exo1 are required for G1 checkpoint activation in budding yeast

DNA repair
2013 | Journal article
Source: Self-asserted source
Andrew Truman

The yin and yang of cyclin control by nutrients

Cell Cycle
2013 | Journal article
Source: Self-asserted source
Andrew Truman

CDK-dependent Hsp70 phosphorylation controls G1 cyclin abundance and cell-cycle progression

Cell
2012 | Journal article
Source: Self-asserted source
Andrew Truman

Cell Cycle: Regulation by Cyclins

eLS
2012 | Journal article
Source: Self-asserted source
Andrew Truman

Threonine 22 phosphorylation attenuates Hsp90 interaction with cochaperones and affects its chaperone activity

Molecular cell
2011 | Journal article
Source: Self-asserted source
Andrew Truman

Epigenetic modifications in double-strand break DNA damage signaling and repair

Clinical Cancer Research
2010 | Journal article
Source: Self-asserted source
Andrew Truman

Yeast Mpk1 cell wall integrity mitogen-activated protein kinase regulates nucleocytoplasmic shuttling of the Swi6 transcriptional regulator

Molecular biology of the cell
2010 | Journal article
Source: Self-asserted source
Andrew Truman

Mechanism of Mpk1 mitogen-activated protein kinase binding to the Swi4 transcription factor and its regulation by a novel caffeine-induced phosphorylation

Molecular and cellular biology
2009 | Journal article
Source: Self-asserted source
Andrew Truman

Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37

Molecular cell
2008 | Journal article
Source: Self-asserted source
Andrew Truman

Yeast Mpk1 mitogen-activated protein kinase activates transcription through Swi4/Swi6 by a noncatalytic mechanism that requires upstream signal

Molecular and cellular biology
2008 | Journal article
Source: Self-asserted source
Andrew Truman

Expressed as the sole Hsp90 of yeast, the $α$ and $β$ isoforms of human Hsp90 differ with regard to their capacities for activation of certain client proteins, whereas only Hsp90$β$ generates sensitivity to the Hsp90 inhibitor radicicol

FEBS Journal
2007 | Journal article
Source: Self-asserted source
Andrew Truman

In the yeast heat shock response, Hsf1-directed induction of Hsp90 facilitates the activation of the Slt2 (Mpk1) mitogen-activated protein kinase required for cell integrity

Eukaryotic cell
2007 | Journal article
Source: Self-asserted source
Andrew Truman

Expressed in the yeast Saccharomyces cerevisiae, human ERK5 is a client of the Hsp90 chaperone that complements loss of the Slt2p (Mpk1p) cell integrity stress-activated protein kinase

Eukaryotic cell
2006 | Journal article
Source: Self-asserted source
Andrew Truman

Hsp90 chaperone control over transcriptional regulation by the yeast Slt2 (Mpk1) p and human ERK5 mitogen-activated protein kinases (MAPKs)

Biochemical Society Transactions
2006 | Journal article
Source: Self-asserted source
Andrew Truman
Items per page:
Page 1 of 2

Peer review (33 reviews for 12 publications/grants)

Review activity for BMC biology. (1)
Review activity for Cell chemical biology. (1)
Review activity for Cell metabolism. (1)
Review activity for Cell reports. (1)
Review activity for Cell stress & chaperones. (16)
Review activity for Communications biology. (1)
Review activity for Faculty Opinions (5)
Review activity for JoVE. (1)
Review activity for Nature communications (2)
Review activity for Nature reviews. (1)
Review activity for PLOS genetics. (2)
Review activity for Review Commons (1)
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