Personal information

Czech Republic

Activities

Employment (2)

General University hospital: Prague, CZ

2013-04-01 to present
Employment
Source: Self-asserted source
Martin Šíma

Charles University: Prague, CZ

2013-03-01 to present (Institute of Pharmacology, First Faculty of Medicine)
Employment
Source: Self-asserted source
Martin Šíma

Education and qualifications (3)

Charles University: Prague, CZ

2021-12-01 to present | Associate professor
Qualification
Source: Self-asserted source
Martin Šíma

First faculty of Medicine, Charles University in Prague: Prague, CZ

2012-10-01 to 2017-10-19 | Ph.D.
Education
Source: Self-asserted source
Martin Šíma

Faculty of Pharmacy, Charles University in Prague: Hradec Králové, CZ

2001-10-01 to 2006-06-30 | PharmDr.
Education
Source: Self-asserted source
Martin Šíma

Professional activities (2)

Czech Medical Association of J.E. Purkyne: Prague, CZ

(Czech Society for Experimental and Clinical Pharmacology and Toxicology; Czech Professional Society of Clinical Pharmacy)
Membership
Source: Self-asserted source
Martin Šíma

Pharmaceutical Applied Research Center: Prague, CZ

2018 to present | Scientific group leader
Invited position
Source: Self-asserted source
Martin Šíma

Works (50 of 93)

Items per page:
Page 1 of 2

Pharmacokinetic-based Dosing Individualization of Mycophenolate Mofetil in Solid Organ Transplanted Patients

Prague Medical Report
2024 | Journal article
Part of ISSN: 2336-2936
Contributors: Sara Merdita; Pavel Ryšánek; Jan Miroslav Hartinger; Ondřej Slanař; Martin Šíma
Source: Self-asserted source
Martin Šíma via Crossref Metadata Search

Evaluation of adherence to abiraterone therapy in prostate cancer patients based on a population pharmacokinetic model

British Journal of Clinical Pharmacology
2024-07-03 | Journal article | Author
Part of ISSN: 1365-2125
Contributors: Sara Merdita; Martin Šíma; Jan Dvořák; Martin Matějů; Igor Richter; Petr Kozlík; Tomáš Křížek; Jana Královičová; Jan Bosák; Luboš Petruželka et al.
Source: Self-asserted source
Martin Šíma via Crossref Metadata Search

Vancomycin loading dose individualization in a population of obese patients undergoing haemodialysis based on population pharmacokinetic model.

Journal of chemotherapy (Florence, Italy)
2024-06 | Journal article
Contributors: Polášková L; Hartinger JM; Murínová I; Michálek P; Slanař O; Šíma M
Source: Self-asserted source
Martin Šíma via Europe PubMed Central

Vancomycin population pharmacokinetics and dosing proposal for the initial treatment in obese adult patients.

Frontiers in pharmacology
2024-06 | Journal article
Contributors: Polášková L; Murínová I; Gregorová J; Slanař O; Šíma M
Source: Self-asserted source
Martin Šíma via Europe PubMed Central

Development of immediate-release formulation with reliable absorption of rivaroxaban in various meal regimes.

Clinical and translational science
2024-05 | Journal article
Contributors: Bosák J; Šíma M; Krejčí T; Obadalová I; Šmardová J; Kozlík P; Křížek T; Beránek J; Hauser T; Slanař O
Source: Self-asserted source
Martin Šíma via Europe PubMed Central
grade
Preferred source (of 2)‎

A novel dosing approach for rituximab in glomerular diseases based on a population pharmacokinetic analysis.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
2024-04 | Journal article
Contributors: Hartinger JM; Šíma M; Hrušková Z; Pilková A; Krátký V; Ryšavá R; Jančová E; Bobek D; Douša J; Francová I et al.
Source: Self-asserted source
Martin Šíma via Europe PubMed Central
grade
Preferred source (of 2)‎

Ivacaftor pharmacokinetics and lymphatic transport after enteral administration in rats.

Frontiers in pharmacology
2024-02 | Journal article
Contributors: Pozniak J; Ryšánek P; Smrčka D; Kozlík P; Křížek T; Šmardová J; Nováková A; Das D; Bobek D; Arora M et al.
Source: Self-asserted source
Martin Šíma via Europe PubMed Central
grade
Preferred source (of 4)‎

Evidence for Therapeutic Drug Monitoring of Atypical Antipsychotics.

Prague medical report
2024-01 | Journal article
Contributors: Krejčí V; Murínová I; Slanař O; Šíma M
Source: Self-asserted source
Martin Šíma via Europe PubMed Central
grade
Preferred source (of 2)‎

Demonstration of the Rationale for Therapeutic Drug Monitoring of Isavuconazole: A Case Report with a Lung Transplant Recipient

Prague medical report
2023 | Journal article
EID:

2-s2.0-85179650147

Part of ISSN: 12146994
Contributors: Dvořáčková, E.; Zajacová, A.; Havlín, J.; Klapková, E.; Lischke, R.; Slanař, O.; Šíma, M.
Source: Self-asserted source
Martin Šíma via Scopus - Elsevier

MIDOSTAURIN - THE FIRST TARGETED THERAPY DRUG FOR PATIENTS WITH ACUTE MYELOID LEUKAEMIA WITH FLT3 MUTATION

Acta Poloniae Pharmaceutica - Drug Research
2023 | Journal article
EID:

2-s2.0-85151408093

Part of ISSN: 00016837
Contributors: Nowicka, A.; Szałek, E.; Gil, L.; Šima, M.; Karbownik, A.
Source: Self-asserted source
Martin Šíma via Scopus - Elsevier
grade
Preferred source (of 2)‎

Population approach in pharmacokinetic analysis,Populační přístup ve farmakokinetické analýze

Klinicka Farmakologie a Farmacie
2023 | Journal article
EID:

2-s2.0-85192059619

Part of ISSN: 18035353 12127973
Contributors: Hlaváč, J.; Šíma, M.; Slanař, O.
Source: Self-asserted source
Martin Šíma via Scopus - Elsevier

The frequency of, and predisposing risk factors for, ciprofl oxacin-induced neuro-psychiatric adverse drug reactions

Bratislava Medical Journal
2023 | Journal article
EID:

2-s2.0-85172351322

Part of ISSN: 13360345 00069248
Contributors: Hartinger, J.M.; Dvorackova, E.; Myslivecek, M.; Hruskova, Z.; Satny, M.; Zlatohlavek, L.; Krizova, J.; Sima, M.; Tesar, V.; Slanar, O.
Source: Self-asserted source
Martin Šíma via Scopus - Elsevier

The European List of Key Medicines for Medical Education: A Modified Delphi Study.

Clinical pharmacology and therapeutics
2023-12 | Journal article
Contributors: Donker EM; Spitaleri Timpone P; Brinkman DJ; Richir MC; Papaioannidou P; Likic R; Sanz EJ; Christiaens T; Costa JN; De Ponti F et al.
Source: Self-asserted source
Martin Šíma via Europe PubMed Central

Disposition of levobupivacaine during intraoperative continuous caudal epidural analgesia in a preterm neonate.

Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia
2023-11 | Journal article
Contributors: Sipek J; Pokorna P; Sima M; Styblova J; Mixa V
Source: Self-asserted source
Martin Šíma via Europe PubMed Central
grade
Preferred source (of 2)‎

Dasatinib anhydrate containing oral formulation improves variability and bioavailability in humans.

Leukemia
2023-10 | Journal article
Contributors: Hofmann J; Bartůněk A; Hauser T; Sedmak G; Beránek J; Ryšánek P; Šíma M; Slanař O
Source: Self-asserted source
Martin Šíma via Europe PubMed Central
grade
Preferred source (of 2)‎

Dosing Optimization of Posaconazole in Lung-Transplant Recipients Based on Population Pharmacokinetic Model

Antibiotics
2023-09 | Journal article | Author
Contributors: Eliška Dvořáčková; Martin Šíma; Andrea Zajacová; Kristýna Vyskočilová; Tereza Kotowski; Kateřina Dunovská; Eva Klapková; Jan Havlín; Robert Lischke; Ondrej Slanar
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Dose Optimization and Targeting Strategies of Anti-Infective Agents

Pharmaceutics
2023-07 | Journal article | Author
Contributors: Martin Šíma; Ondrej Slanar
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Editorial: Pharmacology of autoimmune and neuroinflammatory disease from a preclinical and clinical perspective.

Frontiers in pharmacology
2023-06 | Journal article
Contributors: Šíma M; Laslop A; Borg JJ; Poništ S; Melchiorri D; Dráfi F
Source: Self-asserted source
Martin Šíma via Europe PubMed Central
grade
Preferred source (of 2)‎

Population pharmacokinetics and covariate-based dosing individualization of voriconazole in lung transplant recipients.

Journal of chemotherapy (Florence, Italy)
2023-06 | Journal article
Contributors: Dvorackova E; Sima M; Vyskocilova K; Kotowski T; Dunovská K; Klapkova E; Havlin J; Lischke R; Slanar O
Source: Self-asserted source
Martin Šíma via Europe PubMed Central
grade
Preferred source (of 2)‎

Better Outcome of Off-Label High-Dose Ceftazidime in Hemato-Oncological Patients with Infections Caused by Extensively Drug-Resistant <i>Pseudomonas Aeruginosa</i>.

Mediterranean journal of hematology and infectious diseases
2023-01 | Journal article
Contributors: Zavrelova A; Paterova P; Zak P; Visek B; Sima M; Radocha J
Source: Self-asserted source
Martin Šíma via Europe PubMed Central
grade
Preferred source (of 4)‎

Effects of Cannabidiol in Inflammation: A Review of Pre-clinical and Clinical Findings.

Prague medical report
2023-01 | Journal article
Contributors: Sklenárová M; Šíma M; Slanař O
Source: Self-asserted source
Martin Šíma via Europe PubMed Central
grade
Preferred source (of 2)‎

Pathogenesis of Collagen-Induced Arthritis: Role of Immune Cells with Associated Cytokines and Antibodies, Comparison with Rheumatoid Arthritis.

Folia biologica
2023-01 | Journal article
Contributors: Šteigerová M; Šíma M; Slanař O
Source: Self-asserted source
Martin Šíma via Europe PubMed Central
grade
Preferred source (of 2)‎

Plasma concentrations of levobupivacaine in neonates during caudal epidural analgesia maintained over 48 hours.

Bratislavske lekarske listy
2023-01 | Journal article
Contributors: Sipek J; Pokorna P; Sima M; Berka I; Hlozek T; Styblova J; Mixa V; Nedomova B
Source: Self-asserted source
Martin Šíma via Europe PubMed Central
grade
Preferred source (of 2)‎

Population pharmacokinetic model-based dosing proposal for ampicillin prophylaxis in cardiac surgery patients with cardiopulmonary bypass.

Journal of chemotherapy (Florence, Italy)
2023-01 | Journal article
Contributors: Urbánek K; Šantavý P; Zuščich O; Kubíčková V; Michaličková D; Slanař O; Šíma M
Source: Self-asserted source
Martin Šíma via Europe PubMed Central
grade
Preferred source (of 2)‎

Serum and lymph pharmacokinetics of nilotinib delivered by yeast glucan particles per os.

International journal of pharmaceutics
2023-01 | Journal article
Contributors: Šalamúnová P; Krejčí T; Ryšánek P; Saloň I; Kroupová J; Hubatová-Vacková A; Petřík J; Grus T; Lukáč P; Kozlík P et al.
Source: Self-asserted source
Martin Šíma via Europe PubMed Central
grade
Preferred source (of 2)‎

Therapeutic Drug Monitoring of Protein Kinase Inhibitors in the Treatment of Non-small Cell Lung Cancer.

Prague medical report
2023-01 | Journal article
Contributors: Staša J; Gregorová J; Slanař O; Šíma M
Source: Self-asserted source
Martin Šíma via Europe PubMed Central
grade
Preferred source (of 2)‎

Analgesic effects of piritramide in acute postoperative pain – comparison of intramuscular administration with patient-controlled intravenous analgesia and impact of OPRM1 and ABCB1 polymorphisms

Biomedical Papers
2022 | Journal article
EID:

2-s2.0-85126490986

Part of ISSN: 18047521 12138118
Contributors: Bartosova, O.; Sima, M.; Polanecky, O.; Perlik, F.; Adamek, S.; Lischke, R.; Slanar, O.
Source: Self-asserted source
Martin Šíma via Scopus - Elsevier
grade
Preferred source (of 2)‎

Changes in Rosuvastatin Pharmacokinetics During Postnatal Ontogenesis in Rats

Journal of Pharmacy and Pharmaceutical Sciences
2022 | Journal article
EID:

2-s2.0-85123271054

Contributors: Roušarová, J.; Šíma, M.; Kozlík, P.; Křížek, T.; Slanař, O.
Source: Self-asserted source
Martin Šíma via Scopus - Elsevier
grade
Preferred source (of 2)‎

Edaravone Attenuates Disease Severity of Experimental Auto-Immune Encephalomyelitis and Increases Gene Expression of Nrf2 and HO-1

Physiological Research
2022 | Journal article
EID:

2-s2.0-85128000650

Part of ISSN: 18029973 08628408
Contributors: Michaličková, D.; Öztürk, H.K.; Hroudová, J.; Ľupták, M.; Kučera, T.; Hrnčíř, T.; Canová, N.K.; Šíma, M.; Slanař, O.
Source: Self-asserted source
Martin Šíma via Scopus - Elsevier

Factors Affecting Drug Exposure after Inhalation

Prague Medical Report
2022 | Journal article
EID:

2-s2.0-85137855606

Part of ISSN: 23362936 12146994
Contributors: Nováková, A.; Šíma, M.; Slanař, O.
Source: Self-asserted source
Martin Šíma via Scopus - Elsevier
grade
Preferred source (of 2)‎

Pharmacokinetic principles of dose adjustment of mTOR inhibitors in solid organ transplanted patients

Journal of Clinical Pharmacy and Therapeutics
2022 | Journal article
EID:

2-s2.0-85135461034

Part of ISSN: 13652710 02694727
Contributors: Hartinger, J.M.; Ryšánek, P.; Slanař, O.; Šíma, M.
Source: Self-asserted source
Martin Šíma via Scopus - Elsevier
grade
Preferred source (of 2)‎

Vancomycin pharmacokinetics in patients treated with intermittent haemodialysis based on therapeutic drug monitoring

Journal of Chemotherapy
2022 | Journal article
EID:

2-s2.0-85115415756

Contributors: Hartinger, J.M.; Šíma, M.; Hronová, K.; Halouzková, B.A.; Szonowská, B.; Polakovič, V.; Bednářová, V.; Hladinová, Z.; Tesař, V.; Slanař, O.
Source: Self-asserted source
Martin Šíma via Scopus - Elsevier
grade
Preferred source (of 2)‎

Novel approach to adherence assessment based on parent drug and metabolite pharmacokinetics: pilot study with spironolactone.

Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia
2022-12 | Journal article
Contributors: Pilkova A; Sima M; Hartinger JM; Nikrynova Nguyen TMP; Maresova V; Kurcova I; Slanar O; Widimsky J
Source: Self-asserted source
Martin Šíma via Europe PubMed Central

Population Pharmacokinetic Analysis Proves Superiority of Continuous Infusion in PK/PD Target Attainment with Oxacillin in Staphylococcal Infections

Antibiotics
2022-12 | Journal article | Author
Contributors: Irena Murínová; Martin Švidrnoch; Tomáš Gucký; Jan Hlaváč; Pavel Michalek; Ondrej Slanar; Martin Šíma
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Application of Oil-in-Water Cannabidiol Emulsion for the Treatment of Rheumatoid Arthritis.

Cannabis and cannabinoid research
2022-11 | Journal article
Contributors: Jelínek P; Roušarová J; Ryšánek P; Ježková M; Havlůjová T; Pozniak J; Kozlík P; Křížek T; Kučera T; Šíma M et al.
Source: Self-asserted source
Martin Šíma via Europe PubMed Central
grade
Preferred source (of 2)‎

Population Pharmacokinetics of Prophylactic Cefazolin in Cardiac Surgery with Standard and Minimally Invasive Extracorporeal Circulation

Antibiotics
2022-11 | Journal article | Author
Contributors: Petr Šantavý; Martin Šíma; Ondřej Zuščich; Vendula Kubíčková; Danica Michaličková; Ondřej Slanař; Karel Urbánek
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Superiority of ceftazidime off-label high-dose regimen in PK/PD target attainment during treatment of extensively drug resistant Pseudomonas aeruginosa infections in cancer patients.

British journal of clinical pharmacology
2022-11 | Journal article
Contributors: Zavrelova A; Sima M; Malakova J; Rozsivalova P; Paterova P; Zak P; Visek B; Michalickova D; Slanar O; Radocha J
Source: Self-asserted source
Martin Šíma via Europe PubMed Central
grade
Preferred source (of 2)‎

Meropenem population pharmacokinetics and model-based dosing optimisation in patients with serious bacterial infection.

European journal of hospital pharmacy : science and practice
2022-10 | Journal article
Contributors: Murínová I; Švidrnoch M; Gucký T; Řezáč D; Hlaváč J; Slanař O; Šíma M
Source: Self-asserted source
Martin Šíma via Europe PubMed Central
grade
Preferred source (of 2)‎

Factors Affecting the Metabolic Conversion of Ciprofloxacin and Exposure to Its Main Active Metabolites in Critically Ill Patients: Population Pharmacokinetic Analysis of Desethylene Ciprofloxacin

Pharmaceutics
2022-08 | Journal article | Author
Contributors: Martin Šíma; Daniel Bobek; Petra Cihlářová; Pavel Rysanek; Jaroslava Roušarová; Jan Beroušek; Martin Kuchar; Tomáš Vymazal; Ondrej Slanar
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Population pharmacokinetics of three alternative prophylactic antibiotics during cardiac surgery with extracorporeal circulation

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub .
2022-06-29 | Journal article
Source: Self-asserted source
Martin Šíma
grade
Preferred source (of 2)‎

Myths and facts about hormonal contraception

Praktické lékárenství
2022-06-22 | Journal article
Source: Self-asserted source
Martin Šíma

Explaining dissolution properties of rivaroxaban cocrystals.

International journal of pharmaceutics
2022-05 | Journal article
Contributors: Hriňová E; Skořepová E; Čerňa I; Královičová J; Kozlík P; Křížek T; Roušarová J; Ryšánek P; Šíma M; Slanař O et al.
Source: Self-asserted source
Martin Šíma via Europe PubMed Central
grade
Preferred source (of 2)‎

The Role of Cryotherapy in Vitreous Concentrations of Topotecan Delivered by Episcleral Hydrogel Implant

Pharmaceutics
2022-04 | Journal article | Author
Contributors: Martina Kodetova; Radka Hobzova; Jakub Sirc; Jiri Uhlik; Katerina Dunovska; Karel Svojgr; Ana-Irina Cocarta; Andrea Felsoova; Ondrej Slanar; Martin Šíma et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Pharmacokinetic Variability in Pre-Clinical Studies: Sample Study with Abiraterone in Rats and Implications for Short-Term Comparative Pharmacokinetic Study Designs

Pharmaceutics
2022-03 | Journal article | Author
Contributors: Jana Královičová; Aleš Bartůněk; Jiří Hofmann; Tomáš Křížek; Petr Kozlík; Jaroslava Roušarová; Pavel Rysanek; Martin Šíma; Ondrej Slanar
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Ganciclovir Pharmacokinetics and Individualized Dosing Based on Covariate in Lung Transplant Recipients

Pharmaceutics
2022-02 | Journal article | Author
Contributors: Eliška Dvořáčková; Martin Šíma; Jakub Petrus; Eva Klapková; Petr Hubáček; Jiří Pozniak; Jan Havlin; Robert Lischke; Ondrej Slanar
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Detection of galanin receptors in the spinal cord in experimental autoimmune encephalomyelitis.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub.
2022-02-11 | Journal article
Source: Self-asserted source
Martin Šíma
grade
Preferred source (of 2)‎

Impact of haemolysis on vancomycin disposition in a full-term neonate treated with extracorporeal membrane oxygenation

Perfusion (United Kingdom)
2021 | Journal article
EID:

2-s2.0-85096158270

Contributors: Pokorná, P.; Šíma, M.; Tibboel, D.; Slanař, O.
Source: Self-asserted source
Martin Šíma via Scopus - Elsevier
grade
Preferred source (of 2)‎

Initial dosing of intermittent vancomycin in adults: Estimation of dosing interval in relation to dose and renal function

European Journal of Hospital Pharmacy
2021 | Journal article
EID:

2-s2.0-85070687535

Contributors: Šíma, M.; Hartinger, J.; Grus, T.; Slanař, O.
Source: Self-asserted source
Martin Šíma via Scopus - Elsevier

Recent advances in the personalized treatment of estrogen receptor-positive breast cancer with tamoxifen: a focus on pharmacogenomics

Expert Opinion on Drug Metabolism and Toxicology
2021 | Journal article
EID:

2-s2.0-85098549853

Contributors: Slanař, O.; Hronová, K.; Bartošová, O.; Šíma, M.
Source: Self-asserted source
Martin Šíma via Scopus - Elsevier
grade
Preferred source (of 2)‎

Sufentanil Disposition and Pharmacokinetic Model-Based Dosage Regimen for Sufentanil in Ventilated Full-Term Neonates

Pharmacology
2021 | Journal article
EID:

2-s2.0-85107707322

Part of ISSN: 14230313 00317012
Contributors: Pokorná, P.; Šíma, M.; Koch, B.; Tibboel, D.; Slanař, O.
Source: Self-asserted source
Martin Šíma via Scopus - Elsevier
grade
Preferred source (of 2)‎
Items per page:
Page 1 of 2