Personal information

Metabolomics, Chemoetrics, Analytical Platforms, Plant Science, Biomarker discovery
Denmark

Biography

My research focuses on metabolomics. Metabolomics is a way to investigate biological systems by measuring their metabolomes (collection of all detectable metabolites) as a function of some biotic or abiotic factors. I aim to improve and implement new and more robust methodologies for metabolomics data acquisition and processing by optimizing and standardizing protocols. GC-MS and NMR are the main analytical platforms I use in daily bases.

Activities

Employment (1)

University of Copenhagen: Copenhagen, Copenhagen, DK

2013-11-15 to present | Postdoc in Metabolomics (Department of Food Science)
Employment
Source: Self-asserted source
Bekzod Khakimov

Education and qualifications (2)

University of Copenhagen: Copenhagen, Copenhagen, DK

2010-07 to 2013-11 | PhD in Plant Metabolomics (Department of Food Science)
Education
Source: Self-asserted source
Bekzod Khakimov

Queen Mary University of London: London, London, GB

2008-06 to 2009-10 | MSc in Chemical Research (School of Biological and Chemical Sciences)
Education
Source: Self-asserted source
Bekzod Khakimov

Works (50 of 81)

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Page 1 of 2

Altered hepatic metabolism mediates sepsis preventive effects of reduced glucose supply in infected preterm newborns

2024-12-03 | Preprint
Contributors: Ole Bæk; Tik Muk; Ziyuan Wu; Yongxin Ye; Bekzod Khakimov; Alessandra Maria Casano; Bagirath Gangadharan; Ivan Bilic; Anders Brunse; Per Torp Sangild et al.
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Crossref

Altered hepatic metabolism mediates sepsis preventive effects of reduced glucose supply in infected preterm newborns

2024-12-03 | Preprint
Contributors: Ole Bæk; Tik Muk; Ziyuan Wu; Yongxin Ye; Bekzod Khakimov; Alessandra Maria Casano; Bagirath Gangadharan; Ivan Bilic; Anders Brunse; Per Torp Sangild et al.
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Crossref

Green preparation of small-sized starch nanoparticles using nanoprecipitation

Food Hydrocolloids
2024-08 | Journal article
Contributors: Yongxian Chen; Li Ding; Hongmei Di; Jacob Judas Kain Kirkensgaard; Bekzod Khakimov; Bo Sun; Chengfang Pang; Junsheng Chen; Andreas Blennow
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Crossref

Altered hepatic metabolism mediates sepsis preventive effects of reduced glucose supply in infected preterm newborns

2024-07-01 | Preprint
Contributors: Ole Bæk; Tik Muk; Ziyuan Wu; Yongxin Ye; Bekzod Khakimov; Alessandra Maria Casano; Bagirath Gangadharan; Ivan Bilic; Anders Brunse; Per Torp Sangild et al.
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Crossref

Efficient Quantification of Milk Metabolites from 1H NMR Spectra Using the Signature Mapping (SigMa) Approach: Chemical Shift Library Development for Cows’ Milk and Colostrum

Analytical Chemistry
2024-02-06 | Journal article
Contributors: Paraskevi Tsermoula; Niels Bastian Kristensen; Nabiollah Mobaraki; So̷ren B. Engelsen; Bekzod Khakimov
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Crossref

Molecular profiling of whey permeate reveals new insights into molecular affinities related to industrial unit operations during lactose production

Food Chemistry
2023-09 | Journal article
Contributors: Paraskevi Tsermoula; Mie Rostved Bechshøft; Christoffer Friis; Søren Balling Engelsen; Bekzod Khakimov
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Crossref

Altered hepatic metabolism mediates sepsis preventive effects of reduced glucose supply in infected preterm newborns

2023-09-14 | Preprint
Contributors: Ole Bæk; Tik Muk; Ziyuan Wu; Yongxin Ye; Bekzod Khakimov; Alessandra Maria Casano; Bagirath Gangadharan; Ivan Bilic; Anders Brunse; Per Torp Sangild et al.
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Crossref

Insights into high hydrostatic pressure pre-treatment generating a more efficient catalytic mode of maltogenic α-amylase: Effect of multi-level structure on retrogradation properties of maize starch

Food Hydrocolloids
2023-05 | Journal article
Contributors: Zhenyu Liu; Yuyue Zhong; Bekzod Khakimov; Yongxia Fu; Tomasz Pawel Czaja; Jacob Judas Kain Kirkensgaard; Andreas Blennow; Qun Shen; Søren Balling Engelsen
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Crossref

The relationship between starch structure and digestibility by time-course digestion of amylopectin-only and amylose-only barley starches

Food Hydrocolloids
2023-05 | Journal article
Contributors: Wenxin Liang; Li Ding; Ke Guo; Yang Liu; Xiaoxia Wen; Jacob Judas Kain Kirkensgaard; Bekzod Khakimov; Kasper Enemark-Rasmussen; Kim Henrik Hebelstrup; Klaus Herburger et al.
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Crossref

Soluble, Diferuloylated Corn Bran Glucuronoarabinoxylans Modulate the Human Gut Microbiota In Vitro

Journal of Agricultural and Food Chemistry
2023-03-01 | Journal article
Contributors: Shang Lin; Xinming Xu; Jesper Holck; Jane Wittrup Agger; Casper Wilkens; Zhuqing Xie; Bekzod Khakimov; Dennis S. Nielsen; Anne S. Meyer
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Crossref

Alterations of NMR-Based Lipoprotein Profile Distinguish Unstable Angina Patients with Different Severity of Coronary Lesions

Metabolites
2023-02 | Journal article | Author
Contributors: Yongxin Ye; Jiahua Fan; Zhi-Teng Chen; Xiuwen Li; Maoxiong Wu; Wenhao Liu; Shiyi zhou; Morten Arendt Rasmussen; Søren Balling Engelsen; Yangxin Chen et al.
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Multidisciplinary Digital Publishing Institute

Alterations in Healthy Adult Canine Faecal Microbiome and Selected Metabolites as a Result of Feeding a Commercial Complete Synbiotic Diet with Enterococcus faecium NCIMB 10415

Animals
2022-12-30 | Journal article
Contributors: Stinna Nybroe; Pernille B. Horsman; Kamilla Krag; Therese G. Hosbjerg; Kathrine Stenberg; Bekzod Khakimov; Jørgen Baymler; Charlotte R. Bjørnvad; Ida N. Kieler
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1–2 Drinks Per Day Affect Lipoprotein Composition after 3 Weeks—Results from a Cross-Over Pilot Intervention Trial in Healthy Adults Using Nuclear Magnetic Resonance-Measured Lipoproteins and Apolipoproteins

Nutrients
2022-11-27 | Journal article
Contributors: Trine Levring Wilkens; Zabrina Ziegler; Violetta Aru; Bekzod Khakimov; Snædís Lilja Overgaard; Søren Balling Engelsen; Lars Ove Dragsted
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Gut Microbiome and Its Cofactors Are Linked to Lipoprotein Distribution Profiles

Microorganisms
2022-10-31 | Journal article
Contributors: Josué L. Castro-Mejía; Bekzod Khakimov; Violetta Aru; Mads V. Lind; Eva Garne; Petronela Paulová; Elnaz Tavakkoli; Lars H. Hansen; Age K. Smilde; Lars Holm et al.
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Effect of refinement and production technology on the molecular composition of edible cottonseed oils from a large industrial scale production

2022-03-22 | Preprint
Contributors: Bekzod Khakimov; Yongxin Ye; Jaloliddin Khushvakov; Akmal Boboev; Rano Akramova; Obidjon Yunusov; Dilbar Dalimova; Shahlo Turdikulova; Sharafitdin Mirzaakhmedov; Søren Engelsen
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Crossref

Ethanol pretreatment increases the efficiency of maltogenic α-amylase and branching enzyme to modify the structure of granular native maize starch

Food Hydrocolloids
2022-02 | Journal article
Contributors: Yuyue Zhong; Klaus Herburger; Jinchuan Xu; Jacob Judas Kain Kirkensgaard; Bekzod Khakimov; Aleksander Riise Hansen; Andreas Blennow
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Crossref

Human Blood Lipoprotein Predictions from 1H NMR Spectra: Protocol, Model Performances, and Cage of Covariance

Analytical Chemistry
2022-01-18 | Journal article
Contributors: Bekzod Khakimov; Huub C. J. Hoefsloot; Nabiollah Mobaraki; Violetta Aru; Mette Kristensen; Mads V. Lind; Lars Holm; Josué L. Castro-Mejía; Dennis S. Nielsen; Doris M. Jacobs et al.
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Crossref

Urinary and plasma metabolome of farm mink (Neovison vison) after an intervention with raw or cooked poultry offal: a 1H NMR investigation

Archives of Animal Nutrition
2022-01-02 | Journal article
Contributors: Alessia Trimigno; Bekzod Khakimov; Michelle Lauge Quaade; Oliver Legarth Honoré; Tove Clausen; Karoline Blaabjerg; Søren Balling Engelsen; Anne Sofie Vedsted Hammer
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Crossref

Digestion patterns of proteins in pasteurized and ultra-high temperature milk using in vitro gastric models of adult and elderly

Journal of Food Engineering
2021 | Journal article
EID:

2-s2.0-85089891145

Part of ISBN:

02608774

Contributors: Aalaei, K.; Khakimov, B.; De Gobba, C.; Ahrné, L.
Source: Self-asserted source
Bekzod Khakimov via Scopus - Elsevier

Generation of short-chained granular corn starch by maltogenic α-amylase and transglucosidase treatment

Carbohydrate Polymers
2021 | Journal article
EID:

2-s2.0-85090552700

Part of ISBN:

01448617

Contributors: Zhong, Y.; Keeratiburana, T.; Kain Kirkensgaard, J.J.; Khakimov, B.; Blennow, A.; Hansen, A.R.
Source: Self-asserted source
Bekzod Khakimov via Scopus - Elsevier

Sequential maltogenic α-amylase and branching enzyme treatment to modify granular corn starch

Food Hydrocolloids
2021-11 | Journal article
Contributors: Yuyue Zhong; Klaus Herburger; Jacob Judas Kain Kirkensgaard; Bekzod Khakimov; Aleksander Riise Hansen; Andreas Blennow
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Crossref

Cascading Effects of Root Microbial Symbiosis on the Development and Metabolome of the Insect Herbivore Manduca sexta L.

Metabolites
2021-10-25 | Journal article
Contributors: Dimitra Papantoniou; Fredd Vergara; Alexander Weinhold; Teresa Quijano; Bekzod Khakimov; David I. Pattison; Søren Bak; Nicole M. van Dam; Ainhoa Martínez-Medina
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Human Fecal Metabolome Reflects Differences in Body Mass Index, Physical Fitness, and Blood Lipoproteins in Healthy Older Adults

Metabolites
2021-10-21 | Journal article
Contributors: Mengni Cui; Alessia Trimigno; Josue L. Castro-Mejía; Søren Reitelseder; Jacob Bülow; Rasmus Leidesdorff Bechshøft; Dennis Sandris Nielsen; Lars Holm; Søren Balling Engelsen; Bekzod Khakimov
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Gut microbiome and its cofactors are linked to lipoprotein distribution profiles

2021-09-02 | Other
Contributors: Josué L. Castro-Mejía; Bekzod Khakimov; Mads V. Lind; Eva Garne; Petronela Paulová; Elnaz Tavakkoli; Lars H. Hansen; Age K. Smilde; Lars Holm; Søren B. Engelsen et al.
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Crossref

Progression of Postprandial Blood Plasma Phospholipids Following Acute Intake of Different Dairy Matrices: A Randomized Crossover Trial

Metabolites
2021-07-14 | Journal article
Contributors: Rebekka Thøgersen; Ida Emilie I. Lindahl; Bekzod Khakimov; Louise Kjølbæk; Klaus Juhl Jensen; Arne Astrup; Marianne Hammershøj; Anne Raben; Hanne Christine Bertram
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Influence of Age, Sex, and Diet on the Human Fecal Metabolome Investigated by 1H NMR Spectroscopy

Journal of Proteome Research
2021-07-02 | Journal article
Contributors: Mengni Cui; Alessia Trimigno; Violetta Aru; Morten A. Rasmussen; Bekzod Khakimov; Søren Balling Engelsen
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Crossref

The plasma metabolome of Atlantic salmon as studied by 1H NMR spectroscopy using standard operating procedures: effect of aquaculture location and growth stage

Metabolomics
2021-06 | Journal article
Contributors: Violetta Aru; Bekzod Khakimov; Klavs Martin Sørensen; Elvis Mashingaidze Chikwati; Trond M. Kortner; Paul Midtlyng; Åshild Krogdahl; Søren Balling Engelsen
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Crossref

Physiological Genetics Reformed: Bridging the Genome-to-Phenome Gap by Coherent Chemical Fingerprints – the Global Coordinator

Trends in Plant Science
2021-04 | Journal article
Contributors: Lars Munck; Åsmund Rinnan; Bekzod Khakimov; Birthe Møller Jespersen; Søren Balling Engelsen
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Crossref

Plasma Metabolomics to Evaluate Progression of Necrotising Enterocolitis in Preterm Pigs

Metabolites
2021-04-29 | Journal article
Contributors: Yan-Nan Jiang; Yong-Xin Ye; Per Torp Sangild; Thomas Thymann; Søren Balling Engelsen; Bekzod Khakimov; Ping-Ping Jiang
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Gastric Digestion of Milk Proteins in Adult and Elderly: Effect of High-Pressure Processing

Foods
2021-04-06 | Journal article
Contributors: Kataneh Aalaei; Bekzod Khakimov; Cristian De Gobba; Lilia Ahrné
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Human blood lipoprotein predictions from1H NMR spectra: protocol, model performances and cage of covariance

2021-02-25 | Preprint
Contributors: Bekzod Khakimov; Huub C.J. Hoefsloot; Nabiollah Mobaraki; Violetta Aru; Mette Kristensen; Mads V. Lind; Lars Holm; Josué L Castro-Mejía; Dennis S Nielsen; Doris M. Jacobs et al.
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Crossref

Comparison of statistical methods for predicting penetration capacity of drugs into human breast milk using physicochemical, pharmacokinetic and chromatographic descriptors

SAR and QSAR in Environmental Research
2020 | Journal article
EID:

2-s2.0-85087470488

Part of ISBN:

1029046X 1062936X

Contributors: Wanat, K.; Khakimov, B.; Brzezińska, E.
Source: Self-asserted source
Bekzod Khakimov via Scopus - Elsevier

Human urine <sup>1</sup>H NMR metabolomics reveals alterations of the protein and carbohydrate metabolism when comparing habitual Average Danish diet vs. healthy New Nordic diet

Nutrition
2020 | Journal article
EID:

2-s2.0-85087209364

Part of ISBN:

18731244 08999007

Contributors: Trimigno, A.; Khakimov, B.; Savorani, F.; Poulsen, S.K.; Astrup, A.; Dragsted, L.O.; Engelsen, S.B.
Source: Self-asserted source
Bekzod Khakimov via Scopus - Elsevier

Structurally different mixed linkage β-glucan supplements differentially increase secondary bile acid excretion in hypercholesterolaemic rat faeces

Food & Function
2020 | Journal article
Contributors: Nunzia Iaccarino; Bekzod Khakimov; Mette Skau Mikkelsen; Tina Skau Nielsen; Morten Georg Jensen; Antonio Randazzo; Søren Balling Engelsen
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First-principles identification of C-methyl-scyllo-inositol (mytilitol) – A new species-specific metabolite indicator of geographic origin for marine bivalve molluscs (Mytilus and Ruditapes spp.)

Food Chemistry
2020-10 | Journal article
Contributors: Violetta Aru; Mohammed Saddik Motawie; Bekzod Khakimov; Klavs Martin Sørensen; Birger Lindberg Møller; Søren Balling Engelsen
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Synthetic Biology of Cannabinoids and Cannabinoid Glucosides in Nicotiana benthamiana and Saccharomyces cerevisiae

Journal of Natural Products
2020-10-23 | Journal article
Contributors: Thies Gülck; J. K. Booth; Â. Carvalho; B. Khakimov; C. Crocoll; M. S. Motawia; B. L. Møller; J. Bohlmann; N. J. Gallage
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Crossref

A Multi-Omics Approach Reveals New Signatures in Obese Allergic Asthmatic Children

Biomedicines
2020-09-18 | Journal article
Contributors: Mª Amelia Gomez-Llorente; Ana Martínez-Cañavate; Natalia Chueca; Mª de la Cruz Rico; Raquel Romero; Augusto Anguita-Ruiz; Concepción Mª Aguilera; Mercedes Gil-Campos; Maria D Mesa; Bekzod Khakimov et al.
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Human Faecal 1H NMR Metabolomics: Evaluation of Solvent and Sample Processing on Coverage and Reproducibility of Signature Metabolites

Analytical Chemistry
2020-07-21 | Journal article
Contributors: Mengni Cui; Alessia Trimigno; Violetta Aru; Bekzod Khakimov; Søren Balling Engelsen
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Signature Mapping (SigMa): An efficient approach for processing complex human urine 1H NMR metabolomics data

Analytica Chimica Acta
2020-04 | Journal article
Contributors: Bekzod Khakimov; Nabiollah Mobaraki; Alessia Trimigno; Violetta Aru; Søren Balling Engelsen
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Physical fitness in community‐dwelling older adults is linked to dietary intake, gut microbiota, and metabolomic signatures

Aging Cell
2020-03 | Journal article
Contributors: Josué L. Castro‐Mejía; Bekzod Khakimov; Łukasz Krych; Jacob Bülow; Rasmus L. Bechshøft; Grith Højfeldt; Kenneth H. Mertz; Eva Stahl Garne; Simon R. Schacht; Hajar F. Ahmad et al.
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Biomarkers of Individual Foods, and Separation of Diets Using Untargeted LC–MS-based Plasma Metabolomics in a Randomized Controlled Trial

Molecular Nutrition and Food Research
2019 | Journal article
EID:

2-s2.0-85052449986

Part of ISBN:

16134133 16134125

Contributors: Acar, E.; Gürdeniz, G.; Khakimov, B.; Savorani, F.; Korndal, S.K.; Larsen, T.M.; Engelsen, S.B.; Astrup, A.; Dragsted, L.O.
Source: Self-asserted source
Bekzod Khakimov via Scopus - Elsevier

Corrigendum to “Quantification of lipoprotein profiles by nuclear magnetic resonance spectroscopy and multivariate data analysis” [Trends Anal Chem 94 (2017) 210–219](S0165993617301024)(10.1016/j.trac.2017.07.009))

TrAC - Trends in Analytical Chemistry
2019 | Journal article
EID:

2-s2.0-85071627366

Part of ISBN:

18793142 01659936

Contributors: Aru, V.; Lam, C.; Khakimov, B.; Hoefsloot, H.C.J.; Zwanenburg, G.; Lind, M.V.; Schäfer, H.; van Duynhoven, J.; Jacobs, D.M.; Smilde, A.K. et al.
Source: Self-asserted source
Bekzod Khakimov via Scopus - Elsevier

Effect of fecal microbiota transplantation route of administration on gut colonization and host response in preterm pigs

ISME Journal
2019 | Journal article
EID:

2-s2.0-85055686663

Part of ISBN:

17517370 17517362

Contributors: Brunse, A.; Martin, L.; Rasmussen, T.S.; Christensen, L.; Skovsted Cilieborg, M.; Wiese, M.; Khakimov, B.; Pieper, R.; Nielsen, D.S.; Sangild, P.T. et al.
Source: Self-asserted source
Bekzod Khakimov via Scopus - Elsevier

Investigation of Variations in the Human Urine Metabolome amongst European Populations: An Exploratory Search for Biomarkers of People at Risk-of-Poverty

Molecular Nutrition and Food Research
2019 | Journal article
EID:

2-s2.0-85059437231

Part of ISBN:

16134133 16134125

Contributors: Trimigno, A.; Khakimov, B.; Savorani, F.; Tenori, L.; Hendrixson, V.; Čivilis, A.; Glibetic, M.; Gurinovic, M.; Pentikäinen, S.; Sallinen, J. et al.
Source: Self-asserted source
Bekzod Khakimov via Scopus - Elsevier

The effect of charcoal on medicinal compounds of seeds of fenugreek (Trigonella foenum-graecum L.) exposed to drought stress

Industrial Crops and Products
2019 | Journal article
EID:

2-s2.0-85061151528

Part of ISBN:

09266690

Contributors: Bitarafan, Z.; Asghari, H.R.; Hasanloo, T.; Gholami, A.; Moradi, F.; Khakimov, B.; Liu, F.; Andreasen, C.
Source: Self-asserted source
Bekzod Khakimov via Scopus - Elsevier

Physical fitness in community dwelling older adults is linked to dietary intake, gut microbiota and metabolomic signatures

2019-10-08 | Other
Contributors: Josué L. Castro-Mejía; Bekzod Khakimov; Łukasz Krych; Jacob Bülow; Rasmus L. Bechshøft; Grith Højfeldt; Kenneth H. Mertz; Eva Stahl Garne; Simon R. Schacht; Hajar F. Ahmad et al.
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Crossref

The cytochrome P450 CYP72A552 is key to production of hederagenin‐based saponins that mediate plant defense against herbivores

New Phytologist
2019-05 | Journal article
Contributors: Qing Liu; Bekzod Khakimov; Pablo D. Cárdenas; Federico Cozzi; Carl Erik Olsen; Karen Rysbjerg Jensen; Thure Pavlo Hauser; Søren Bak
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A single oxidosqualene cyclase produces the seco-triterpenoid α-onocerin

Plant Physiology
2018 | Journal article
EID:

2-s2.0-85041741074

Part of ISBN:

15322548 00320889

Contributors: Almeida, A.; Dong, L.; Khakimov, B.; Bassard, J.-E.; Moses, T.; Lota, F.; Goossens, A.; Appendino, G.; Bak, S.
Source: Self-asserted source
Bekzod Khakimov via Scopus - Elsevier

Biogenic amines: a key freshness parameter of animal protein products in the coming circular economy

Current Opinion in Food Science
2018 | Journal article
EID:

2-s2.0-85049891546

Part of ISBN:

22147993

Contributors: Sørensen, K.M.; Aru, V.; Khakimov, B.; Aunskjær, U.; Engelsen, S.B.
Source: Self-asserted source
Bekzod Khakimov via Scopus - Elsevier

CHAPTER 8: NMR Foodomics

New Developments in NMR
2018 | Book chapter
EID:

2-s2.0-85041721231

Part of ISBN:

20442548 2044253X

Contributors: Savorani, F.; Khakimov, B.; Viereck, N.; Engelsen, Sø.B.
Source: Self-asserted source
Bekzod Khakimov via Scopus - Elsevier
Items per page:
Page 1 of 2

Peer review (2 reviews for 2 publications/grants)

Review activity for Journal of proteome research. (1)
Review activity for PloS one. (1)