Personal information

Emails & domains

Verified email addresses

Verified email domains

Websites & social links

Google Scholar
Gage Lab Website

Other IDs

Scopus Author ID: 36571666600

Keywords

Human Embryonic Stem Cells, Human Development, Liver Sinusoidal Endothelial Cells, Hemophilia A, Liver Disease, Diabetes, Pancreas

Countries

Canada

Biography

As a Canadian Stem Cell scientist, I have focused my career on using stem cells to understand and fight human disease. My PhD work in the field of diabetes explored how stem cell-derived pancreatic endocrine cell fates are regulated by transcription factors. Moving to the liver and its diseases, my postdoctoral work used human pluripotent stem cells to make special vascular cells of the liver known as Liver Sinusoidal Endothelial Cells (LSECs) which represent a potential cell therapy to treat human diseases like Hemophilia A, NASH, and cancer. In my own lab at the Ottawa Hospital Research Institute, we are continuing this work to discover regulators of endothelial functions to build new therapeutics.

Activities

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Employment (7)

University of Ottawa: Ottawa, CA

2024-02-01 to present | Assistant Professor (Cellular and Molecular Medicine)
Employment
Source: Self-asserted source
Blair K. Gage

Ottawa Hospital Research Institute: Ottawa, Ontario, CA

2023-12-01 to present | Scientist (Regenerative Medicine Program)
Employment
Source: Self-asserted source
Blair K. Gage

University Health Network: Toronto, Ontario, CA

2014-11-17 to 2023-12-01 | Post Doctoral Fellow / Research Associate (McEwen Stem Cell Institute)
Employment
Source: Self-asserted source
Blair K. Gage

University of British Columbia: Vancouver, British Columbia, CA

2008-09-01 to 2014-08-31 | Graduate Student - Kieffer Lab (Cellular and Physiological Sciences)
Employment
Source: Self-asserted source
Blair K. Gage

University of British Columbia: Vancouver, British Columbia, CA

2007-01-01 to 2007-08-31 | Research Assistant - Co-op Student (Cellular and Physiological Sciences - Kieffer Lab)
Employment
Source: Self-asserted source
Blair K. Gage

University of British Columbia: Vancouver, British Columbia, CA

2006-05-01 to 2006-08-31 | Research Assistant - Co-op Student (Chemistry - Burtnick Lab)
Employment
Source: Self-asserted source
Blair K. Gage

Pacific Agricultural Research Center: Agassiz, British Columbia, CA

2005-05-01 to 2005-08-31 | Research Assistant - Co-op Student (Agri-food Canada - Vernon Lab)
Employment
Source: Self-asserted source
Blair K. Gage

Education and qualifications (3)

University of British Columbia: Vancouver, British Columbia, CA

2008-09-01 to 2014-08-31 | PhD. Cell and Developmental Biology (Cellular and Physiological Sciences)
Education
Source: Self-asserted source
Blair K. Gage

University of British Columbia: Vancouver, British Columbia, CA

2004-09-01 to 2008-05-31 | Bachelor of Science, Hon. Co-op - Major: Biotechnology (Microbiology and Immunology)
Education
Source: Self-asserted source
Blair K. Gage

British Columbia Institute of Technology: Burnaby, British Columbia, CA

2004-09-01 to 2006-05-31 | Diploma of Technology - Major: Biotechnology (School of Health Sciences)
Education
Source: Self-asserted source
Blair K. Gage

Professional activities (1)

International Society for Stem Cell Research: Skokie, IL, US

2010-09-01 to present | Post Doctoral Fellow / Research Associate (McEwen Stem Cell Institute)
Membership
Source: Self-asserted source
Blair K. Gage

Funding (7)

Regulating the Functions of Human Liver Sinusoidal Endothelial Cells to Fight Liver Disease (518024)

2024-10 to 2029-09 | Grant
CANADIAN INSTITUTES OF HEALTH RESEARCH (Ottawa, CA)
GRANT_NUMBER:

518024
Source: Self-asserted source
Blair K. Gage

Generating Functional Liver Sinusoidal Endothelial Cells from Human Pluripotent Stem Cells

2015-04-01 to 2018-03-31 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.7633301
GRANT_NUMBER:

27ce9c1205e89d387ecdbb90198f677c
Source: Self-asserted source
Blair K. Gage via DimensionsWizard

Embryonic Stem Cells to Pancreatic ß-cells: Developmental Guidance by Transcription Factors

2011-04-01 to 2012-03-31 | Grant
Natural Sciences and Engineering Research Council (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.2812649
GRANT_NUMBER: 486735
Source: Self-asserted source
Blair K. Gage via DimensionsWizard

Embryonic Stem Cells to Pancreatic ß-cells: Developmental Guidance by Transcription Factors

2010-04-01 to 2011-03-31 | Grant
Natural Sciences and Engineering Research Council (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.2856639
GRANT_NUMBER: 465394
Source: Self-asserted source
Blair K. Gage via DimensionsWizard

Defining the Transcription Factors Capable of Forming Pancreatic Beta-Cells from Human Embryonic Stem Cells

2009-10-01 to 2011-08-15 | Grant
Michael Smith Health Research BC (Vancouver, CA)
URL: https://app.dimensions.ai/details/grant/grant.4118695
GRANT_NUMBER:

11738
Source: Self-asserted source
Blair K. Gage via DimensionsWizard

Stem Cell Biology: An Investigation of the Influential Factors Involved in the Targeted Differentiation of Amniotic Fluid Stem Cells

2009-04-01 to 2010-03-31 | Grant
Natural Sciences and Engineering Research Council (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.2798004
GRANT_NUMBER: 433187
Source: Self-asserted source
Blair K. Gage via DimensionsWizard

Stem Cell Biology: An Investigation of the Influential Factors Involved in the Targeted Differentiation of Amniotic Fluid Stem Cells

2008-04-01 to 2009-03-31 | Grant
Natural Sciences and Engineering Research Council (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.2879638
GRANT_NUMBER: 404764
Source: Self-asserted source
Blair K. Gage via DimensionsWizard

Works (18)

Human liver sinusoidal endothelial cells support the development of functional human pluripotent stem cell-derived Kupffer cells

Cell Reports
2024-08 | Journal article
DOI: 10.1016/j.celrep.2024.114629
Contributors: Gregory M. Kent; Michael H. Atkins; Bryan Lung; Adele Nikitina; Ian M. Fernandes; Jamie J. Kwan; Tallulah S. Andrews; Sonya A. MacParland; Gordon M. Keller; Blair K. Gage
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Erratum: Therapeutic correction of hemophilia A by transplantation of hPSC-derived liver sinusoidal endothelial cell progenitors (Cell Reports (2022) 39(1), (S2211124722003692), (10.1016/j.celrep.2022.110621))

Cell Reports
2022 | Journal article
DOI: 10.1016/j.celrep.2022.110759
EID:

2-s2.0-85128923189

Part of ISSN: 22111247
Contributors: Gage, B.K.; Merlin, S.; Olgasi, C.; Follenzi, A.; Keller, G.M.
Source: Self-asserted source
Blair K. Gage via Scopus - Elsevier

Therapeutic correction of hemophilia A by transplantation of hPSC-derived liver sinusoidal endothelial cell progenitors

Cell Reports
2022 | Journal article
DOI: 10.1016/j.celrep.2022.110621
EID:

2-s2.0-85127472392

Part of ISSN: 22111247
Contributors: Gage, B.K.; Merlin, S.; Olgasi, C.; Follenzi, A.; Keller, G.M.
Source: Self-asserted source
Blair K. Gage via Scopus - Elsevier
grade
Preferred source (of 2)‎

One‐Step Formation of Protein‐Based Tubular Structures for Functional Devices and Tissues

Advanced Healthcare Materials
2021-04 | Journal article
DOI: 10.1002/adhm.202001746
Part of ISSN: 2192-2640
Part of ISSN: 2192-2659
Contributors: Wuyang Gao; Nima Vaezzadeh; Kelvin Chow; Haotian Chen; Patricia Lavender; Mark D. Jeronimo; Arianna McAllister; Onofrio Laselva; Jia‐Xin Jiang; Blair K. Gage et al.
Source: Self-asserted source
Blair K. Gage
grade
Preferred source (of 2)‎

Generation of Functional Liver Sinusoidal Endothelial Cells from Human Pluripotent Stem-Cell-Derived Venous Angioblasts

Cell Stem Cell
2020-08 | Journal article
DOI: 10.1016/j.stem.2020.06.007
Part of ISSN: 1934-5909
Contributors: Blair K. Gage; Jeff C. Liu; Brendan T. Innes; Sonya A. MacParland; Ian D. McGilvray; Gary D. Bader; Gordon M. Keller
Source: Self-asserted source
Blair K. Gage
grade
Preferred source (of 2)‎

Nanoparticle Uptake in a Spontaneous and Immunocompetent Woodchuck Liver Cancer Model

ACS Nano
2020-04-28 | Journal article
DOI: 10.1021/acsnano.0c00468
Part of ISSN: 1936-0851
Part of ISSN: 1936-086X
Contributors: Lewis Y. Liu; Xue-Zhong Ma; Ben Ouyang; Danielle P. Ings; Sagar Marwah; Jeff Liu; Annie Y. Chen; Rahul Gupta; Justin Manuel; Xu-Chun Chen et al.
Source: Self-asserted source
Blair K. Gage
grade
Preferred source (of 2)‎

Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations

Nature Communications
2018-10-22 | Journal article
DOI: 10.1038/s41467-018-06318-7
Part of ISSN: 2041-1723
Contributors: Sonya A. MacParland; Jeff C. Liu; Xue-Zhong Ma; Brendan T Innes; Agata M. Bartczak; Blair K. Gage; Justin Manuel; Nicholas Khuu; Juan Echeverri; Ivan Linares et al.
Source: Self-asserted source
Blair K. Gage
grade
Preferred source (of 2)‎

Generating pancreatic endocrine cells from pluripotent stem cells

Islets of Langerhans, Second Edition
2015 | Book chapter
Part of DOI: 10.1007/978-94-007-6686-0_49
EID:

2-s2.0-84943279699

Part of ISBN: 9789400766860 9789400766853
Contributors: Gage, B.K.; Wideman, R.D.; Kieffer, T.J.
Source: Self-asserted source
Blair K. Gage via Scopus - Elsevier

The Role of ARX in Human Pancreatic Endocrine Specification

PLOS ONE
2015-12-03 | Journal article
DOI: 10.1371/journal.pone.0144100
Part of ISSN: 1932-6203
Contributors: Blair K. Gage; Ali Asadi; Robert K. Baker; Travis D. Webber; Rennian Wang; Masayuki Itoh; Masaharu Hayashi; Rie Miyata; Takumi Akashi; Timothy J. Kieffer
Source: Self-asserted source
Blair K. Gage
grade
Preferred source (of 2)‎

Process Analytical Utility of Raman Microspectroscopy in the Directed Differentiation of Human Pancreatic Insulin-Positive Cells

Analytical Chemistry
2015-11-03 | Journal article
DOI: 10.1021/acs.analchem.5b03295
Part of ISSN: 0003-2700
Part of ISSN: 1520-6882
Contributors: Stanislav O. Konorov; H. Georg Schulze; Blair K. Gage; Timothy J. Kieffer; James M. Piret; Michael W. Blades; Robin F. B. Turner
Source: Self-asserted source
Blair K. Gage
grade
Preferred source (of 2)‎

Overexpression of PAX4 reduces glucagon expression in differentiating hESCs

Islets
2014-03 | Journal article
DOI: 10.4161/isl.29236
Part of ISSN: 1938-2014
Part of ISSN: 1938-2022
Contributors: Blair K Gage; Robert K Baker; Timothy J Kieffer
Source: Self-asserted source
Blair K. Gage
grade
Preferred source (of 2)‎

Initial Cell Seeding Density Influences Pancreatic Endocrine Development During in vitro Differentiation of Human Embryonic Stem Cells

PLoS ONE
2013-12-04 | Journal article
DOI: 10.1371/journal.pone.0082076
Part of ISSN: 1932-6203
Contributors: Blair K. Gage; Travis D. Webber; Timothy J. Kieffer
Source: Self-asserted source
Blair K. Gage
grade
Preferred source (of 2)‎

A human embryonic stem cell line adapted for high throughput screening

Biotechnology and Bioengineering
2013-10 | Journal article
DOI: 10.1002/bit.24936
Part of ISSN: 0006-3592
Contributors: Nicolas J. Caron; Blair K. Gage; Michael D. O'Connor; Connie J. Eaves; Timothy J. Kieffer; James M. Piret
Source: Self-asserted source
Blair K. Gage
grade
Preferred source (of 2)‎

Musashi expression in β-cells coordinates insulin expression, apoptosis and proliferation in response to endoplasmic reticulum stress in diabetes

Cell Death & Disease
2011-11-24 | Journal article
DOI: 10.1038/cddis.2011.119
Part of ISSN: 2041-4889
Contributors: M Szabat; T B Kalynyak; G E Lim; K Y Chu; Y H Yang; A Asadi; B K Gage; Z Ao; G L Warnock; J M Piret et al.
Source: Self-asserted source
Blair K. Gage
grade
Preferred source (of 2)‎

Cellular reprogramming of human amniotic fluid cells to express insulin

Differentiation
2010-09 | Journal article
DOI: 10.1016/j.diff.2010.05.007
Part of ISSN: 0301-4681
Contributors: Blair K. Gage; Michael J. Riedel; Francis Karanu; Alireza Rezania; Yukihiro Fujita; Travis D. Webber; Robert K. Baker; Rhonda D. Wideman; Timothy J. Kieffer
Source: Self-asserted source
Blair K. Gage
grade
Preferred source (of 2)‎

A Multi-Parameter, High-Content, High-Throughput Screening Platform to Identify Natural Compounds that Modulate Insulin and Pdx1 Expression

PLoS ONE
2010-09-23 | Journal article
DOI: 10.1371/journal.pone.0012958
Part of ISSN: 1932-6203
Contributors: Jessica A. Hill; Marta Szabat; Corinne A. Hoesli; Blair K. Gage; Yu Hsuan C. Yang; David E. Williams; Michael J. Riedel; Dan S. Luciani; Tatyana B. Kalynyak; Kevin Tsai et al.
Source: Self-asserted source
Blair K. Gage
grade
Preferred source (of 2)‎

Transitional sublethal and lethal effects of insecticides after dermal exposures to five economic species of wireworms (coleoptera: Elateridae)

Journal of Economic Entomology
2008 | Journal article
DOI: 10.1603/0022-0493(2008)101[365:TSALEO]2.0.CO;2
EID:

2-s2.0-38849156636

Part of ISSN: 00220493
Contributors: Vernon, R.S.; Van Herk, W.; Tolman, J.; Saavedra, H.O.; Clodius, M.; Gage, B.
Source: Self-asserted source
Blair K. Gage via Scopus - Elsevier

Transitional Sublethal and Lethal Effects of Insecticides After Dermal Exposures to Five Economic Species of Wireworms (Coleoptera: Elateridae)

Journal of Economic Entomology
2008-04-01 | Journal article
DOI: 10.1093/jee/101.2.365
Part of ISSN: 1938-291X
Part of ISSN: 0022-0493
Contributors: R. S. Vernon; W. Van Herk; J. Tolman; H. Ortiz Saavedra; M. Clodius; B. Gage
Source: Self-asserted source
Blair K. Gage

Peer review (3 reviews for 2 publications/grants)

Review activity for Molecular therapy. (2)
Review activity for Stem cell reports. (1)
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