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Scopus Author ID: 57224800774

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Cambridge University Hospitals NHS Foundation Trust: Cambridge, Cambridgeshire, GB

1996-06-01 to present | Consultant Medical Microbiologist (Clinical Microbiology and Public Health Laboratory)
Employment
Source: Self-asserted source
Nicholas Brown

Works (50 of 93)

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Bloodstream Infections in Critical Care Units in England, April 2017 to March 2023: Results from the First Six Years of a National Surveillance Programme

Microorganisms
2025-01 | Journal article | Author
DOI: 10.3390/microorganisms13010183
Contributors: Olivia D. Conroy; Andrea Mazzella; Hannah Choi; Jocelyn Elmes; Matt Wilson; Dimple Y. Chudasama; Sarah M. Gerver; Miroslava Mihalkova; Andrew Rhodes; Andrew Wilson et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

Development and implementation of a customised rapid syndromic diagnostic test for severe pneumonia [version 3; peer review: 2 approved]

2022-10-12 | Journal article
DOI: 10.12688/wellcomeopenres.17099.3
Part of ISSN: 2398-502X
Funded by GRANT_NUMBER: 18135
Funded by GRANT_NUMBER:

205214

Funded by GRANT_NUMBER:

HICF-510-078;094949/Z/10/X

Funded by GRANT_NUMBER: MR/V006118/1
Contributors: Vilas Navapurkar; Josefin Bartholdson Scott; Mailis Maes; Thomas P Hellyer; Ellen Higginson; Sally Forrest; Joana Pereira-Dias; Surendra Parmar; Emma Heasman-Hunt; Petra Polgarova et al.
Source: check_circle
Wellcome Open Research

A2B-COVID: A tool for rapidly evaluating potential SARS-CoV-2 transmission events.

Molecular biology and evolution
2022-02 | Journal article
DOI: 10.1093/molbev/msac025
PMID: 35106603
Contributors: Illingworth CJR; Hamilton WL; Jackson C; Warne B; Popay A; Meredith L; Hosmillo M; Jahun A; Fieldman T; Routledge M et al.
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission.

Nature communications
2022-02 | Journal article
DOI: 10.1038/s41467-021-27942-w
PMID: 35136068
PMC: PMC8826310
Contributors: Aggarwal D; Warne B; Jahun AS; Hamilton WL; Fieldman T; du Plessis L; Hill V; Blane B; Watkins E; Wright E et al.
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

Evaluation of methods for whole genome sequencing of Enterococcus faecium in a diagnostic laboratory

2021-11 | Preprint
DOI: 10.1101/2021.11.09.21265457
PPR: PPR418906
Contributors: Raven KE; Leek D; Blane B; Girgis ST; Akram A; Brown N; Peacock SJ
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

Defining nosocomial transmission of <i>Escherichia coli</i> and antimicrobial resistance genes: a genomic surveillance study.

The Lancet. Microbe
2021-09 | Journal article
DOI: 10.1016/s2666-5247(21)00117-8
PMID: 34485958
PMC: PMC8410606
Contributors: Ludden C; Coll F; Gouliouris T; Restif O; Blane B; Blackwell GA; Kumar N; Naydenova P; Crawley C; Brown NM et al.
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

Evaluating the Sensitivity and Specificity of Siemens Clinitest Lateral Flow Test and the Simple AMplification-Based Assay (SAMBA)-2 PCR Test for SARS-CoV-2 Infection.

Cureus
2021-09 | Journal article
DOI: 10.7759/cureus.18319
PMID: 34725589
PMC: PMC8553283
Contributors: Boyle AA; Hardwick S; Warne B; Nwuba CK; Brown N; Shaw A
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

Superspreaders drive the largest outbreaks of hospital onset COVID-19 infections.

eLife
2021-08 | Journal article
DOI: 10.7554/elife.67308
PMID: 34425938
PMC: PMC8384420
Contributors: Illingworth CJ; Hamilton WL; Warne B; Routledge M; Popay A; Jackson C; Fieldman T; Meredith LW; Houldcroft CJ; Hosmillo M et al.
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

A prospective surveillance study to determine the prevalence of 16S rRNA methyltransferase-producing Gram-negative bacteria in the UK

Journal of Antimicrobial Chemotherapy
2021-08-12 | Journal article
DOI: 10.1093/jac/dkab186
Contributors: Emma Taylor; Abhijit M. Bal; Indran Balakrishnan; Nicholas M. Brown; Phillipa Burns; Marilyn Clark; Mathew Diggle; Hugo Donaldson; Ian Eltringham; Jonathan Folb et al.
Source: check_circle
Crossref

Improving diagnostic stewardship in urinary tract infections: a service evaluation of selective urine culture.

The Journal of hospital infection
2021-07 | Journal article
DOI: 10.1016/j.jhin.2021.07.008
PMID: 34303736
Contributors: Wright L; Heywood N; Cooke FJ; Brown NM
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

Treatment of methicillin-resistant Staphylococcus aureus (MRSA): updated guidelines from the UK

Journal of Antimicrobial Chemotherapy
2021-05-12 | Journal article
DOI: 10.1093/jac/dkab036
Contributors: Nicholas M Brown; Erwin M Brown; Nicholas M Brown; Anna L Goodman; Carolyne Horner; Abi Jenkins; Erwin M Brown
Source: check_circle
Crossref

Correction to: Ventilator-associated pneumonia in critically ill patients with COVID-19.

Critical care (London, England)
2021-04 | Journal article
DOI: 10.1186/s13054-021-03560-2
PMID: 33823901
PMC: PMC8023782
Contributors: Maes M; Higginson E; Pereira-Dias J; Curran MD; Parmar S; Khokhar F; Cuchet-Lourenço D; Lux J; Sharma-Hajela S; Ravenhill B et al.
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

Genomic epidemiology of COVID-19 in care homes in the east of England.

eLife
2021-03 | Journal article
DOI: 10.7554/elife.64618
PMID: 33650490
PMC: PMC7997667
Contributors: Hamilton WL; Tonkin-Hill G; Smith ER; Aggarwal D; Houldcroft CJ; Warne B; Meredith LW; Hosmillo M; Jahun AS; Curran MD et al.
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

Treatment of methicillin-resistant <i>Staphylococcus aureus</i> (MRSA): updated guidelines from the UK.

JAC-antimicrobial resistance
2021-02 | Journal article
DOI: 10.1093/jacamr/dlaa114
PMID: 34223066
PMC: PMC8210269
Contributors: Brown NM; Goodman AL; Horner C; Jenkins A; Brown EM
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

A common protocol for the simultaneous processing of multiple clinically relevant bacterial species for whole genome sequencing.

Scientific reports
2021-01 | Journal article
DOI: 10.1038/s41598-020-80031-8
PMID: 33420120
PMC: PMC7794230
Contributors: Raven KE; Girgis ST; Akram A; Blane B; Leek D; Brown N; Peacock SJ
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

Ventilator-associated pneumonia in critically ill patients with COVID-19.

Critical care (London, England)
2021-01 | Journal article
DOI: 10.1186/s13054-021-03460-5
PMID: 33430915
PMC: PMC7797892
Contributors: Maes M; Higginson E; Pereira-Dias J; Curran MD; Parmar S; Khokhar F; Cuchet-Lourenço D; Lux J; Sharma-Hajela S; Ravenhill B et al.
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

Consensus-based antimicrobial resistance and stewardship competencies for UK undergraduate medical students.

JAC-antimicrobial resistance
2020-12 | Journal article
DOI: 10.1093/jacamr/dlaa096
PMID: 34223048
PMC: PMC8210211
Contributors: McMaster D; Courtenay M; Santucci C; Davies AP; Kirby A; Seddon O; Price DA; Barlow G; Lim FH; Davies BS et al.
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

Diagnostic tool or screening programme? Asymptomatic testing for SARS-CoV-2 needs clear goals and protocols.

The Lancet regional health. Europe
2020-12 | Journal article
DOI: 10.1016/j.lanepe.2020.100002
PMID: 34173617
PMC: PMC7834146
Contributors: Skittrall JP; Fortune MD; Jalal H; Zhang H; Enoch DA; Brown NM; Swift A
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

A2B-COVID: A method for evaluating potential SARS-CoV-2 transmission events

2020-10 | Preprint
DOI: 10.1101/2020.10.26.20219642
PPR: PPR230592
Contributors: Illingworth CJR; Hamilton WL; Jackson C; Popay A; Meredith L; Houldcroft CJ; Hosmillo M; Jahun A; Routledge M; Warne B et al.
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

Quantifying acquisition and transmission of Enterococcus faecium using genomic surveillance.

Nature microbiology
2020-10 | Journal article
DOI: 10.1038/s41564-020-00806-7
PMID: 33106672
PMC: PMC7610418
Contributors: Gouliouris T; Coll F; Ludden C; Blane B; Raven KE; Naydenova P; Crawley C; Török ME; Enoch DA; Brown NM et al.
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

Genomic epidemiology of COVID-19 in care homes in the East of England

2020-09 | Preprint
DOI: 10.1101/2020.08.26.20182279
PPR: PPR208003
Contributors: Hamilton WL; Tonkin-Hill G; Smith E; Aggarwal D; Houldcroft CJ; Warne B; Brown CS; Meredith LW; Hosmillo M; Jahun AS et al.
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19.

eLife
2020-06 | Journal article
DOI: 10.7554/elife.59391
PMID: 32558644
PMC: PMC7326489
Contributors: Jones NK; Rivett L; Sparkes D; Forrest S; Sridhar S; Young J; Pereira-Dias J; Cormie C; Gill H; Reynolds N et al.
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

Secondary pneumonia in critically ill ventilated patients with COVID-19

2020-06 | Preprint
DOI: 10.1101/2020.06.26.20139873
PPR: PPR180947
Contributors: Maes M; Higginson E; Pereira-Dias J; Curran M; Parmar S; Khokhar F; Cuchet-Lourenço D; Lux J; Sharma-Hajela S; Ravenhill B et al.
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

Evaluation of a fully automated bioinformatics tool to predict antibiotic resistance from MRSA genomes.

The Journal of antimicrobial chemotherapy
2020-05 | Journal article
DOI: 10.1093/jac/dkz570
PMID: 32025709
PMC: PMC7177496
Contributors: Kumar N; Raven KE; Blane B; Leek D; Brown NM; Bragin E; Rhodes PA; Parkhill J; Peacock SJ
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission.

eLife
2020-05 | Journal article
DOI: 10.7554/elife.58728
PMID: 32392129
PMC: PMC7314537
Contributors: Rivett L; Sridhar S; Sparkes D; Routledge M; Jones NK; Forrest S; Young J; Pereira-Dias J; Hamilton WL; Ferris M et al.
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

Genomic Surveillance of Methicillin-resistant Staphylococcus aureus: A Mathematical Early Modeling Study of Cost-effectiveness.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2020-04 | Journal article
DOI: 10.1093/cid/ciz480
PMID: 31219153
PMC: PMC7145999
Contributors: Dymond A; Davies H; Mealing S; Pollit V; Coll F; Brown NM; Peacock SJ
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

A One Health Study of the Genetic Relatedness of Klebsiella pneumoniae and Their Mobile Elements in the East of England.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2020-01 | Journal article
DOI: 10.1093/cid/ciz174
PMID: 30840764
PMC: PMC6938978
Contributors: Ludden C; Moradigaravand D; Jamrozy D; Gouliouris T; Blane B; Naydenova P; Hernandez-Garcia J; Wood P; Hadjirin N; Radakovic M et al.
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

Contrasting approaches to genome-wide association studies impact the detection of resistance mechanisms in Staphylococcus aureus

2019-09 | Preprint
DOI: 10.1101/758144
PPR: PPR91227
Contributors: Wheeler NE; Reuter S; Chewapreecha C; Lees JA; Blane B; Horner C; Enoch D; Brown NM; Estée Török M; Aanensen DM et al.
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

Contrasting patterns of longitudinal population dynamics and antimicrobial resistance mechanisms in two priority bacterial pathogens over 7 years in a single center.

Genome biology
2019-09 | Journal article
DOI: 10.1186/s13059-019-1785-1
PMID: 31477167
PMC: PMC6717969
Contributors: Ellington MJ; Heinz E; Wailan AM; Dorman MJ; de Goffau M; Cain AK; Henson SP; Gleadall N; Boinett CJ; Dougan G et al.
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

Rapid sequencing of MRSA direct from clinical plates in a routine microbiology laboratory.

The Journal of antimicrobial chemotherapy
2019-08 | Journal article
DOI: 10.1093/jac/dkz170
PMID: 31039248
PMC: PMC6640301
Contributors: Blane B; Raven KE; Leek D; Brown N; Parkhill J; Peacock SJ
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

An outbreak of meticillin-resistant Staphylococcus aureus colonization in a neonatal intensive care unit: use of a case-control study to investigate and control it and lessons learnt.

The Journal of hospital infection
2019-05 | Journal article
DOI: 10.1016/j.jhin.2019.05.009
PMID: 31132394
Contributors: Brown NM; Reacher M; Rice W; Roddick I; Reeve L; Verlander NQ; Broster S; Ogilvy-Stuart AL; D'Amore A; Ahluwalia J et al.
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

Genomic surveillance of Escherichia coli in municipal wastewater treatment plants as an indicator of clinically relevant pathogens and their resistance genes.

Microbial genomics
2019-05 | Journal article
DOI: 10.1099/mgen.0.000267
PMID: 31107200
PMC: PMC6562247
Contributors: Raven KE; Ludden C; Gouliouris T; Blane B; Naydenova P; Brown NM; Parkhill J; Peacock SJ
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

Detection of vancomycin-resistant <i>Enterococcus faecium</i> hospital-adapted lineages in municipal wastewater treatment plants indicates widespread distribution and release into the environment.

Genome research
2019-03 | Journal article
DOI: 10.1101/gr.232629.117
PMID: 30898881
PMC: PMC6442392
Contributors: Gouliouris T; Raven KE; Moradigaravand D; Ludden C; Coll F; Blane B; Naydenova P; Horner C; Brown NM; Corander J et al.
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

One Health Genomic Surveillance of Escherichia coli Demonstrates Distinct Lineages and Mobile Genetic Elements in Isolates from Humans versus Livestock.

mBio
2019-01 | Journal article
DOI: 10.1128/mbio.02693-18
PMID: 30670621
PMC: PMC6343043
Contributors: Ludden C; Raven KE; Jamrozy D; Gouliouris T; Blane B; Coll F; de Goffau M; Naydenova P; Horner C; Hernandez-Garcia J et al.
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

Genomic Surveillance of Enterococcus faecium Reveals Limited Sharing of Strains and Resistance Genes between Livestock and Humans in the United Kingdom.

mBio
2018-11 | Journal article
DOI: 10.1128/mbio.01780-18
PMID: 30401778
PMC: PMC6222123
Contributors: Gouliouris T; Raven KE; Ludden C; Blane B; Corander J; Horner CS; Hernandez-Garcia J; Wood P; Hadjirin NF; Radakovic M et al.
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

Transmission of toxigenic <i>Corynebacterium diphtheriae</i> by a fully immunised resident returning from a visit to West Africa, United Kingdom, 2017.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
2018-09 | Journal article
DOI: 10.2807/1560-7917.es.2018.23.39.1700681
PMID: 30280689
PMC: PMC6169202
Contributors: Edwards D; Kent D; Lester C; Brown CS; Murphy ME; Brown NM; Sule O; Itani A; Chand M; Trindall A et al.
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

Changing the paradigm for hospital outbreak detection by leading with genomic surveillance of nosocomial pathogens.

Microbiology (Reading, England)
2018-07 | Journal article
DOI: 10.1099/mic.0.000700
PMID: 30052172
PMC: PMC7611365
Contributors: Peacock SJ; Parkhill J; Brown NM
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

Duration of exposure to multiple antibiotics is associated with increased risk of VRE bacteraemia: a nested case-control study.

The Journal of antimicrobial chemotherapy
2018-06 | Journal article
DOI: 10.1093/jac/dky075
PMID: 29548009
PMC: PMC5961253
Contributors: Gouliouris T; Warne B; Cartwright EJP; Bedford L; Weerasuriya CK; Raven KE; Brown NM; Török ME; Limmathurotsakul D; Peacock SJ
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

Micafungin use in a UK tertiary referral hospital.

Journal of global antimicrobial resistance
2018-06 | Journal article
DOI: 10.1016/j.jgar.2018.06.009
PMID: 29969751
Contributors: Enoch DA; Murphy ME; Micallef C; Yang H; Brown NM; Aliyu SH
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

Point-prevalence survey of carbapenemase-producing Enterobacteriaceae and vancomycin-resistant enterococci in adult inpatients in a university teaching hospital in the UK.

The Journal of hospital infection
2018-06 | Journal article
DOI: 10.1016/j.jhin.2018.06.024
PMID: 29969691
Contributors: Wilson HJ; Khokhar F; Enoch DA; Brown NM; Ahluwalia J; Dougan G; Török ME
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

Real-world use of fidaxomicin in a large UK tertiary hospital: how effective is it for treating recurrent disease?

The Journal of hospital infection
2018-05 | Journal article
DOI: 10.1016/j.jhin.2018.05.001
PMID: 29746874
Contributors: Enoch DA; Santos R; Phillips CJ; Micallef C; Murphy ME; Aliyu SH; Massey D; Brown NM
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

Recent Progress for the Effective Prevention and Treatment of Recurrent Clostridium difficile Infection.

Infectious diseases
2018-03 | Journal article
DOI: 10.1177/1178633718758023
PMID: 29535530
PMC: PMC5844436
Contributors: Ramsay I; Brown NM; Enoch DA
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

Within-host evolution of Enterococcus faecium during longitudinal carriage and transition to bloodstream infection in immunocompromised patients.

Genome medicine
2017-12 | Journal article
DOI: 10.1186/s13073-017-0507-0
PMID: 29282103
PMC: PMC5744393
Contributors: Moradigaravand D; Gouliouris T; Blane B; Naydenova P; Ludden C; Crawley C; Brown NM; Török ME; Parkhill J; Peacock SJ
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

Longitudinal genomic surveillance of MRSA in the UK reveals transmission patterns in hospitals and the community.

Science translational medicine
2017-10 | Journal article
DOI: 10.1126/scitranslmed.aak9745
PMID: 29070701
PMC: PMC5683347
Contributors: Coll F; Harrison EM; Toleman MS; Reuter S; Raven KE; Blane B; Palmer B; Kappeler ARM; Brown NM; Török ME et al.
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

Multi-disciplinary review is an effective tool in reducing Clostridium difficile infection in hospitals.

The Journal of hospital infection
2017-09 | Journal article
DOI: 10.1016/j.jhin.2017.09.022
PMID: 28964885
Contributors: Bedford L; Aliyu SH; Brown NM; Cerny P; Haynes S; Thaxter R; Enoch DA
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

Community outbreaks of group A Streptococcus revealed by genome sequencing.

Scientific reports
2017-08 | Journal article
DOI: 10.1038/s41598-017-08914-x
PMID: 28819111
PMC: PMC5561225
Contributors: Turner CE; Bedford L; Brown NM; Judge K; Török ME; Parkhill J; Peacock SJ
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

Genomic surveillance reveals low prevalence of livestock-associated methicillin-resistant Staphylococcus aureus in the East of England.

Scientific reports
2017-08 | Journal article
DOI: 10.1038/s41598-017-07662-2
PMID: 28785112
PMC: PMC5547075
Contributors: Harrison EM; Coll F; Toleman MS; Blane B; Brown NM; Török ME; Parkhill J; Peacock SJ
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

Longitudinal genomic surveillance of multidrug-resistant Escherichia coli carriage in a long-term care facility in the United Kingdom.

Genome medicine
2017-07 | Journal article
DOI: 10.1186/s13073-017-0457-6
PMID: 28738847
PMC: PMC5525225
Contributors: Brodrick HJ; Raven KE; Kallonen T; Jamrozy D; Blane B; Brown NM; Martin V; Török ME; Parkhill J; Peacock SJ
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

Population genetic structuring of methicillin-resistant <i>Staphylococcus aureus</i> clone EMRSA-15 within UK reflects patient referral patterns.

Microbial genomics
2017-07 | Journal article
DOI: 10.1099/mgen.0.000113
PMID: 29026654
PMC: PMC5605955
Contributors: Donker T; Reuter S; Scriberras J; Reynolds R; Brown NM; Török ME; James R; Network EOEMR; Aanensen DM; Bentley SD et al.
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central

Sharing of carbapenemase-encoding plasmids between Enterobacteriaceae in UK sewage uncovered by MinION sequencing.

Microbial genomics
2017-07 | Journal article
DOI: 10.1099/mgen.0.000114
PMID: 29026655
PMC: PMC5605956
Contributors: Ludden C; Reuter S; Judge K; Gouliouris T; Blane B; Coll F; Naydenova P; Hunt M; Tracey A; Hopkins KL et al.
Source: Self-asserted source
Nicholas Brown via Europe PubMed Central
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