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Works (41)

Mitochondria Targeting of Oxidative Phosphorylation Inhibitors to Alleviate Hypoxia and Enhance Anticancer Treatment Efficacy

Clinical Cancer Research
2025-02-20 | Journal article
DOI: 10.1158/1078-0432.CCR-24-3296
Contributors: Anne P.M. Beerkens; Sandra Heskamp; Flavia V. Reinema; Gosse J. Adema; Paul N. Span; Johan Bussink
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Crossref

Saponin-based adjuvant uptake and induction of antigen cross-presentation by CD11b+ dendritic cells and macrophages

npj Vaccines
2025-01-22 | Journal article
DOI: 10.1038/s41541-024-01056-y
Contributors: Lisa GM Huis in ’t Veld; Lenneke AM Cornelissen; Lune van den Bogaard; Marleen Ansems; Nataschja I Ho; Gosse J Adema
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Siglec‐7 and Siglec‐9 expression in primary triple negative and oestrogen receptor positive breast cancer and in vitro signalling

Clinical & Translational Immunology
2024-09 | Journal article
DOI: 10.1002/cti2.1524
Contributors: Eline JH van Houtum; Anne HC Valk; Daniel Granado; Jasper Lok; Lune van den Bogaard; Naomi Remkes; Jesper van Eck van der Sluijs; Paul N Span; Lenneke AM Cornelissen; Gosse J Adema
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Crossref

Tumor cell-intrinsic and tumor microenvironmental conditions co-determine signaling by the glycoimmune checkpoint receptor Siglec-7

Cellular and Molecular Life Sciences
2023-06 | Journal article
DOI: 10.1007/s00018-023-04816-6
Contributors: Eline J. H. van Houtum; Esther D. Kers-Rebel; Maaike W. Looman; Erik Hooijberg; Christian Büll; Daniel Granado; Lenneke A. M. Cornelissen; Gosse J. Adema
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Data from Adenosine A2a Receptor Antagonism Restores Additive Cytotoxicity by Cytotoxic T Cells in Metabolically Perturbed Tumors

2023-04-04 | Preprint
DOI: 10.1158/2326-6066.c.6551043.v1
Contributors: Jeroen Slaats; Esther Wagena; Daan Smits; Annemarie A. Berends; Ella Peters; Gert-Jan Bakker; Merijn van Erp; Bettina Weigelin; Gosse J. Adema; Peter Friedl
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Data from Adenosine A2a Receptor Antagonism Restores Additive Cytotoxicity by Cytotoxic T Cells in Metabolically Perturbed Tumors

2023-04-04 | Preprint
DOI: 10.1158/2326-6066.c.6551043
Contributors: Jeroen Slaats; Esther Wagena; Daan Smits; Annemarie A. Berends; Ella Peters; Gert-Jan Bakker; Merijn van Erp; Bettina Weigelin; Gosse J. Adema; Peter Friedl
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Crossref

Supplementary Data from Adenosine A2a Receptor Antagonism Restores Additive Cytotoxicity by Cytotoxic T Cells in Metabolically Perturbed Tumors

2023-04-04 | Preprint
DOI: 10.1158/2326-6066.22545897
Contributors: Jeroen Slaats; Esther Wagena; Daan Smits; Annemarie A. Berends; Ella Peters; Gert-Jan Bakker; Merijn van Erp; Bettina Weigelin; Gosse J. Adema; Peter Friedl
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Crossref

Supplementary Data from Adenosine A2a Receptor Antagonism Restores Additive Cytotoxicity by Cytotoxic T Cells in Metabolically Perturbed Tumors

2023-04-04 | Preprint
DOI: 10.1158/2326-6066.22545897.v1
Contributors: Jeroen Slaats; Esther Wagena; Daan Smits; Annemarie A. Berends; Ella Peters; Gert-Jan Bakker; Merijn van Erp; Bettina Weigelin; Gosse J. Adema; Peter Friedl
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Crossref

Supplementary Data from Adenosine A2a Receptor Antagonism Restores Additive Cytotoxicity by Cytotoxic T Cells in Metabolically Perturbed Tumors

2023-04-04 | Preprint
DOI: 10.1158/2326-6066.22546646
Contributors: Jeroen Slaats; Esther Wagena; Daan Smits; Annemarie A. Berends; Ella Peters; Gert-Jan Bakker; Merijn van Erp; Bettina Weigelin; Gosse J. Adema; Peter Friedl
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Crossref

Supplementary Data from Adenosine A2a Receptor Antagonism Restores Additive Cytotoxicity by Cytotoxic T Cells in Metabolically Perturbed Tumors

2023-04-04 | Preprint
DOI: 10.1158/2326-6066.22546646.v1
Contributors: Jeroen Slaats; Esther Wagena; Daan Smits; Annemarie A. Berends; Ella Peters; Gert-Jan Bakker; Merijn van Erp; Bettina Weigelin; Gosse J. Adema; Peter Friedl
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Crossref

Supplementary Data from Adenosine A2a Receptor Antagonism Restores Additive Cytotoxicity by Cytotoxic T Cells in Metabolically Perturbed Tumors

2023-04-04 | Preprint
DOI: 10.1158/2326-6066.22546643
Contributors: Jeroen Slaats; Esther Wagena; Daan Smits; Annemarie A. Berends; Ella Peters; Gert-Jan Bakker; Merijn van Erp; Bettina Weigelin; Gosse J. Adema; Peter Friedl
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Crossref

Supplementary Data from Adenosine A2a Receptor Antagonism Restores Additive Cytotoxicity by Cytotoxic T Cells in Metabolically Perturbed Tumors

2023-04-04 | Preprint
DOI: 10.1158/2326-6066.22546640.v1
Contributors: Jeroen Slaats; Esther Wagena; Daan Smits; Annemarie A. Berends; Ella Peters; Gert-Jan Bakker; Merijn van Erp; Bettina Weigelin; Gosse J. Adema; Peter Friedl
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Crossref

Supplementary Data from Adenosine A2a Receptor Antagonism Restores Additive Cytotoxicity by Cytotoxic T Cells in Metabolically Perturbed Tumors

2023-04-04 | Preprint
DOI: 10.1158/2326-6066.22545891
Contributors: Jeroen Slaats; Esther Wagena; Daan Smits; Annemarie A. Berends; Ella Peters; Gert-Jan Bakker; Merijn van Erp; Bettina Weigelin; Gosse J. Adema; Peter Friedl
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Crossref

Supplementary Data from Adenosine A2a Receptor Antagonism Restores Additive Cytotoxicity by Cytotoxic T Cells in Metabolically Perturbed Tumors

2023-04-04 | Preprint
DOI: 10.1158/2326-6066.22545891.v1
Contributors: Jeroen Slaats; Esther Wagena; Daan Smits; Annemarie A. Berends; Ella Peters; Gert-Jan Bakker; Merijn van Erp; Bettina Weigelin; Gosse J. Adema; Peter Friedl
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Crossref

Supplementary Data from Adenosine A2a Receptor Antagonism Restores Additive Cytotoxicity by Cytotoxic T Cells in Metabolically Perturbed Tumors

2023-04-04 | Preprint
DOI: 10.1158/2326-6066.22546643.v1
Contributors: Jeroen Slaats; Esther Wagena; Daan Smits; Annemarie A. Berends; Ella Peters; Gert-Jan Bakker; Merijn van Erp; Bettina Weigelin; Gosse J. Adema; Peter Friedl
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Crossref

Supplementary Data from Adenosine A2a Receptor Antagonism Restores Additive Cytotoxicity by Cytotoxic T Cells in Metabolically Perturbed Tumors

2023-04-04 | Preprint
DOI: 10.1158/2326-6066.22545888.v1
Contributors: Jeroen Slaats; Esther Wagena; Daan Smits; Annemarie A. Berends; Ella Peters; Gert-Jan Bakker; Merijn van Erp; Bettina Weigelin; Gosse J. Adema; Peter Friedl
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Crossref

Supplementary Data from Adenosine A2a Receptor Antagonism Restores Additive Cytotoxicity by Cytotoxic T Cells in Metabolically Perturbed Tumors

2023-04-04 | Preprint
DOI: 10.1158/2326-6066.22546649
Contributors: Jeroen Slaats; Esther Wagena; Daan Smits; Annemarie A. Berends; Ella Peters; Gert-Jan Bakker; Merijn van Erp; Bettina Weigelin; Gosse J. Adema; Peter Friedl
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Crossref

Supplementary Data from Adenosine A2a Receptor Antagonism Restores Additive Cytotoxicity by Cytotoxic T Cells in Metabolically Perturbed Tumors

2023-04-04 | Preprint
DOI: 10.1158/2326-6066.22546649.v1
Contributors: Jeroen Slaats; Esther Wagena; Daan Smits; Annemarie A. Berends; Ella Peters; Gert-Jan Bakker; Merijn van Erp; Bettina Weigelin; Gosse J. Adema; Peter Friedl
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Crossref

Supplementary Data from Adenosine A2a Receptor Antagonism Restores Additive Cytotoxicity by Cytotoxic T Cells in Metabolically Perturbed Tumors

2023-04-04 | Preprint
DOI: 10.1158/2326-6066.22545888
Contributors: Jeroen Slaats; Esther Wagena; Daan Smits; Annemarie A. Berends; Ella Peters; Gert-Jan Bakker; Merijn van Erp; Bettina Weigelin; Gosse J. Adema; Peter Friedl
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Crossref

Supplementary Data from Adenosine A2a Receptor Antagonism Restores Additive Cytotoxicity by Cytotoxic T Cells in Metabolically Perturbed Tumors

2023-04-04 | Preprint
DOI: 10.1158/2326-6066.22546640
Contributors: Jeroen Slaats; Esther Wagena; Daan Smits; Annemarie A. Berends; Ella Peters; Gert-Jan Bakker; Merijn van Erp; Bettina Weigelin; Gosse J. Adema; Peter Friedl
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Crossref

Supplementary Figure from Adenosine A2a Receptor Antagonism Restores Additive Cytotoxicity by Cytotoxic T Cells in Metabolically Perturbed Tumors

2023-04-04 | Preprint
DOI: 10.1158/2326-6066.22545885
Contributors: Jeroen Slaats; Esther Wagena; Daan Smits; Annemarie A. Berends; Ella Peters; Gert-Jan Bakker; Merijn van Erp; Bettina Weigelin; Gosse J. Adema; Peter Friedl
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Crossref

Supplementary Figure from Adenosine A2a Receptor Antagonism Restores Additive Cytotoxicity by Cytotoxic T Cells in Metabolically Perturbed Tumors

2023-04-04 | Preprint
DOI: 10.1158/2326-6066.22545882
Contributors: Jeroen Slaats; Esther Wagena; Daan Smits; Annemarie A. Berends; Ella Peters; Gert-Jan Bakker; Merijn van Erp; Bettina Weigelin; Gosse J. Adema; Peter Friedl
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Crossref

Supplementary Figure from Adenosine A2a Receptor Antagonism Restores Additive Cytotoxicity by Cytotoxic T Cells in Metabolically Perturbed Tumors

2023-04-04 | Preprint
DOI: 10.1158/2326-6066.22545882.v1
Contributors: Jeroen Slaats; Esther Wagena; Daan Smits; Annemarie A. Berends; Ella Peters; Gert-Jan Bakker; Merijn van Erp; Bettina Weigelin; Gosse J. Adema; Peter Friedl
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Crossref

Supplementary Figure from Adenosine A2a Receptor Antagonism Restores Additive Cytotoxicity by Cytotoxic T Cells in Metabolically Perturbed Tumors

2023-04-04 | Preprint
DOI: 10.1158/2326-6066.22545879.v1
Contributors: Jeroen Slaats; Esther Wagena; Daan Smits; Annemarie A. Berends; Ella Peters; Gert-Jan Bakker; Merijn van Erp; Bettina Weigelin; Gosse J. Adema; Peter Friedl
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Crossref

Supplementary Figure from Adenosine A2a Receptor Antagonism Restores Additive Cytotoxicity by Cytotoxic T Cells in Metabolically Perturbed Tumors

2023-04-04 | Preprint
DOI: 10.1158/2326-6066.22545879
Contributors: Jeroen Slaats; Esther Wagena; Daan Smits; Annemarie A. Berends; Ella Peters; Gert-Jan Bakker; Merijn van Erp; Bettina Weigelin; Gosse J. Adema; Peter Friedl
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Crossref

Supplementary Figure from Adenosine A2a Receptor Antagonism Restores Additive Cytotoxicity by Cytotoxic T Cells in Metabolically Perturbed Tumors

2023-04-04 | Preprint
DOI: 10.1158/2326-6066.22545876.v1
Contributors: Jeroen Slaats; Esther Wagena; Daan Smits; Annemarie A. Berends; Ella Peters; Gert-Jan Bakker; Merijn van Erp; Bettina Weigelin; Gosse J. Adema; Peter Friedl
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Crossref

Supplementary Figure from Adenosine A2a Receptor Antagonism Restores Additive Cytotoxicity by Cytotoxic T Cells in Metabolically Perturbed Tumors

2023-04-04 | Preprint
DOI: 10.1158/2326-6066.22545885.v1
Contributors: Jeroen Slaats; Esther Wagena; Daan Smits; Annemarie A. Berends; Ella Peters; Gert-Jan Bakker; Merijn van Erp; Bettina Weigelin; Gosse J. Adema; Peter Friedl
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Crossref

Supplementary Figure from Adenosine A2a Receptor Antagonism Restores Additive Cytotoxicity by Cytotoxic T Cells in Metabolically Perturbed Tumors

2023-04-04 | Preprint
DOI: 10.1158/2326-6066.22545873
Contributors: Jeroen Slaats; Esther Wagena; Daan Smits; Annemarie A. Berends; Ella Peters; Gert-Jan Bakker; Merijn van Erp; Bettina Weigelin; Gosse J. Adema; Peter Friedl
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Crossref

Supplementary Figure from Adenosine A2a Receptor Antagonism Restores Additive Cytotoxicity by Cytotoxic T Cells in Metabolically Perturbed Tumors

2023-04-04 | Preprint
DOI: 10.1158/2326-6066.22545873.v1
Contributors: Jeroen Slaats; Esther Wagena; Daan Smits; Annemarie A. Berends; Ella Peters; Gert-Jan Bakker; Merijn van Erp; Bettina Weigelin; Gosse J. Adema; Peter Friedl
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Crossref

Supplementary Figure from Adenosine A2a Receptor Antagonism Restores Additive Cytotoxicity by Cytotoxic T Cells in Metabolically Perturbed Tumors

2023-04-04 | Preprint
DOI: 10.1158/2326-6066.22545876
Contributors: Jeroen Slaats; Esther Wagena; Daan Smits; Annemarie A. Berends; Ella Peters; Gert-Jan Bakker; Merijn van Erp; Bettina Weigelin; Gosse J. Adema; Peter Friedl
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Adenosine A2a Receptor Antagonism Restores Additive Cytotoxicity by Cytotoxic T Cells in Metabolically Perturbed Tumors

Cancer Immunology Research
2022-12-02 | Journal article
DOI: 10.1158/2326-6066.CIR-22-0113
Contributors: Jeroen Slaats; Esther Wagena; Daan Smits; Annemarie A. Berends; Ella Peters; Gert-Jan Bakker; Merijn van Erp; Bettina Weigelin; Gosse J. Adema; Peter Friedl
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NSAIDs affect dendritic cell cytokine production

PLOS ONE
2022-10-13 | Journal article
DOI: 10.1371/journal.pone.0275906
Contributors: Tonke K. Raaijmakers; Silke Appel; Renske J. E. van den Bijgaart; Gert Jan Scheffer; Marleen Ansems; Gosse J. Adema
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Saponin-based adjuvant-induced dendritic cell cross-presentation is dependent on PERK activation

Cellular and Molecular Life Sciences
2022-05 | Journal article
DOI: 10.1007/s00018-022-04253-x
Contributors: Lisa G. M. Huis in ’t Veld; Nataschja I. Ho; Melisssa Wassink; Martijn H. den Brok; Gosse J. Adema
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Sialic acid blockade in dendritic cells enhances CD8+ T cell responses by facilitating high-avidity interactions

Cellular and Molecular Life Sciences
2022-02 | Journal article
DOI: 10.1007/s00018-021-04027-x
Contributors: N. Balneger; L. A. M. Cornelissen; M. Wassink; S. J. Moons; T. J. Boltje; Y. E. Bar-Ephraim; K. K. Das; J. N. Søndergaard; C. Büll; G. J. Adema
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Merkel Cell Carcinoma: New Trends

Cancers
2021-03-31 | Journal article
DOI: 10.3390/cancers13071614
Contributors: Ellen M. Zwijnenburg; Satish F.K. Lubeek; Johanna E.M. Werner; Avital L. Amir; Willem L.J. Weijs; Robert P. Takes; Sjoert A.H. Pegge; Carla M.L. van Herpen; Gosse J. Adema; Johannes H. A. M. Kaanders
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Enhanced lipid biosynthesis in human tumor-induced macrophages contributes to their protumoral characteristics

Journal for ImmunoTherapy of Cancer
2020-09 | Journal article
DOI: 10.1136/jitc-2020-000638
Contributors: Katrin Rabold; Anna Aschenbrenner; Christoph Thiele; Collins K Boahen; Alexander Schiltmans; Johannes W A Smit; Joachim L Schultze; Mihai G Netea; Gosse J Adema; Romana T Netea-Maier
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Tumor ablation plus co-administration of CpG and saponin adjuvants affects IL-1 production and multifunctional T cell numbers in tumor draining lymph nodes

Journal for ImmunoTherapy of Cancer
2020-05 | Journal article
DOI: 10.1136/jitc-2020-000649
Contributors: Tonke K Raaijmakers; Renske J E van den Bijgaart; Martijn H den Brok; Melissa Wassink; Annemarie de Graaf; Jori A Wagenaars; Stefan Nierkens; Marleen Ansems; Gert Jan Scheffer; Gosse J Adema
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Anti-GD2 antibody and Vorinostat immunocombination therapy is highly effective in an aggressive orthotopic neuroblastoma model

OncoImmunology
2020-01 | Journal article
DOI: 10.1080/2162402X.2020.1817653
Contributors: Renske J. E. van den Bijgaart; Michiel Kroesen; Ingrid C. Brok; Daphne Reijnen; Melissa Wassink; Louis Boon; Peter M. Hoogerbrugge; Gosse J Adema
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Immunotherapy and the Interventional Oncologist: Challenges and Opportunities—A Society of Interventional Oncology White Paper

Radiology
2019-07 | Journal article
DOI: 10.1148/radiol.2019182326
Contributors: Joseph P. Erinjeri; Gabriel C. Fine; Gosse J. Adema; Muneeb Ahmed; Julius Chapiro; Martijn den Brok; Rafael Duran; Stephen J. Hunt; D. Thor Johnson; Jens Ricke et al.
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Steering Siglec–Sialic Acid Interactions on Living Cells using Bioorthogonal Chemistry

Angewandte Chemie
2017-03-13 | Journal article
DOI: 10.1002/ange.201612193
Contributors: Christian Büll; Torben Heise; Niek van Hilten; Johan F. A. Pijnenborg; Victor R. L. J. Bloemendal; Lotte Gerrits; Esther D. Kers‐Rebel; Tina Ritschel; Martijn H. den Brok; Gosse J. Adema et al.
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Steering Siglec–Sialic Acid Interactions on Living Cells using Bioorthogonal Chemistry

Angewandte Chemie International Edition
2017-03-13 | Journal article
DOI: 10.1002/anie.201612193
Contributors: Christian Büll; Torben Heise; Niek van Hilten; Johan F. A. Pijnenborg; Victor R. L. J. Bloemendal; Lotte Gerrits; Esther D. Kers‐Rebel; Tina Ritschel; Martijn H. den Brok; Gosse J. Adema et al.
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Peer review (6 reviews for 4 publications/grants)

Review activity for Journal for immunotherapy of cancer. (3)
Review activity for Nature communications (1)
Review activity for Nature immunology. (1)
Review activity for PloS one. (1)
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