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Employment (2)

Radboud University Nijmegen: Nijmegen, NL

2021-09-01 to present | Postdoctoral Scientist (Raboud Institute of Molecular Life Sciences)
Employment
Source: Self-asserted source
Dulce Lima Cunha

University College London: London, London, GB

2019-01 to 2021-08 | Research Fellow (Institute of Ophthalmology)
Employment
Source: Self-asserted source
Dulce Lima Cunha

Education and qualifications (3)

Innsbruck Medical University: Innsbruck, AT

2013 to 2018 | PhD Medical Sciences (Department of Human Genetics)
Education
Source: Self-asserted source
Dulce Lima Cunha

University of Minho: Braga, PT

2009 to 2012 | MSc Molecular Genetics (Department of Biology)
Education
Source: Self-asserted source
Dulce Lima Cunha

University of Porto: Porto, PT

2005 to 2008 | BSc Biology (Faculty of Sciences)
Education
Source: Self-asserted source
Dulce Lima Cunha

Works (19)

Prediction of Cell States and Key Transcription Factors of the Human Cornea through Integrated Single-Cell Omics Analyses

2024-12-20 | Preprint
DOI: 10.1101/2024.12.19.629354
Contributors: Julian A. Arts; Sofia Fallo; Melanie S. Florencio; Jos G.A. Smits; Dulce Lima Cunha; Janou A.Y. Roubroeks; Mor Dickman; Vanessa L.S. LaPointe; Rosemary Yu; Huiqing Zhou
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Crossref

Metabolic and neuroactivity imbalances in plasma from aniridia patients withPAX6haploinsufficiency

2024-11-08 | Preprint
DOI: 10.1101/2024.11.07.622475
Contributors: Dulce Lima Cunha; Vivienne Kit; Jane Skinner; Ailsa A Welch; Mariya Moosajee
Source: check_circle
Crossref

Deciphering the heterogeneity of differentiating hPSC-derived corneal limbal stem cells through single-cell RNA-sequencing

2023-11-24 | Preprint
DOI: 10.1101/2023.11.24.568553
Contributors: Meri Vattulainen; Jos G.A. Smits; Dulce Lima Cunha; Tanja Ilmarinen; Heli Skottman; Huiqing Zhou
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Crossref

Identification of the regulatory circuit governing corneal epithelial fate determination and disease

PLOS Biology
2023-10-19 | Journal article
DOI: 10.1371/journal.pbio.3002336
Part of ISSN: 1545-7885
Contributors: Jos G. A. Smits; Dulce Lima Cunha; Maryam Amini; Marina Bertolin; Camille Laberthonnière; Jieqiong Qu; Nicholas Owen; Lorenz Latta; Berthold Seitz; Lauriane N. Roux et al.
Source: Self-asserted source
Dulce Lima Cunha

Restoration of functional PAX6 in aniridia patient iPSC-derived ocular tissue models using repurposed nonsense suppression drugs

Molecular Therapy - Nucleic Acids
2023-09 | Journal article
DOI: 10.1016/j.omtn.2023.06.016
Part of ISSN: 2162-2531
Contributors: Dulce Lima Cunha; Hajrah Sarkar; Jonathan Eintracht; Philippa Harding; Jo Huiqing Zhou; Mariya Moosajee
Source: Self-asserted source
Dulce Lima Cunha

<i>PAX6</i> disease models for aniridia.

Indian journal of ophthalmology
2022-12 | Journal article
DOI: 10.4103/ijo.ijo_316_22
PMID: 36453299
Contributors: Abdolkarimi D; Cunha DL; Lahne M; Moosajee M
Source: Self-asserted source
Dulce Lima Cunha via Europe PubMed Central

Restoration of functional PAX6 in aniridia patient iPSC-derived ocular tissue models using repurposed nonsense suppression drugs

2022-10-12 | Preprint
DOI: 10.1101/2022.10.12.511600
Contributors: Dulce Lima Cunha; Jonathan Eintracht; Philippa Harding; Jo Huiqing Zhou; Mariya Moosajee
Source: check_circle
Crossref

Multi-omics analyses identify transcription factor interplay in corneal epithelial fate determination and disease

2022-07-14 | Preprint
DOI: 10.1101/2022.07.13.499857
Contributors: Jos GA Smits; Dulce Lima Cunha; Maryam Amini; Marina Bertolin; Camille Laberthonnière; Jieqiong Qu; Nicholas Owen; Lorenz Latta; Berthold Seitz; Lauriane N Roux et al.
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Crossref

Longitudinal genotype-phenotype analysis in 86 patients with PAX6-related aniridia

JCI Insight
2021-07-22 | Journal article
DOI: 10.1172/jci.insight.148406
Contributors: Vivienne Kit; Dulce Lima Cunha; Ahmed M. Hagag; Mariya Moosajee
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Crossref

Generation of two human iPSC lines from patients with autosomal dominant retinitis pigmentosa (UCLi014-A) and autosomal recessive Leber congenital amaurosis (UCLi015-A), associated with RDH12 variants.

Stem cell research
2021-06-28 | Journal article
DOI: 10.1016/j.scr.2021.102449
PMID: 34216980
PMC: PMC8363920
Source: Self-asserted source
Dulce Lima Cunha

REP1 deficiency causes systemic dysfunction of lipid metabolism and oxidative stress in choroideremia

JCI Insight
2021-05-10 | Journal article
DOI: 10.1172/jci.insight.146934
Contributors: Dulce Lima Cunha; Rose Richardson; Dhani Tracey-White; Alessandro Abbouda; Andreas Mitsios; Verena Horneffer-van der Sluis; Panteleimon Takis; Nicholas Owen; Jane Skinner; Ailsa A. Welch et al.
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Crossref

hiPSC-Derived Epidermal Keratinocytes from Ichthyosis Patients Show Altered Expression of Cornification Markers.

International journal of molecular sciences
2021-02-11 | Journal article
DOI: 10.3390/ijms22041785
PMID: 33670118
PMC: PMC7916893
Source: Self-asserted source
Dulce Lima Cunha

PAX6 missense variants in two families with isolated foveal hypoplasia and nystagmus: evidence of paternal postzygotic mosaicism

European Journal of Human Genetics
2021-02-06 | Journal article
DOI: 10.1038/s41431-020-00737-1
Contributors: Dulce Lima Cunha; Nicholas Owen; Vijay Tailor; Marta Corton; Maria Theodorou; Mariya Moosajee
Source: check_circle
Crossref

Generation of human iPSC line (UCLi013-A) from a patient with microphthalmia and aniridia, carrying a heterozygous missense mutation c.372C>A p.(Asn124Lys) in PAX6.

Stem cell research
2021-01-18 | Journal article
DOI: 10.1016/j.scr.2021.102184
PMID: 33524672
Source: Self-asserted source
Dulce Lima Cunha

Generation of two human control iPS cell lines (UCLi016-A and UCLi017-A) from healthy donors with no known ocular conditions.

Stem cell research
2020-12-08 | Journal article
DOI: 10.1016/j.scr.2020.102113
PMID: 33370878
PMC: PMC7768179
Source: Self-asserted source
Dulce Lima Cunha
grade
Preferred source (of 2)‎

The Spectrum of PAX6 Mutations and Genotype-Phenotype Correlations in the Eye.

Genes
2019-12-17 | Journal article
DOI: 10.3390/genes10121050
PMID: 31861090
PMC: PMC6947179
Source: Self-asserted source
Dulce Lima Cunha

Unknown mutations and genotype/phenotype correlations of autosomal recessive congenital ichthyosis in patients from Saudi Arabia and Pakistan

Molecular Genetics & Genomic Medicine
2019-03 | Journal article
DOI: 10.1002/mgg3.539
Contributors: Dulce Lima Cunha; Omar Mohammed Alakloby; Robert Gruber; Naseebullah Kakar; Jamil Ahmad; Salem Alawbathani; Roswitha Plank; Katja Eckl; Birgit Krabichler; Janine Altmüller et al.
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Crossref
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Transglutaminase 1 Replacement Therapy Successfully Mitigates the ARCI Phenotype in Full-Thickness Skin Disease Equivalents.

The Journal of investigative dermatology
2018-11 | Journal article
DOI: 10.1016/j.jid.2018.11.002
PMID: 30448383
Contributors: Plank R; Yealland G; Miceli E; Lima Cunha D; Graff P; Thomforde S; Gruber R; Moosbrugger-Martinz V; Eckl K; Calderón M et al.
Source: Self-asserted source
Dulce Lima Cunha via Europe PubMed Central

Cisplatin-induced cell death in Saccharomyces cerevisiae is programmed and rescued by proteasome inhibition.

DNA repair
2013-06 | Journal article
DOI: 10.1016/j.dnarep.2013.02.005
PMID: 23602516
Contributors: Cunha D; Cunha R; Côrte-Real M; Chaves SR
Source: Self-asserted source
Dulce Lima Cunha via Europe PubMed Central
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