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Scopus Author ID: 6603714820
ResearcherID: N-7503-2016
Loop profile: 517887

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Employment (1)

Universidad de Castilla-La Mancha: Ciudad Real, Castilla-La Mancha, ES

2010-01-01 to present | Professor (Ciencias Medicas)
Employment
Source: Self-asserted source
Francisco Javier Alcain

Education and qualifications (1)

Universidad de Córdoba: Cordoba, Andalucía, ES

1983-06-18 to present | Doctor (Ciencias Biologicas)
Education
Source: Self-asserted source
Francisco Javier Alcain

Funding (3)

Papel del estrés oxidativo en el desarrollo de la ansiedad en el modelo murino de Alzheimer 3xTg-AD. Búsqueda de marcadores tempranos de la neurodegeneración

2014-09 to 2017-08 | Grant
Consejería de Educación Ciencia y Cultura, Junta de Comunidades de Castilla la Mancha (Toledo, Castilla La Mancha, ES)
GRANT_NUMBER:

PPII-2014-010-P
Source: Self-asserted source
Francisco Javier Alcain

The effect of ubiquinol in the protection of endothelial function during Alzheimer disease in animal model.

2013-05 to 2015-12 | Contract
Kaneka Corp (Osaka, JP)
Source: Self-asserted source
Francisco Javier Alcain

Administration of coenzyme-Q plus antithrombotics could sensitize glioblastoma cells to the effect of chemotherapeuticals

2013-01 to 2013-12 | Grant
James S. McDonnell Foundation (MO, MO, US)
Source: Self-asserted source
Francisco Javier Alcain

Works (50 of 73)

Items per page:
Page 1 of 2

Spatial and Temporal Protein Modules Signatures Associated with Alzheimer Disease in 3xTg-AD Mice Are Restored by Early Ubiquinol Supplementation

Antioxidants
2023-03-19 | Journal article
DOI: 10.3390/antiox12030747
Contributors: Emilio Llanos-González; Francisco J. Sancho-Bielsa; Javier Frontiñán-Rubio; Yoana Rabanal-Ruíz; Sonia García-Carpintero; Eduardo Chicano; Isabel Úbeda-Banon; Alicia Flores-Cuadrado; Lydia Giménez-Llort; Francisco Javier Alcaín et al.
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Environmental and health risk implications of unregulated emissions from advanced biofuels in a Euro 6 engine

Chemosphere
2023-02 | Journal article
DOI: 10.1016/j.chemosphere.2022.137462
Part of ISSN: 0045-6535
Contributors: Silvana Arias; John R. Agudelo; Francisco J. Molina; Emilio Llanos-González; Francisco J. Alcaín; Rosario Ballesteros; Magín Lapuerta
Source: Self-asserted source
Francisco Javier Alcain

CoQ10 reduces glioblastoma growth and infiltration through proteome remodeling and inhibition of angiogenesis and inflammation

Cellular Oncology
2022-11-02 | Journal article
DOI: 10.1007/s13402-022-00734-0
Part of ISSN: 2211-3428
Contributors: Javier Frontiñán-Rubio; Emilio Llanos-González; Sonia García-Carpintero; Juan Ramón Peinado; Inmaculada Ballesteros-Yáñez; Margarita Villar Rayo; José de la Fuente; Víctor M. Pérez-García; Luis A. Perez-Romasanta; Marcos Malumbres et al.
Source: Self-asserted source
Francisco Javier Alcain via Crossref Metadata Search

The Protective Effect of Ubiquinone against the Amyloid Peptide in Endothelial Cells Is Isoprenoid Chain Length-Dependent

Antioxidants
2021-11-13 | Journal article
DOI: 10.3390/antiox10111806
Contributors: Javier Frontiñán-Rubio; Yoana Rabanal-Ruiz; Mario Durán-Prado; Francisco Javier Alcain
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Biological Significance of the Protein Changes Occurring in the Cerebrospinal Fluid of Alzheimer’s Disease Patients: Getting Clues from Proteomic Studies

Diagnostics
2021-09-09 | Journal article
DOI: 10.3390/diagnostics11091655
Contributors: Cristina M. Pedrero-Prieto; Javier Frontiñán-Rubio; Francisco J. Alcaín; Mario Durán-Prado; Juan R. Peinado; Yoana Rabanal-Ruiz
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The Spanish Intergenerational Study: Beliefs, Stereotypes, and Metacognition about Older People and Grandparents to Tackle Ageism

Geriatrics
2021-09-03 | Journal article
DOI: 10.3390/geriatrics6030087
Contributors: Aida Muntsant; Paula Ramírez-Boix; Rocío Leal-Campanario; Francisco Javier Alcaín; Lydia Giménez-Llort
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The Use of Coenzyme Q10 in Cardiovascular Diseases

Antioxidants
2021-05-10 | Journal article
DOI: 10.3390/antiox10050755
Contributors: Yoana Rabanal-Ruiz; Emilio Llanos-González; Francisco Javier Alcain
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Ubiquinol Supplementation Improves Gender-Dependent Cerebral Vasoreactivity and Ameliorates Chronic Inflammation and Endothelial Dysfunction in Patients with Mild Cognitive Impairment

Antioxidants
2021-01-20 | Journal article
DOI: 10.3390/antiox10020143
Contributors: Sonia García-Carpintero; Javier Domínguez-Bértalo; Cristina Pedrero-Prieto; Javier Frontiñán-Rubio; Mariano Amo-Salas; Mario Durán-Prado; Eloy García-Pérez; Julia Vaamonde; Francisco J. Alcain
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Crossref
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Preferred source (of 2)‎

SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases

Frontiers in Pharmacology
2021-01-12 | Journal issue or edition
DOI: 10.3389/fphar.2020.585821
Source: Self-asserted source
Francisco Javier Alcain

Coenzyme Q and Age-Related Neurodegenerative Disorders: Parkinson and Alzheimer Diseases

Coenzyme Q in Aging
2020 | Book chapter
DOI: 10.1007/978-3-030-45642-9_12
Part of ISBN: 9783030456412
Part of ISBN: 9783030456429
Source: Self-asserted source
Francisco Javier Alcain

A comprehensive systematic review of CSF proteins and peptides that define Alzheimer’s disease

Clinical Proteomics
2020-12 | Journal article
DOI: 10.1186/s12014-020-09276-9
Part of ISSN: 1542-6416
Part of ISSN: 1559-0275
Source: Self-asserted source
Francisco Javier Alcain

Interplay Between Mitochondrial Oxidative Disorders and Proteostasis in Alzheimer’s Disease

Frontiers in Neuroscience
2020-01-29 | Journal article
DOI: 10.3389/fnins.2019.01444
Part of ISSN: 1662-453X
Source: Self-asserted source
Francisco Javier Alcain

Human amyloid-β enriched extracts: evaluation of in vitro and in vivo internalization and molecular characterization

Alzheimer's Research & Therapy
2019-12 | Journal article
DOI: 10.1186/s13195-019-0513-0
Part of ISSN: 1758-9193
Source: Self-asserted source
Francisco Javier Alcain

Sex-dependent co-occurrence of hypoxia and β-amyloid plaques in hippocampus and entorhinal cortex is reversed by long-term treatment with ubiquinol and ascorbic acid in the 3 × Tg-AD mouse model of Alzheimer's disease

Molecular and Cellular Neuroscience
2018-10 | Journal article
DOI: 10.1016/j.mcn.2018.06.005
Contributors: Javier Frontiñán-Rubio; Francisco J. Sancho-Bielsa; Juan R. Peinado; Frank M. LaFerla; Lydia Giménez-Llort; Mario Durán-Prado; Francisco J. Alcain
Source: check_circle
Crossref

Regulation of the oxidative balance with coenzyme Q10 sensitizes human glioblastoma cells to radiation and temozolomide.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
2018-05 | Journal article
DOI: 10.1016/j.radonc.2018.04.033
PMID: 29784452
Contributors: Frontiñán-Rubio J; Santiago-Mora RM; Nieva-Velasco CM; Ferrín G; Martínez-González A; Gómez MV; Moreno M; Ariza J; Lozano E; Arjona-Gutiérrez J et al.
Source: Self-asserted source
Francisco Javier Alcain via Europe PubMed Central

Therapeutic Potential of Sirtuin Inhibitors in Cancer

Anti-aging Drugs: From Basic Research to Clinical Practice
2017-10-12 | Book chapter
DOI: 10.1002/cmdc.201700585
Part of ISBN: 178262435X
Source: Self-asserted source
Francisco Javier Alcain

Antioxidant and therapeutic potential of coenzyme Q-related compounds.

Coenzyme Q10: From Fact to Fiction
2015-07-15 | Book chapter
ISBN: 978-1634828222
Source: Self-asserted source
Francisco Javier Alcain

Coenzyme Q10 protects human endothelial cells from β-Amyloid uptake and oxidative stress-induced injury

PLoS ONE
2014 | Journal article
DOI: 10.1371/journal.pone.0109223
EID:

2-s2.0-84907546074
Contributors: Durán-Prado, M.; Frontiñán, J.; Santiago-Mora, R.; Peinado, J.R.; Parrado-Fernández, C.; Gómez-Almagro, M.V.; Moreno, M.; López-Domínguez, J.A.; Villalba, J.M.; Alcaín, F.J.
Source: Self-asserted source
Francisco Javier Alcain via Scopus - Elsevier

Neophobia, NQO1 and SIRT1 as premorbid and prodromal indicators of AD in 3xTg-AD mice

Behavioural Brain Research
2014 | Journal article
DOI: 10.1016/j.bbr.2014.04.055
EID:

2-s2.0-84902690102
Contributors: Torres-Lista, V.; Parrado-Fernández, C.; Alvarez-Montón, I.; Frontiñán-Rubio, J.; Durán-Prado, M.; Peinado, J.R.; Johansson, B.; Alcaín, F.J.; Giménez-Llort, L.
Source: Self-asserted source
Francisco Javier Alcain via Scopus - Elsevier

Combined therapies of antithrombotics and antioxidants delay in silico brain tumour progression.

2014-02 | Journal article
DOI: 10.1093/imammb/dqu002
PMID: 24562299
Contributors: Martínez-González A; Durán-Prado M; Calvo GF; Alcaín FJ; Pérez-Romasanta LA; Pérez-García VM
Source: Self-asserted source
Francisco Javier Alcain via Europe PubMed Central

A patent review of sirtuin activators: An update

Expert Opinion on Therapeutic Patents
2012 | Journal article
DOI: 10.1517/13543776.2012.669374
EID:

2-s2.0-84859597181
Contributors: Villalba, J.M.; De Cabo, R.; Alcain, F.J.
Source: Self-asserted source
Francisco Javier Alcain via Scopus - Elsevier

Sirtuin activators and inhibitors

BioFactors
2012 | Journal article
DOI: 10.1002/biof.1032
EID:

2-s2.0-84867702707
Contributors: Villalba, J.M.; Alcaín, F.J.
Source: Self-asserted source
Francisco Javier Alcain via Scopus - Elsevier

Genetic deletion of Nrf2 promotes immortalization and decreases life span of murine embryonic fibroblasts

Journals of Gerontology - Series A Biological Sciences and Medical Sciences
2011 | Journal article
DOI: 10.1093/gerona/glq181
EID:

2-s2.0-79955154110
Contributors: Jódar, L.; Mercken, E.M.; Ariza, J.; Younts, C.; González-Reyes, J.A.; Alcaín, F.J.; Burón, I.; De Cabo, R.; Villalba, J.M.
Source: Self-asserted source
Francisco Javier Alcain via Scopus - Elsevier

ES936 stimulates DNA synthesis in HeLa cells independently on NAD(P)H:quinone oxidoreductase 1 inhibition, through a mechanism involving p38 MAPK

Chemico-Biological Interactions
2010 | Journal article
DOI: 10.1016/j.cbi.2010.04.022
EID:

2-s2.0-77953539064
Contributors: González-Aragón, D.; Alcaín, F.J.; Ariza, J.; Jódar, L.; Barbarroja, N.; López-Pedrera, C.; Villalba, J.M.
Source: Self-asserted source
Francisco Javier Alcain via Scopus - Elsevier

Small Molecule Modulators of Sirtuin Activity

The Future of Aging: Pathways to Human Life Extension
2010 | Book chapter
DOI: 10.1007/978-90-481-3999-6_10
ISBN: 978-90-481-3999-6
Source: Self-asserted source
Francisco Javier Alcain

Therapeutic use of coenzyme Q10 and coenzyme Q10-related compounds and formulations

Expert Opinion on Investigational Drugs
2010 | Journal article
DOI: 10.1517/13543781003727495
EID:

2-s2.0-77952518304
Contributors: Villalba, J.M.; Parrado, C.; Santos-Gonzalez, M.; Alcain, F.J.
Source: Self-asserted source
Francisco Javier Alcain via Scopus - Elsevier

Sirtuin activators

Expert Opinion on Therapeutic Patents
2009 | Journal article
DOI: 10.1517/13543770902762893
EID:

2-s2.0-67649603984
Contributors: Alcaín, F.J.; Villalba, J.M.
Source: Self-asserted source
Francisco Javier Alcain via Scopus - Elsevier

Sirtuin inhibitors

Expert Opinion on Therapeutic Patents
2009 | Journal article
DOI: 10.1517/13543770902755111
EID:

2-s2.0-67649397497
Contributors: Alcaín, F.J.; Villalba, J.M.
Source: Self-asserted source
Francisco Javier Alcain via Scopus - Elsevier

Urotensin II and urotensin II-related peptide activate somatostatin receptor subtypes 2 and 5

Peptides
2008 | Journal article
DOI: 10.1016/j.peptides.2007.12.015
EID:

2-s2.0-42049112265
Contributors: Malagon, M.M.; Molina, M.; Gahete, M.D.; Duran-Prado, M.; Martinez-Fuentes, A.J.; Alcain, F.J.; Tonon, M.-C.; Leprince, J.; Vaudry, H.; Castaño, J.P. et al.
Source: Self-asserted source
Francisco Javier Alcain via Scopus - Elsevier

NQO1-directed antitumour quinones

Expert Opinion on Therapeutic Patents
2007 | Journal article
DOI: 10.1517/13543776.17.6.649
EID:

2-s2.0-34447290437
Contributors: Alcaín, F.J.; Villalba, J.M.
Source: Self-asserted source
Francisco Javier Alcain via Scopus - Elsevier

Cellular density and cell type are the key factors in growth inhibition induced by 2,5bis [1-aziridinyl]-1,4 benzoquinone (DZQ).

2006 | Journal article
PMID: 17094478
Contributors: Córdoba-Pedregosa Mdel C; Villalba JM; González-Aragón D; Bello RI; Alcaín FJ
Source: Self-asserted source
Francisco Javier Alcain via Europe PubMed Central

Stimulation of polyprenyl 4-hydroxybenzoate transferase activity by sodium cholate and 3-[(cholamidopropyl)dimethylammonio]-1-propanesulfonate

Analytical Biochemistry
2006 | Journal article
DOI: 10.1016/j.ab.2006.03.029
EID:

2-s2.0-33646573066
Contributors: Burón, M.I.; Hermán, M.D.; Alcaín, F.J.; Villalba, J.M.
Source: Self-asserted source
Francisco Javier Alcain via Scopus - Elsevier

Determination of coenzyme Q biosynthesis in cultured cells without the necessity for lipid extraction

Analytical Biochemistry
2005 | Journal article
DOI: 10.1016/j.ab.2004.09.031
EID:

2-s2.0-9944226678
Contributors: Córdoba-Pedregosa, M.D.C.; Villalba, J.M.; Alcaín, F.J.
Source: Self-asserted source
Francisco Javier Alcain via Scopus - Elsevier

Enhanced anti-oxidant protection of liver membranes in long-lived rats fed on a coenzyme Q10-supplemented diet

Experimental Gerontology
2005 | Journal article
DOI: 10.1016/j.exger.2005.07.003
EID:

2-s2.0-24644463306
Contributors: Bello, R.I.; Gómez-Díaz, C.; Burón, M.I.; Alcaín, F.J.; Navas, P.; Villalba, J.M.
Source: Self-asserted source
Francisco Javier Alcain via Scopus - Elsevier

Inhibition of COX activity by NSAIDs or ascorbate increases cAMP levels and enhances differentiation in 1α,25-dihydroxyvitamin D3-induced HL-60 cells

Archives of Biochemistry and Biophysics
2005 | Journal article
DOI: 10.1016/j.abb.2004.12.031
EID:

2-s2.0-14744300086
Contributors: López-Lluch, G.; Fernández-Ayala, D.J.M.; Alcaín, F.J.; Burón, M.I.; Quesada, J.M.; Navas, P.
Source: Self-asserted source
Francisco Javier Alcain via Scopus - Elsevier

Effect of dietary coenzyme Q and fatty acids on the antioxidant status of rat tissues

Protoplasma
2003 | Journal article
DOI: 10.1007/s00709-002-0067-y
EID:

2-s2.0-0038687200
Contributors: Gómez-Díaz, C.; Burón, M.I.; Alcaín, F.J.; González-Ojeda, R.; González-Reyes, J.A.; Bello, R.I.; Herman, M.D.; Navas, P.; Villalba, J.M.
Source: Self-asserted source
Francisco Javier Alcain via Scopus - Elsevier

Hydrogen peroxide- and cell-density-regulated expression of NADH-cytochrome b5 reductase in HeLa cells

Journal of Bioenergetics and Biomembranes
2003 | Journal article
DOI: 10.1023/A:1023702321148
EID:

2-s2.0-0038340914
Contributors: Bello, R.I.; Alcaín, F.J.; Gómez-Díaz, C.; López-Lluch, G.; Navas, P.; Villalba, J.M.
Source: Self-asserted source
Francisco Javier Alcain via Scopus - Elsevier

Regeneration of lipophilic antioxidants by NAD(P)H:quinone oxidoreductase 1

Protoplasma
2003 | Journal article
DOI: 10.1007/s00709-002-0068-x
EID:

2-s2.0-0038348622
Contributors: Bello, R.I.; Kagan, V.E.; Tyurin, V.; Navarro, F.; Alcaín, F.J.; Villalba, J.M.
Source: Self-asserted source
Francisco Javier Alcain via Scopus - Elsevier

Cellular redox state and activating protein-1 are involved in ascorbate effect on calcitriol-induced differentiation

Protoplasma
2001 | Journal article
DOI: 10.1007/BF01289422
EID:

2-s2.0-0034960316
Contributors: López-Lluch, G.; Blázquez, M.-V.; Pérez-Vicente, R.; Macho, A.; Burón, M.I.; Alcaín, F.J.; Muñoz, E.; Navas, P.
Source: Self-asserted source
Francisco Javier Alcain via Scopus - Elsevier

Expression of NAD(P)H:Quinone oxidoreductase 1 in HeLa cells: Role of hydrogen peroxide and growth phase

Journal of Biological Chemistry
2001 | Journal article
DOI: 10.1074/jbc.M107168200
EID:

2-s2.0-0035977034
Contributors: Bello, R.I.; Gómez-Díaz, C.; Navarro, F.; Alcaín, F.J.; Villalba, J.M.
Source: Self-asserted source
Francisco Javier Alcain via Scopus - Elsevier

Interactions between ascorbyl free radical and coenzyme Q at the plasma membrane

Journal of Bioenergetics and Biomembranes
2000 | Journal article
DOI: 10.1023/A:1005568132027
EID:

2-s2.0-0033854973
Contributors: Arroyo, A.; Navarro, F.; Gómez-Díaz, C.; Crane, F.L.; Alcaín, F.J.; Navas, P.; Villalba, J.M.
Source: Self-asserted source
Francisco Javier Alcain via Scopus - Elsevier

Redox regulation of cAMP levels by ascorbate in 1,25-dihydroxy- vitamin D3-induced differentiation of HL-60 cells.

1998-04 | Journal article
DOI: 10.1042/bj3310021
PMID: 9512457
Source: Self-asserted source
Francisco Javier Alcain
grade
Preferred source (of 2)‎

Ceruloplasmin releases pH-induced inhibition of cell proliferation stimulated by growth factors.

1997 | Journal article
DOI: 10.1080/13510002.1997.11747125
PMID: 9754327
Source: Self-asserted source
Francisco Javier Alcain
grade
Preferred source (of 2)‎

Inhibition of DNA synthesis in CCL 39 cells by impermeable iron chelators.

1997-02 | Journal article
DOI: 10.1080/15216549700201311
PMID: 9063570
Source: Self-asserted source
Francisco Javier Alcain
grade
Preferred source (of 3)‎

Ascorbate increases the 1,25 dihydroxyvitamin D3-Induced monocytic differentiation of HL-60 cells

Calcified Tissue International
1996 | Journal article
DOI: 10.1007/s002239900123
EID:

2-s2.0-0029803643
Contributors: Quesada, J.M.; Lopez-LLuch, G.; Buron, M.I.; Alcain, F.J.; Borrego, F.; Velde, J.P.; Blanco, I.; Bouillon, R.; Navas, P.
Source: Self-asserted source
Francisco Javier Alcain via Scopus - Elsevier

Iron at the cell surface controls both DNA synthesis and plasma membrane redox system

Protoplasma
1995 | Journal article
DOI: 10.1007/BF01276926
EID:

2-s2.0-0001220225
Contributors: Alcaín, F.J.; Löw, H.; Crane, F.L.
Source: Self-asserted source
Francisco Javier Alcain via Scopus - Elsevier

Plasma membrane redox system during HL-60 induced differentiation

Protoplasma
1995 | Journal article
DOI: 10.1007/BF01276915
EID:

2-s2.0-0029103468
Contributors: López-Lluch, G.; Burón, M.I.; Alcaín, F.J.; Rodríguez-Aguilera, J.C.; Navas, P.
Source: Self-asserted source
Francisco Javier Alcain via Scopus - Elsevier

Stimulation of onion root elongation by ascorbate and ascorbate free radical in Allium cepa L.

Protoplasma
1995 | Journal article
DOI: 10.1007/BF01276898
EID:

2-s2.0-0029168519
Contributors: González-Reyes, J.A.; Alcaín, F.J.; Caler, J.A.; Serrano, A.; Córdoba, F.; Navas, P.
Source: Self-asserted source
Francisco Javier Alcain via Scopus - Elsevier

Vitamin C stabilization as a consequence of the plasma membrane redox system

Protoplasma
1995 | Journal article
DOI: 10.1007/BF01276925
EID:

2-s2.0-0001220226
Contributors: Rodríguez-Aguilera, J.C.; Navarro, F.; Arroyo, A.; Alcaín, F.J.; Villalba, J.M.; Navas, P.
Source: Self-asserted source
Francisco Javier Alcain via Scopus - Elsevier

Ascorbate on cell growth and differentiation

Journal of Bioenergetics and Biomembranes
1994 | Journal article
DOI: 10.1007/BF00762780
EID:

2-s2.0-0028021021
Contributors: Alcaín, F.J.; Burón, M.I.
Source: Self-asserted source
Francisco Javier Alcain via Scopus - Elsevier
Items per page:
Page 1 of 2

Peer review (3 reviews for 3 publications/grants)

Review activity for Antioxidants. (1)
Review activity for Molecular and cellular biochemistry. (1)
Review activity for Molecules. (1)
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