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Activities

Employment (1)

University of Manitoba: Winnipeg, MB, CA

2024 to present | Assistant Professor (Rady Faculty of Health Sciences)
Employment
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University of Manitoba via ORCID Member Portal

Funding (1)

Advancing cancer immunotherapies with unique gene editing tools

2024 to 2027 | Contract
Marsden Fund (Wellington, NZ)
PROPOSAL_ID:

MFP-23-UOA-231

GRANT_NUMBER:

MFP-UOA2302

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Royal Society Te Apārangi

Works (14)

Tracking the gene expression programs and clonal relationships that underlie mast, myeloid, and T lineage specification from stem cells

Cell Systems
2024-12 | Journal article
Contributors: Yale S. Michaels; Matthew C. Major; Becca Bonham-Carter; Jingqi Zhang; Tiam Heydari; John M. Edgar; Mona M. Siu; Laura Greenstreet; Roser Vilarrasa-Blasi; Seungjoon Kim et al.
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Crossref

Publisher Correction: Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells

Nature Communications
2024-04-24 | Journal article
Contributors: Mike B. Barnkob; Yale S. Michaels; Violaine André; Philip S. Macklin; Uzi Gileadi; Salvatore Valvo; Margarida Rei; Corinna Kulicke; Ji-Li Chen; Vitul Jain et al.
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Crossref

Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells

Nature Communications
2024-04-12 | Journal article
Contributors: Mike B. Barnkob; Yale S. Michaels; Violaine André; Philip S. Macklin; Uzi Gileadi; Salvatore Valvo; Margarida Rei; Corinna Kulicke; Ji-Li Chen; Vitul Jain et al.
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Crossref

Time- and lineage-resolved transcriptional profiling uncovers gene expression programs and clonal relationships that underlie human T lineage specification

2023-10-10 | Preprint
Contributors: Yale S. Michaels; Matthew C. Major; Becca Bonham-Carter; Jingqi Zhang; Tiam Heydari; John M. Edgar; Laura Greenstreet; Roser Vilarrasa-Blasi; Seungjoon Kim; Elizabeth L. Castle et al.
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Crossref

Synthetic gene circuits for cell state detection and protein tuning in human pluripotent stem cells

Molecular Systems Biology
2022-11 | Journal article
Contributors: Laura Prochazka; Yale S Michaels; Charles Lau; Ross D Jones; Mona Siu; Ting Yin; Diana Wu; Esther Jang; Mercedes Vázquez‐Cantú; Penney M Gilbert et al.
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Crossref

DLL4 and VCAM1 enhance the emergence of T cell–competent hematopoietic progenitors from human pluripotent stem cells

Science Advances
2022-08-26 | Journal article
Contributors: Yale S. Michaels; John M. Edgar; Matthew C. Major; Elizabeth L. Castle; Carla Zimmerman; Ting Yin; Andrew Hagner; Charles Lau; Han Hsuan Hsu; M. Iliana Ibañez-Rios et al.
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Crossref

Multi-objective optimization reveals time- and dose-dependent inflammatory cytokine-mediated regulation of human stem cell derived T-cell development

npj Regenerative Medicine
2022-01-27 | Journal article
Contributors: John M. Edgar; Yale S. Michaels; Peter W. Zandstra
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Crossref

FOXN1 forms higher-order nuclear condensates displaced by mutations causing immunodeficiency

Science Advances
2021-12-03 | Journal article
Contributors: Ioanna A. Rota; Adam E. Handel; Stefano Maio; Fabian Klein; Fatima Dhalla; Mary E. Deadman; Stanley Cheuk; Joseph A. Newman; Yale S. Michaels; Saulius Zuklys et al.
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Crossref

DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells

2021-11-27 | Other
Contributors: Yale S. Michaels; John M. Edgar; Matthew C. Major; Elizabeth L. Castle; Carla Zimmerman; Ting Yin; Andrew Hagner; Charles Lau; M. Iliana Ibañez-Rios; David J.H.F. Knapp et al.
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Crossref

Semaphorin 3A induces cytoskeletal paralysis in tumor-specific CD8+ T cells

2019-11-20 | Other
Contributors: Mike B Barnkob; Yale S Michaels; Violaine André; Philip S Macklin; Uzi Gileadi; Salvatore Valvo; Margarida Rei; Corinna Kulicke; Ji-Li Chen; Vitul Jain et al.
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Crossref

Addendum: Precise tuning of gene expression levels in mammalian cells

Nature Communications
2019-06-10 | Journal article
Contributors: Yale S. Michaels; Mike B. Barnkob; Hector Barbosa; Toni A. Baeumler; Mary K. Thompson; Violaine Andre; Huw Colin-York; Marco Fritzsche; Uzi Gileadi; Hilary M. Sheppard et al.
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Crossref

Decoupling tRNA promoter and processing activities enables specific Pol-II Cas9 guide RNA expression

Nature Communications
2019-04-02 | Journal article
Contributors: David J. H. F. Knapp; Yale S. Michaels; Max Jamilly; Quentin R. V. Ferry; Hector Barbosa; Thomas A. Milne; Tudor A. Fulga
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Crossref

Precise tuning of gene expression levels in mammalian cells

Nature Communications
2019-02-18 | Journal article
Contributors: Yale S. Michaels; Mike B. Barnkob; Hector Barbosa; Toni A. Baeumler; Mary K. Thompson; Violaine Andre; Huw Colin-York; Marco Fritzsche; Uzi Gileadi; Hilary M. Sheppard et al.
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Crossref

Precise tuning of gene expression output levels in mammalian cells

2018-06-20 | Other
Contributors: Yale S. Michaels; Mike B. Barnkob; Hector Barbosa; Toni A. Baeumler; Mary K. Thompson; Violaine Andre; Huw Colin-York; Marco Fritzsche; Uzi Gileadi; Hilary M. Sheppard et al.
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Crossref