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On the processes limiting oral drug absorption when amorphous solid dispersions are administered after a high-calorie, high-fat meal: Sporanox® pellets

European Journal of Pharmaceutical Sciences
2024-08 | Journal article
Contributors: Shirin Dietrich; Myrto Dimoula; Theodoros Argyropoulos; Jens Ceulemans; Konstantinos Goumas; Maria Vertzoni; Christos Reppas
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Understanding the Conditions Under Which Drugs are Transferred from the Stomach Through the Upper Small Intestine After a High-Calorie, High-Fat Meal

Journal of Pharmaceutical Sciences
2024-06 | Journal article
Contributors: Shirin Dietrich; Jens Ceulemans; Eline Hermans; Theodoros Argyropoulos; Konstantinos Goumas; Maria Vertzoni; Christos Reppas
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Drug Dissolution in Oral Drug Absorption: Workshop Report

AAPS Journal
2023 | Journal article
EID:

2-s2.0-85175996134

Part of ISSN: 15507416
Contributors: Raines, K.; Agarwal, P.; Augustijns, P.; Alayoubi, A.; Attia, L.; Bauer-Brandl, A.; Brandl, M.; Chatterjee, P.; Chen, H.; Yu, Y.C. et al.
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Christos Reppas via Scopus - Elsevier

Leveraging the use of in vitro and computational methods to support the development of enabling oral drug products: An InPharma commentary

European Journal of Pharmaceutical Sciences
2023 | Journal article
EID:

2-s2.0-85164995541

Part of ISSN: 18790720 09280987
Contributors: Reppas, C.; Kuentz, M.; Bauer-Brandl, A.; Carlert, S.; Dallmann, A.; Dietrich, S.; Dressman, J.; Ejskjaer, L.; Frechen, S.; Guidetti, M. et al.
Source: Self-asserted source
Christos Reppas via Scopus - Elsevier

Screening for Differences in Early Exposure in the Fasted State with in Vitro Methodologies can be Challenging: Experience with the BioGIT System

Journal of Pharmaceutical Sciences
2023 | Journal article
EID:

2-s2.0-85150758875

Part of ISSN: 15206017 00223549
Contributors: Kostantini, C.; Spilioti, E.; Bevernage, J.; Ceulemans, J.; Hansmann, S.; Hellemans, K.; Jede, C.; Kourentas, A.; Reggane, M.; Shah, L. et al.
Source: Self-asserted source
Christos Reppas via Scopus - Elsevier

The impact of advanced age on gastrointestinal characteristics that are relevant to oral drug absorption: An AGePOP review

European Journal of Pharmaceutical Sciences
2023 | Journal article
EID:

2-s2.0-85162220428

Part of ISSN: 18790720 09280987
Contributors: Stillhart, C.; Asteriadis, A.; Bocharova, E.; Eksteen, G.; Harder, F.; Kusch, J.; Tzakri, T.; Augustijns, P.; Matthys, C.; Vertzoni, M. et al.
Source: Self-asserted source
Christos Reppas via Scopus - Elsevier

Usefulness of the Beagle Model in the Evaluation of Paracetamol and Ibuprofen Exposure after Oral Administration to Pediatric Populations: An Exploratory Study

Molecular Pharmaceutics
2023 | Journal article
EID:

2-s2.0-85159613081

Part of ISSN: 15438392 15438384
Contributors: Statelova, M.; Holm, R.; Fotaki, N.; Reppas, C.; Vertzoni, M.
Source: Self-asserted source
Christos Reppas via Scopus - Elsevier

Usefulness of the BioGIT system in screening for differences in early exposure in the fasted state on an a priori basis

International Journal of Pharmaceutics
2023 | Journal article
EID:

2-s2.0-85147879867

Part of ISSN: 18733476 03785173
Contributors: Kostantini, C.; Spilioti, E.; Bevernage, J.; Ceulemans, J.; Hansmann, S.; Hellemans, K.; Jede, C.; Kourentas, A.; Reggane, M.; Shah, L. et al.
Source: Self-asserted source
Christos Reppas via Scopus - Elsevier

Managing the clinical effects of drug-induced intestinal dysbiosis with a focus to antibiotics: Challenges and opportunities

European Journal of Pharmaceutical Sciences
2023-09 | Journal article
Contributors: Lea Gnatzy; George Ismailos; Maria Vertzoni; Christos Reppas
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Integration of advanced methods and models to study drug absorption and related processes: An UNGAP perspective

European Journal of Pharmaceutical Sciences
2022 | Journal article
EID:

2-s2.0-85125491441

Part of ISSN: 18790720 09280987
Contributors: Wilson, C.G.; Aarons, L.; Augustijns, P.; Brouwers, J.; Darwich, A.S.; De Waal, T.; Garbacz, G.; Hansmann, S.; Hoc, D.; Ivanova, A. et al.
Source: Self-asserted source
Christos Reppas via Scopus - Elsevier

On the usefulness of four in vitro methodologies in screening for product related differences in tacrolimus exposure after oral administration of amorphous solid dispersions with modified release characteristics in the fasted state

Journal of Drug Delivery Science and Technology
2022 | Journal article
EID:

2-s2.0-85125150007

Part of ISSN: 17732247
Contributors: Tsakiridou, G.; O'Dwyer, P.J.; Margaritis, A.; Box, K.J.; Vertzoni, M.; Kalantzi, L.; Reppas, C.
Source: Self-asserted source
Christos Reppas via Scopus - Elsevier

On the usefulness of four in vitro methods in assessing the intraluminal performance of poorly soluble, ionisable compounds in the fasted state

European Journal of Pharmaceutical Sciences
2022 | Journal article
EID:

2-s2.0-85117393484

Part of ISSN: 18790720 09280987
Contributors: O'Dwyer, P.J.; Box, K.J.; Imanidis, G.; Vertzoni, M.; Reppas, C.
Source: Self-asserted source
Christos Reppas via Scopus - Elsevier

UNGAP best practice for improving solubility data quality of orally administered drugs

European Journal of Pharmaceutical Sciences
2022 | Journal article
EID:

2-s2.0-85118509657

Part of ISSN: 18790720 09280987
Contributors: Vertzoni, M.; Alsenz, J.; Augustijns, P.; Bauer-Brandl, A.; Bergström, C.A.S.; Brouwers, J.; Müllerz, A.; Perlovich, G.; Saal, C.; Sugano, K. et al.
Source: Self-asserted source
Christos Reppas via Scopus - Elsevier

Usefulness of Optimized Human Fecal Material in Simulating the Bacterial Degradation of Sulindac and Sulfinpyrazone in the Lower Intestine

Molecular Pharmaceutics
2022 | Journal article
EID:

2-s2.0-85134083159

Part of ISSN: 15438392 15438384
Contributors: Kostantini, C.; Arora, S.; Söderlind, E.; Ceulemans, J.; Reppas, C.; Vertzoni, M.
Source: Self-asserted source
Christos Reppas via Scopus - Elsevier

In Vitro Simulation of the Environment in the Upper Gastrointestinal Lumen After Drug Administration in the Fed State Using the TIM-1 System and Comparison With Luminal Data in Adults

Journal of Pharmaceutical Sciences
2022-01 | Journal article
Contributors: Christina Pentafragka; Irena Tomaszewska; Susann Bellmann; Mans Minekus; Ronald Schilderink; Maria Vertzoni; Mark McAllister; Christos Reppas
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Jennifer Dressman - 40 years of Oral Drug Absorption

Journal of Pharmaceutical Sciences
2022-01 | Journal article
Contributors: Bertil Abrahamsson; James Butler; Rodrigo Cristofoletti; Edmund Kostewicz; Christoph Saal; Christos Reppas
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Characteristics of Contents of Lower intestine in the 65–74 Years of Age Range Could Impact the Performance of Safe and Efficacious Modified Release Products

Journal of Pharmaceutical Sciences
2021 | Journal article
EID:

2-s2.0-85094839650

Part of ISSN: 15206017 00223549
Contributors: Vertzoni, M.; Sulaiman, S.; Goumas, K.; Kersten, E.; Anlahr, J.; Muenster, U.; Reppas, C.
Source: Self-asserted source
Christos Reppas via Scopus - Elsevier

Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network

Advanced Drug Delivery Reviews
2021 | Journal article
EID:

2-s2.0-85101727356

Part of ISSN: 18728294 0169409X
Contributors: Vinarov, Z.; Abrahamsson, B.; Artursson, P.; Batchelor, H.; Berben, P.; Bernkop-Schnürch, A.; Butler, J.; Ceulemans, J.; Davies, N.; Dupont, D. et al.
Source: Self-asserted source
Christos Reppas via Scopus - Elsevier

Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: An UNGAP review

European Journal of Pharmaceutical Sciences
2021 | Journal article
EID:

2-s2.0-85103697111

Part of ISSN: 18790720 09280987
Contributors: Vinarov, Z.; Abdallah, M.; Agundez, J.A.G.; Allegaert, K.; Basit, A.W.; Braeckmans, M.; Ceulemans, J.; Corsetti, M.; Griffin, B.T.; Grimm, M. et al.
Source: Self-asserted source
Christos Reppas via Scopus - Elsevier

The luminal environment in the proximal colon

Oral Drug Delivery for Modified Release Formulations
2021 | Book chapter
EID:

2-s2.0-85136769988

Contributors: Vertzoni, M.; Reppas, C.
Source: Self-asserted source
Christos Reppas via Scopus - Elsevier

Oral biopharmaceutics tools: recent progress from partnership through the Pharmaceutical Education and Research with Regulatory Links collaboration

Journal of Pharmacy and Pharmacology
2021-04-01 | Journal article
Contributors: Patrick J O’Dwyer; Karl J Box; Jennifer Dressman; Brendan T Griffin; Laura J Henze; Chara Litou; Christina Pentafragka; Marina Statelova; Maria Vertzoni; Christos Reppas
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Characteristics of contents in the upper gastrointestinal lumen after a standard high-calorie high-fat meal and implications for the in vitro drug product performance testing conditions

European Journal of Pharmaceutical Sciences
2020 | Journal article
EID:

2-s2.0-85090349286

Part of ISSN: 18790720 09280987
Contributors: Pentafragka, C.; Vertzoni, M.; Dressman, J.; Symillides, M.; Goumas, K.; Reppas, C.
Source: Self-asserted source
Christos Reppas via Scopus - Elsevier

Dissolution testing of modified release products with biorelevant media: An OrBiTo ring study using the USP apparatus III and IV

European Journal of Pharmaceutics and Biopharmaceutics
2020 | Journal article
EID:

2-s2.0-85090334277

Part of ISSN: 18733441 09396411
Contributors: Reppas, C.; Vrettos, N.-N.; Dressman, J.; Andreas, C.J.; Miyaji, Y.; Brown, J.; Etherson, K.; Hanley, S.; Karkossa, F.; Karlsson, E. et al.
Source: Self-asserted source
Christos Reppas via Scopus - Elsevier

Exploring the impact of Crohn's disease on the intragastric environment of fasted adults

ADMET and DMPK
2020 | Journal article
EID:

2-s2.0-85089223917

Part of ISSN: 18487718
Contributors: Vertzoni, M.; Koulouri, C.; Poulou, A.; Goumas, K.; Reppas, C.
Source: Self-asserted source
Christos Reppas via Scopus - Elsevier

Factors Affecting Successful Extrapolation of Ibuprofen Exposure from Adults to Pediatric Populations After Oral Administration of a Pediatric Aqueous Suspension

AAPS Journal
2020 | Journal article
EID:

2-s2.0-85095950101

Part of ISSN: 15507416
Contributors: Statelova, M.; Holm, R.; Fotaki, N.; Reppas, C.; Vertzoni, M.
Source: Self-asserted source
Christos Reppas via Scopus - Elsevier

Novel Biphasic Lipolysis Method to Predict in Vivo Performance of Lipid-Based Formulations

Molecular Pharmaceutics
2020 | Journal article
EID:

2-s2.0-85087670799

Part of ISSN: 15438392 15438384
Contributors: O'Dwyer, P.J.; Box, K.J.; Koehl, N.J.; Bennett-Lenane, H.; Reppas, C.; Holm, R.; Kuentz, M.; Griffin, B.T.
Source: Self-asserted source
Christos Reppas via Scopus - Elsevier

On the Design of Food Effect Studies in Adults for Extrapolating Oral Drug Absorption Data to Infants: an Exploratory Study Highlighting the Importance of Infant Food

AAPS Journal
2020 | Journal article
EID:

2-s2.0-85076053623

Part of ISSN: 15507416
Contributors: Statelova, M.; Goumas, K.; Fotaki, N.; Holm, R.; Symillides, M.; Reppas, C.; Vertzoni, M.
Source: Self-asserted source
Christos Reppas via Scopus - Elsevier

On the usefulness of compendial setups and tiny-TIM system in evaluating the in vivo performance of oral drug products with various release profiles in the fasted state: Case example sodium salt of A6197

European Journal of Pharmaceutics and Biopharmaceutics
2020 | Journal article
EID:

2-s2.0-85079655990

Part of ISSN: 18733441 09396411
Contributors: Schilderink, R.; Protopappa, M.; Fleth-James, J.; Vertzoni, M.; Schaefer, K.; Havenaar, R.; Kulla, I.; Metzger, M.; Reppas, C.
Source: Self-asserted source
Christos Reppas via Scopus - Elsevier

On the usefulness of two small-scale in vitro setups in the evaluation of luminal precipitation of lipophilic weak bases in early formulation development

Pharmaceutics
2020 | Journal article
EID:

2-s2.0-85081542579

Part of ISSN: 19994923
Contributors: O’Dwyer, P.J.; Imanidis, G.; Box, K.J.; Reppas, C.
Source: Self-asserted source
Christos Reppas via Scopus - Elsevier

Successful Extrapolation of Paracetamol Exposure from Adults to Infants After Oral Administration of a Pediatric Aqueous Suspension Is Highly Dependent on the Study Dosing Conditions

AAPS Journal
2020 | Journal article
EID:

2-s2.0-85091724039

Part of ISSN: 15507416
Contributors: Statelova, M.; Holm, R.; Fotaki, N.; Reppas, C.; Vertzoni, M.
Source: Self-asserted source
Christos Reppas via Scopus - Elsevier

Workshop report: USP workshop on advancements in in vitro performance testing of drug products

Dissolution Technologies
2020 | Journal article
EID:

2-s2.0-85088824608

Part of ISSN: 1521298X
Contributors: Hermans, A.; Dorozynski, P.; Muzzio, F.J.; Li, H.; Nielsen, S.; Chen, S.; Reppas, C.; Klein, S.; Patel, S.; Wacker, M. et al.
Source: Self-asserted source
Christos Reppas via Scopus - Elsevier

Unraveling the behavior of oral drug products inside the human gastrointestinal tract using the aspiration technique: History, methodology and applications

European Journal of Pharmaceutical Sciences
2020-12 | Journal article
Contributors: Patrick Augustijns; Maria Vertzoni; Christos Reppas; Peter Langguth; Hans Lennernäs; Bertil Abrahamsson; William L. Hasler; Jason R. Baker; Tim Vanuytsel; Jan Tack et al.
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Exploring impact of supersaturated lipid-based drug delivery systems of celecoxib on in vitro permeation across PermeapadⓇ membrane and in vivo absorption

European Journal of Pharmaceutical Sciences
2020-09 | Journal article
Contributors: Alexandra-Roxana Ilie; Brendan T. Griffin; Martin Brandl; Annette Bauer-Brandl; Ann-Christin Jacobsen; Maria Vertzoni; Martin Kuentz; Ruzica Kolakovic; René Holm
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The effect of reduced gastric acid secretion on the gastrointestinal disposition of a ritonavir amorphous solid dispersion in fasted healthy volunteers: an in vivo - in vitro investigation.

European Journal of Pharmaceutical Sciences
2020-08 | Journal article
Contributors: Jens Van Den Abeele; Christina Kostantini; Richard Barker; Alexandros Kourentas; James C. Mann; Maria Vertzoni; Stefania Beato; Christos Reppas; Jan Tack; Patrick Augustijns
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Disposition of two highly permeable drugs in the upper gastrointestinal lumen of healthy adults after a standard high-calorie, high-fat meal

European Journal of Pharmaceutical Sciences
2020-06 | Journal article
Contributors: Christina Pentafragka; Maria Vertzoni; Mira Symillides; Konstantinos Goumas; Christos Reppas
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Measuring pH and Buffer Capacity in Fluids Aspirated from the Fasted Upper Gastrointestinal Tract of Healthy Adults

Pharmaceutical Research
2020-03 | Journal article
Contributors: Chara Litou; Dimitrios Psachoulias; Maria Vertzoni; Jennifer Dressman; Christos Reppas
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The mechanism of solifenacin release from a pH-responsive ion-complex oral suspension in the fasted upper gastrointestinal lumen

European Journal of Pharmaceutical Sciences
2020-01 | Journal article
Contributors: Yosuke Yamamoto; Harumi Kumagai; Moe Haneda; Maria Vertzoni; Niels Ouwerkerk; Daisuke Murayama; Yoshifumi Katakawa; Kei Motonaga; Christos Reppas; Tomokazu Tajiri
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A novel rheological method to assess drug-polymer interactions regarding miscibility and crystallization of drug in amorphous solid dispersions for oral drug delivery

Pharmaceutics
2019 | Journal article
EID:

2-s2.0-85075517043

Part of ISSN: 19994923
Contributors: Tsakiridou, G.; Reppas, C.; Kuentz, M.; Kalantzi, L.
Source: Self-asserted source
Christos Reppas via Scopus - Elsevier

Formulation, characterization and antimicrobial activity of tablets of essential oil prepared by compression of spray-dried powder

Journal of Drug Delivery Science and Technology
2019 | Journal article
EID:

2-s2.0-85060766507

Part of ISSN: 17732247
Contributors: Partheniadis, I.; Vergkizi, S.; Lazari, D.; Reppas, C.; Nikolakakis, I.
Source: Self-asserted source
Christos Reppas via Scopus - Elsevier

In vitro models for the prediction of in vivo performance of oral dosage forms: Recent progress from partnership through the IMI OrBiTo collaboration

European Journal of Pharmaceutics and Biopharmaceutics
2019 | Journal article
EID:

2-s2.0-85060160593

Part of ISSN: 18733441 09396411
Contributors: Butler, J.; Hens, B.; Vertzoni, M.; Brouwers, J.; Berben, P.; Dressman, J.; Andreas, C.J.; Schaefer, K.J.; Mann, J.; McAllister, M. et al.
Source: Self-asserted source
Christos Reppas via Scopus - Elsevier

The mechanisms of pharmacokinetic food-drug interactions – A perspective from the UNGAP group

European Journal of Pharmaceutical Sciences
2019 | Journal article
EID:

2-s2.0-85064453188

Part of ISSN: 18790720 09280987
Contributors: Koziolek, M.; Alcaro, S.; Augustijns, P.; Basit, A.W.; Grimm, M.; Hens, B.; Hoad, C.L.; Jedamzik, P.; Madla, C.M.; Maliepaard, M. et al.
Source: Self-asserted source
Christos Reppas via Scopus - Elsevier

Workshop report: USP workshop on exploring the science of drug absorption

Dissolution Technologies
2019 | Journal article
EID:

2-s2.0-85073534533

Part of ISSN: 1521298X
Contributors: Martinez, M.N.; Bhoopathy, S.; Carlert, S.; Cirit, M.; Fahmy, R.; Flanagan, T.; Forbes, B.; Jamei, M.; Khan, M.A.; Lukacova, V. et al.
Source: Self-asserted source
Christos Reppas via Scopus - Elsevier

Toward the establishment of a standardized pre-clinical porcine model to predict food effects – Case studies on fenofibrate and paracetamol

International Journal of Pharmaceutics: X
2019-12 | Journal article
Contributors: Laura J. Henze; Niklas J. Koehl; Joseph P. O'Shea; René Holm; Maria Vertzoni; Brendan T. Griffin
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Biphasic drug release testing coupled with diffusing wave spectroscopy for mechanistic understanding of solid dispersion performance

European Journal of Pharmaceutical Sciences
2019-09 | Journal article
Contributors: Sandra Jankovic; Patrick J. O'Dwyer; Karl J. Box; Georgios Imanidis; Christos Reppas; Martin Kuentz
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Impact of regional differences along the gastrointestinal tract of healthy adults on oral drug absorption: An UNGAP review

European Journal of Pharmaceutical Sciences
2019-06 | Journal article
Contributors: Maria Vertzoni; Patrick Augustijns; Michael Grimm; Mirko Koziolek; Glenn Lemmens; Neil Parrott; Christina Pentafragka; Christos Reppas; Jari Rubbens; Jens Van Den Αbeele et al.
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Biopharmaceutical considerations in paediatrics with a view to the evaluation of orally administered drug products – a PEARRL review

Journal of Pharmacy and Pharmacology
2019-04-01 | Journal article
Contributors: Mariana Guimarães; Marina Statelova; René Holm; Christos Reppas; Moira Symilllides; Maria Vertzoni; Nikoletta Fotaki
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In vitro methods to assess drug precipitation in the fasted small intestine – a PEARRL review

Journal of Pharmacy and Pharmacology
2019-04-01 | Journal article
Contributors: Patrick J O'Dwyer; Chara Litou; Karl J Box; Jennifer B Dressman; Edmund S Kostewicz; Martin Kuentz; Christos Reppas
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The impact of food intake on the luminal environment and performance of oral drug products with a view to in vitro and in silico simulations: a PEARRL review

Journal of Pharmacy and Pharmacology
2019-04-01 | Journal article
Contributors: Christina Pentafragka; Mira Symillides; Mark McAllister; Jennifer Dressman; Maria Vertzoni; Christos Reppas
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FIP Guidelines for Dissolution Testing of Solid Oral Products

Journal of Pharmaceutical Sciences
2018 | Journal article
EID:

2-s2.0-85055128786

Part of ISSN: 15206017 00223549
Contributors: Friedel, H.D.; Brown, C.K.; Barker, A.R.; Buhse, L.F.; Keitel, S.; Kraemer, J.; Morris, J.M.; Reppas, C.; Sperry, D.C.; Sakai-Kato, K. et al.
Source: Self-asserted source
Christos Reppas via Scopus - Elsevier

Physiologically Based Absorption Modeling of Salts of Weak Bases Based on Data in Hypochlorhydric and Achlorhydric Biorelevant Media

AAPS PharmSciTech
2018 | Journal article
EID:

2-s2.0-85048054188

Part of ISSN: 15309932
Contributors: Kesisoglou, F.; Vertzoni, M.; Reppas, C.
Source: Self-asserted source
Christos Reppas via Scopus - Elsevier
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Peer review (3 reviews for 2 publications/grants)

Review activity for European journal of pharmaceutical sciences. (2)
Review activity for Journal of drug delivery science and technology. (1)