Personal information

Emails & domains

Verified email domains

Websites & social links

Blokesch lab webpage

Keywords

Vibrio cholerae, Natural competence for transformation, Chitin, Quorum sensing, Type VI secretion

Countries

Switzerland

Activities

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Employment (3)

Swiss Federal Institute of Technology Lausanne (EPFL): Lausanne, CH

2021-06-01 to present | Full Professor (School of Life Sciences)
Employment
Source: Self-asserted source
Melanie Blokesch

Swiss Federal Institute of Technology Lausanne (EPFL): Lausanne, CH

2016-06-01 to 2021-05-31 | Associate Professor (tenured) (School of Life Sciences)
Employment
Source: Self-asserted source
Melanie Blokesch

Swiss Federal Institute of Technology Lausanne (EPFL): Lausanne, CH

2009-05-01 to 2016-05-31 | Assistant Professor (tenure-track); Head of the Laboratory of Molecular Microbiology (School of Life Sciences)
Employment
Source: Self-asserted source
Melanie Blokesch

Education and qualifications (2)

Stanford University: Stanford, CA, US

2005-02-11 to 2009-03-15 | postdoctoral fellow (Microbiology & Immunology)
Education
Source: Self-asserted source
Melanie Blokesch

Ludwig-Maximilians-Universitat Munchen: Munchen, Bayern, DE

2000-07-01 to 2004-11-09 | PHD (DR.RER.NAT.)
Education
Source: Self-asserted source
Melanie Blokesch

Professional activities (12)

Life Sciences Switzerland (LS2): Zurich, CH

Membership
Source: Self-asserted source
Melanie Blokesch

International Society for Microbial Ecology (ISME): Arnhem, NL

2013 to present
Membership
Source: Self-asserted source
Melanie Blokesch

Swiss Society for Microbiology (SSM): Cheseaux-sur- Lausanne, CH

2009 to present
Membership
Source: Self-asserted source
Melanie Blokesch

Amercian Society for Microbiology (ASM): Washington, US

2003 to present
Membership
Source: Self-asserted source
Melanie Blokesch

Vereinigung für Allgemeine und Angewandte Mikrobiologie (VAAM): Frankfurt, DE

1999 to present
Membership
Source: Self-asserted source
Melanie Blokesch

American Academy of Microbiology: Washington, DC, US

2022-02-15 | Elected member of the American Academy of Microbiology
Distinction
Source: Self-asserted source
Melanie Blokesch

German National Academy of Sciences Leopoldina: Halle, DE

2021-06 | Elected member of the Leopoldina
Distinction
Source: Self-asserted source
Melanie Blokesch

European Molecular Biology Organization (EMBO): Heidelberg, DE

2019-06-11 | Elected member of EMBO
Distinction
Source: Self-asserted source
Melanie Blokesch

European Academy of Microbiology (EAM) : Delft, NL

2018-01-16 | Elected member of EAM
Distinction
Source: Self-asserted source
Melanie Blokesch

Association for General and Applied Microbiology (VAAM): Frankfurt, DE

2015 | Research Award 2015 of VAAM
Distinction
Source: Self-asserted source
Melanie Blokesch

Deutsche Akademie der Naturforscher LEOPOLDINA eV: Halle, Sachsen-Anhalt, DE

2005 | Prize for Junior Scientists
Distinction
Source: Self-asserted source
Melanie Blokesch

Association for General and Applied Microbiology (VAAM): Frankfurt, DE

2005 | Thesis Award 2005 of VAAM
Distinction
Source: Self-asserted source
Melanie Blokesch

Funding (15)

DNA & phage defense systems of Vibrio cholerae

2024-07-01 to 2028-06-30 | Grant
Swiss National Science Foundation (Bern, CH)
URL: https://app.dimensions.ai/details/grant/grant.14020465
GRANT_NUMBER: 10000385
Source: Self-asserted source
Melanie Blokesch via DimensionsWizard

Studying how pathogens become even more dangerous: Horizontal gene transfer in Acinetobacter baumannii

2022-01-01 to 2025-12-31 | Grant
Swiss National Science Foundation (Bern, CH)
URL: https://app.dimensions.ai/details/grant/grant.9993788
GRANT_NUMBER: 204335
Source: Self-asserted source
Melanie Blokesch via DimensionsWizard

Collaboration, competition, and other strategies that opportunistic pathogens use to adapt to environmental niches

2019-07-01 to 2023-06-30 | Grant
Swiss National Science Foundation (Bern, CH)
URL: https://app.dimensions.ai/details/grant/grant.8483674
GRANT_NUMBER: 185022
Source: Self-asserted source
Melanie Blokesch via DimensionsWizard

Elucidating the role of R-bodies in the biology of vibrios

2018-07-01 to 2018-08-31 | Grant
Swiss National Science Foundation (Bern, CH)
URL: https://app.dimensions.ai/details/grant/grant.7612641
GRANT_NUMBER: 181044
Source: Self-asserted source
Melanie Blokesch via DimensionsWizard

Pathoecology of Vibrio cholerae to better understand cholera index cases in endemic areas

2018-02 to 2023-07 | Grant
H2020 European Research Council (Brussels, BE)
GRANT_NUMBER: 724630-CholeraIndex
Source: Self-asserted source
Melanie Blokesch

HHMI International Research Scholar - The pathoecology of Vibrio cholerae

2017-09 to 2022-08 | Grant
Howard Hughes Medical Institute (HHMI) (Chevy Chase, MD, US)
GRANT_NUMBER: 55008726
Source: Self-asserted source
Melanie Blokesch

Contribution of natural transformation to the transmission of resistance genes in hospital-acquired pathogens

Source: Self-asserted source
Melanie Blokesch via DimensionsWizard

The interplay between two nanomachines drives horizontal gene transfer in Vibrio cholerae

Source: Self-asserted source
Melanie Blokesch via DimensionsWizard

High Frequency Mass Spectrometer for Advanced Proteomics Analysis

2015-12-01 to 2016-11-30 | Grant
Swiss National Science Foundation (Berne, CH)
URL: https://grants.uberresearch.com/100008367/164075/High-Frequency-Mass-Spectrometer-for-Advanced-Proteomics-Analysis
GRANT_NUMBER: 164075
Source: Self-asserted source
Melanie Blokesch via DimensionsWizard

Multicolour 3D STED Microscope

2015-12-01 to 2016-11-30 | Grant
Swiss National Science Foundation (Berne, CH)
URL: https://grants.uberresearch.com/100008367/164106/Multicolour-3D-STED-Microscope
GRANT_NUMBER: 164106
Source: Self-asserted source
Melanie Blokesch via DimensionsWizard

Request for a Serial Block Face Scanning Electron Microscope

2014-12-01 to 2015-12-31 | Grant
Swiss National Science Foundation (Berne, CH)
URL: https://grants.uberresearch.com/100008367/157883/Request-for-a-Serial-Block-Face-Scanning-Electron-Microscope
GRANT_NUMBER: 157883
Source: Self-asserted source
Melanie Blokesch via DimensionsWizard

Virulence factors of facultative pathogens and their role outside the human host

2013-02-01 to 2018-01-31 | Grant
European Research Council (Saint-Josse-ten-Noode, BE)
URL: https://grants.uberresearch.com/501100000781/106868/Virulence-factors-of-facultative-pathogens-and-their-role-outside-the-human-host
GRANT_NUMBER: 309064
Source: Self-asserted source
Melanie Blokesch via DimensionsWizard
grade
Preferred source (of 2)‎

Understanding the dynamics of competence induction and DNA uptake in Vibrio cholerae

2013-01-01 to 2015-12-31 | Grant
Swiss National Science Foundation (Berne, CH)
URL: https://grants.uberresearch.com/100008367/143356/Understanding-the-dynamics-of-competence-induction-and-DNA-uptake-in-Vibrio-cholerae
GRANT_NUMBER: 143356
Source: Self-asserted source
Melanie Blokesch via DimensionsWizard

Linking the natural competence program of Vibrio cholerae to its environmental niche.

2010-01-01 to 2012-12-31 | Grant
Swiss National Science Foundation (Berne, CH)
URL: https://grants.uberresearch.com/100008367/127029/Linking-the-natural-competence-program-of-Vibrio-cholerae-to-its-environmental-niche
GRANT_NUMBER: 127029
Source: Self-asserted source
Melanie Blokesch via DimensionsWizard

Role of ChiRP, a type IV pilus, in chitin surface colonization and the environmental survival of Vibrio cholerae

Source: Self-asserted source
Melanie Blokesch via DimensionsWizard

Works (50 of 93)

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Structure and Activation Mechanism of a Lamassu Phage Defence System

2025-03-15 | Preprint
DOI: 10.1101/2025.03.14.643221
Contributors: Yan Li; David W. Adams; Hon Wing Liu; Steven J. Shaw; Emiko Uchikawa; Milena Jaskólska; Sandrine Stutzmann; Laurie Righi; Mark D. Szczelkun; Melanie Blokesch et al.
Source: check_circle
Crossref

Capsular polysaccharide restrains type VI secretion in Acinetobacter baumannii

eLife
2025-01-03 | Journal article
DOI: 10.7554/eLife.101032
Contributors: Nicolas Flaugnatti; Loriane Bader; Mary Croisier-Coeytaux; Melanie Blokesch
Source: check_circle
Crossref

Diverse phage defence systems define West African South American pandemicVibrio cholerae

2024-11-24 | Preprint
DOI: 10.1101/2024.11.23.624991
Contributors: David W. Adams; Milena Jaskólska; Alexandre Lemopoulos; Sandrine Stutzmann; Laurie Righi; Loriane Bader; Melanie Blokesch
Source: check_circle
Crossref

Vibrio cholerae pathogenicity island 2 encodes two distinct types of restriction systems

Journal of Bacteriology
2024-09-19 | Journal article
DOI: 10.1128/jb.00145-24
Contributors: Grazia Vizzarro; Alexandre Lemopoulos; David William Adams; Melanie Blokesch; Joseph Bondy-Denomy
Source: check_circle
Crossref

Exploring Mobile Genetic Elements in Vibrio cholerae

2024-07-25 | Preprint
DOI: 10.1101/2024.07.25.605194
Contributors: Natalia C. Drebes Dörr; Alexandre Lemopoulos; Melanie Blokesch
Source: check_circle
Crossref

Molecular mechanism of plasmid elimination by the DdmDE defense system

Science
2024-07-12 | Journal article
DOI: 10.1126/science.adq0534
Contributors: Luuk Loeff; David W. Adams; Christelle Chanez; Sandrine Stutzmann; Laurie Righi; Melanie Blokesch; Martin Jinek
Source: check_circle
Crossref

Interactions between pili affect the outcome of bacterial competition driven by the type VI secretion system

Current Biology
2024-06 | Journal article
DOI: 10.1016/j.cub.2024.04.041
Contributors: Simon B. Otto; Richard Servajean; Alexandre Lemopoulos; Anne-Florence Bitbol; Melanie Blokesch
Source: check_circle
Crossref

Molecular mechanism of plasmid elimination by the DdmDE defense system

2024-05-10 | Preprint
DOI: 10.1101/2024.05.10.593530
Contributors: L. Loeff; D.W. Adams; C. Chanez; S. Stutzmann; L. Righi; M. Blokesch; M. Jinek
Source: check_circle
Crossref

Capsular Polysaccharide Restrains Type VI Secretion inAcinetobacter baumannii

2024-04-23 | Preprint
DOI: 10.1101/2024.04.23.590769
Contributors: Nicolas Flaugnatti; Loriane Bader; Mary Croisier-Coeytaux; Melanie Blokesch
Source: check_circle
Crossref

Vibrio choleraepathogenicity island 2 encodes two distinct types of restriction systems

2024-04-04 | Preprint
DOI: 10.1101/2024.04.04.588119
Contributors: Grazia Vizzarro; Alexandre Lemopoulos; David William Adams; Melanie Blokesch
Source: check_circle
Crossref

Genome sequences of Vibrio cholerae strains isolated in the DRC between 2009 and 2012

Microbiology Resource Announcements
2024-03-12 | Journal article
DOI: 10.1128/mra.00827-23
Contributors: Alexandre Lemopoulos; Berthe Miwanda; Natália C. Drebes Dörr; Sandrine Stutzmann; Didier Bompangue; Jean-Jacques Muyembe-Tamfum; Melanie Blokesch; Catherine Putonti
Source: check_circle
Crossref

Interactions between pili affect the outcome of bacterial competition driven by the type VI secretion system

2023-10-26 | Preprint
DOI: 10.1101/2023.10.25.564063
Contributors: Simon B. Otto; Richard Servajean; Alexandre Lemopoulos; Anne-Florence Bitbol; Melanie Blokesch
Source: check_circle
Crossref

DNA modifications impact natural transformation of Acinetobacter baumannii

Nucleic Acids Research
2023-06-23 | Journal article
DOI: 10.1093/nar/gkad377
Contributors: Nina Vesel; Christian Iseli; Nicolas Guex; Alexandre Lemopoulos; Melanie Blokesch
Source: check_circle
Crossref

Sporadic type VI secretion in seventh pandemic Vibrio cholerae

Microbiology
2023-05-03 | Journal article
DOI: 10.1099/mic.0.001329
Contributors: Alexis Proutière; Natália C. Drebes Dörr; Loriane Bader; Sandrine Stutzmann; Lisa C. Metzger; Sandrine Isaac; Nicolas Chiaruttini; Melanie Blokesch
Source: check_circle
Crossref

Single nucleotide polymorphism determines constitutive versus inducible type VI secretion in Vibrio cholerae

The ISME Journal
2022-07-01 | Journal article
DOI: 10.1038/s41396-022-01234-7
Contributors: Natália C Drebes Dörr; Alexis Proutière; Milena Jaskólska; Sandrine Stutzmann; Loriane Bader; Melanie Blokesch
Source: check_circle
Crossref

Two defence systems eliminate plasmids from seventh pandemic Vibrio cholerae

Nature
2022-04-14 | Journal article
DOI: 10.1038/s41586-022-04546-y
Contributors: Milena Jaskólska; David W. Adams; Melanie Blokesch
Source: check_circle
Crossref

The VarA-CsrA regulatory pathway influences cell shape in Vibrio cholerae

PLOS Genetics
2022-03-28 | Journal article
DOI: 10.1371/journal.pgen.1010143
Contributors: Leonardo F. Lemos Rocha; Josep Casadesús; Katharina Peters; Jacob Biboy; Jamie S. Depelteau; Ariane Briegel; Waldemar Vollmer; Melanie Blokesch
Source: check_circle
Crossref

Human commensal gut Proteobacteria withstand type VI secretion attacks through immunity protein-independent mechanisms

Nature Communications
2021-10-01 | Journal article
DOI: 10.1038/s41467-021-26041-0
Part of ISSN: 2041-1723
Source: Self-asserted source
Melanie Blokesch

Pilus Production in Acinetobacter baumannii Is Growth Phase Dependent and Essential for Natural Transformation

Journal of Bacteriology
2021-03-23 | Journal article
DOI: 10.1128/JB.00034-21
Contributors: Nina Vesel; Melanie Blokesch; Thomas J. Silhavy
Source: check_circle
Crossref

Growing away from monocultures – interdependent growth conditions for studying antibacterial and antiphage systems

Environmental Microbiology Reports
2021-02 | Journal article
DOI: 10.1111/1758-2229.12899
Contributors: Melanie Blokesch
Source: check_circle
Crossref

Comparison of chitin‐induced natural transformation in pandemic Vibrio choleraeO1 El Tor strains

Environmental Microbiology
2020-10 | Journal article
DOI: 10.1111/1462-2920.15214
Contributors: Sandrine Stutzmann; Melanie Blokesch
Source: check_circle
Crossref

Interbacterial competition and anti‐predatory behaviour of environmental Vibrio cholerae strains

Environmental Microbiology
2020-10 | Journal article
DOI: 10.1111/1462-2920.15224
Contributors: Natália C. Drebes Dörr; Melanie Blokesch
Source: check_circle
Crossref

Interbacterial competition and anti-predatory behavior of environmentalVibrio choleraestrains

2020-07-24 | Preprint
DOI: 10.1101/2020.07.24.220178
Contributors: Natália C. Drebes Dörr; Melanie Blokesch
Source: check_circle
Crossref

A Vibriophage Takes Antirepression to the Next Level.

Cell Host & Microbe
2020-04-01 | Journal article
DOI: 10.1016/j.chom.2020.03.019
PMID: 32272072
Source: Self-asserted source
Melanie Blokesch

The type IV pilus protein PilU functions as a PilT-dependent retraction ATPase

PLOS Genetics
2019-09-16 | Journal article
DOI: 10.1371/journal.pgen.1008393
Contributors: David W. Adams; Tracy Palmer; Jorge M. Pereira; Candice Stoudmann; Sandrine Stutzmann; Melanie Blokesch
Source: check_circle
Crossref

Neighbor predation linked to natural competence fosters the transfer of large genomic regions in Vibrio cholerae

eLife
2019-09-03 | Journal article
DOI: 10.7554/eLife.48212
Contributors: Noémie Matthey; Sandrine Stutzmann; Candice Stoudmann; Nicolas Guex; Christian Iseli; Melanie Blokesch
Source: check_circle
Crossref

Mechanisms of DNA Uptake by Naturally Competent Bacteria.

Annual review of genetics
2019-08 | Journal article
DOI: 10.1146/annurev-genet-112618-043641
PMID: 31433955
Contributors: Dubnau D; Blokesch M
Source: Self-asserted source
Melanie Blokesch via Europe PubMed Central

Selection of Vibrio crassostreae relies on a plasmid expressing a type 6 secretion system cytotoxic for host immune cells.

Environmental microbiology
2019-08-07 | Journal article
DOI: 10.1111/1462-2920.14776
PMID: 31390475
Source: Self-asserted source
Melanie Blokesch

Ecological implications of gene regulation by TfoX and TfoY among diverse Vibrio species

Environmental Microbiology
2019-07 | Journal article
DOI: 10.1111/1462-2920.14562
Contributors: Lisa C. Metzger; Noémie Matthey; Candice Stoudmann; Esther J. Collas; Melanie Blokesch
Source: check_circle
Crossref

DNA-uptake pili of Vibrio cholerae are required for chitin colonization and capable of kin recognition via sequence-specific self-interaction

Nature Microbiology
2019-06-10 | Journal article
DOI: 10.1038/s41564-019-0479-5
Contributors: David. W. Adams; Sandrine Stutzmann; Candice Stoudmann; Melanie Blokesch
Source: check_circle
Crossref

Cellular microbiology interview—Dr. Melanie Blokesch

Cellular Microbiology
2019-05-15 | Journal article
DOI: 10.1111/cmi.13002
Contributors: Melanie Blokesch
Source: check_circle
Crossref

Neighbor predation linked to natural competence fosters the transfer of large genomic regions in Vibrio cholerae

2019-04-24 | Other
DOI: 10.1101/618009
Contributors: Noémie Matthey; Sandrine Stutzmann; Candice Stoudmann; Nicolas Guex; Christian Iseli; Melanie Blokesch
Source: check_circle
Crossref

Long-Read-Based Genome Sequences of Pandemic and Environmental Vibrio cholerae Strains.

Microbiology resource announcements
2018-12 | Journal article
DOI: 10.1128/mra.01574-18
PMID: 30574591
PMC: PMC6298558
Contributors: Matthey N; Drebes Dörr NC; Blokesch M
Source: Self-asserted source
Melanie Blokesch via Europe PubMed Central

Bacterial type VI secretion system facilitates niche domination

Proceedings of the National Academy of Sciences
2018-09-04 | Journal article
DOI: 10.1073/pnas.1812776115
Contributors: Natália C. Drebes Dörr; Melanie Blokesch
Source: check_circle
Crossref

Molecular insights into Vibrio cholerae’s intra-amoebal host-pathogen interactions

Nature Communications
2018-08-27 | Journal article
DOI: 10.1038/s41467-018-05976-x
Contributors: Charles Van der Henst; Audrey Sophie Vanhove; Natália Carolina Drebes Dörr; Sandrine Stutzmann; Candice Stoudmann; Stéphanie Clerc; Tiziana Scrignari; Catherine Maclachlan; Graham Knott; Melanie Blokesch
Source: check_circle
Crossref

QstR-dependent regulation of natural competence and type VI secretion in Vibrio cholerae

Nucleic Acids Research
2018-08-08 | Journal article
DOI: 10.1093/nar/gky717
Contributors: Milena Jaskólska; Sandrine Stutzmann; Candice Stoudmann; Melanie Blokesch
Source: check_circle
Crossref

Eco-Evolutionary Dynamics Linked to Horizontal Gene Transfer in Vibrios.

Annual review of microbiology
2018-06 | Journal article
DOI: 10.1146/annurev-micro-090817-062148
PMID: 29897833
Contributors: Le Roux F; Blokesch M
Source: Self-asserted source
Melanie Blokesch via Europe PubMed Central

DNA-uptake pilus of Vibrio cholerae capable of kin-discriminated auto-aggregation

2018-06-26 | Other
DOI: 10.1101/354878
Contributors: David. W. Adams; Sandrine Stutzmann; Candice Stoudmann; Melanie Blokesch
Source: check_circle
Crossref

Molecular insights into Vibrio cholerae’s intra-amoebal host-pathogen interactions

2017-12-18 | Other
DOI: 10.1101/235598
Contributors: Charles Van der Henst; Stéphanie Clerc; Sandrine Stutzmann; Candice Stoudmann; Tiziana Scrignari; Catherine Maclachlan; Graham Knott; Melanie Blokesch
Source: check_circle
Crossref

Interbacterial predation as a strategy for DNA acquisition in naturally competent bacteria.

Nature reviews. Microbiology
2017-10 | Journal article
DOI: 10.1038/nrmicro.2017.66
PMID: 28690319
Source: Self-asserted source
Melanie Blokesch via Europe PubMed Central

Modeling Key Drivers of Cholera Transmission Dynamics Provides New Perspectives for Parasitology.

2017-05 | Journal article
DOI: 10.1016/j.pt.2017.04.002
PMID: 28483382
Contributors: Rinaldo A; Bertuzzo E; Blokesch M; Mari L; Gatto M
Source: Self-asserted source
Melanie Blokesch via Europe PubMed Central

In and out-contribution of natural transformation to the shuffling of large genomic regions.

2017-04 | Journal article
DOI: 10.1016/j.mib.2017.04.001
PMID: 28458094
Contributors: Blokesch M
Source: Self-asserted source
Melanie Blokesch via Europe PubMed Central

Regulation of competence-mediated horizontal gene transfer in the natural habitat of Vibrio cholerae

Current Opinion in Microbiology
2016 | Journal article
DOI: 10.1016/j.mib.2015.10.007
Source: Self-asserted source
Melanie Blokesch

Natural competence for transformation.

2016-11 | Journal article
DOI: 10.1016/j.cub.2016.08.058
PMID: 27825443
Contributors: Blokesch M
Source: Self-asserted source
Melanie Blokesch via Europe PubMed Central

Circulation of a Quorum-Sensing-Impaired Variant of Vibrio cholerae Strain C6706 Masks Important Phenotypes

mSphere
2016-05-25 | Journal article
DOI: 10.1128/mSphere.00098-16
Source: Self-asserted source
Melanie Blokesch

Independent Regulation of Type VI Secretion in Vibrio cholerae by TfoX and TfoY.

Cell Rep
2016-05-03 | Journal article
DOI: 10.1016/j.celrep.2016.03.092
PMID: 27117415
Source: Self-asserted source
Melanie Blokesch

An intracellular replication niche for Vibrio cholerae in the amoeba Acanthamoeba castellanii

The ISME Journal
2016-04 | Journal article
DOI: 10.1038/ismej.2015.165
PMC: 26394005
Source: Self-asserted source
Melanie Blokesch

Competence-induced type VI secretion might foster intestinal colonization by Vibrio cholerae

BioEssays
2015 | Journal article
DOI: 10.1002/bies.201500101
Source: Self-asserted source
Melanie Blokesch

Leben und sterben lassen-horizontaler Gentransfer in Vibrio cholerae

BIOspektrum
2015 | Journal article
DOI: 10.1007/s12268-015-0572-0
Source: Self-asserted source
Melanie Blokesch

Protocols for Visualizing Horizontal Gene Transfer in Gram-Negative Bacteria Through Natural Competence

Springer Protocols Handbooks
2015 | Journal article
DOI: 10.1007/8623_2015_46
Source: Self-asserted source
Melanie Blokesch
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