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Employment (8)

Yale University School of Medicine: New Haven, CT, US

2010 to present | Associate Professor (Neurology)
Employment
Source: Self-asserted source
Kevin C. O'Connor

Harvard Medical School: Boston, MA, US

2007 to 2010 | Assistant Professor (Neurology)
Employment
Source: Self-asserted source
Kevin C. O'Connor

Brigham and Women's Hospital: Boston, MA, US

2007 to 2009 | Associate Scientist (Center for Neurologic Diseases, Department of Neurology)
Employment
Source: Self-asserted source
Kevin C. O'Connor

Tufts University School of Medicine: Boston, MA, US

2002 to 2008 | Adjunct Lecturer
Employment
Source: Self-asserted source
Kevin C. O'Connor

Harvard Medical School: Boston, MA, US

2003 to 2006 | Instructor in Neurology
Employment
Source: Self-asserted source
Kevin C. O'Connor

Brigham and Women's Hospital: Boston, MA, US

2003 to 2006 | Research Associate (Center for Neurologic Diseases, Neurology)
Employment
Source: Self-asserted source
Kevin C. O'Connor

Ares-Serono Pharmaceuticals: Randolph, MA, US

1992 to 1994 | Associate Scientist
Employment
Source: Self-asserted source
Kevin C. O'Connor

Waters Chromatography Div. of Millipore: Milford, MA, US

1988 to 1991 | Applications Chemist
Employment
Source: Self-asserted source
Kevin C. O'Connor

Education and qualifications (3)

Harvard Medical School: Boston, MA, US

2003 | Post-doctoral (Immunology )
Education
Source: Self-asserted source
Kevin C. O'Connor

Tufts University School of Medicine: Boston, MA, US

2000 | PhD (Biochemistry)
Education
Source: Self-asserted source
Kevin C. O'Connor

University of Massachusetts Amherst: Amherst, MA, US

1988 | BS (Chemistry )
Education
Source: Self-asserted source
Kevin C. O'Connor

Works (25)

Luck gone cold: A trifecta of B cell mutations associates with cryoglobulinemia

Science Immunology
2025-04-04 | Journal article | Author
DOI: 10.1126/sciimmunol.adx6827
Contributors: Kevin C. O'Connor; Kangzhi Chen
Source: check_circle
AAAS - Science
grade
Preferred source (of 2)‎

Composition and function of AChR chimeric autoantibody receptor T cells for antigen-specific B cell depletion in myasthenia gravis

Science Advances
2025-02-28 | Journal article | Author
DOI: 10.1126/sciadv.adt0795
Contributors: Aimee S Payne; Kevin C. O'Connor; Sangwook Oh; Fatemeh Khani-Habibabadi
Source: check_circle
AAAS - Science
grade
Preferred source (of 2)‎

Autoimmune mechanisms elucidated through muscle acetylcholine receptor structures

2024-12-20 | Preprint
DOI: 10.1101/2024.12.18.629229
Contributors: Huanhuan Li; Minh C Pham; Jinfeng Teng; Kevin C O'Connor; Colleen M Noviello; Ryan E Hibbs
Source: check_circle
Crossref

Tricky Ts play possum to propagate autoimmune disease

Science Immunology
2024-10-04 | Journal article | Author
DOI: 10.1126/sciimmunol.adt4136
Contributors: Kevin C. O'Connor
Source: check_circle
AAAS - Science
grade
Preferred source (of 2)‎

Distribution and Temporal Changes of Autoantibody-Mediated Pathogenic Mechanisms Among Acetylcholine Receptor-Positive Myasthenia Gravis Patients

2024-08-28 | Preprint
DOI: 10.1101/2024.08.28.24312367
Contributors: Fatemeh Khani-Habibabadi; Bhaskar Roy; Minh C Pham; Abeer H Obaid; Beata Filipek; Richard J Nowak; Kevin C O’Connor
Source: check_circle
Crossref

Hide-&-Go-PhiP-Seq: Finding an elusive predictive MS biomarker

Science Immunology
2024-06-07 | Journal article
DOI: 10.1126/sciimmunol.adq7284
Contributors: Annabel Wallace; Kevin C. O’Connor
Source: check_circle
Crossref

A Noncanonical CD56dimCD16dim/− NK Cell Subset Indicative of Prior Cytotoxic Activity Is Elevated in Patients with Autoantibody-Mediated Neurologic Diseases

The Journal of Immunology
2024-03-01 | Journal article
DOI: 10.4049/jimmunol.2300015
Contributors: Soumya S Yandamuri; Beata Filipek; Nikhil Lele; Inessa Cohen; Jeffrey L Bennett; Richard J Nowak; Elias S Sotirchos; Erin E Longbrake; Emily M Mace; Kevin C O’Connor
Source: check_circle
Crossref

From drab to Fab; PLP1’s fit is redressed for MS

Science Immunology
2023-10-27 | Journal article
DOI: 10.1126/sciimmunol.adl0618
Contributors: Alexandra C. Bayer; Kevin C. O’Connor
Source: check_circle
Crossref

Individual myasthenia gravis autoantibody clones can efficiently mediate multiple mechanisms of pathology

Acta Neuropathologica
2023-08 | Journal article
DOI: 10.1007/s00401-023-02603-y
Contributors: Minh C. Pham; Gianvito Masi; Rosa Patzina; Abeer H. Obaid; Seneca R. Oxendine; Sangwook Oh; Aimee S. Payne; Richard J. Nowak; Kevin C. O’Connor
Source: check_circle
Crossref

Toddler's T cells are taught in muco-school

Science Immunology
2023-08-04 | Journal article
DOI: 10.1126/sciimmunol.adj9555
Contributors: Fatemeh Khani-Habibabadi; Kevin C. O’Connor
Source: check_circle
Crossref

Clinicoserological insights into patients with immune checkpoint inhibitor‐induced myasthenia gravis

Annals of Clinical and Translational Neurology
2023-05 | Journal article
DOI: 10.1002/acn3.51761
Contributors: Gianvito Masi; Minh C. Pham; Tabitha Karatz; Sangwook Oh; Aimee S. Payne; Richard J. Nowak; James F. Howard, Jr; Jeffrey T. Guptill; Vern C. Juel; Kevin C. O'Connor
Source: check_circle
Crossref

The Plasma Cell Infiltrate Populating the Muscle Tissue of Patients with Inclusion Body Myositis Features Distinct B Cell Receptor Repertoire Properties

ImmunoHorizons
2023-05-01 | Journal article
DOI: 10.4049/immunohorizons.2200078
Contributors: Roy Jiang; Bhaskar Roy; Qian Wu; Subhasis Mohanty; Richard J Nowak; Albert C Shaw; Steven H Kleinstein; Kevin C O’Connor
Source: check_circle
Crossref

Plasmablasts from the past: Nostalgic B cells can’t let go

Science Immunology
2023-03-31 | Journal article
DOI: 10.1126/sciimmunol.adh3115
Contributors: Sarah N. Ohashi; Kevin C. O’Connor
Source: check_circle
Crossref

EBVerified TCRs and multiple sclerosis

Science Immunology
2022-10-28 | Journal article
DOI: 10.1126/sciimmunol.adf0763
Contributors: Esen Sefik; Kevin C. O’Connor
Source: check_circle
Crossref

Heterogeneity of Acetylcholine Receptor Autoantibody–Mediated Complement Activity in Patients With Myasthenia Gravis

Neurology Neuroimmunology & Neuroinflammation
2022-07 | Journal article
DOI: 10.1212/NXI.0000000000001169
Contributors: Abeer H. Obaid; Chryssa Zografou; Douangsone D. Vadysirisack; Bailey Munro-Sheldon; Miriam L. Fichtner; Bhaskar Roy; William M. Philbrick; Jeffrey L. Bennett; Richard J. Nowak; Kevin C. O'Connor
Source: check_circle
Crossref

Heterogeneity of acetylcholine receptor autoantibody-mediated complement activity in patients with myasthenia gravis

2021-10-07 | Preprint
DOI: 10.1101/2021.10.05.21264566
Contributors: Abeer H. Obaid; Chryssa Zografou; Douangsone D. Vadysirisack; Bailey Munro-Sheldon; Miriam L. Fichtner; Bhaskar Roy; William M. Philbrick; Jeffrey L. Bennett; Richard J. Nowak; Kevin C. O’Connor
Source: check_circle
Crossref

CD4+ follicular regulatory T cells optimize the influenza virus–specific B cell response

Journal of Experimental Medicine
2021-03-01 | Journal article
DOI: 10.1084/jem.20200547
Contributors: Yisi Lu; Roy Jiang; Alec W. Freyn; Jiawei Wang; Shirin Strohmeier; Katlyn Lederer; Michela Locci; Hongyu Zhao; Davide Angeletti; Kevin C. O’Connor et al.
Source: check_circle
Crossref

Complement activity in myasthenia gravis is independent of autoantibody titer and disease severity

2021-01-20 | Preprint
DOI: 10.1101/2021.01.15.21249875
Contributors: Miriam L. Fichtner; Michelle D. Hoarty; Douangsone D. Vadysirisack; Richard J. Nowak; Kevin C. O’Connor
Source: check_circle
Crossref

Single-cell repertoire tracing identifies rituximab-resistant B cells during myasthenia gravis relapses

JCI Insight
2020-07-23 | Journal article
DOI: 10.1172/jci.insight.136471
Contributors: Ruoyi Jiang; Miriam L. Fichtner; Kenneth B. Hoehn; Minh C. Pham; Panos Stathopoulos; Richard J. Nowak; Steven H. Kleinstein; Kevin C. O’Connor
Source: check_circle
Crossref

Impaired B‐cell tolerance checkpoints promote the development of autoimmune diseases and pathogenic autoantibodies

Immunological Reviews
2019-11 | Journal article
DOI: 10.1111/imr.12821
Contributors: Eric Meffre; Kevin C. O'Connor
Source: check_circle
Crossref

Single-cell repertoire tracing identifies rituximab refractory B cells during myasthenia gravis relapses

2019-11-14 | Preprint
DOI: 10.1101/840389
Contributors: Ruoyi Jiang; Miriam L. Fichtner; Kenneth B. Hoehn; Panos Stathopoulos; Richard J. Nowak; Steven H. Kleinstein; Kevin C. O’Connor
Source: check_circle
Crossref

Phenotypic and Ig Repertoire Analyses Indicate a Common Origin of IgD−CD27− Double Negative B Cells in Healthy Individuals and Multiple Sclerosis Patients

The Journal of Immunology
2019-09-15 | Journal article
DOI: 10.4049/jimmunol.1801236
Contributors: Judith Fraussen; Susanna Marquez; Kazushiro Takata; Lien Beckers; Gwendoline Montes Diaz; Chrysoula Zografou; Bart Van Wijmeersch; Luisa M Villar; Kevin C O’Connor; Steven H Kleinstein et al.
Source: check_circle
Crossref

Mechanisms underlying B cell immune dysregulation and autoantibody production in MuSK myasthenia gravis

Annals of the New York Academy of Sciences
2018-01 | Journal article
DOI: 10.1111/nyas.13535
Contributors: Panos Stathopoulos; Aditya Kumar; Jason A. Vander Heiden; Elba Pascual‐Goñi; Richard J. Nowak; Kevin C. O'Connor
Source: check_circle
Crossref

Dysregulation of B Cell Repertoire Formation in Myasthenia Gravis Patients Revealed through Deep Sequencing

The Journal of Immunology
2017-02-15 | Journal article
DOI: 10.4049/jimmunol.1601415
Contributors: Jason A. Vander Heiden; Panos Stathopoulos; Julian Q. Zhou; Luan Chen; Tamara J. Gilbert; Christopher R. Bolen; Richard J. Barohn; Mazen M. Dimachkie; Emma Ciafaloni; Teresa J. Broering et al.
Source: check_circle
Crossref

A Model of Somatic Hypermutation Targeting in Mice Based on High-Throughput Ig Sequencing Data

The Journal of Immunology
2016-11-01 | Journal article
DOI: 10.4049/jimmunol.1502263
Contributors: Ang Cui; Roberto Di Niro; Jason A Vander Heiden; Adrian W Briggs; Kris Adams; Tamara Gilbert; Kevin C O’Connor; Francois Vigneault; Mark J Shlomchik; Steven H Kleinstein
Source: check_circle
Crossref

Peer review (2 reviews for 2 publications/grants)

Review activity for iScience. (1)
Review activity for Journal of neuroinflammation (1)
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