Renhong Yan (0000-0002-7122-6547)

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Biography

Renhong Yan is an Assistant Professor, Associate Researcher and a Ph.D. supervisor at Southern University of Science and Technology (SUSTech). He graduated with a Bachelor's degree from the School of Life Sciences at Shandong University in July 2014 and obtained his Ph.D. from the School of Life Sciences at Tsinghua University in July 2019, under the supervision of Academician Nieng Yan. He then conducted postdoctoral research at the School of Life Sciences at Westlake University under Academician Yigong Shi. In November 2021, he joined the School of Medicine at SUSTech to establish his research group.

In the past five years, his research has primarily focused on the molecular mechanisms of pathogenicity in emerging and re-emerging infectious diseases and the development of targeted drugs, as well as the molecular mechanisms maintaining amino acid metabolism homeostasis in humans. Prior to establishing his independent research group, he published several top-tier papers as the first author or co-first author, including two papers in Nature and three in Science. Since becoming independent, he has published nine high-level papers as the corresponding author, including one in Nature Structural & Molecular Biology, two in Nature Communications, two in Science Advances, and four in Cell Discovery.

His work has been cited over 8,800 times according to Google Scholar. He was named an Elsevier "Highly Cited Chinese Researcher" in 2022 and 2023. His other accolades include the First Prize in Natural Science from Zhejiang Province in 2021 (as the second contributor), recognition for significant medical advancements in six major fields in China in 2020, being named one of MIT Technology Review's 35 Innovators Under 35 in 2020, inclusion in the "Top Ten Innovative Achievements" of the National Postdoctoral Program in 2020, and significant medical progress in the field of pharmacy in 2019.

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Southern University of Science and Technology: Shenzhen, CN

2021-11-09 to present | Assistant Professor/Associate Researcher/Ph.D. supervisor (Department of Biochemistry, School of Medicine)

Employment

Renhong Yan

https://orcid.org/0000-0002-7122-6547

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Biography

Activities

Employment (1)

Southern University of Science and Technology: Shenzhen, CN

Education and qualifications (2)

Tsinghua University: Beijing, CN

Shandong University: Jinan, CN

Professional activities (8)

Elsevier: Amsterdam, Netherlands, NL

Elsevier: Amsterdam, Netherlands, NL

The Post Doctoral Management Office of China: Beijing, China, CN

People's Government of Zhejiang Province: Zhejiang Province, China, CN

Chinese Academy of Medical Sciences: Beijing, China, CN

The Post Doctoral Management Office of China: Beijing, China, CN

MIT Technology Review China: Beijing, China, CN

Chinese Academy of Medical Sciences: Beijing, China, CN

Works (21)

A structural snapshot of the multiple working states of the Mpox virus helicase–primase D5

Molecular basis of inhibition of the amino acid transporter B0AT1 (SLC6A19)

Structural basis for the inhibition mechanism of LAT1-4F2hc complex by JPH203

Structural basis for the inhibition mechanism of the DNA polymerase holoenzyme from mpox virus

The complete assembly of human LAT1-4F2hc complex provides insights into its regulation, function and localisation

Cryo-EM structure of the human Asc-1 transporter complex

Structural insight into the assembly and working mechanism of helicase-primase D5 from Mpox virus

The cryo-EM structure of homotetrameric attachment glycoprotein from langya henipavirus

Structural Basis for the Enhanced Infectivity and Immune Evasion of Omicron Subvariants

Structural basis for the assembly of the DNA polymerase holoenzyme from a monkeypox virus variant

Cryo-EM structures of recombinant human sodium-potassium pump determined in three different states

The structure of erastin-bound xCT–4F2hc complex reveals molecular mechanisms underlying erastin-induced ferroptosis

Cryo-EM structures of the human sodium-potassium pump revealing the gating mechanism on the cytoplasmic side

Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies

Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter

A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols

Structural insight into the substrate recognition and transport mechanism of the human LAT2–4F2hc complex

A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2

Cryo-EM structure of the human heteromeric amino acid transporter b 0,+ AT-rBAT

Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2

Structure of the human LAT1-4F2hc heteromeric amino acid transporter complex.

Peer review (6 reviews for 4 publications/grants)