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Drug Discovery Network

Other IDs

Scopus Author ID: 57222611438

Keywords

Ovarian Cancer, Mass Spectrometry, MS-based Proteomics, Drug Discovery, Trypanosoma brucei, Colorectal Carcinoma, Enzymology, Tropical Neglected Diseases, Leishmaniasis

Countries

Italy

Activities

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Employment (1)

Università degli Studi di Modena e Reggio Emilia: Modena, Emilia-Romagna, IT

2019-09 to 2021-11 | Junior Research Fellow (Life Sciences)
Employment
Source: Self-asserted source
Lorenzo Tagliazucchi

Education and qualifications (3)

University of Modena and Reggio Emilia: Modena, IT

2021 to present | PhD (Clinical and Experimental Medicine (CEM))
Education
Source: Self-asserted source
Lorenzo Tagliazucchi

University of Modena and Reggio Emilia: Modena, IT

2020 to 2021 | Junior research fellow (Life Sciences)
Education
Source: Self-asserted source
Lorenzo Tagliazucchi

Università degli Studi di Modena e Reggio Emilia: Modena, Emilia-Romagna, IT

2014 to 2019 | Master Degree in Medicinal Chemistry (Life Sciences)
Education
Source: Self-asserted source
Lorenzo Tagliazucchi

Professional activities (1)

Società Chimica Italiana: Rome, Lazio, IT

Membro ordinario (Divisione di Chimica Farmaceutica)
Membership
Source: Self-asserted source
Lorenzo Tagliazucchi

Funding (3)

TEAD ligands prevent YAP binding and combat colorectal cancer growth and resistance.

2022 to present | Grant
Italian Ministers of University and Research (Rome, IT)
Source: Self-asserted source
Lorenzo Tagliazucchi

CA21111 - One Health drugs against parasitic vector borne diseases in Europe and beyond

2022 to 2026 | Grant
European Commission (Brussels, BE)
URL: https://www.cost.eu/actions/CA21111/
Part of GRANT_NUMBER: CA21111
Source: Self-asserted source
Lorenzo Tagliazucchi

Thymidylate synthase dimer disrupters induce DNA damage, halt cell growth, overcome drug resistance in colorectal cancer

2021 to 2026 | Grant
Associazione Italiana per la Ricerca sul Cancro (Milano, Italy, IT)
Part of GRANT_NUMBER:

AIRC2021-IG25785
Source: Self-asserted source
Lorenzo Tagliazucchi

Works (13)

Deciphering Host–Parasite Interplay in Leishmania Infection through a One Health View of Proteomics Studies on Drug Resistance

ACS Infectious Diseases
2024-09-13 | Journal article
DOI: 10.1021/acsinfecdis.4c00185
Contributors: Lorenzo Tagliazucchi; Diego Pinetti; Filippo Genovese; Giulia Malpezzi; Ana Perea Martinez; José I. Manzano; Raquel García-Hernández; Alexander R. Cole; Ba Reum Kwon; Daniele Aiello et al.
Source: check_circle
Crossref

Identification of Innovative Folate Inhibitors Leveraging the Amino Dihydrotriazine Motif from Cycloguanil for Their Potential as Anti-Trypanosoma brucei Agents

ACS Infectious Diseases
2024-08-09 | Journal article
DOI: 10.1021/acsinfecdis.4c00113
Contributors: Valeria Francesconi; Marco Rizzo; Cecilia Pozzi; Lorenzo Tagliazucchi; Claude U. Konchie Simo; Giulia Saporito; Giacomo Landi; Stefano Mangani; Anna Carbone; Silvia Schenone et al.
Source: check_circle
Crossref

Antitarget, Anti-SARS-CoV-2 Leads, Drugs, and the Drug Discovery–Genetics Alliance Perspective

Journal of Medicinal Chemistry
2023-03-23 | Journal article
DOI: 10.1021/acs.jmedchem.2c01229
Contributors: Cecilia Pozzi; Anne Vanet; Valeria Francesconi; Lorenzo Tagliazucchi; Giusy Tassone; Alberto Venturelli; Francesca Spyrakis; Marco Mazzorana; Maria P. Costi; Michele Tonelli
Source: check_circle
Crossref

Label-Free Mass Spectrometry Proteomics Reveals Different Pathways Modulated in THP-1 Cells Infected with Therapeutic Failure and Drug Resistance <i>Leishmania infantum</i> Clinical Isolates

ACS Infectious Diseases
2023-02-10 | Journal article
DOI: 10.1021/acsinfecdis.2c00457
Part of ISSN: 2373-8227
Part of ISSN: 2373-8227
Contributors: Lorenzo Tagliazucchi; Ana Perea-Martinez; Greta Fiorini; Jose Ignacio Manzano; Filippo Genovese; Raquel García-Hernández; Diego Pinetti; Francisco Gamarro; Maria Paola Costi
Source: Self-asserted source
Lorenzo Tagliazucchi

Serum Mass Spectrometry Proteomics and Protein Set Identification in Response to FOLFOX-4 in Drug-Resistant Ovarian Carcinoma

Cancers
2023-01-08 | Journal article
DOI: 10.3390/cancers15020412
Contributors: Domenico D’Arca; Leda Severi; Stefania Ferrari; Luca Dozza; Gaetano Marverti; Fulvio Magni; Clizia Chinello; Lisa Pagani; Lorenzo Tagliazucchi; Marco Villani et al.
Source: check_circle
Crossref
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Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth

eLife
2022-12-07 | Journal article
DOI: 10.7554/elife.73862
Part of ISSN: 2050-084X
Contributors: Lorenzo Tagliazucchi; Luca Costantino; Stefania Ferrari; Matteo Santucci; Outi M. H. Salo-Ahen; Emanuele Carosati; Silvia Franchini; Angela Lauriola; Cecilia Pozzi; Matteo Trande et al.
Source: Self-asserted source
Lorenzo Tagliazucchi

Current Treatments to Control African Trypanosomiasis and One Health Perspective

Microorganisms
2022-06-27 | Journal article
DOI: 10.3390/microorganisms10071298
Contributors: Alberto Venturelli; Lorenzo Tagliazucchi; Clara Lima; Federica Venuti; Giulia Malpezzi; George E. Magoulas; Nuno Santarem; Theodora Calogeropoulou; Anabela Cordeiro-da-Silva; Maria Paola Costi
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Characterization and Valorization of the Agricultural Waste Obtained from Lavandula Steam Distillation for Its Reuse in the Food and Pharmaceutical Fields

Molecules
2022-02-28 | Journal article
DOI: 10.3390/molecules27051613
Contributors: Eleonora Truzzi; Mohamed Aymen Chaouch; Gaia Rossi; Lorenzo Tagliazucchi; Davide Bertelli; Stefania Benvenuti
Source: check_circle
Crossref
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Identification of a Quinone Derivative as a YAP/TEAD Activity Modulator from a Repurposing Library

Pharmaceutics
2022-02-10 | Journal article
DOI: 10.3390/pharmaceutics14020391
Contributors: Angela Lauriola; Elisa Uliassi; Matteo Santucci; Maria Laura Bolognesi; Marco Mor; Laura Scalvini; Gian Marco Elisi; Gaia Gozzi; Lorenzo Tagliazucchi; Gaetano Marverti et al.
Source: check_circle
Crossref
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Repurposing the Trypanosomatidic GSK Kinetobox for the Inhibition of Parasitic Pteridine and Dihydrofolate Reductases

Pharmaceuticals
2021-11-30 | Journal article
DOI: 10.3390/ph14121246
Contributors: Matteo Santucci; Rosaria Luciani; Eleonora Gianquinto; Cecilia Pozzi; Flavio di Pisa; Lucia dello Iacono; Giacomo Landi; Lorenzo Tagliazucchi; Stefano Mangani; Francesca Spyrakis et al.
Source: check_circle
Crossref
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Evidence of Pyrimethamine and Cycloguanil Analogues as Dual Inhibitors of Trypanosoma brucei Pteridine Reductase and Dihydrofolate Reductase

Pharmaceuticals
2021-06-30 | Journal article
DOI: 10.3390/ph14070636
Contributors: Giusy Tassone; Giacomo Landi; Pasquale Linciano; Valeria Francesconi; Michele Tonelli; Lorenzo Tagliazucchi; Maria Paola Costi; Stefano Mangani; Cecilia Pozzi
Source: check_circle
Crossref
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Structural Bases for the Synergistic Inhibition of Human Thymidylate Synthase and Ovarian Cancer Cell Growth by Drug Combinations

Cancers
2021-04-24 | Journal article
DOI: 10.3390/cancers13092061
Contributors: Cecilia Pozzi; Matteo Santucci; Gaetano Marverti; Domenico D’Arca; Lorenzo Tagliazucchi; Stefania Ferrari; Gaia Gozzi; Lorena Losi; Giusy Tassone; Stefano Mangani et al.
Source: check_circle
Crossref
grade
Preferred source (of 3)‎

Folic Acid–Peptide Conjugates Combine Selective Cancer Cell Internalization with Thymidylate Synthase Dimer Interface Targeting

Journal of Medicinal Chemistry
2021-03-12 | Journal article
DOI: 10.1021/acs.jmedchem.0c02107
PMID: 33710891
Source: Self-asserted source
Lorenzo Tagliazucchi
grade
Preferred source (of 2)‎

Peer review (1 review for 1 publication/grant)

Review activity for The lancet. (1)
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