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smartbax GmbH
Sylvia Varland

Other IDs

ResearcherID: D-8128-2018
Scopus Author ID: 56682828400

Keywords

N-terminal acetylation, N-terminal acetyltransferase, Functional genomics, Yeast, Antibiotics

Countries

Norway, Germany

Activities

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Employment (3)

smartbax GmbH: Munich, DE

2022-10 to present | Senior Scientist
Employment
Source: Self-asserted source
Sylvia Varland

University of Bergen: Bergen, NO

2019-09-18 to 2022-02-15 | Researcher (Department of Biomedicine)
Employment
Source: Self-asserted source
Sylvia Varland

University of Toronto: Toronto, ON, CA

2017-09-18 to 2019-09-17 | Visiting PostDoc (Donnelly Centre for Cellular and Biomolecular Research)
Employment
Source: Self-asserted source
Sylvia Varland

Education and qualifications (2)

University of Bergen: Bergen, NO

2012-10-01 to 2016-10-21 | PhD in Molecular Biology (Department of Molecular Biology)
Education
Source: Self-asserted source
Sylvia Varland

University of Bergen: Bergen, Hordaland, NO

2010-08 to 2012-06 | MSc in Molecular Biology (Department of Molecular Biology)
Education
Source: Self-asserted source
Sylvia Varland

Funding (1)

NatFUGE

2017-09 to 2021-09 | Grant
Research Council of Norway (Oslo, NO)
Source: Self-asserted source
Sylvia Varland

Works (14)

A nonsense variant in the N‐terminal acetyltransferase NAA30 may be associated with global developmental delay and tracheal cleft

American Journal of Medical Genetics Part A
2023-09 | Journal article
DOI: 10.1002/ajmg.a.63338
Contributors: Sylvia Varland; Kirsten Marie Brønstad; Stephanie J. Skinner; Thomas Arnesen
Source: check_circle
Crossref

N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity

2022-09-02 | Preprint
DOI: 10.1101/2022.09.01.505523
Contributors: Sylvia Varland; Rui Duarte Silva; Ine Kjosås; Alexandra Faustino; Annelies Bogaert; Maximilian Billmann; Hadi Boukhatmi; Barbara Kellen; Michael Costanzo; Adrian Drazic et al.
Source: check_circle
Crossref

Human NAA30 can rescue yeast mak3∆ mutant growth phenotypes

Bioscience Reports
2021-03-26 | Journal article
DOI: 10.1042/BSR20202828
Contributors: Adrian Drazic; Sylvia Varland
Source: check_circle
Crossref

PFN2 and NAA80 cooperate to efficiently acetylate the N-terminus of actin

Journal of Biological Chemistry
2020-12 | Journal article
DOI: 10.1074/jbc.RA120.015468
Contributors: Rasmus Ree; Laura Kind; Anna Kaziales; Sylvia Varland; Minglu Dai; Klaus Richter; Adrian Drazic; Thomas Arnesen
Source: check_circle
Crossref

PFN2 and NAA80 cooperate to efficiently acetylate the N-terminus of actin

2020-07-15 | Preprint
DOI: 10.1101/2020.07.15.202630
Contributors: Rasmus Ree; Laura Kind; Anna Kaziales; Sylvia Varland; Minglu Dai; Klaus Richter; Adrian Drazic; Thomas Arnesen
Source: check_circle
Crossref

Actin Post-translational Modifications: The Cinderella of Cytoskeletal Control

Trends Biochem Sci.
2019-06 | Journal article
DOI: 10.1016/j.tibs.2018.11.010
Source: Self-asserted source
Sylvia Varland

Investigating the functionality of a ribosome-binding mutant of NAA15 using Saccharomyces cerevisiae

BMC Research Notes
2018-12 | Journal article
DOI: 10.1186/s13104-018-3513-4
Contributors: Sylvia Varland; Thomas Arnesen
Source: check_circle
Crossref

N-terminal Acetylation Levels Are Maintained During Acetyl-CoA Deficiency in Saccharomyces cerevisiae

Molecular & Cellular Proteomics
2018-12-27 | Journal article
DOI: 10.1074/mcp.RA118.000982
Contributors: Sylvia Varland; Henriette Aksnes; Fedor Kryuchkov; Francis Impens; Delphi Van Haver; Veronique Jonckheere; Mathias Ziegler; Kris Gevaert; Petra Van Damme; Thomas Arnesen
Source: check_circle
Crossref

Spotlight on protein N-terminal acetylation

Experimental & Molecular Medicine
2018-07 | Journal article
DOI: 10.1038/s12276-018-0116-z
Contributors: Rasmus Ree; Sylvia Varland; Thomas Arnesen
Source: check_circle
Crossref

Truncating Variants in NAA15 Are Associated with Variable Levels of Intellectual Disability, Autism Spectrum Disorder, and Congenital Anomalies

The American Journal of Human Genetics
2018-05 | Journal article
DOI: 10.1016/j.ajhg.2018.03.004
Part of ISSN: 0002-9297
Contributors: Hanyin Cheng; Avinash V. Dharmadhikari; Sylvia Varland; Ning Ma; Deepti Domingo; Robert Kleyner; Alan F. Rope; Margaret Yoon; Asbjørg Stray-Pedersen; Jennifer E. Posey et al.
Source: Self-asserted source
Sylvia Varland via Crossref Metadata Search

NAA80 is actin’s N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility

Proceedings of the National Academy of Sciences
2018-03 | Journal article
DOI: 10.1073/pnas.1718336115
Part of ISSN: 0027-8424
Contributors: Adrian Drazic; Henriette Aksnes; Michaël Marie; Malgorzata Boczkowska; Sylvia Varland; Evy Timmerman; Håvard Foyn; Nina Glomnes; Grzegorz Rebowski; Francis Impens et al.
Source: Self-asserted source
Sylvia Varland via Crossref Metadata Search

Structural determinants and cellular environment define processed actin as the sole substrate of the N-terminal acetyltransferase NAA80

Proceedings of the National Academy of Sciences
2018-03 | Journal article
DOI: 10.1073/pnas.1719251115
Part of ISSN: 0027-8424
Contributors: Marianne Goris; Robert S. Magin; Håvard Foyn; Line M. Myklebust; Sylvia Varland; Rasmus Ree; Adrian Drazic; Parminder Bhambra; Svein I. Støve; Markus Baumann et al.
Source: Self-asserted source
Sylvia Varland via Crossref Metadata Search

Identification of an alternatively spliced nuclear isoform of human N-terminal acetyltransferase Naa30.

Gene
2018-02 | Journal article
DOI: 10.1016/j.gene.2017.12.019
PMID: 29247799
Contributors: Varland S; Myklebust LM; Goksøyr SØ; Glomnes N; Torsvik J; Varhaug JE; Arnesen T
Source: Self-asserted source
Sylvia Varland via Europe PubMed Central

N-terminal modifications of cellular proteins: The enzymes involved, their substrate specificities and biological effects.

2015-07 | Journal article
DOI: 10.1002/pmic.201400619
PMID: 25914051
PMC: PMC4692089
Contributors: Varland S; Osberg C; Arnesen T
Source: Self-asserted source
Sylvia Varland via Europe PubMed Central
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