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Institut de Biologie Structurale: Grenoble, Rhône-Alpes, FR

Senior scientist (Complement, Antibodies and Infectious Diseases)
Employment
Source: Self-asserted source
Nicole Thielens

Works (50 of 166)

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Page 1 of 4

The Fc fragment of soluble IgMs binds C1q to activate the classical complement pathway, while inhibiting complement-dependent cytotoxicity

2024-07-11 | Preprint
DOI: 10.1101/2024.07.10.602503
Contributors: Andre J. Pinto; Anne Chouquet; Isabelle Bally; Nicole M. Thielens; Chantal Dumestre-Perard; Renate Kunert; Christine Gaboriaud; Wai Li W Ling; Jean-Baptiste REISER
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Crossref

HMGB1 cleavage by complement C1s and its potent anti-inflammatory product

Frontiers in Immunology
2023-04-26 | Journal article
DOI: 10.3389/fimmu.2023.1151731
Part of ISSN: 1664-3224
Contributors: Marie Lorvellec; Anne Chouquet; Jonas Koch; Isabelle Bally; Luca Signor; Jeanne Vigne; Fabien Dalonneau; Nicole M. Thielens; Thierry Rabilloud; Bastien Dalzon et al.
Source: Self-asserted source
Nicole Thielens

Degradation of collagen I by activated C1s in periodontal Ehlers-Danlos Syndrome

Frontiers in Immunology
2023-03-07 | Journal article
DOI: 10.3389/fimmu.2023.1157421
Part of ISSN: 1664-3224
Contributors: Albert Amberger; Johanna Pertoll; Pia Traunfellner; Ines Kapferer-Seebacher; Heribert Stoiber; Lars Klimaschewski; Nicole Thielens; Christine Gaboriaud; Johannes Zschocke
Source: Self-asserted source
Nicole Thielens

Nanoscale imaging of CD47 informs how plasma membrane modifications shape apoptotic cell recognition

Communications Biology
2023-02-22 | Journal article
DOI: 10.1038/s42003-023-04558-y
Contributors: Samy Dufour; Pascale Tacnet-Delorme; Jean-Philippe Kleman; Oleksandr Glushonkov; Nicole Thielens; Dominique Bourgeois; Philippe Frachet
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Crossref

Rationally designed Gla-domainless FXa as TFPI bait in hemophilia

2022-08-04 | Preprint
DOI: 10.1101/2022.08.03.502629
Contributors: Marie-Claire Dagher; Atanur Ersayin; Landry Seyve; Mathieu Castellan; Cyril Moreau; Luc Choisnard; Nicole Thielens; Raphaël Marlu; Benoît Polack; Aline Thomas
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Crossref

Structures of the MASP Proteases and Comparison with Complement C1r and C1s

The Collectin Protein Family and Its Multiple Biological Activities
2021 | Book chapter
DOI: 10.1007/978-3-030-67048-1_4
Part of ISBN: 9783030670474
Part of ISBN: 9783030670481
Source: Self-asserted source
Nicole Thielens

Insights into the ligand binding specificity of SREC‐II (scavenger receptor expressed by endothelial cells)

FEBS Open Bio
2021-10 | Journal article
DOI: 10.1002/2211-5463.13260
Contributors: Catherine Wicker‐Planquart; Pascale Tacnet‐Delorme; Laurence Preisser; Samy Dufour; Yves Delneste; Dominique Housset; Philippe Frachet; Nicole M Thielens; Jörg Kobarg
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Crossref

Biophysical characterization of the oligomeric states of recombinant Immunoglobulins type-M and their C1q binding kinetics by Biolayer Interferometry

2021-10-01 | Other
DOI: 10.1101/2021.09.30.460443
Contributors: Anne Chouquet; Andrea J. Pinto; Julia Hennicke; Wai Li Ling; Isabelle Bally; Linda Schwaigerlehner; Nicole M. Thielens; Renate Kunert; Jean-Baptiste Reiser
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Crossref

Complement Alternative and Mannose-Binding Lectin Pathway Activation Is Associated With COVID-19 Mortality.

Frontiers in immunology
2021-09-10 | Journal article
DOI: 10.3389/fimmu.2021.742446
PMID: 34567008
PMC: PMC8461024
Source: Self-asserted source
Nicole Thielens

Soluble FAS Ligand Enhances Suboptimal CD40L/IL-21–Mediated Human Memory B Cell Differentiation into Antibody-Secreting Cells

The Journal of Immunology
2021-07-15 | Journal article
DOI: 10.4049/jimmunol.2001390
Contributors: Saskia D van Asten; Peter-Paul Unger; Casper Marsman; Sophie Bliss; Tineke Jorritsma; Nicole M Thielens; S Marieke van Ham; Robbert M Spaapen
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Crossref

DC/L-SIGN recognition of spike glycoprotein promotes SARS-CoV-2 trans-infection and can be inhibited by a glycomimetic antagonist

PLOS Pathogens
2021-05-20 | Journal article
DOI: 10.1371/journal.ppat.1009576
Contributors: Michel Thépaut; Andrew Pekosz; Joanna Luczkowiak; Corinne Vivès; Nuria Labiod; Isabelle Bally; Fátima Lasala; Yasmina Grimoire; Daphna Fenel; Sara Sattin et al.
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Crossref

Molecular Basis of Complement C1q Collagen-Like Region Interaction with the Immunoglobulin-Like Receptor LAIR-1

International Journal of Molecular Sciences
2021-05-12 | Journal article
DOI: 10.3390/ijms22105125
Contributors: Guillaume Fouët; Isabelle Bally; Anne Chouquet; Jean-Baptiste Reiser; Nicole M. Thielens; Christine Gaboriaud; Véronique Rossi
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Crossref
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Headless C1q: a new molecular tool to decipher its collagen‐like functions

The FEBS Journal
2021-03 | Journal article
DOI: 10.1111/febs.15543
Contributors: Guillaume Fouët; Isabelle Bally; Luca Signor; Katharina Häußermann; Nicole M. Thielens; Véronique Rossi; Christine Gaboriaud
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Crossref

Analysis of the Ligand Recognition Specificities of Human Ficolins Using Surface Plasmon Resonance.

Methods in molecular biology (Clifton, N.J.)
2021-01-01 | Journal article
DOI: 10.1007/978-1-0716-1016-9_19
PMID: 33847944
Source: Self-asserted source
Nicole Thielens

Anti-Ficolin-2 and Anti-Ficolin-3 Autoantibody Detection by ELISA.

Methods in molecular biology (Clifton, N.J.)
2021-01-01 | Journal article
DOI: 10.1007/978-1-0716-1016-9_12
PMID: 33847937
Source: Self-asserted source
Nicole Thielens

Soluble FAS Ligand directs human memory B cells towards antibody-secreting cells

2020-12-06 | Preprint
DOI: 10.1101/2020.12.04.411959
Contributors: Saskia D. van Asten; Peter-Paul Unger; Casper Marsman; Sophie Bliss; Tineke Jorritsma; Nicole M. Thielens; S. Marieke van Ham; Robbert M. Spaapen
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Crossref

Contribution of rare and predicted pathogenic gene variants to childhood-onset lupus: a large, genetic panel analysis of British and French cohorts

The Lancet Rheumatology
2020-01 | Journal article
DOI: 10.1016/s2665-9913(19)30142-0
Part of ISSN: 2665-9913
Source: Self-asserted source
Nicole Thielens

Two Different Missense C1S Mutations, Associated to Periodontal Ehlers-Danlos Syndrome, Lead to Identical Molecular Outcomes.

Frontiers in immunology
2019-12-18 | Journal article
DOI: 10.3389/fimmu.2019.02962
PMID: 31921203
PMC: PMC6930149
Source: Self-asserted source
Nicole Thielens

The Immunopathology of Complement Proteins and Innate Immunity in Autoimmune Disease

Clinical Reviews in Allergy & Immunology
2019-12-13 | Journal article
DOI: 10.1007/s12016-019-08774-5
Part of ISSN: 1080-0549
Part of ISSN: 1559-0267
Source: Self-asserted source
Nicole Thielens

Recombinant C1q variants modulate macrophage responses but do not activate the classical complement pathway.

Molecular immunology
2019-11-15 | Journal article
DOI: 10.1016/j.molimm.2019.10.008
PMID: 31739194
Source: Self-asserted source
Nicole Thielens

C1R Mutations Trigger Constitutive Complement 1 Activation in Periodontal Ehlers-Danlos Syndrome

Frontiers in Immunology
2019-11-05 | Journal article
DOI: 10.3389/fimmu.2019.02537
ISSN: 1664-3224
Source: Self-asserted source
Nicole Thielens

Complement C1r serine protease contributes to kidney fibrosis

American Journal of Physiology-Renal Physiology
2019-11-01 | Journal article
DOI: 10.1152/ajprenal.00357.2019
ISSN: 1931-857X
ISSN: 1522-1466
Source: Self-asserted source
Nicole Thielens

Editorial: The Role of Complement in Health and Disease

Frontiers in Immunology
2019-08-07 | Journal article
DOI: 10.3389/fimmu.2019.01869
Part of ISSN: 1664-3224
Source: Self-asserted source
Nicole Thielens

Interaction of C1q With Pentraxin 3 and IgM Revisited: Mutational Studies With Recombinant C1q Variants.

Frontiers in immunology
2019-03 | Journal article
DOI: 10.3389/fimmu.2019.00461
PMID: 30923526
PMC: PMC6426777
Contributors: Bally I; Inforzato A; Dalonneau F; Stravalaci M; Bottazzi B; Gaboriaud C; Thielens NM
Source: Self-asserted source
Nicole Thielens via Europe PubMed Central

Involvement of Surfactant Protein D in Ebola Virus Infection Enhancement via Glycoprotein Interaction

Viruses
2018-12 | Journal article | Author
DOI: 10.3390/v11010015
Contributors: Anne-Laure Favier; Olivier Reynard; Evelyne Gout; Martin van Eijk; Henk Haagsman; Erika Crouch; Viktor Volchkov; Christophe Peyrefitte; Nicole Thielens
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Multidisciplinary Digital Publishing Institute
grade
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Active Human Complement Reduces the Zika Virus Load via Formation of the Membrane-Attack Complex.

Frontiers in immunology
2018-10 | Journal article
DOI: 10.3389/fimmu.2018.02177
PMID: 30386325
PMC: PMC6199351
Contributors: Schiela B; Bernklau S; Malekshahi Z; Deutschmann D; Koske I; Banki Z; Thielens NM; Würzner R; Speth C; Weiss G et al.
Source: Self-asserted source
Nicole Thielens via Europe PubMed Central

Recognition protein C1q of innate immunity agglutinates nanodiamonds without activating complement.

Nanomedicine : nanotechnology, biology, and medicine
2018-10 | Journal article
DOI: 10.1016/j.nano.2018.09.009
PMID: 30368000
Contributors: Belime A; Thielens NM; Gravel E; Frachet P; Ancelet S; Tacnet P; Caneiro C; Chuprin J; Gaboriaud C; Schoehn G et al.
Source: Self-asserted source
Nicole Thielens via Europe PubMed Central

Antibodies targeting circulating protective molecules in lupus nephritis: Interest as serological biomarkers.

Autoimmunity reviews
2018-07 | Journal article
DOI: 10.1016/j.autrev.2018.03.013
PMID: 30009962
Contributors: Dumestre-Pérard C; Clavarino G; Colliard S; Cesbron JY; Thielens NM
Source: Self-asserted source
Nicole Thielens via Europe PubMed Central

Autoantibodies Targeting Ficolin-2 in Systemic Lupus Erythematosus Patients With Active Nephritis.

Arthritis care & research
2018-06 | Journal article
DOI: 10.1002/acr.23449
PMID: 29045037
Contributors: Colliard S; Jourde-Chiche N; Clavarino G; Sarrot-Reynauld F; Gout E; Deroux A; Fougere M; Bardin N; Bouillet L; Cesbron JY et al.
Source: Self-asserted source
Nicole Thielens via Europe PubMed Central

C1q restrains autoimmunity and viral infection by regulating CD8 + T cell metabolism

Science
2018-05-04 | Journal article
DOI: 10.1126/science.aao4555
Contributors: Guang Sheng Ling; Greg Crawford; Norzawani Buang; Istvan Bartok; Kunyuan Tian; Nicole M. Thielens; Isabelle Bally; James A. Harker; Philip G. Ashton-Rickardt; Sophie Rutschmann et al.
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Crossref

C1q and Mannose-Binding Lectin Interact with CR1 in the Same Region on CCP24-25 Modules.

Frontiers in immunology
2018-03 | Journal article
DOI: 10.3389/fimmu.2018.00453
PMID: 29563915
PMC: PMC5845983
Contributors: Jacquet M; Cioci G; Fouet G; Bally I; Thielens NM; Gaboriaud C; Rossi V
Source: Self-asserted source
Nicole Thielens via Europe PubMed Central

Impact of the surface charge of polydiacetylene micelles on their interaction with human innate immune protein C1q and the complement system.

International journal of pharmaceutics
2017-12 | Journal article
DOI: 10.1016/j.ijpharm.2017.11.072
PMID: 29208412
Contributors: Thielens NM; Belime A; Gravel E; Ancelet S; Caneiro C; Doris E; Ling WL
Source: Self-asserted source
Nicole Thielens via Europe PubMed Central

Interaction of Complement Defence Collagens C1q and Mannose-Binding Lectin with BMP-1/Tolloid-like Proteinases.

Scientific reports
2017-12 | Journal article
DOI: 10.1038/s41598-017-17318-w
PMID: 29209066
PMC: PMC5717261
Contributors: Lacroix M; Tessier A; Dumestre-Pérard C; Vadon-Le Goff S; Gout E; Bruckner-Tuderman L; Kiritsi D; Nyström A; Ricard-Blum S; Moali C et al.
Source: Self-asserted source
Nicole Thielens via Europe PubMed Central

Catalytically inactive Gla-domainless factor Xa binds to TFPI and restores ex vivo coagulation in hemophilia plasma.

Haematologica
2017-10 | Journal article
DOI: 10.3324/haematol.2017.174037
PMID: 28983056
PMC: PMC5709117
Contributors: Ersayin A; Thomas A; Seyve L; Thielens N; Castellan M; Marlu R; Polack B; Dagher MC
Source: Self-asserted source
Nicole Thielens via Europe PubMed Central

Mode of PEG Coverage on Carbon Nanotubes Affects Binding of Innate Immune Protein C1q.

The journal of physical chemistry. B
2017-09 | Journal article
DOI: 10.1021/acs.jpcb.7b06596
PMID: 28915042
Contributors: Belime A; Gravel E; Brenet S; Ancelet S; Caneiro C; Hou Y; Thielens N; Doris E; Ling WL
Source: Self-asserted source
Nicole Thielens via Europe PubMed Central

Structure of the C1 complex of complement.

Proceedings of the National Academy of Sciences of the United States of America
2017-07 | Journal article
DOI: 10.1073/pnas.1703977114
PMID: 28701384
PMC: PMC5530679
Contributors: Arlaud GJ; Gaboriaud C; Ling WL; Thielens NM
Source: Self-asserted source
Nicole Thielens via Europe PubMed Central

C1q: A fresh look upon an old molecule.

Molecular immunology
2017-06 | Journal article
DOI: 10.1016/j.molimm.2017.05.025
PMID: 28601358
PMC: PMC5582005
Contributors: Thielens NM; Tedesco F; Bohlson SS; Gaboriaud C; Tenner AJ
Source: Self-asserted source
Nicole Thielens via Europe PubMed Central

Human Immune Protein C1q Selectively Disaggregates Carbon Nanotubes.

Nano letters
2017-05 | Journal article
DOI: 10.1021/acs.nanolett.7b00189
PMID: 28530824
Contributors: Saint-Cricq M; Carrete J; Gaboriaud C; Gravel E; Doris E; Thielens N; Mingo N; Ling WL
Source: Self-asserted source
Nicole Thielens via Europe PubMed Central

Deciphering Key Residues Involved in the Virulence-promoting Interactions between Streptococcus pneumoniae and Human Plasminogen.

The Journal of biological chemistry
2016-12 | Journal article
DOI: 10.1074/jbc.M116.764209
PMID: 28011643
PMC: PMC5313095
Contributors: Moreau C; Terrasse R; Thielens NM; Vernet T; Gaboriaud C; Di Guilmi AM
Source: Self-asserted source
Nicole Thielens via Europe PubMed Central

Editorial: State-of-the-Art Research on C1q and the Classical Complement Pathway.

Frontiers in immunology
2016-10 | Journal article
DOI: 10.3389/fimmu.2016.00398
PMID: 27757112
PMC: PMC5047878
Contributors: Kishore U; Thielens NM; Gaboriaud C
Source: Self-asserted source
Nicole Thielens via Europe PubMed Central

Periodontal Ehlers-Danlos Syndrome Is Caused by Mutations in C1R and C1S, which Encode Subcomponents C1r and C1s of Complement.

American journal of human genetics
2016-10 | Journal article
DOI: 10.1016/j.ajhg.2016.08.019
PMID: 27745832
PMC: PMC5097948
Contributors: Kapferer-Seebacher I; Pepin M; Werner R; Aitman TJ; Nordgren A; Stoiber H; Thielens N; Gaboriaud C; Amberger A; Schossig A et al.
Source: Self-asserted source
Nicole Thielens via Europe PubMed Central

Association between the Presence of Autoantibodies Targeting Ficolin-3 and Active Nephritis in Patients with Systemic Lupus Erythematosus.

PloS one
2016-09 | Journal article
DOI: 10.1371/journal.pone.0160879
PMID: 27631981
PMC: PMC5025237
Contributors: Plawecki M; Lheritier E; Clavarino G; Jourde-Chiche N; Ouili S; Paul S; Gout E; Sarrot-Reynauld F; Bardin N; Boëlle PY et al.
Source: Self-asserted source
Nicole Thielens via Europe PubMed Central

Structures of parasite calreticulins provide insights into their flexibility and dual carbohydrate/peptide-binding properties.

IUCrJ
2016-09 | Journal article
DOI: 10.1107/S2052252516012847
PMID: 27840680
PMC: PMC5094443
Contributors: Moreau C; Cioci G; Iannello M; Laffly E; Chouquet A; Ferreira A; Thielens NM; Gaboriaud C
Source: Self-asserted source
Nicole Thielens via Europe PubMed Central

First Membrane Proximal External Region–Specific Anti-HIV1 Broadly Neutralizing Monoclonal IgA1 Presenting Short CDRH3 and Low Somatic Mutations

The Journal of Immunology
2016-09-01 | Journal article
DOI: 10.4049/jimmunol.1600309
Contributors: Fahd Benjelloun; Zeliha Oruc; Nicole Thielens; Bernard Verrier; Gael Champier; Nadine Vincent; Nicolas Rochereau; Alexandre Girard; Fabienne Jospin; Blandine Chanut et al.
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Crossref

Enhancement of Ebola Virus Infection via Ficolin-1 Interaction with the Mucin Domain of GP Glycoprotein.

Journal of virology
2016-05 | Journal article
DOI: 10.1128/JVI.00232-16
PMID: 26984723
PMC: PMC4934759
Contributors: Favier AL; Gout E; Reynard O; Ferraris O; Kleman JP; Volchkov V; Peyrefitte C; Thielens NM
Source: Self-asserted source
Nicole Thielens via Europe PubMed Central

Structural and Functional Characterization of a Single-Chain Form of the Recognition Domain of Complement Protein C1q.

Frontiers in immunology
2016-03 | Journal article
DOI: 10.3389/fimmu.2016.00079
PMID: 26973654
PMC: PMC4774423
Contributors: Moreau C; Bally I; Chouquet A; Bottazzi B; Ghebrehiwet B; Gaboriaud C; Thielens N
Source: Self-asserted source
Nicole Thielens via Europe PubMed Central

Peptide Inhibitor of Complement C1 (PIC1) Rapidly Inhibits Complement Activation after Intravascular Injection in Rats.

PloS one
2015-07 | Journal article
DOI: 10.1371/journal.pone.0132446
PMID: 26196285
PMC: PMC4511006
Contributors: Sharp JA; Hair PS; Pallera HK; Kumar PS; Mauriello CT; Nyalwidhe JO; Phelps CA; Park D; Thielens NM; Pascal SM et al.
Source: Self-asserted source
Nicole Thielens via Europe PubMed Central

Deciphering the fine details of c1 assembly and activation mechanisms: "mission impossible"?

Frontiers in immunology
2014-11 | Journal article
DOI: 10.3389/fimmu.2014.00565
PMID: 25414705
PMC: PMC4222235
Contributors: Gaboriaud C; Ling WL; Thielens NM; Bally I; Rossi V
Source: Self-asserted source
Nicole Thielens via Europe PubMed Central

Human ficolin-2 recognition versatility extended: an update on the binding of ficolin-2 to sulfated/phosphated carbohydrates.

FEBS letters
2014-11 | Journal article
DOI: 10.1016/j.febslet.2014.10.042
PMID: 25447524
Contributors: Laffly E; Lacroix M; Martin L; Vassal-Stermann E; Thielens NM; Gaboriaud C
Source: Self-asserted source
Nicole Thielens via Europe PubMed Central

Human L-ficolin recognizes phosphocholine moieties of pneumococcal teichoic acid.

Journal of immunology (Baltimore, Md. : 1950)
2014-10 | Journal article
DOI: 10.4049/jimmunol.1400127
PMID: 25344472
Contributors: Vassal-Stermann E; Lacroix M; Gout E; Laffly E; Pedersen CM; Martin L; Amoroso A; Schmidt RR; Zähringer U; Gaboriaud C et al.
Source: Self-asserted source
Nicole Thielens via Europe PubMed Central
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Peer review (5 reviews for 2 publications/grants)

Review activity for Pharmacological research. (1)
Review activity for Protein expression and purification. (4)
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