My research is focussed on Alzheimer’s Drug Discovery and compounds that modify amyloid fibril toxicity. I have discovered amyloid peptide interactions with the Kisspeptin, Kissorphin and Neuropeptide-FF peptides, which prevent the toxicity of the amyloid peptides in vitro. I discovered that endocannabinoids are neuroprotective against the Alzheimer’s Amyloid-beta peptide in vitro. I have characterized interactions between amyloid peptides and the enzymes Catalase and Cyclin-Dependent-Kinase-1.
Most recent paper is: Chilumuri, A., Markiv, A. & Milton, N.G.N. (2014) Immunocytochemical staining of endogenous nuclear proteins with the HIS-1 anti-poly-histidine monoclonal antibody: a potential source of error in His-tagged protein detection. Acta Histochemica, 116, 1022-1028.