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Funding (5)

アンドロゲンシグナルから捉えるCOPD病態の解析と治療薬の探索

2022-04-01 to 2025-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
URL: https://app.dimensions.ai/details/grant/grant.12872980
GRANT_NUMBER: 22K06715
Source: Self-asserted source
Junichi Matsumoto via DimensionsWizard

Invovlvement of increased vascular permeability in bortezomib-induced lung toxicity

2021-04-01 to 2024-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
URL: https://app.dimensions.ai/details/grant/grant.9681784
GRANT_NUMBER: 21K06703
Source: Self-asserted source
Junichi Matsumoto via DimensionsWizard

アンドロゲンを核とする内分泌系－肺－脳の臓器連関異常化によるCOPD病態増悪機構

2021-04-01 to 2024-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
URL: https://app.dimensions.ai/details/grant/grant.9681764
GRANT_NUMBER: 21K06683
Source: Self-asserted source
Junichi Matsumoto via DimensionsWizard

エクソソームが駆動する慢性閉塞性肺疾患の血液脳関門病変化と薬剤中枢性副作用

2019-04-01 to 2022-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
URL: https://app.dimensions.ai/details/grant/grant.8419794
GRANT_NUMBER: 19K16433
Source: Self-asserted source
Junichi Matsumoto via DimensionsWizard

腸炎症に起因した脳ペリサイト異常化が駆動する脳内αシヌクレインの凝集・蓄積亢進

2019-04-01 to 2022-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
URL: https://app.dimensions.ai/details/grant/grant.8437733
GRANT_NUMBER: 19K07338
Source: Self-asserted source
Junichi Matsumoto via DimensionsWizard

Works (35)

α-Synuclein Degradation in Brain Pericytes Is Mediated via Akt, ERK, and p38 MAPK Signaling Pathways

International Journal of Molecular Sciences
2025-02-14 | Journal article
DOI: 10.3390/ijms26041615
Contributors: Miki Yokoya; Fuyuko Takata; Takuro Iwao; Junichi Matsumoto; Yasuyoshi Tanaka; Hisataka Aridome; Miho Yasunaga; Junko Mizoguchi; Kazunori Sano; Shinya Dohgu
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Crossref
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Association of T cell infiltration and morphological change of thymus gland with the aggravation of pulmonary emphysema in testosterone deficiency

Biochemistry and Biophysics Reports
2023-07 | Journal article
DOI: 10.1016/j.bbrep.2023.101489
Contributors: Kentaro Aono; Junichi Matsumoto; Taichi Matsumoto; Mitsuhisa Koga; Keisuke Migita; Koji Tominaga; Shinsuke Nakagawa; Atsushi Yamauchi
Source: check_circle
Crossref

Bortezomib Increased Vascular Permeability by Decreasing Cell–Cell Junction Molecules in Human Pulmonary Microvascular Endothelial Cells

International Journal of Molecular Sciences
2023-06-29 | Journal article
DOI: 10.3390/ijms241310842
Contributors: Taichi Matsumoto; Junichi Matsumoto; Yuka Matsushita; Moeno Arimura; Kentaro Aono; Mikiko Aoki; Kazuki Terada; Masayoshi Mori; Yutaka Haramaki; Takuya Imatoh et al.
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Crossref
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Senescence in brain pericytes attenuates blood-brain barrier function in vitro: A comparison of serially passaged and isolated pericytes from aged rat brains

Biochemical and Biophysical Research Communications
2023-02 | Journal article
DOI: 10.1016/j.bbrc.2023.01.037
Contributors: Takuro Iwao; Fuyuko Takata; Junichi Matsumoto; Yuki Goto; Hisataka Aridome; Miho Yasunaga; Miki Yokoya; Yasufumi Kataoka; Shinya Dohgu
Source: check_circle
Crossref

Aging decreases docosahexaenoic acid transport across the blood-brain barrier in C57BL/6J mice.

PloS one
2023-02-16 | Journal article
DOI: 10.1371/journal.pone.0281946
PMID: 36795730
PMC: PMC9934487
Contributors: Iwao T; Takata F; Matsumoto J; Aridome H; Yasunaga M; Yokoya M; Kataoka Y; Shinya Dohgu
Source: Self-asserted source
Junichi Matsumoto

Levetiracetam Suppresses the Infiltration of Neutrophils and Monocytes and Downregulates Many Inflammatory Cytokines during Epileptogenesis in Pilocarpine-Induced Status Epilepticus Mice.

International journal of molecular sciences
2022-07-12 | Journal article
DOI: 10.3390/ijms23147671
PMID: 35887020
PMC: PMC9319101
Contributors: Matsuo T; Komori R; Nakatani M; Ochi S; Aya Yokota-Nakatsuma; Matsumoto J; Takata F; Shinya Dohgu; Ishihara Y; Itoh K
Source: Self-asserted source
Junichi Matsumoto

Blood-Brain Barrier Dysfunction Amplifies the Development of Neuroinflammation: Understanding of Cellular Events in Brain Microvascular Endothelial Cells for Prevention and Treatment of BBB Dysfunction.

Frontiers in cellular neuroscience
2021-09-13 | Journal article
DOI: 10.3389/fncel.2021.661838
PMID: 34588955
PMC: PMC8475767
Contributors: Takata F; Nakagawa S; Matsumoto J; Dohgu S
Source: Self-asserted source
Junichi Matsumoto

Testosterone deficiency promotes the development of pulmonary emphysema in orchiectomized mice exposed to elastase

Biochemical and Biophysical Research Communications
2021-06 | Journal article
DOI: 10.1016/j.bbrc.2021.04.051
Contributors: Kentaro Aono; Junichi Matsumoto; Shinsuke Nakagawa; Taichi Matsumoto; Mitsuhisa Koga; Keisuke Migita; Koji Tominaga; Yuna Sakai; Atsushi Yamauchi
Source: check_circle
Crossref

Serum amyloid A-induced blood-brain barrier dysfunction associated with decreased claudin-5 expression in rat brain endothelial cells and its inhibition by high-density lipoprotein in vitro.

Neuroscience letters
2020-09-12 | Journal article
DOI: 10.1016/j.neulet.2020.135352
PMID: 32931862
Contributors: Matsumoto J; Shinya Dohgu; Takata F; Iwao T; Kimura I; Tomohiro M; Aono K; Kataoka Y; Yamauchi A
Source: Self-asserted source
Junichi Matsumoto

Erythrocytic α-synuclein contained in microvesicles regulates astrocytic glutamate homeostasis: a new perspective on Parkinson's disease pathogenesis.

Acta neuropathologica communications
2020-07-08 | Journal article
DOI: 10.1186/s40478-020-00983-w
PMID: 32641150
PMC: PMC7346449
Contributors: Lifu Sheng; Stewart T; Yang D; Thorland E; Soltys D; Aro P; Khrisat T; Xie Z; Li N; Liu Z et al.
Source: Self-asserted source
Junichi Matsumoto

Oncostatin-M-Reactive Pericytes Aggravate Blood-Brain Barrier Dysfunction by Activating JAK/STAT3 Signaling In Vitro.

Neuroscience
2019-11-06 | Journal article
DOI: 10.1016/j.neuroscience.2019.10.014
PMID: 31705893
Contributors: Takata F; Dohgu S; Sakaguchi S; Sakai K; Yamanaka G; Iwao T; Matsumoto J; Kimura I; Sezaki Y; Tanaka Y et al.
Source: Self-asserted source
Junichi Matsumoto

Oligodendrocytes upregulate blood-brain barrier function through mechanisms other than the PDGF-BB/PDGFRα pathway in the barrier-tightening effect of oligodendrocyte progenitor cells.

Neuroscience letters
2019-10-31 | Journal article
DOI: 10.1016/j.neulet.2019.134594
PMID: 31678431
Contributors: Kimura I; Shinya Dohgu; Takata F; Matsumoto J; Watanabe T; Iwao T; Yamauchi A; Kataoka Y
Source: Self-asserted source
Junichi Matsumoto

Monomeric α-synuclein induces blood-brain barrier dysfunction through activated brain pericytes releasing inflammatory mediators in vitro.

Microvascular research
2019-03-15 | Journal article
DOI: 10.1016/j.mvr.2019.03.005
PMID: 30885616
Contributors: Dohgu S; Takata F; Matsumoto J; Kimura I; Yamauchi A; Kataoka Y
Source: Self-asserted source
Junichi Matsumoto

Feeding-produced subchronic high plasma levels of uric acid improve behavioral dysfunction in 6-hydroxydopamine-induced mouse model of Parkinson's disease.

Behavioural pharmacology
2019-02-01 | Journal article
DOI: 10.1097/fbp.0000000000000413
PMID: 29847340
Contributors: Nakashima A; Yamauchi A; Matsumoto J; Dohgu S; Takata F; Koga M; Fukae J; Tsuboi Y; Kataoka Y
Source: Self-asserted source
Junichi Matsumoto

Activation of the α7 nicotinic acetylcholine receptor upregulates blood-brain barrier function through increased claudin-5 and occludin expression in rat brain endothelial cells.

Neuroscience letters
2018-11-16 | Journal article
DOI: 10.1016/j.neulet.2018.11.022
PMID: 30452951
Contributors: Kimura I; Dohgu S; Takata F; Matsumoto J; Kawahara Y; Nishihira M; Sakada S; Saisho T; Yamauchi A; Kataoka Y
Source: Self-asserted source
Junichi Matsumoto

Oncostatin M-induced blood-brain barrier impairment is due to prolonged activation of STAT3 signaling in vitro.

Journal of cellular biochemistry
2018-08-04 | Journal article
DOI: 10.1002/jcb.27162
PMID: 30076740
Contributors: Fuyuko Takata; Dohgu S; Matsumoto J; Machida T; Sakaguchi S; Kimura I; Yamauchi A; Kataoka Y
Source: Self-asserted source
Junichi Matsumoto

TNF-α-sensitive brain pericytes activate microglia by releasing IL-6 through cooperation between IκB-NFκB and JAK-STAT3 pathways.

Brain research
2018-04-24 | Journal article
DOI: 10.1016/j.brainres.2018.04.023
PMID: 29702085
Contributors: Matsumoto J; Dohgu S; Takata F; Machida T; Bölükbaşi Hatip FF; Hatip-Al-Khatib I; Yamauchi A; Kataoka Y
Source: Self-asserted source
Junichi Matsumoto

Transmission of α-synuclein-containing erythrocyte-derived extracellular vesicles across the blood-brain barrier via adsorptive mediated transcytosis: another mechanism for initiation and progression of Parkinson's disease?

Acta neuropathologica communications
2017-09-13 | Journal article
DOI: 10.1186/s40478-017-0470-4
PMID: 28903781
PMC: PMC5598000
Contributors: Matsumoto J; Stewart T; Lifu Sheng; Li N; Bullock K; Song N; Shi M; Banks WA; Jing Zhang
Source: Self-asserted source
Junichi Matsumoto

Contribution of thrombin-reactive brain pericytes to blood-brain barrier dysfunction in an in vivo mouse model of obesity-associated diabetes and an in vitro rat model.

PloS one
2017-05-10 | Journal article
DOI: 10.1371/journal.pone.0177447
PMID: 28489922
PMC: PMC5425209
Contributors: Machida T; Takata F; Matsumoto J; Miyamura T; Hirata R; Kimura I; Kataoka Y; Dohgu S; Yamauchi A
Source: Self-asserted source
Junichi Matsumoto

Role of thrombin-PAR1-PKCθ/δ axis in brain pericytes in thrombin-induced MMP-9 production and blood-brain barrier dysfunction in vitro.

Neuroscience
2017-03-24 | Journal article
DOI: 10.1016/j.neuroscience.2017.03.026
PMID: 28344073
Contributors: Machida T; Dohgu S; Takata F; Matsumoto J; Kimura I; Koga M; Nakamoto K; Yamauchi A; Kataoka Y
Source: Self-asserted source
Junichi Matsumoto

The Transport Mechanism of Extracellular Vesicles at the Blood-Brain Barrier.

Current pharmaceutical design
2017-01-01 | Journal article
DOI: 10.2174/1381612823666170913164738
PMID: 28914201
Contributors: Matsumoto J; Stewart T; Banks WA; Zhang J
Source: Self-asserted source
Junichi Matsumoto

Brain pericytes are the most thrombin-sensitive matrix metalloproteinase-9-releasing cell type constituting the blood-brain barrier in vitro.

Neuroscience letters
2015-05-19 | Journal article
DOI: 10.1016/j.neulet.2015.05.028
PMID: 26002077
Contributors: Machida T; Takata F; Matsumoto J; Takenoshita H; Kimura I; Yamauchi A; Dohgu S; Kataoka Y
Source: Self-asserted source
Junichi Matsumoto

Brain pericyte-derived soluble factors enhance insulin sensitivity in GT1-7 hypothalamic neurons.

Biochemical and biophysical research communications
2015-01-15 | Journal article
DOI: 10.1016/j.bbrc.2015.01.016
PMID: 25597994
Contributors: Takahashi H; Takata F; Matsumoto J; Machida T; Yamauchi A; Dohgu S; Kataoka Y
Source: Self-asserted source
Junichi Matsumoto

Nifedipine prevents sodium caprate-induced barrier dysfunction in human epidermal keratinocyte cultures.

Biological & pharmaceutical bulletin
2015-01-01 | Journal article
DOI: 10.1248/bpb.b14-00854
PMID: 26027835
Contributors: Uchino Y; Matsumoto J; Watanabe T; Hamabashiri M; Tsuchiya T; Kimura I; Yamauchi A; Kataoka Y
Source: Self-asserted source
Junichi Matsumoto

Tumor necrosis factor-α reduces beta-amyloid accumulation primarily by lowering cellular prion protein levels in a brain endothelial cell line.

FEBS letters
2014-12-10 | Journal article
DOI: 10.1016/j.febslet.2014.12.007
PMID: 25497018
Contributors: Yasutaka Y; Watanabe T; Nakashima A; Matsumoto J; Futagami K; Yamauchi A; Kataoka Y
Source: Self-asserted source
Junichi Matsumoto

Tumor necrosis factor-α-stimulated brain pericytes possess a unique cytokine and chemokine release profile and enhance microglial activation.

Neuroscience letters
2014-06-30 | Journal article
DOI: 10.1016/j.neulet.2014.06.052
PMID: 24993300
Contributors: Matsumoto J; Takata F; Machida T; Takahashi H; Soejima Y; Funakoshi M; Futagami K; Yamauchi A; Shinya Dohgu; Kataoka Y
Source: Self-asserted source
Junichi Matsumoto

Metformin induces up-regulation of blood-brain barrier functions by activating AMP-activated protein kinase in rat brain microvascular endothelial cells.

Biochemical and biophysical research communications
2013-03-21 | Journal article
DOI: 10.1016/j.bbrc.2013.03.036
PMID: 23523792
Contributors: Takata F; Dohgu S; Matsumoto J; Machida T; Kaneshima S; Matsuo M; Sakaguchi S; Takeshige Y; Yamauchi A; Kataoka Y
Source: Self-asserted source
Junichi Matsumoto

In vitro blood-brain barrier models using brain capillary endothelial cells isolated from neonatal and adult rats retain age-related barrier properties.

PloS one
2013-01-31 | Journal article
DOI: 10.1371/journal.pone.0055166
PMID: 23383092
PMC: PMC3561369
Contributors: Takata F; Dohgu S; Yamauchi A; Matsumoto J; Machida T; Fujishita K; Shibata K; Youichi Shinozaki; Sato K; Kataoka Y et al.
Source: Self-asserted source
Junichi Matsumoto

Lipopolysaccharide-activated microglia lower P-glycoprotein function in brain microvascular endothelial cells.

Neuroscience letters
2012-07-16 | Journal article
DOI: 10.1016/j.neulet.2012.07.004
PMID: 22801252
Contributors: Matsumoto J; Dohgu S; Takata F; Nishioku T; Sumi N; Machida T; Takahashi H; Yamauchi A; Kataoka Y
Source: Self-asserted source
Junichi Matsumoto

Brain pericytes among cells constituting the blood-brain barrier are highly sensitive to tumor necrosis factor-α, releasing matrix metalloproteinase-9 and migrating in vitro.

Journal of neuroinflammation
2011-08-26 | Journal article
DOI: 10.1186/1742-2094-8-106
PMID: 21867555
PMC: PMC3182916
Contributors: Takata F; Dohgu S; Matsumoto J; Takahashi H; Machida T; Wakigawa T; Harada E; Miyaji H; Koga M; Nishioku T et al.
Source: Self-asserted source
Junichi Matsumoto

Partial hepatectomy aggravates cyclosporin A-induced neurotoxicity by lowering the function of the blood-brain barrier in mice.

Life sciences
2011-01-22 | Journal article
DOI: 10.1016/j.lfs.2011.01.012
PMID: 21262237
Contributors: Yamauchi A; Dohgu S; Takata F; Watanabe T; Nishioku T; Matsumoto J; Ohkubo Y; Shuto H; Kataoka Y
Source: Self-asserted source
Junichi Matsumoto

Autocrine and paracrine up-regulation of blood-brain barrier function by plasminogen activator inhibitor-1.

Microvascular research
2010-10-29 | Journal article
DOI: 10.1016/j.mvr.2010.10.004
PMID: 21036181
Contributors: Dohgu S; Takata F; Matsumoto J; Oda M; Harada E; Watanabe T; Nishioku T; Shuto H; Yamauchi A; Kataoka Y
Source: Self-asserted source
Junichi Matsumoto

Medication use as a risk factor for inpatient falls in an acute care hospital: a case-crossover study.

British journal of clinical pharmacology
2010-05-01 | Journal article
DOI: 10.1111/j.1365-2125.2010.03613.x
PMID: 20573090
PMC: PMC2856055
Contributors: Shuto H; Imakyure O; Matsumoto J; Egawa T; Jiang Y; Hirakawa M; Kataoka Y; Yanagawa T
Source: Self-asserted source
Junichi Matsumoto

Tumor necrosis factor-alpha mediates the blood-brain barrier dysfunction induced by activated microglia in mouse brain microvascular endothelial cells.

Journal of pharmacological sciences
2010-01-30 | Journal article
DOI: 10.1254/jphs.09292sc
PMID: 20118615
Contributors: Nishioku T; Matsumoto J; Dohgu S; Sumi N; Miyao K; Takata F; Shuto H; Yamauchi A; Kataoka Y
Source: Self-asserted source
Junichi Matsumoto

Lipopolysaccharide-activated microglia induce dysfunction of the blood-brain barrier in rat microvascular endothelial cells co-cultured with microglia.

Cellular and molecular neurobiology
2009-08-29 | Journal article
DOI: 10.1007/s10571-009-9446-7
PMID: 19728078
Contributors: Sumi N; Nishioku T; Takata F; Matsumoto J; Watanabe T; Shuto H; Yamauchi A; Dohgu S; Kataoka Y
Source: Self-asserted source
Junichi Matsumoto
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