Personal information

Tuberculosis
South Africa

Activities

Employment (3)

Task Applied Science: Cape Town, ZA

2017-01-11 to present | Investigator
Employment
Source: Self-asserted source
Caryn Upton

Western Cape Department of Health: Cape Town, ZA

2016-01-11 to 2017-01-10 | Medical doctor (Brooklyn Chest Hospital)
Employment
Source: Self-asserted source
Caryn Upton

Gauteng Department of Health: Johannesburg, Gauteng, ZA

2014-01-01 to 2015-12-31 | Medical doctor (Charlotte Maxeke Johannesburg Academic Hospital)
Employment
Source: Self-asserted source
Caryn Upton

Education and qualifications (3)

Radboudumc: Nijmegen, N/A, NL

2018-09-05 to present | PhD candidate
Qualification
Source: Self-asserted source
Caryn Upton

University of the Witwatersrand Faculty of Health Sciences: Johannesburg, Gauteng, ZA

2010-01-01 to 2013-12-31 | MBBCh (Faculty of Health Science)
Education
Source: Self-asserted source
Caryn Upton

University of the Witwatersrand Faculty of Health Sciences: Johannesburg, Gauteng, ZA

2007-01-01 to 2009-12-31 | Bachelor of Health Science (Faculty of Health Science)
Education
Source: Self-asserted source
Caryn Upton

Works (12)

Power to identify exposure‐response relationships in phase IIa pulmonary tuberculosis trials with multi‐dimensional bacterial load modeling

CPT: Pharmacometrics & Systems Pharmacology
2024-03 | Journal article
Contributors: Simon E. Koele; Thomas P. C. Dorlo; Caryn M. Upton; Rob E. Aarnoutse; Elin M. Svensson
Source: check_circle
Crossref

Cough as Noninvasive Biomarker for Monitoring Tuberculosis Treatment: A Proof-of-Concept Study

Annals of the American Thoracic Society
2023-12 | Journal article
Contributors: Saskia Janssen; Caryn M. Upton; Veronique R. De Jager; Alan Faraj; Madhurananda Pahar; Igor D. S. Miranda; Andreas H. Diacon; Ulrika S. H. Simonsson; Thomas R. Niesler
Source: check_circle
Crossref

Transrenal Mycobacterium tuberculosis DNA in pulmonary tuberculosis patients during the first 14 days of treatment

Microbiology Spectrum
2023-12-12 | Journal article
Contributors: Irina Kontsevaya; Jan Heyckendorf; Frauke Koops; Doris Hillemann; Torsten Goldmann; Caryn M. Upton; Veronique De Jager; Andreas Diacon; Christoph Lange; Po-Yu Liu et al.
Source: check_circle
Crossref

Reproducibility in pharmacometrics applied in a phase III trial of BCG-vaccination for COVID-19

Scientific Reports
2023-09-28 | Journal article
Contributors: Rob C. van Wijk; Laurynas Mockeliunas; Gerben van den Hoogen; Caryn M. Upton; Andreas H. Diacon; Ulrika S. H. Simonsson
Source: check_circle
Crossref

Cerebrospinal Fluid and Tuberculous Meningitis

Clinical Infectious Diseases
2023-07-05 | Journal article
Contributors: Caryn M Upton; Lubbe Wiesner; Kelly E Dooley; Gary Maartens
Source: check_circle
Crossref

Safety and efficacy of BCG re-vaccination in relation to COVID-19 morbidity in healthcare workers: A double-blind, randomised, controlled, phase 3 trial

eClinicalMedicine
2022-06 | Journal article
Contributors: Caryn M. Upton; Rob C. van Wijk; Laurynas Mockeliunas; Ulrika S.H. Simonsson; Kirsten McHarry; Gerben van den Hoogen; Chantal Muller; Arne von Delft; Helene-Mari van der Westhuizen; Reinout van Crevel et al.
Source: check_circle
Crossref

High Prevalence of Tuberculosis Infection and Disease in Child Household Contacts of Adults With Rifampin-resistant Tuberculosis

Pediatric Infectious Disease Journal
2022-05 | Journal article
Contributors: Soyeon Kim; Xingye Wu; Michael D. Hughes; Caryn Upton; Kim Narunsky; Alberto Mendoza-Ticona; Saltnat Khajenoori; Pedro Gonzales; Sharlaa Badal-Faesen; Justin Shenje et al.
Source: check_circle
Crossref

Pharmacokinetics of bedaquiline in cerebrospinal fluid (CSF) in patients with pulmonary tuberculosis (TB)

Journal of Antimicrobial Chemotherapy
2022-05-29 | Journal article
Contributors: Caryn M Upton; Chanel I Steele; Gary Maartens; Andreas H Diacon; Lubbe Wiesner; Kelly E Dooley
Source: check_circle
Crossref

Resistance-Conferring Mycobacterial Mutations and Quantification of Early Bactericidal Activity.

American journal of respiratory and critical care medicine
2021-03 | Journal article
Contributors: le Roux SP; Upton C; Vanker N; Dooley KE; Diacon AH; A5312 Study Team
Source: Self-asserted source
Caryn Upton via Europe PubMed Central
grade
Preferred source (of 2)‎

Drug susceptibility patterns of Mycobacterium tuberculosis from adults with multidrug-resistant tuberculosis and implications for a household contact preventive therapy trial.

BMC infectious diseases
2021-02 | Journal article
Contributors: Demers AM; Kim S; McCallum S; Eisenach K; Hughes M; Naini L; Mendoza-Ticona A; Pradhan N; Narunsky K; Poongulali S et al.
Source: Self-asserted source
Caryn Upton via Europe PubMed Central

QT effects of bedaquiline, delamanid, or both in patients with rifampicin-resistant tuberculosis: a phase 2, open-label, randomised, controlled trial.

The Lancet. Infectious diseases
2021-02 | Journal article
Contributors: Dooley KE; Rosenkranz SL; Conradie F; Moran L; Hafner R; von Groote-Bidlingmaier F; Lama JR; Shenje J; De Los Rios J; Comins K et al.
Source: Self-asserted source
Caryn Upton via Europe PubMed Central

Treatment of Highly Drug-Resistant Pulmonary Tuberculosis.

The New England journal of medicine
2020-03 | Journal article
Contributors: Conradie F; Diacon AH; Ngubane N; Howell P; Everitt D; Crook AM; Mendel CM; Egizi E; Moreira J; Timm J et al.
Source: Self-asserted source
Caryn Upton via Europe PubMed Central