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Keywords

Chaperone, Yeast, Heat Shock Protein, Prion, Fungi, Gliotoxin

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Employment (5)

Leeds Beckett University: Leeds, West Yorkshire, GB

2016-02-01 to present | Professor of Biomedical Sciences (School of Clinical and Applied Sciences)
Employment
Source: Self-asserted source
Gary Jones

National University of Ireland Maynooth Department of Biology: Maynooth, IE

2004-01-01 to 2016-01-31 | Lecturer and Senior Lecturer (Biology)
Employment
Source: Self-asserted source
Gary Jones

National Institutes of Health: Bethesda, MD, US

1998-10-01 to 2003-09-30 | Fogarty International Fellow (NIDDK/LBG)
Employment
Source: Self-asserted source
Gary Jones

University College London: London, GB

1996-10-01 to 1998-09-30 | Wellcome Trust Postdoc (Biochemistry and Molecular Biology)
Employment
Source: Self-asserted source
Gary Jones

Swansea University: Swansea, Swansea, GB

1995-08-19 to 1996-09-30 | MRC Postdoc (Genetics)
Employment
Source: Self-asserted source
Gary Jones

Education and qualifications (1)

University of Liverpool: Liverpool, Liverpool, GB

1988-09-01 to 1995-08-01 | BSc (Hons) and PhD (Genetics)
Education
Source: Self-asserted source
Gary Jones

Works (50 of 59)

Items per page:
Page 1 of 2

Mutational analysis of the Hsp70 substrate‐binding domain: Correlating molecular‐level changes with in vivo function

Molecular Microbiology
2021-06 | Journal article
DOI: 10.1111/mmi.14671
Contributors: Linan Xu; Hong Zhang; Daragh D. Cuskelly; Sean Doyle; Sarah Perrett; Gary W. Jones
Source: check_circle
Crossref

Rapid deacetylation of yeast Hsp70 mediates the cellular response to heat stress

Scientific Reports
2019-11-07 | Journal article
DOI: 10.1038/s41598-019-52545-3
Contributors: Linan Xu; Nitika; Naushaba Hasin; Daragh D. Cuskelly; Donald Wolfgeher; Sean Doyle; Paul Moynagh; Sarah Perrett; Gary W. Jones; Andrew W. Truman
Source: check_circle
Crossref

Systems impact of zinc chelation by the epipolythiodioxopiperazine dithiol gliotoxin in Aspergillus fumigatus: a new direction in natural product functionality

2018 | Journal article
DOI: 10.1039/c8mt00052b
Part of ISSN: 1756-5901
Part of ISSN: 1756-591X
Source: Self-asserted source
Gary Jones
grade
Preferred source (of 2)‎

Using steered molecular dynamics to study the interaction between ADP and the nucleotide-binding domain of yeast Hsp70 protein Ssa1

2018-11 | Journal article
DOI: 10.1007/s10822-018-0136-8
Part of ISSN: 0920-654X
Part of ISSN: 1573-4951
Source: Self-asserted source
Gary Jones

Is the absence of alpha-helix 2 in the appendant structure region the major contributor to structural instability of human cystatin C?

2018-11-28 | Journal article
DOI: 10.1080/07391102.2018.1552625
Part of ISSN: 0739-1102
Part of ISSN: 1538-0254
Source: Self-asserted source
Gary Jones

The C-terminal GGAP motif of Hsp70 mediates substrate recognition and stress response in yeast

2018-11-16 | Journal article
DOI: 10.1074/jbc.ra118.002691
Part of ISSN: 0021-9258
Part of ISSN: 1083-351X
Source: Self-asserted source
Gary Jones

The same but different: the role of Hsp70 in heat shock response and prion propagation

2018-07-04 | Journal article
DOI: 10.1080/19336896.2018.1507579
Part of ISSN: 1933-6896
Part of ISSN: 1933-690X
Source: Self-asserted source
Gary Jones

Dysregulated gliotoxin biosynthesis attenuates the production of unrelated biosynthetic gene cluster-encoded metabolites in Aspergillus fumigatus

2018-04 | Journal article
DOI: 10.1016/j.funbio.2017.12.007
Part of ISSN: 1878-6146
Source: Self-asserted source
Gary Jones
grade
Preferred source (of 2)‎

The β6/β7 region of the Hsp70 substrate-binding domain mediates heat-shock response and prion propagation

2018-04 | Journal article
DOI: 10.1007/s00018-017-2698-3
Part of ISSN: 1420-682X
Part of ISSN: 1420-9071
Source: Self-asserted source
Gary Jones
grade
Preferred source (of 2)‎

Aspergillus fumigatus protein phosphatase PpzA is involved in iron assimilation, secondary metabolite production, and virulence

2017-12 | Journal article
DOI: 10.1111/cmi.12770
Part of ISSN: 1462-5814
Source: Self-asserted source
Gary Jones

Steered molecular dynamics simulation of the binding of the bovine auxilin J domain to the Hsc70 nucleotide-binding domain

2017-11 | Journal article
DOI: 10.1007/s00894-017-3453-2
Part of ISSN: 1610-2940
Part of ISSN: 0948-5023
Source: Self-asserted source
Gary Jones

Insights into the mechanism of how Morin suppresses amyloid fibrillation of hen egg white lysozyme.

International journal of biological macromolecules
2017-08 | Journal article
DOI: 10.1016/j.ijbiomac.2017.03.107
PMID: 28341174
Source: Self-asserted source
Gary Jones via Europe PubMed Central

Molecular dynamics simulations of Hsp40 J-domain mutants identifies disruption of the critical HPD-motif as the key factor for impaired curing in vivo of the yeast prion [URE3].

Journal of biomolecular structure & dynamics
2017-08 | Journal article
DOI: 10.1080/07391102.2017.1334594
PMID: 28766406
Source: Self-asserted source
Gary Jones via Europe PubMed Central

The double life of the ribosome: When its protein folding activity supports prion propagation.

Prion
2017-03 | Journal article
DOI: 10.1080/19336896.2017.1303587
PMID: 28362551
Source: Self-asserted source
Gary Jones via Europe PubMed Central

Structural, mechanistic and functional insight into gliotoxin bis-thiomethylation in Aspergillus fumigatus.

Open biology
2017-02 | Journal article
DOI: 10.1098/rsob.160292
PMID: 28179499
PMC: PMC5356443
Source: Self-asserted source
Gary Jones via Europe PubMed Central

Protein Folding Activity of the Ribosome is involved in Yeast Prion Propagation.

Scientific Reports
2016 | Journal article
DOI: 10.1038/srep32117
PMID: 27633137
PMC: PMC5025663
Source: Self-asserted source
Gary Jones via Europe PubMed Central

Distinct structural changes in wild-type and amyloidogenic chicken cystatin caused by disruption of C95-C115 disulfide bond.

Journal of biomolecular structure & dynamics
2016-12 | Journal article
PMID: 26629743
Source: Self-asserted source
Gary Jones via Europe PubMed Central

The Aspergillus fumigatus SchASCH9 kinase modulates SakAHOG1 MAP kinase activity and it is essential for virulence.

Molecular microbiology
2016-11 | Journal article
DOI: 10.1111/mmi.13484
PMID: 27538790
PMC: PMC5207228
Source: Self-asserted source
Gary Jones via Europe PubMed Central

Ergothioneine Biosynthesis and Functionality in the Opportunistic Fungal Pathogen, Aspergillus fumigatus.

Scientific Reports
2016-10 | Journal article
DOI: 10.1038/srep35306
PMID: 27748436
PMC: PMC5066259
Source: Self-asserted source
Gary Jones via Europe PubMed Central

Towards understanding the gliotoxin detoxification mechanism: in vivo thiomethylation protects yeast from gliotoxin cytotoxicity.

Microbial cell (Graz, Austria)
2016-02 | Journal article
DOI: 10.15698/mic2016.03.485
PMID: 28357342
PMC: PMC5349022
Source: Self-asserted source
Gary Jones via Europe PubMed Central

Quantitative proteomics reveals the mechanism and consequence of gliotoxin-mediated dysregulation of the methionine cycle in Aspergillus niger.

Journal of proteomics
2016-01 | Journal article
DOI: 10.1016/j.jprot.2015.10.024
PMID: 26498071
Source: Self-asserted source
Gary Jones via Europe PubMed Central

Interplay between Gliotoxin Resistance, Secretion, and the Methyl/Methionine Cycle in Aspergillus fumigatus.

Eukaryotic cell
2015-09 | Journal article
DOI: 10.1128/ec.00055-15
PMID: 26150413
PMC: PMC4551589
Source: Self-asserted source
Gary Jones via Europe PubMed Central

Resistance is not futile: gliotoxin biosynthesis, functionality and utility.

Trends in microbiology
2015-07 | Journal article
DOI: 10.1016/j.tim.2015.02.005
PMID: 25766143
Source: Self-asserted source
Gary Jones via Europe PubMed Central

Systematic Global Analysis of Genes Encoding Protein Phosphatases in Aspergillus fumigatus.

G3 (Bethesda, Md.)
2015-07 | Journal article
DOI: 10.1534/g3.115.016766
PMID: 25943523
PMC: PMC4502386
Source: Self-asserted source
Gary Jones via Europe PubMed Central

(-)-epigallocatechin-3-gallate inhibits fibrillogenesis of chicken cystatin.

Journal of agricultural and food chemistry
2015-02 | Journal article
DOI: 10.1021/jf505277e
PMID: 25620201
Source: Self-asserted source
Gary Jones via Europe PubMed Central

A proteomic approach to investigating gene cluster expression and secondary metabolite functionality in Aspergillus fumigatus.

PloS one
2014 | Journal article
DOI: 10.1371/journal.pone.0106942
PMID: 25198175
PMC: PMC4157829
Source: Self-asserted source
Gary Jones via Europe PubMed Central

Global transcript and phenotypic analysis of yeast cells expressing Ssa1, Ssa2, Ssa3 or Ssa4 as sole source of cytosolic Hsp70-Ssa chaperone activity.

BMC genomics
2014 | Journal article
DOI: 10.1186/1471-2164-15-194
PMID: 24628813
PMC: PMC4022180
Source: Self-asserted source
Gary Jones via Europe PubMed Central

RNA-seq reveals the pan-transcriptomic impact of attenuating the gliotoxin self-protection mechanism in Aspergillus fumigatus.

BMC genomics
2014 | Journal article
DOI: 10.1186/1471-2164-15-894
PMID: 25311525
PMC: PMC4209032
Source: Self-asserted source
Gary Jones via Europe PubMed Central

Yeast models for amyloid disease.

Essays in biochemistry
2014 | Journal article
DOI: 10.1042/bse0560085
PMID: 25131588
Source: Self-asserted source
Gary Jones via Europe PubMed Central

Myricetin prevents fibrillogenesis of hen egg white lysozyme.

Journal of agricultural and food chemistry
2014-10 | Journal article
DOI: 10.1021/jf5025449
PMID: 25196984
Source: Self-asserted source
Gary Jones via Europe PubMed Central

The evolutionary history of the genes involved in the biosynthesis of the antioxidant ergothioneine.

Gene
2014-10 | Journal article
DOI: 10.1016/j.gene.2014.07.065
PMID: 25068406
Source: Self-asserted source
Gary Jones via Europe PubMed Central

Regulation of nonribosomal peptide synthesis: bis-thiomethylation attenuates gliotoxin biosynthesis in Aspergillus fumigatus.

Chemistry & biology
2014-08 | Journal article
DOI: 10.1016/j.chembiol.2014.07.006
PMID: 25126990
Source: Self-asserted source
Gary Jones via Europe PubMed Central

Using steered molecular dynamics to predict and assess Hsp70 substrate-binding domain mutants that alter prion propagation.

PLoS computational biology
2013 | Journal article
DOI: 10.1371/journal.pcbi.1002896
PMID: 23382668
PMC: PMC3561046
Source: Self-asserted source
Gary Jones via Europe PubMed Central

Molecular dynamics simulation to investigate the impact of disulfide bond formation on conformational stability of chicken cystatin I66Q mutant.

Journal of biomolecular structure & dynamics
2013-10 | Journal article
DOI: 10.1080/07391102.2012.721498
PMID: 23030454
Source: Self-asserted source
Gary Jones via Europe PubMed Central

Mutational analysis of Sse1 (Hsp110) suggests an integral role for this chaperone in yeast prion propagation in vivo.

G3 (Bethesda, Md.)
2013-08 | Journal article
DOI: 10.1534/g3.113.007112
PMID: 23797105
PMC: PMC3737180
Source: Self-asserted source
Gary Jones via Europe PubMed Central

Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences
2013-05 | Journal article
DOI: 10.1098/rstb.2011.0410
PMID: 23530260
PMC: PMC3638396
Source: Self-asserted source
Gary Jones via Europe PubMed Central

Steered molecular dynamics simulations on the binding of the appendant structure and helix-β2 in domain-swapped human cystatin C dimer.

Journal of biomolecular structure & dynamics
2012 | Journal article
DOI: 10.1080/07391102.2012.689698
PMID: 22731964
Source: Self-asserted source
Gary Jones via Europe PubMed Central

CDK-dependent Hsp70 Phosphorylation controls G1 cyclin abundance and cell-cycle progression.

Cell
2012-12 | Journal article
DOI: 10.1016/j.cell.2012.10.051
PMID: 23217712
PMC: PMC3778871
Source: Self-asserted source
Gary Jones via Europe PubMed Central

The Aspergillus fumigatus protein GliK protects against oxidative stress and is essential for gliotoxin biosynthesis.

Eukaryotic cell
2012-10 | Journal article
DOI: 10.1128/ec.00113-12
PMID: 22903976
PMC: PMC3485926
Source: Self-asserted source
Gary Jones via Europe PubMed Central

Molecular characterization of an adaptive response to alkylating agents in the opportunistic pathogen Aspergillus fumigatus.

Nucleic acids research
2012-09 | Journal article
DOI: 10.1093/nar/gks522
PMID: 22669901
PMC: PMC3439912
Source: Self-asserted source
Gary Jones via Europe PubMed Central

Gliotoxin effects on fungal growth: mechanisms and exploitation.

Fungal genetics and biology : FG & B
2012-04 | Journal article
DOI: 10.1016/j.fgb.2012.02.003
PMID: 22405895
Source: Self-asserted source
Gary Jones via Europe PubMed Central

Assessment of inactivating stop codon mutations in forty Saccharomyces cerevisiae strains: implications for [PSI] prion- mediated phenotypes.

PloS one
2011 | Journal article
DOI: 10.1371/journal.pone.0028684
PMID: 22194885
PMC: PMC3240633
Source: Self-asserted source
Gary Jones via Europe PubMed Central

Reconstructing the fungal tree of life using phylogenomics and a preliminary investigation of the distribution of yeast prion-like proteins in the fungal kingdom.

Journal of molecular evolution
2011-10 | Journal article
DOI: 10.1007/s00239-011-9461-4
PMID: 21938499
Source: Self-asserted source
Gary Jones via Europe PubMed Central

Self-protection against gliotoxin--a component of the gliotoxin biosynthetic cluster, GliT, completely protects Aspergillus fumigatus against exogenous gliotoxin.

PLoS pathogens
2010 | Journal article
DOI: 10.1371/journal.ppat.1000952
PMID: 20548963
PMC: PMC2883607
Source: Self-asserted source
Gary Jones via Europe PubMed Central

Influence of Hsp70 chaperone machinery on yeast prion propagation.

Protein and peptide letters
2009 | Journal article
DOI: 10.2174/092986609788490168
PMID: 19519515
Source: Self-asserted source
Gary Jones via Europe PubMed Central

Alcohol oxidase (AOX1) from Pichia pastoris is a novel inhibitor of prion propagation and a potential ATPase.

Molecular microbiology
2009-02 | Journal article
DOI: 10.1111/j.1365-2958.2008.06557.x
PMID: 19040632
Source: Self-asserted source
Gary Jones via Europe PubMed Central

Insights into the mechanism of prion propagation.

Current opinion in structural biology
2008-02 | Journal article
DOI: 10.1016/j.sbi.2007.12.005
PMID: 18243685
Source: Self-asserted source
Gary Jones via Europe PubMed Central

Hsp40 interacts directly with the native state of the yeast prion protein Ure2 and inhibits formation of amyloid-like fibrils.

The Journal of biological chemistry
2007-04 | Journal article
DOI: 10.1074/jbc.m606856200
PMID: 17324933
Source: Self-asserted source
Gary Jones via Europe PubMed Central

Importance of the Hsp70 ATPase domain in yeast prion propagation.

Genetics
2007-02 | Journal article
DOI: 10.1534/genetics.106.066019
PMID: 17151238
PMC: PMC1800594
Source: Self-asserted source
Gary Jones via Europe PubMed Central

The yeast prion protein Ure2: structure, function and folding.

Biochimica et biophysica acta
2006-03 | Journal article
DOI: 10.1016/j.bbapap.2005.11.016
PMID: 16427819
Source: Self-asserted source
Gary Jones via Europe PubMed Central
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