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Virus entry, Viral receptor, Hepatitis B virus, SARS-CoV-2, AAV, Gene Therapy
United States

Activities

Employment (7)

University of Massachusetts Chan Medical School: Worcester, MA, US

2022-07-01 to present | Principal Investigator / Assistant Professor (RNA Therapeutics Institute; Department of Biochemistry and Molecular Biotechnology; Gene Therapy Center)
Employment
Source: Self-asserted source
Guocai Zhong

UF Scripps Biomedical Research: Jupiter, FL, US

2021-12-16 to 2022-06-20 | Assistant Professor of Immunology and Microbiology (Department of Immunology and Microbiology)
Employment
Source: Self-asserted source
Guocai Zhong

Peking University Shenzhen Graduate School: Shenzhen, Guangdong, CN

2019-12-23 to 2021-12-15 | Assistant Professor (Principal Investigator) (School of Chemical Biology and Biotechnology)
Employment
Source: Self-asserted source
Guocai Zhong

Shenzhen Bay Laboratory (SZBL): Shenzhen, Guangdong, CN

2019-09-26 to 2021-12-15 | Assistant Professor (Principal Investigator) (Scripps Research | SZBL Chemical Biology Institute)
Employment
Source: Self-asserted source
Guocai Zhong

Scripps Florida: Jupiter, FL, US

2018-06-30 to 2019-09-24 | Staff Scientist (Immunology and Microbiology)
Employment
Source: Self-asserted source
Guocai Zhong

Scripps Florida: Jupiter, FL, US

2013-09-16 to 2018-06-29 | Research Asssociate (Infectious Diseases)
Employment
Source: Self-asserted source
Guocai Zhong

National Institute of Biological Sciences: Beijing, CN

2009-07 to 2013-09 | Postdoctoral research fellow
Employment
Source: Self-asserted source
Guocai Zhong

Works (22)

Characterization of SARS-CoV-2 Variants B.1.617.1 (Kappa), B.1.617.2 (Delta), and B.1.618 by Cell Entry and Immune Evasion.

mBio
2022-03-10 | Journal article
Contributors: Guocai Zhong
Source: Self-asserted source
Guocai Zhong

Mutation Y453F in the spike protein of SARS-CoV-2 enhances interaction with the mink ACE2 receptor for host adaption.

PLoS pathogens
2021-11-08 | Journal article
Contributors: Guocai Zhong
Source: Self-asserted source
Guocai Zhong

Reprogramming of the heavy-chain CDR3 regions of a human antibody repertoire.

Molecular therapy : the journal of the American Society of Gene Therapy
2021-11-02 | Journal article
Contributors: Guocai Zhong
Source: Self-asserted source
Guocai Zhong

Characterization of SARS-CoV-2 variants B.1.617.1 (Kappa), B.1.617.2 (Delta) and B.1.618 on cell entry, host range, and sensitivity to convalescent plasma and ACE2 decoy receptor

2021-09-03 | Other
Contributors: Wenlin Ren; Xiaohui Ju; Mingli Gong; Jun Lan; Yanying Yu; Quanxin Long; Yu Zhang; Jin Zhong; Guocai Zhong; Xinquan Wang et al.
Source: check_circle
Crossref

Potent prophylactic and therapeutic efficacy of recombinant human ACE2-Fc against SARS-CoV-2 infection in vivo.

Cell discovery
2021-08-12 | Journal article
Contributors: Guocai Zhong
Source: Self-asserted source
Guocai Zhong

An Engineered Receptor-Binding Domain Improves the Immunogenicity of Multivalent SARS-CoV-2 Vaccines.

mBio
2021-05-11 | Journal article
Contributors: Guocai Zhong
Source: Self-asserted source
Guocai Zhong

A more efficient CRISPR-Cas12a variant derived from <i>Lachnospiraceae bacterium</i> MA2020.

Molecular therapy. Nucleic acids
2021-02-18 | Journal article
Contributors: Guocai Zhong
Source: Self-asserted source
Guocai Zhong

Circulating SARS-CoV-2 variants B.1.1.7, 501Y.V2, and P.1 have gained ability to utilize rat and mouse Ace2 and altered in vitro sensitivity to neutralizing antibodies and ACE2-Ig

2021-01-28 | Other
Contributors: Weitong Yao; Yifei Wang; Danting Ma; Xiaojuan Tang; Haimin Wang; Chao Li; Hua Lin; Yujun Li; Guocai Zhong
Source: check_circle
Crossref

SARS-CoV-2 and Three Related Coronaviruses Utilize Multiple ACE2 Orthologs and Are Potently Blocked by an Improved ACE2-Ig

Journal of Virology
2020-08-26 | Journal article
Part of ISSN: 0022-538X
Part of ISSN: 1098-5514
Source: Self-asserted source
Guocai Zhong

A reversible RNA on-switch that controls gene expression of AAV-delivered therapeutics in vivo

Nature Biotechnology
2020-02-23 | Journal article
Contributors: Guocai Zhong; Haimin Wang; Wenhui He; Yujun Li; Huihui Mou; Zachary J. Tickner; Mai H. Tran; Tianling Ou; Yiming Yin; Huitian Diao et al.
Source: check_circle
Crossref

Conditional Regulation of Gene Expression by Ligand-Induced Occlusion of a MicroRNA Target Sequence

Molecular Therapy
2018-05 | Journal article
Part of ISSN: 1525-0016
Source: Self-asserted source
Guocai Zhong

Cpf1 proteins excise CRISPR RNAs from mRNA transcripts in mammalian cells

Nature Chemical Biology
2017-08 | Journal article
Contributors: Guocai Zhong; Haimin Wang; Yujun Li; Mai H Tran; Michael Farzan
Source: check_circle
Crossref

Rational design of aptazyme riboswitches for efficient control of gene expression in mammalian cells

eLife
2016-11-02 | Journal article
Part of ISSN: 2050-084X
Source: Self-asserted source
Guocai Zhong

IFITM-Family Proteins: The Cell's First Line of Antiviral Defense

Annual Review of Virology
2014-06-27 | Journal article
Source: Self-asserted source
Guocai Zhong

Nonmuscle myosin heavy chain IIA is a critical factor contributing to the efficiency of early infection of severe fever with thrombocytopenia syndrome virus.

2014-01 | Journal article
DOI:

10.1128/JVI.02141-13

PMID:

24155382

Contributors: Sun Y; Qi Y; Liu C; Gao W; Chen P; Fu L; Peng B; Wang H; Jing Z; Zhong G et al.
Source: Self-asserted source
Guocai Zhong via Europe PubMed Central

Compositions and uses of functional receptor for hbv/hdv virus

2013-10-31 | Patent
OTHER-ID:

WO2013159243 A1

Contributors: Guocai Zhong
Source: Self-asserted source
Guocai Zhong

Molecular determinants of hepatitis B and D virus entry restriction in mouse sodium taurocholate cotransporting polypeptide.

2013-07 | Journal article
DOI:

10.1128/JVI.03540-12

PMID:

23678176

PMC:

PMC3700185

Contributors: Yan H; Peng B; He W; Zhong G; Qi Y; Ren B; Gao Z; Jing Z; Song M; Xu G et al.
Source: Self-asserted source
Guocai Zhong via Europe PubMed Central

Sodium taurocholate cotransporting polypeptide mediates woolly monkey hepatitis B virus infection of Tupaia hepatocytes.

2013-06 | Journal article
DOI:

10.1128/JVI.03533-12

PMID:

23596296

PMC:

PMC3676132

Contributors: Zhong G; Yan H; Wang H; He W; Jing Z; Qi Y; Fu L; Gao Z; Huang Y; Xu G et al.
Source: Self-asserted source
Guocai Zhong via Europe PubMed Central

Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus.

2012 | Journal article
DOI:

10.7554/eLife.00049

PMID:

23150796

PMC:

PMC3485615

Contributors: Yan H; Zhong G; Xu G; He W; Jing Z; Gao Z; Huang Y; Qi Y; Peng B; Wang H et al.
Source: Self-asserted source
Guocai Zhong via Europe PubMed Central

Improved expression of secretory and trimeric proteins in mammalian cells via the introduction of a new trimer motif and a mutant of the tPA signal sequence.

2011-08 | Journal article
DOI:

10.1007/s00253-011-3297-0

PMID:

21556920

Contributors: Wang JY; Song WT; Li Y; Chen WJ; Yang D; Zhong GC; Zhou HZ; Ren CY; Yu HT; Ling H
Source: Self-asserted source
Guocai Zhong via Europe PubMed Central

Protein trimerization motif and its application

2010-12-29 | Patent
Contributors: Guocai Zhong
Source: Self-asserted source
Guocai Zhong

A sensitive HIV-1 envelope induced fusion assay identifies fusion enhancement of thrombin.

2010-01 | Journal article
DOI:

10.1016/j.bbrc.2009.12.155

PMID:

20045672

Contributors: Cheng DC; Zhong GC; Su JX; Liu YH; Li Y; Wang JY; Hattori T; Ling H; Zhang FM
Source: Self-asserted source
Guocai Zhong via Europe PubMed Central

Peer review (7 reviews for 6 publications/grants)

Review activity for ACS synthetic biology. (1)
Review activity for Cell discovery. (1)
Review activity for Communications biology. (1)
Review activity for Molecular therapy. (2)
Review activity for Nature communications (1)
Review activity for Nature structural & molecular biology. (1)