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Activities

Employment (1)

University of Iowa: Iowa City, IA, US

2009 to present | Associate Professor (Chemistry)
Employment
Source: Self-asserted source
Hien M. Nguyen

Education and qualifications (3)

Stanford University: Stanford, CA, US

2004-01 to 2006-07 | Postdoctoral Associate (Chemistry)
Education
Source: Self-asserted source
Hien M. Nguyen

University of Illinois : Urbana, IL, US

1998-08 to 2003-12 | PhD (Chemistry)
Education
Source: Self-asserted source
Hien M. Nguyen

Tufts University: Medford, MA, US

1992-08 to 1996-05 | Bachelor (Chemistry)
Education
Source: Self-asserted source
Hien M. Nguyen

Funding (3)

Catalytic Methods for Stereoselective 1,2-Cis Glycosylation

2016-09-01 to 2020-05-31 | Grant
National Institute of General Medical Sciences (Bethesda, US)
GRANT_NUMBER: U01GM120293
Source: Self-asserted source
Hien M. Nguyen via DimensionsWizard

Synthesis and Evaluation of Zwitterionic Carbohydrate Immunostimulants

2016-01-15 to 2017-12-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: R21AI117379
Source: Self-asserted source
Hien M. Nguyen via DimensionsWizard

Synthesis of Complex Carbohydrates.

2012-04-01 to 2017-03-31 | Grant
National Institute of General Medical Sciences (Bethesda, US)
GRANT_NUMBER: R01GM098285
Source: Self-asserted source
Hien M. Nguyen via DimensionsWizard

Works (31)

Why is thiol unexpectedly less reactive but more selective than alcohol in phenanthroline-catalyzed 1,2-cis O- and S-furanosylations?

Organic & Biomolecular Chemistry
2025 | Journal article
Contributors: Boddu S. Ramakrishna; Neha Rani; Hengfu Xu; Cyrus Alan-Lee; H. Bernhard Schlegel; Hien M. Nguyen
Source: check_circle
Crossref

Rhodium-Catalyzed Allylic Amination for the Enantioselective Synthesis of Tertiary β-Fluoroamines

Organic Letters
2025-01-03 | Journal article
Contributors: Felix O. Chukwu; Madhawee K. Arachchi; Hien M. Nguyen
Source: check_circle
Crossref

Highly stereoselective synthesis of α-glycosylated carboxylic acids by phenanthroline catalysis

Organic Chemistry Frontiers
2024 | Journal article
Contributors: Nur-E. Alom; Neha Rani; H. Bernhard Schlegel; Hien M. Nguyen
Source: check_circle
Crossref

Cooperative Catalysis in Stereoselective O- and N-Glycosylations with Glycosyl Trichloroacetimidates Mediated by Singly Protonated Phenanthrolinium Salt and Trichloroacetamide

Journal of the American Chemical Society
2024-12-18 | Journal article
Contributors: Jayanta Ghorai; Leila Almounajed; Suendues Noori; Hien M. Nguyen
Source: check_circle
Crossref

Rhodium‐Catalyzed Asymmetric Synthesis of 1,2‐Disubstituted Allylic Fluorides

Angewandte Chemie International Edition
2023-11-27 | Journal article
Contributors: Fuad O. Usman; Achyut R. Gogoi; Jason C. Mixdorf; Osvaldo Gutierrez; Hien M. Nguyen
Source: check_circle
Crossref

Rhodium‐Catalyzed Asymmetric Synthesis of 1,2‐Disubstituted Allylic Fluorides

Angewandte Chemie
2023-11-27 | Journal article
Contributors: Fuad O. Usman; Achyut R. Gogoi; Jason C. Mixdorf; Osvaldo Gutierrez; Hien M. Nguyen
Source: check_circle
Crossref

Heparan Sulfate-Mimicking Glycopolymers Bind SARS-CoV-2 Spike Protein in a Length- and Sulfation Pattern-Dependent Manner

ACS Medicinal Chemistry Letters
2023-10-12 | Journal article
Contributors: Hawau Abdulsalam; Jiayi Li; Ravi S. Loka; Eric T. Sletten; Hien M. Nguyen
Source: check_circle
Crossref

Overcoming the Potential Window-Limited Functional Group Compatibility by Alternating Current Electrolysis

Journal of the American Chemical Society
2023-10-11 | Journal article
Contributors: Sachini Rodrigo; Atanu Hazra; Jyoti P. Mahajan; Hien M. Nguyen; Long Luo
Source: check_circle
Crossref

Scope and Mechanistic Probe into Asymmetric Synthesis of α-Trisubstituted-α-Tertiary Amines by Rhodium Catalysis

Journal of the American Chemical Society
2023-09-13 | Journal article
Contributors: Madhawee K. Arachchi; Richard N. Schaugaard; H. Bernhard Schlegel; Hien M. Nguyen
Source: check_circle
Crossref

Rational Design and Expedient Synthesis of Heparan Sulfate Mimetics from Natural Aminoglycosides for Structure and Activity Relationship Studies

Angewandte Chemie International Edition
2023-08-07 | Journal article
Contributors: Joseph Wakpal; Vishaka Pathiranage; Alice R. Walker; Hien M. Nguyen
Source: check_circle
Crossref

Rational Design and Expedient Synthesis of Heparan Sulfate Mimetics from Natural Aminoglycosides for Structure and Activity Relationship Studies

Angewandte Chemie
2023-08-07 | Journal article
Contributors: Joseph Wakpal; Vishaka Pathiranage; Alice R. Walker; Hien M. Nguyen
Source: check_circle
Crossref

Phenanthroline Catalysis in Stereoselective 1,2-cis Glycosylations

Accounts of Chemical Research
2022-12-20 | Journal article
Contributors: Jiayi Li; Hien M. Nguyen
Source: check_circle
Crossref

Heparan Sulfate Mimicking Glycopolymer Prevents Pancreatic β Cell Destruction and Suppresses Inflammatory Cytokine Expression in Islets under the Challenge of Upregulated Heparanase

ACS Chemical Biology
2022-06-17 | Journal article
Contributors: Ravi S. Loka; Zhenfeng Song; Eric T. Sletten; Yasmin Kayal; Israel Vlodavsky; Kezhong Zhang; Hien M. Nguyen
Source: check_circle
Crossref

Stereoselective 1,2-cis Furanosylations Catalyzed by Phenanthroline

Journal of the American Chemical Society
2022-04-27 | Journal article
Contributors: Hengfu Xu; Richard N. Schaugaard; Jiayi Li; H. Bernhard Schlegel; Hien M. Nguyen
Source: check_circle
Crossref

Correction to “Phenanthroline-Catalyzed Stereoselective Formation of α-1,2-cis 2-Deoxy-2-Fluoro Glycosides”

ACS Catalysis
2022-01-21 | Journal article
Contributors: Paul M. DeMent; Chenlu Liu; Joseph Wakpal; Richard N. Schaugaard; H. Bernhard Schlegel; Hien M. Nguyen
Source: check_circle
Crossref

Iridium‐Catalyzed Enantioselective Allylic Substitutions of Racemic, Branched Trichloroacetimidates with Heteroatom Nucleophiles: Formation of Allylic C−O, C−N, and C−S Bonds

Advanced Synthesis & Catalysis
2021-09-07 | Journal article
Contributors: Madhawee K. Arachchi; Hien M. Nguyen
Source: check_circle
Crossref

A Mechanistic Probe into 1,2‐cis Glycoside Formation Catalyzed by Phenanthroline and Further Expansion of Scope

Advanced Synthesis & Catalysis
2021-08-13 | Journal article
Contributors: Jiayi Li; Hien M. Nguyen
Source: check_circle
Crossref

Phenanthroline-Catalyzed Stereoselective Formation of α-1,2-cis 2-Deoxy-2-Fluoro Glycosides

ACS Catalysis
2021-02-19 | Journal article
Contributors: Paul M. DeMent; Chenlu Liu; Joseph Wakpal; Richard N. Schaugaard; H. Bernhard Schlegel; Hien M. Nguyen
Source: check_circle
Crossref

Advances in Nucleophilic Allylic Fluorination

ACS Catalysis
2020-10-16 | Journal article
Contributors: Alexandre M. Sorlin; Fuad O. Usman; Connor K. English; Hien M. Nguyen
Source: check_circle
Crossref

Modulating Heparanase Activity: Tuning Sulfation Pattern and Glycosidic Linkage of Oligosaccharides

Journal of Medicinal Chemistry
2020-04-23 | Journal article
Contributors: Sanyong Zhu; Jiayi Li; Ravi S. Loka; Zhenfeng Song; Israel Vlodavsky; Kezhong Zhang; Hien M. Nguyen
Source: check_circle
Crossref

Facile triflic acid-catalyzed α-1,2-cis-thio glycosylations: scope and application to the synthesis of S-linked oligosaccharides, glycolipids, sublancin glycopeptides, and TN/TF antigens

Chemical Science
2019 | Journal article
Contributors: Sanyong Zhu; Ganesh Samala; Eric T. Sletten; Jennifer L. Stockdill; Hien M. Nguyen
Source: check_circle
Crossref

The Role of Trichloroacetimidate To Enable Iridium-Catalyzed Regio- and Enantioselective Allylic Fluorination: A Combined Experimental and Computational Study

Journal of the American Chemical Society
2019-09-18 | Journal article
Contributors: Alexandre M. Sorlin; Jason C. Mixdorf; Madeline E. Rotella; Robert T. Martin; Osvaldo Gutierrez; Hien M. Nguyen
Source: check_circle
Crossref

Phenanthroline‐Catalyzed Stereoretentive Glycosylations

Angewandte Chemie International Edition
2019-05-20 | Journal article
Contributors: Fei Yu; Jiayi Li; Paul M. DeMent; Yi‐Jung Tu; H. Bernhard Schlegel; Hien M. Nguyen
Source: check_circle
Crossref

Phenanthroline‐Catalyzed Stereoretentive Glycosylations

Angewandte Chemie
2019-05-20 | Journal article
Contributors: Fei Yu; Jiayi Li; Paul M. DeMent; Yi‐Jung Tu; H. Bernhard Schlegel; Hien M. Nguyen
Source: check_circle
Crossref

Are Brønsted Acids the True Promoter of Metal-Triflate-Catalyzed Glycosylations? A Mechanistic Probe into 1,2-cis-Aminoglycoside Formation by Nickel Triflate

ACS Catalysis
2019-03-01 | Journal article
Contributors: Eric T. Sletten; Yi-Jung Tu; H. Bernhard Schlegel; Hien M. Nguyen
Source: check_circle
Crossref

Specific Inhibition of Heparanase by a Glycopolymer with Well-Defined Sulfation Pattern Prevents Breast Cancer Metastasis in Mice

ACS Applied Materials & Interfaces
2019-01-09 | Journal article
Contributors: Ravi S. Loka; Eric T. Sletten; Uri Barash; Israel Vlodavsky; Hien M. Nguyen
Source: check_circle
Crossref

Iridium-Catalyzed Radiosynthesis of Branched Allylic [18F]Fluorides

Organic Letters
2019-01-04 | Journal article
Contributors: Jason C. Mixdorf; Alexandre M. Sorlin; David W. Dick; Hien M. Nguyen
Source: check_circle
Crossref

Asymmetric Synthesis of Allylic Fluorides via Fluorination of Racemic Allylic Trichloroacetimidates Catalyzed by a Chiral Diene-Iridium Complex

ACS Catalysis
2018-02-02 | Journal article
Contributors: Jason C. Mixdorf; Alexandre M. Sorlin; Qi Zhang; Hien M. Nguyen
Source: check_circle
Crossref

Design, synthesis, and evaluation of heparan sulfate mimicking glycopolymers for inhibiting heparanase activity

Chemical Communications
2017 | Journal article
Contributors: Ravi S. Loka; Fei Yu; Eric T. Sletten; Hien M. Nguyen
Source: check_circle
Crossref

Glycosidase Inhibition by Multivalent Presentation of Heparan Sulfate Saccharides on Bottlebrush Polymers

Biomacromolecules
2017-10-09 | Journal article
Contributors: Eric T. Sletten; Ravi S. Loka; Fei Yu; Hien M. Nguyen
Source: check_circle
Crossref

Enantioselective Synthesis of 1,2-Diamines Containing Tertiary and Quaternary Centers through Rhodium-Catalyzed DYKAT of Racemic Allylic Trichloroacetimidates

Organic Letters
2017-09-15 | Journal article
Contributors: Edward T. Mwenda; Hien M. Nguyen
Source: check_circle
Crossref

Peer review (45 reviews for 8 publications/grants)

Review activity for Accounts of chemical research. (1)
Review activity for ACS applied materials & interfaces. (1)
Review activity for ACS catalysis. (4)
Review activity for ACS central science. (1)
Review activity for Analytical chemistry. (2)
Review activity for Journal of organic chemistry. (5)
Review activity for Journal of the American Chemical Society. (18)
Review activity for Organic letters. (13)