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Employment (1)

Institute for Research in Biomedicine: Bellinzona, CH

2000-10-01 to present (Protein Folding and Quality Control)
Employment
Source: Self-asserted source
Maurizio Molinari

Education and qualifications (1)

ETH Zurich: Zurich, CH

1991 to 1995 | PhD in Biochemistry (Department of Biochemistry)
Education
Source: Self-asserted source
Maurizio Molinari

Professional activities (1)

Faculty Opinions: London, GB

2017-03-27 to present | Faculty Member
Invited position
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Faculty Opinions

Works (50 of 104)

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Page 1 of 3

TMX5/TXNDC15, a natural trapping mutant of the PDI family is a client of the proteostatic factor ERp44

Life Science Alliance
2024-12 | Journal article
DOI: 10.26508/lsa.202403047
Contributors: Tatiana Soldà; Carmela Galli; Concetta Guerra; Carolin Hoefner; Maurizio Molinari
Source: check_circle
Crossref

Pharmacological GCase Activity Enhancement Inhibits Tau Accumulation

2024-08-13 | Preprint
DOI: 10.1101/2024.08.13.607706
Contributors: Matteo Ciccaldo; Natàlia Pérez-Carmona; Ester Piovesana; Sara Cano-Crespo; Ana Ruano; Aida Delgado; Ilaria Fregno; Beatriz Calvo-Flores Guzmán; Manolo Bellotto; Maurizio Molinari et al.
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Crossref

ER-phagy Receptor’s Intrinsically Disordered Modules Drive ER Fragmentation and ER-phagy

2024-06-18 | Preprint
DOI: 10.1101/2024.06.18.599470
Contributors: Mikhail Rudinskiy; Carmela Galli; Andrea Raimondi; Maurizio Molinari
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Crossref

TMX5/TXNDC15, a natural trapping mutant of the PDI family is a client of the proteostatic factor ERp44

2024-06-13 | Preprint
DOI: 10.1101/2024.06.12.598629
Contributors: Tatiana Soldà; Carmela Galli; Concetta Guerra; Carolin Hoefner; Maurizio Molinari
Source: check_circle
Crossref

ER-to-lysosome-associated degradation acts as failsafe mechanism upon ERAD dysfunction

EMBO Reports
2024-05-21 | Journal article
DOI: 10.1038/s44319-024-00165-y
Contributors: Elisa Fasana; Ilaria Fregno; Carmela Galli; Tatiana Soldà; Maurizio Molinari
Source: check_circle
Crossref

Control of nuclear envelope dynamics during acute ER stress by LINC complexes disassembly and selective, asymmetric autophagy of the outer nuclear membrane

Autophagy
2024-05-03 | Journal article
DOI: 10.1080/15548627.2023.2299123
Contributors: Marika K. Kucińska; Maurizio Molinari
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Crossref

ER remodelling by ER-phagy in neurogenesis

Nature Cell Biology
2024-03 | Journal article
DOI: 10.1038/s41556-024-01362-6
Contributors: Maurizio Molinari
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Crossref

FAM134B regulates ER-to-lysosome-associated degradation of misfolded proteins upon pharmacologic or genetic inactivation of ER-associated degradation

2023-11-28 | Preprint
DOI: 10.1101/2023.11.28.569025
Contributors: Elisa Fasana; Ilaria Fregno; Carmela Galli; Maurizio Molinari
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Crossref

ER‐to‐lysosome‐associated degradation in a nutshell: mammalian, yeast, and plant ER‐phagy as induced by misfolded proteins

FEBS Letters
2023-08 | Journal article
DOI: 10.1002/1873-3468.14674
Contributors: Mikhail Rudinskiy; Maurizio Molinari
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Crossref

TMX4-driven LINC complex disassembly and asymmetric autophagy of the nuclear envelope upon acute ER stress

Nature Communications
2023-06-13 | Journal article
DOI: 10.1038/s41467-023-39172-3
Contributors: Marika K. Kucińska; Juliette Fedry; Carmela Galli; Diego Morone; Andrea Raimondi; Tatiana Soldà; Friedrich Förster; Maurizio Molinari
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Crossref

Rescue of secretion of a rare-disease associated mis-folded mutant glycoprotein in UGGT1 knock-out mammalian cells

2023-05-31 | Preprint
DOI: 10.1101/2023.05.30.542711
Contributors: Gabor Tax; Kevin P Guay; Tatiana Solde; Charlie J Hitchman; Johan C Hill; Snezana Vasilievic; Andrea Lia; Carlos P Modenutti; Kornelis R Straatman; Maurizio Molinari et al.
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Crossref

Tandem fluorescent Halo-GFP reporter for quantitative and time-resolved monitoring of organelle and protein delivery to lysosomes

Autophagy Reports
2022-12-31 | Journal article
DOI: 10.1080/27694127.2022.2061679
Contributors: M. Rudinskiy; M. Molinari
Source: check_circle
Crossref

SEC62 and TMX4 control asymmetric autophagy of the nuclear envelope upon LINC complex disassembly

2022-10-05 | Preprint
DOI: 10.1101/2022.10.05.510950
Contributors: Marika K. Kucińska; Juliette Fedry; Carmela Galli; Diego Morone; Andrea Raimondi; Tatiana Soldà; Friedrich Förster; Maurizio Molinari
Source: check_circle
Crossref

ER-phagy: mechanisms, regulation, and diseases connected to the lysosomal clearance of the endoplasmic reticulum

Physiological Reviews
2022-07-01 | Journal article
DOI: 10.1152/physrev.00038.2021
Contributors: Fulvio Reggiori; Maurizio Molinari
Source: check_circle
Crossref

N‐glycan processing selects ERAD‐resistant misfolded proteins for ER‐to‐lysosome‐associated degradation

The EMBO Journal
2021-08-02 | Journal article
DOI: 10.15252/embj.2020107240
Contributors: Ilaria Fregno; Elisa Fasana; Tatiana Soldà; Carmela Galli; Maurizio Molinari
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Crossref

Thioredoxin-Related Transmembrane Proteins: TMX1 and Little Brothers TMX2, TMX3, TMX4 and TMX5

Cells
2020-08-31 | Journal article
DOI: 10.3390/cells9092000
Contributors: Concetta Guerra; Maurizio Molinari
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Mechanistic insights in recov-ER-phagy: micro-ER-phagy to recover from stress

Autophagy
2020-02-01 | Journal article
DOI: 10.1080/15548627.2019.1709767
Contributors: Marisa Loi; Maurizio Molinari
Source: check_circle
Crossref

ESCRT-III-driven piecemeal micro-ER-phagy remodels the ER during recovery from ER stress

Nature Communications
2019-11-07 | Journal article
DOI: 10.1038/s41467-019-12991-z
Contributors: Marisa Loi; Andrea Raimondi; Diego Morone; Maurizio Molinari
Source: check_circle
Crossref

Proteasomal and lysosomal clearance of faulty secretory proteins: ER-associated degradation (ERAD) and ER-to-lysosome-associated degradation (ERLAD) pathways

Critical Reviews in Biochemistry and Molecular Biology
2019-03-04 | Journal article
DOI: 10.1080/10409238.2019.1610351
Contributors: Ilaria Fregno; Maurizio Molinari
Source: check_circle
Crossref

The reductase TMX1 contributes to ERAD by preferentially acting on membrane-associated folding-defective polypeptides

Biochemical and Biophysical Research Communications
2018-09 | Journal article
DOI: 10.1016/j.bbrc.2018.06.099
Contributors: Concetta Guerra; Giorgia Brambilla Pisoni; Tatiana Soldà; Maurizio Molinari
Source: check_circle
Crossref

Three branches to rule them all? UPR signalling in response to chemically versus misfolded proteins‐induced ER stress

Biology of the Cell
2018-09 | Journal article
DOI: 10.1111/boc.201800029
Contributors: Timothy J. Bergmann; Maurizio Molinari
Source: check_circle
Crossref

ER‐to‐lysosome‐associated degradation of proteasome‐resistant ATZ polymers occurs via receptor‐mediated vesicular transport

The EMBO Journal
2018-08-03 | Journal article
DOI: 10.15252/embj.201899259
Part of ISSN: 0261-4189
Contributors: Ilaria Fregno; Elisa Fasana; Timothy J Bergmann; Andrea Raimondi; Marisa Loi; Tatiana Soldà; Carmela Galli; Rocco D'Antuono; Diego Morone; Alberto Danieli et al.
Source: Self-asserted source
Maurizio Molinari via Crossref Metadata Search

Eat it right: ER-phagy and recovER-phagy.

Biochemical Society transactions
2018-05 | Journal article
DOI: 10.1042/bst20170354
PMID: 29802216
Contributors: Loi M; Fregno I; Guerra C; Molinari M
Source: Self-asserted source
Maurizio Molinari via Europe PubMed Central

Chemical stresses fail to mimic the unfolded protein response resulting from luminal load with unfolded polypeptides.

The Journal of biological chemistry
2018-04 | Journal article
DOI: 10.1074/jbc.ra117.001484
PMID: 29453283
Contributors: Bergmann TJ; Fregno I; Fumagalli F; Rinaldi A; Bertoni F; Boersema PJ; Picotti P; Molinari M
Source: Self-asserted source
Maurizio Molinari via Europe PubMed Central

Endoplasmic reticulum turnover: ER-phagy and other flavors in selective and non-selective ER clearance [version 1; referees: awaiting peer review]

2018-04-13 | Journal article
DOI: 10.12688/f1000research.13968.1
Part of ISSN: 2046-1402
Contributors: Ilaria Fregno; Maurizio Molinari
Source: check_circle
F1000
grade
Preferred source (of 2)‎

Ticino at the forefront of medical research

Ticino Wellcome
2017-03 | Magazine article
Source: Self-asserted source
Maurizio Molinari

Ricerche non redditizie per l’industria dei farmaci

Corriere del Ticino
2017-02-08 | Magazine article
Source: Self-asserted source
Maurizio Molinari

Role of Sec62 in ER Maintenance: a Link with ER Stress Tolerance in SEC62 Overexpressing-Tumors?

Mol. Cell. Oncology
2017-01-26 | Journal article
PMID: 28401179
Source: Self-asserted source
Maurizio Molinari

Five Questions (with their Answers) on ER-Associated Degradation

Traffic
2016 | Journal article
DOI: 10.1111/tra.12373
EID:

2-s2.0-84959419572
Contributors: Brambilla Pisoni, G.; Molinari, M.
Source: Self-asserted source
Maurizio Molinari via Scopus - Elsevier

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Autophagy
2016 | Journal article
DOI: 10.1080/15548627.2015.1100356
EID:

2-s2.0-85013763791
Contributors: Klionsky, D.J.; Klionsky, D.J.; Abdelmohsen, K.; Abe, A.; Abedin, M.J.; Abeliovich, H.; Arozena, A.A.; Adachi, H.; Adams, C.M.; Adams, P.D. et al.
Source: Self-asserted source
Maurizio Molinari via Scopus - Elsevier

Quality control mechanisms of protein biogenesis: Proteostasis dies hard

AIMS Biophysics
2016 | Journal article
DOI: 10.3934/biophy.2016.4.456
EID:

2-s2.0-85010981873
Contributors: Bergmann, T.J.; Pisoni, G.B.; Molinari, M.
Source: Self-asserted source
Maurizio Molinari via Scopus - Elsevier

Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery

Nature Cell Biology
2016 | Journal article
DOI: 10.1038/ncb3423
EID:

2-s2.0-84991716246
Contributors: Fumagalli, F.; Noack, J.; Bergmann, T.J.; Presmanes, E.C.; Pisoni, G.B.; Fasana, E.; Fregno, I.; Galli, C.; Loi, M.; Soldà, T. et al.
Source: Self-asserted source
Maurizio Molinari via Scopus - Elsevier

Tutte le Malattie rare ancora da sconfiggere

Il Caffè
2016-12-18 | Magazine article
Source: Self-asserted source
Maurizio Molinari

Le Proteine impazzite che ci fanno ammalare

Il Caffè
2016-10-09 | Magazine article
Source: Self-asserted source
Maurizio Molinari

A novel UGGT1 and p97-dependent checkpoint for native ectodomains with ionizable intramembrane residue

Molecular Biology of the Cell
2015 | Journal article
DOI: 10.1091/mbc.E14-12-1615
EID:

2-s2.0-84928136303
Contributors: Merulla, J.; Soldà, T.; Molinari, M.
Source: Self-asserted source
Maurizio Molinari via Scopus - Elsevier

Correction to How viruses hijack the ERAD tuning machinery [Journal of Virology, 88, 18 (2014) 10272-10275]

Journal of Virology
2015 | Journal article
DOI: 10.1128/JVI.03670-14
EID:

2-s2.0-84924787808
Contributors: Noack, J.; Bernasconi, R.; Molinari, M.
Source: Self-asserted source
Maurizio Molinari via Scopus - Elsevier

Division of labor among oxidoreductases: TMX1 preferentially acts on transmembrane polypeptides

Molecular Biology of the Cell
2015 | Journal article
DOI: 10.1091/mbc.E15-05-0321
EID:

2-s2.0-84943167103
Contributors: Pisoni, G.B.; Ruddock, L.W.; Bulleid, N.; Molinari, M.
Source: Self-asserted source
Maurizio Molinari via Scopus - Elsevier

Glycoprotein maturation and quality control

Seminars in Cell and Developmental Biology
2015 | Journal article
DOI: 10.1016/j.semcdb.2015.05.009
EID:

2-s2.0-84931098603
Contributors: Molinari, M.; Hebert, D.N.
Source: Self-asserted source
Maurizio Molinari via Scopus - Elsevier

N-linked sugar-regulated protein folding and quality control in the ER

Seminars in Cell and Developmental Biology
2015 | Journal article
DOI: 10.1016/j.semcdb.2014.12.001
EID:

2-s2.0-84931565973
Contributors: Tannous, A.; Pisoni, G.B.; Hebert, D.N.; Molinari, M.
Source: Self-asserted source
Maurizio Molinari via Scopus - Elsevier

The protein-disulfide isomerase ERp57 regulates the steady-state levels of the prion protein

Journal of Biological Chemistry
2015 | Journal article
DOI: 10.1074/jbc.M114.635565
EID:

2-s2.0-84942287897
Contributors: Torres, M.; Medinas, D.B.; Matamala, J.M.; Woehlbier, U.; Cornejo, V.H.; Solda, T.; Andreu, C.; Rozas, P.; Matus, S.; Muñoz, N. et al.
Source: Self-asserted source
Maurizio Molinari via Scopus - Elsevier

How viruses hijack the ERAD tuning machinery

Journal of Virology
2014 | Journal article
DOI: 10.1128/JVI.00801-14
EID:

2-s2.0-84906342535
Contributors: Noack, J.; Bernasconi, R.; Molinari, M.
Source: Self-asserted source
Maurizio Molinari via Scopus - Elsevier

Proteostasis: Bad news and good news from the endoplasmic reticulum

Swiss Medical Weekly
2014 | Journal article
DOI: 10.4414/smw.2014.14001
EID:

2-s2.0-84907379812
Contributors: Noack, J.; Brambilla Pisoni, G.; Molinari, M.
Source: Self-asserted source
Maurizio Molinari via Scopus - Elsevier

RESETting proteostasis

Nature Chemical Biology
2014 | Journal article
EID:

2-s2.0-84924331229
Contributors: Noack, J.; Molinari, M.
Source: Self-asserted source
Maurizio Molinari via Scopus - Elsevier

Non-Lipidated LC3 is Essential for Mouse Hepatitis Virus Infection

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging
2013 | Book
DOI: 10.1016/B978-0-12-405877-4.00008-1
EID:

2-s2.0-84903074586
Contributors: Noack, J.; Bernasconi, R.; Molinari, M.
Source: Self-asserted source
Maurizio Molinari via Scopus - Elsevier

Specificity and Regulation of the Endoplasmic Reticulum-Associated Degradation Machinery

Traffic
2013 | Journal article
DOI: 10.1111/tra.12068
EID:

2-s2.0-84878986182
Contributors: Merulla, J.; Fasana, E.; Soldà, T.; Molinari, M.
Source: Self-asserted source
Maurizio Molinari via Scopus - Elsevier

Transgenic expression of β1 antibody in brain neurons impairs age-dependent amyloid deposition in APP23 mice

Neurobiology of Aging
2013 | Journal article
DOI: 10.1016/j.neurobiolaging.2013.06.013
EID:

2-s2.0-84884163070
Contributors: Paganetti, P.; Reichwald, J.; Bleckmann, D.; Abramowski, D.; Ammaturo, D.; Barske, C.; Danner, S.; Molinari, M.; Müller, M.; Papin, S. et al.
Source: Self-asserted source
Maurizio Molinari via Scopus - Elsevier

UDP-glucose:glycoprotein glucosyltransferase (UGGT1) promotes substrate solubility in the endoplasmic reticulum

Molecular Biology of the Cell
2013 | Journal article
DOI: 10.1091/mbc.E13-02-0101
EID:

2-s2.0-84883372465
Contributors: Ferris, S.P.; Jaber, N.S.; Molinari, M.; Arvan, P.; Kaufman, R.J.
Source: Self-asserted source
Maurizio Molinari via Scopus - Elsevier

Flagging and docking: Dual roles for N-glycans in protein quality control and cellular proteostasis

Trends in Biochemical Sciences
2012 | Journal article
DOI: 10.1016/j.tibs.2012.07.005
EID:

2-s2.0-84866623060
Contributors: Hebert, D.N.; Molinari, M.
Source: Self-asserted source
Maurizio Molinari via Scopus - Elsevier

Unconventional roles of nonlipidated LC3 in ERAD tuning and coronavirus infection

Autophagy
2012 | Journal article
DOI: 10.4161/auto.21229
EID:

2-s2.0-84867254461
Contributors: Bernasconi, R.; Noack, J.; Molinari, M.
Source: Self-asserted source
Maurizio Molinari via Scopus - Elsevier

Chronic delivery of antibody fragments using immunoisolated cell implants as a passive vaccination tool

PLoS ONE
2011 | Journal article
DOI: 10.1371/journal.pone.0018268
EID:

2-s2.0-80052151341
Contributors: Marroquin Belaunzaran, O.; Cordero, M.I.; Setola, V.; Bianchi, S.; Galli, C.; Bouche, N.; Mlynarik, V.; Gruetter, R.; Sandi, C.; Bensadoun, J.-C. et al.
Source: Self-asserted source
Maurizio Molinari via Scopus - Elsevier
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Peer review (49 reviews for 3 publications/grants)

Review activity for Faculty Opinions (47)
Review activity for Nature cell biology (1)
Review activity for Review Commons (1)
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