Liang Zhang (0000-0002-7672-1168)

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The research field of my lab spans a broad range of chemical biology, cancer metabolism, enzymatic catalysis, structure biology, epigenetics and drug discovery. We are interested in studying the dynamic catalytic and regulation mechanisms of chemical modifications on biological macromolecules involved in DNA/RNA methylation/demethylation pathways, nucleoside metabolism pathways, and Fatty acid biosynthesis pathways. These processes are vital for all living cells, and the biofunctions of enzymes involved in these processes are restrictively regulated spatio-temporally through chemical modifications. Our researches focus on elucidating the mechanisms of the key enzymes in adding, reading, catalytic changing and removing the chemical modifications on the biological macromolecules, as well as the subsequent corresponding biological effects. We are also establishing efficient high throughput drug screening systems for novel leading drug compounds discovery against these potential drug targets. So far, our lab has published several research articles on Nature Chemical Biology, Nature Communications, Angewandte Chemie International Edition, Cell Research, PNAS, Chemical Science, etc. Our works are supported by numerous grants such as the National Science Fund for Excellent Young Scholars, the Major Research Plan and General Program Research Plan of National Natural Science Foundation of China, etc.

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Shanghai Jiao Tong University: Shanghai, CN

2014-10-01 to present | Professor (Chemical Biology )

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Liang Zhang

https://orcid.org/0000-0002-7672-1168

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Employment (3)

Shanghai Jiao Tong University: Shanghai, CN

The University of Chicago: Chicago, Illinois, US

University of Texas Southwestern Medical Center: Dallas, Texas, US

Education and qualifications (2)

Shanghai Institute of Materia Medica Chinese Academy of Sciences: Shanghai, CN

Fudan University: Shanghai, CN

Professional activities (2)

Chinese Chemical Society: Beijing, CN

Chinese Phamarcological Society: Beijing, CN

Funding (4)

The catalytic mechanism studies and drug discovery of fatty acid dehydrogenase FabX in the fatty acid biosynthesis pathway of Helicobacter pylori

Drug discovery of Tet2 dioxygenase in DNA demethylation pathway

Functional study and drug discovery of human enzymes that involved in the dynamic chemical modifications

Catalytic mechanism and functional study of human Thymine-DNA Glycosylase (TDG) in DNA demethylation pathway

Works (50 of 55)

The Molecular Basis of the β-Ketoacyl-ACP Synthase FabH in Catalyzing C–C Bond Formation of Acetoacetyl-ACP

Antagonist Targeting the Species‐Specific Fatty Acid Dehydrogenase/Isomerase FabX for Anti‐H. pylori Infection

The β‐Ketoacyl‐ACP Synthase FabF Catalyzes Carbon‐Carbon Bond Formation in a Bimodal Pattern for Fatty Acid Biosynthesis

The β‐Ketoacyl‐ACP Synthase FabF Catalyzes Carbon‐Carbon Bond Formation in a Bimodal Pattern for Fatty Acid Biosynthesis

Structural Basis of the Dehydratase Module (hDH) of Human Fatty Acid Synthase

Molecular basis of an atypical dsDNA 5mC/6mA bifunctional dioxygenase CcTet from Coprinopsis cinerea in catalyzing dsDNA 5mC demethylation

The Molecular Basis of Human ALKBH3 Mediated RNA N1‐methyladenosine (m1A) Demethylation

The Molecular Basis of Catalysis by SDR Family Members Ketoacyl‐ACP Reductase FabG and Enoyl‐ACP Reductase FabI in Type‐II Fatty Acid Biosynthesis

Redox switching mechanism of the adenosine 5′-phosphosulfate kinase domain (APSK2) of human PAPS synthase 2

A fungal dioxygenase CcTet serves as a eukaryotic 6mA demethylase on duplex DNA

Nigerin and ochracenes J−L, new sesquiterpenoids from the marine sponge symbiotic fungus Aspergillus niger

Structural basis for the substrate recognition mechanism of ATP-sulfurylase domain of human PAPS synthase 2

High-Throughput-Methyl-Reading (HTMR) assay: a solution based on nucleotide methyl-binding proteins enables large-scale screening for DNA/RNA methyltransferases and demethylases

Helicobacter pylori FabX contains a [4Fe-4S] cluster essential for unsaturated fatty acid synthesis

Structural basis for diguanylate cyclase activation by its binding partner in Pseudomonas aeruginosa

Advances on Mechanism and Drug Discovery of Type-II Fatty Acid Biosynthesis Pathway

A back-door Phenylalanine coordinates the stepwise hexameric loading of acyl carrier protein by the fatty acid biosynthesis enzyme β-hydroxyacyl-acyl carrier protein dehydratase (FabZ)

Structural insights into FTO's catalytic mechanism for the demethylation of multiple RNA substrates

Thymine DNA glycosylase recognizes the geometry alteration of minor grooves induced by 5-formylcytosine and 5-carboxylcytosine

Dynamic modifications of biomacromolecules: mechanism and chemical interventions

Enhanced PAPSS2/VCAN sulfation axis is essential for Snail-mediated breast cancer cell migration and metastasis

Overcoming erlotinib resistance in EGFR mutation-positive lung adenocarcinomas through repression of phosphoglycerate dehydrogenase

Chromate Binding and Removal by the Molybdate-Binding Protein ModA

Crystal structure of FabZ-ACP complex reveals a dynamic seesaw-like catalytic mechanism of dehydratase in fatty acid biosynthesis

A METTL3-METTL14 complex mediates mammalian nuclear RNA N-6-adenosine methylation

A protein engineered to bind uranyl selectively and with femtomolar affinity

A TET Homologue Protein from Coprinopsis cinerea (CcTET) That Biochemically Converts 5-Methylcytosine to 5-Hydroxymethylcytosine, 5-Formylcytosine, and 5-Carboxylcytosine

Crystal structure of the RNA demethylase ALKBH5 from zebrafish

Lysine Acetylation Activates 6-Phosphogluconate Dehydrogenase to Promote Tumor Growth

Total Chemical Synthesis of the Enzyme Sortase A DN59 with Full Catalytic Activity**

Molecular mechanism of quinone signaling mediated through S-quinonization of a YodB family repressor QsrR (vol 110, pg 5010, 2013)

Tet-mediated covalent labelling of 5-methylcytosine for its genome-wide detection and sequencing

Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation

Identification of 5-methyl-c in nucleic acid templates

Base-Resolution Analysis of 5-Hydroxymethylcytosine in the Mammalian Genome

Duplex interrogation by a direct DNA repair protein in search of base damage

Mouse Tet1 Protein can Oxidize 5mC to 5hmC and 5caC on Single-stranded DNA

Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth

Protein cysteine phosphorylation of SarA/MgrA family transcriptional regulators mediates bacterial virulence and antibiotic resistance

Staphylococcus aureus CymR Is a New Thiol-based Oxidation-sensing Regulator of Stress Resistance and Oxidative Response

Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA

Synthesis of DNA oligos containing 2′-deoxy-2′-fluoro-d-arabinofuranosyl-5-carboxylcytosine as hTDG inhibitor

Composition and Methods Related to Modification of 5-methylcytosine (5mC)

A conserved hydrophobic core at Bcl-x(L) mediates its structural stability and binding affinity with BH3-domain peptide of pro-apoptotic protein

Discovering Potent Inhibitors Against the beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ) of Helicobacter pylori: Structure-Based Design, Synthesis, Bioassay, and Crystal Structure Determination

Emodin targets the beta-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: enzymatic inhibition assay with crystal structural and thermodynamic characterization

Enzymatic characterization and crystal structure analysis of the D-alanine-D-alanine ligase from Helicobacter pylori

Natural product juglone targets three key enzymes from Helicobacter pylori: inhibition assay with crystal structure characterization

Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase from E-coli: Enzymatic characterization with crystal structure analysis

Structural basis for catalytic and inhibitory mechanisms of beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ)

Peer review (4 reviews for 3 publications/grants)