Personal information

United Kingdom

Activities

Employment (2)

Blue Burgundy: Ampthill, Bedfordshire, GB

2019-09-01 to present | Principal
Employment
Source: Self-asserted source
Robert Young

GlaxoSmithKline Plc: Stevenage, Hertfordshire, GB

1990-02-14 to 2019-07-05 | GSK Fellow, Senior Scientific Investigator (NCE Medicinal Chemistry)
Employment
Source: Self-asserted source
Robert Young

Education and qualifications (2)

University of Chicago: Chicago, IL, US

1988-02-05 to 1990-02-01 | Research Fellow (Ben May Institute)
Education
Source: Self-asserted source
Robert Young

University of Oxford: Oxford, Oxfordshire, GB

1981-10-15 to 1988-01-25 | MA, DPhil
Education
Source: Self-asserted source
Robert Young

Professional activities (2)

Royal Society of Chemistry: London, London, GB

2008-11-30 to present | CChem FRSC
Membership
Source: Self-asserted source
Robert Young

University of St Andrews: St Andrews, Fife, GB

2001-01-01 to present | Honorary Visiting Professor (Chemistry)
Invited position
Source: Self-asserted source
Robert Young

Works (50 of 105)

Items per page:
Page 1 of 3

Today’s drug discovery and the shadow of the rule of 5

Expert Opinion on Drug Discovery
2023-09-02 | Journal article | Author
Part of ISSN: 1746-0441
Part of ISSN: 1746-045X
Contributors: Robert Young
Source: Self-asserted source
Robert Young

Structure-Guided Design and Synthesis of a Pyridazinone Series of <i>Trypanosoma cruzi</i> Proteasome Inhibitors

Journal of Medicinal Chemistry
2023-08-10 | Journal article
Part of ISSN: 0022-2623
Part of ISSN: 1520-4804
Contributors: Michael Thomas; Kate McGonagle; Paul Rowland; David A. Robinson; Peter G. Dodd; Isabel Camino-Díaz; Lorna Campbell; Juan Cantizani; Pablo Castañeda; Daniel Conn et al.
Source: Self-asserted source
Robert Young

Future challenges and opportunities with fluorine in drugs?

Medicinal Chemistry Research
2023-07 | Journal article
Part of ISSN: 1054-2523
Part of ISSN: 1554-8120
Contributors: David O’Hagan; Robert J. Young
Source: Self-asserted source
Robert Young

Synthesis in Medicinal Chemistry

The Handbook of Medicinal Chemistry
2023-02-03 | Book chapter
Part of ISBN: 9781788018982
Part of ISBN: 9781788018982
Part of ISBN: 9781839165887
Part of ISBN: 9781837671076
Contributors: Allan M. Jordan; Robert J. Young
Source: Self-asserted source
Robert Young

The Time and Place for Nature in Drug Discovery

JACS Au
2022-11-28 | Journal article | Author
Part of ISSN: 2691-3704
Part of ISSN: 2691-3704
Contributors: Robert Young; Sabine Flitsch; Michael Grigalunas; Paul Leeson; Ronald J Quinn; Nicholas Turner; Herbert Waldmann
Source: Self-asserted source
Robert Young

Physicochemical properties and <i>Mycobacterium tuberculosis</i> transporters: keys to efficacious antitubercular drugs?

RSC Medicinal Chemistry
2021 | Journal article | Author
Part of ISSN: 2632-8682
Contributors: Elizabeth Fullam; Robert Young
Source: Self-asserted source
Robert Young

Tactics to Improve Solubility

The Medicinal Chemist's Guide to Solving ADMET Challenges
2021-08-27 | Book chapter
Part of ISBN: 9781788012270
Part of ISBN: 9781788012270
Part of ISBN: 9781839160493
Part of ISBN: 9781788016414
Contributors: Robert J. Young
Source: Self-asserted source
Robert Young

Method Development and Application of an Accelerated Solution Stability Screen for Drug Discovery

SLAS Discovery
2020-12 | Journal article | Author
Part of ISSN: 2472-5552
Contributors: Ruben Gomez-Sanchez; Stephen Besley; Zoe Zeliku; Robert Young
Source: Self-asserted source
Robert Young

Facts, Patterns, and Principles in Drug Discovery: Appraising the Rule of 5 with Measured Physicochemical Data

Journal of Medicinal Chemistry
2020-09-24 | Journal article | Author
Part of ISSN: 0022-2623
Part of ISSN: 1520-4804
Contributors: Christopher P. Tinworth; Robert Young
Source: Self-asserted source
Robert Young

Identification and Optimization of Novel Small c-Abl Kinase Activators Using Fragment and HTS Methodologies

Journal of medicinal chemistry
2019 | Journal article
Source: Self-asserted source
Robert Young

Identification via a Parallel Hit Progression Strategy of Improved Small Molecule Inhibitors of the Malaria Purine Uptake Transporter that Inhibit Plasmodium falciparum Parasite Proliferation

ACS infectious diseases
2019 | Journal article
Source: Self-asserted source
Robert Young

Kallikrein 5 inhibitors identified through structure based drug design in search for a treatment for Netherton Syndrome

Bioorganic & medicinal chemistry letters
2019 | Journal article
Source: Self-asserted source
Robert Young

Revisiting the language of glycoscience: readers, writers and erasers in carbohydrate biochemistry

ChemBioChem
2019 | Journal article
Source: Self-asserted source
Robert Young

Structure guided drug design to develop kallikrein 5 inhibitors to treat Netherton syndrome

Bioorganic & medicinal chemistry letters
2019 | Journal article
Source: Self-asserted source
Robert Young

Using Physicochemical Measurements to Influence Better Compound Design

SLAS DISCOVERY: Advancing Life Sciences R&D
2019 | Journal article
Source: Self-asserted source
Robert Young

Expanding the medicinal chemistry synthetic toolbox

Nature Reviews Drug Discovery
2018 | Journal article
Source: Self-asserted source
Robert Young

Impact of synthetic chemistry methodologies in drug discovery

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
2018 | Conference paper
Source: Self-asserted source
Robert Young

Mapping the efficiency and physicochemical trajectories of successful optimizations

Journal of medicinal chemistry
2018 | Journal article
Source: Self-asserted source
Robert Young

The role and impact of high throughput biomimetic measurements in drug discovery

ADMET and DMPK
2018 | Journal article
Source: Self-asserted source
Robert Young

A new ‘golden age’for the antitubercular target InhA

Drug discovery today
2017 | Journal article
Source: Self-asserted source
Robert Young

Application of Biocatalysis to on-DNA Carbohydrate Library Synthesis

ChemBioChem
2017 | Journal article
Source: Self-asserted source
Robert Young

Cover Picture: Application of Biocatalysis to on-DNA Carbohydrate Library Synthesis (ChemBioChem 9/2017)

ChemBioChem
2017 | Journal article
Source: Self-asserted source
Robert Young

New reactions and reactive intermediates in the pyrolysis of cyclic phosphonium ylides

ARKIVOC
2017 | Journal article
Source: Self-asserted source
Robert Young

Accurate Lipophilicity (log P) Measurements Inform on Subtle Stereoelectronic Effects in Fluorine Chemistry

Angewandte Chemie International Edition
2016 | Journal article
Source: Self-asserted source
Robert Young

Chemoselective sequential click ligations directed by enhanced reactivity of an aromatic ynamine

Organic letters
2016 | Journal article
Source: Self-asserted source
Robert Young

N-Benzyl-4-((heteroaryl) methyl) benzamides: A New Class of Direct NADH-Dependent 2-trans Enoyl--Acyl Carrier Protein Reductase (InhA) Inhibitors with Antitubercular Activity

ChemMedChem
2016 | Journal article
Source: Self-asserted source
Robert Young

New direct inhibitors of InhA with antimycobacterial activity based on a tetrahydropyran scaffold

European journal of medicinal chemistry
2016 | Journal article
Source: Self-asserted source
Robert Young

Präzise Lipophilie (log P)-Messungen geben Auskunft über feine stereoelektronische Effekte in der Fluorchemie

Angewandte Chemie
2016 | Journal article
Source: Self-asserted source
Robert Young

Structurally Diverse Mitochondrial Branched Chain Aminotransferase (BCATm) Leads With Varying Binding Modes Identified by Fragment Screening

Journal of Medicinal Chemistry
2016 | Journal article
Source: Self-asserted source
Robert Young

Molecular property design: does everyone get it?

2015 | Other
Source: Self-asserted source
Robert Young

Release of 50 new, drug-like compounds and their computational target predictions for open source anti-tubercular drug discovery

PloS one
2015 | Journal article
Source: Self-asserted source
Robert Young

The discovery of in vivo active mitochondrial branched-chain aminotransferase (BCATm) inhibitors by hybridizing fragment and HTS hits

Journal of medicinal chemistry
2015 | Journal article
Source: Self-asserted source
Robert Young

Whole cell target engagement identifies novel inhibitors of Mycobacterium tuberculosis decaprenylphosphoryl-$β$-d-ribose oxidase

ACS infectious diseases
2015 | Journal article
Source: Self-asserted source
Robert Young

Design, synthesis, and evaluation of new thiadiazole-based direct inhibitors of enoyl acyl carrier protein reductase (InhA) for the treatment of tuberculosis

Journal of medicinal chemistry
2014 | Journal article
Source: Self-asserted source
Robert Young

Physical properties in drug design

Tactics in Contemporary Drug Design
2014 | Book chapter
Source: Self-asserted source
Robert Young

Physical properties in drug discovery: Facts, patterns, and the principles of good medicinal chemistry practice

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
2014 | Conference paper
Source: Self-asserted source
Robert Young

Structure-guided optimization of small molecule c-Abl activators

Journal of computer-aided molecular design
2014 | Journal article
Source: Self-asserted source
Robert Young

Fueling Open-Source Drug Discovery: 177 Small-Molecule Leads against Tuberculosis

ChemMedChem
2013 | Journal article
Source: Self-asserted source
Robert Young

Practical purification of hydrophilic fragments and lead/drug-like molecules by reverse phase flash chromatography: tips, tricks and contemporary developments

Drug discovery today
2013 | Journal article
Source: Self-asserted source
Robert Young

Discovery of Potent and Long-Acting Oral Factor Xa Inhibitors with Tetrahydroisoquinoline and Benzazepine P4 Motifs.

ChemInform
2011 | Journal article
Source: Self-asserted source
Robert Young

Getting physical in drug discovery II: the impact of chromatographic hydrophobicity measurements and aromaticity

Drug discovery today
2011 | Journal article
Source: Self-asserted source
Robert Young

Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase; the identification of (2R)-2-pyrrolidinecarboxamidine as a potent and selective haem-co-ordinating inhibitor

Bioorganic &amp; medicinal chemistry letters
2011 | Journal article
Source: Self-asserted source
Robert Young

Structure and property based design of factor Xa inhibitors: Pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifs

Bioorganic &amp; medicinal chemistry letters
2011 | Journal article
Source: Self-asserted source
Robert Young

The discovery of potent and long-acting oral factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs

Bioorganic & medicinal chemistry letters
2011 | Journal article
Source: Self-asserted source
Robert Young

The impact of aromatic ring count on compound developability: further insights by examining carbo-and hetero-aromatic and-aliphatic ring types

Drug discovery today
2011 | Journal article
Source: Self-asserted source
Robert Young

The successful quest for oral factor Xa inhibitors; learnings for all of medicinal chemistry?

Bioorganic & medicinal chemistry letters
2011 | Journal article
Source: Self-asserted source
Robert Young

Getting physical in drug discovery: a contemporary perspective on solubility and hydrophobicity

Drug discovery today
2010 | Journal article
Source: Self-asserted source
Robert Young

Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with monoaryl P4 motifs

Bioorganic & medicinal chemistry letters
2010 | Journal article
Source: Self-asserted source
Robert Young

Crystalline derivatives of (E)-2-(5-chlorothien-2-yl)-N-${$(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl$}$ ethenesulfonamide

2010-01 | Other
Source: Self-asserted source
Robert Young

3-Sulfonylamino-Pyrrolidine-2-One Derivatives as Factor Xa Inhibitors

2009-04 | Other
Source: Self-asserted source
Robert Young
Items per page:
Page 1 of 3

Peer review (58 reviews for 12 publications/grants)

Review activity for ACS central science. (1)
Review activity for ACS infectious diseases. (9)
Review activity for ACS medicinal chemistry letters. (2)
Review activity for ACS omega. (1)
Review activity for Bioorganic & medicinal chemistry letters. (1)
Review activity for Chemical Society reviews. (1)
Review activity for Journal of medicinal chemistry. (14)
Review activity for MedChemComm. (1)
Review activity for Medicinal chemistry research. (1)
Review activity for New journal of chemistry. (1)
Review activity for Organic & biomolecular chemistry. (23)
Review activity for RSC medicinal chemistry. (3)