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Cancer Cell Biology
Netherlands

Activities

Employment (6)

University of Amsterdam: Amsterdam, NL

2024-07-01 to present | Assistant Professor (Swammerdam Institute of Life Sciences)
Employment
Source: Self-asserted source
Caitrin Crudden

Universiteit van Amsterdam: N/A, NL

2024-07-01 to present | Academic, Assistant Professor (Molecular Cytology (SILS, FNWI))
Employment
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University of Amsterdam - PURE

Vrije Universiteit Medisch Centrum : Amsterdam, Noord-Holland, NL

2018-07-15 to present | Postdoctoral researcher (Department of Pathology)
Employment
Source: Self-asserted source
Caitrin Crudden

Universiteit van Amsterdam: N/A, NL

2024-07-01 to 2025-12-31 | Academic, Assistant Professor (SILS Other Research (FNWI))
Employment
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University of Amsterdam - PURE

Vrije Universiteit Amsterdam: Amsterdam, NL

2024-06-30
Employment
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Vrije Universiteit Amsterdam

Karolinska Institutet: Stockholm, SE

2014-03-27 to 2018-06-28 | PhD Student (Department of Oncology Pathology)
Employment
Source: Self-asserted source
Caitrin Crudden

Education and qualifications (2)

University of Manchester: Manchester, Manchester, GB

2012-09-01 to 2013-09-01 | MSc. Cancer Research and Molecular Biomedicine (Faculty of Life Sciences)
Education
Source: Self-asserted source
Caitrin Crudden

University of Bradford: Bradford, West Yorkshire, GB

2008-09-15 to 2011-06-30 | BSc Clinical Sciences
Education
Source: Self-asserted source
Caitrin Crudden

Funding (1)

Molecular mechanism and inhibition of extracellular vesicle-mediated PD-L1 release in melanoma cells

2020-02-01 to 2022-01-31 | Grant
European Commission (Brussels, BE)
GRANT_NUMBER: 845391
Source: Self-asserted source
Caitrin Crudden via DimensionsWizard

Works (44)

Disruption of basal CXCR4 oligomers impairs oncogenic properties in lymphoid neoplasms

2024-12-07 | Preprint
Contributors: Simon Mobach; Nick D. Bergkamp; Ziliang Ma; Marco V. Haselager; Stephanie M. Anbuhl; Daphne Jurriens; Jelle van den Bor; Ziming Wang; Caitrin Crudden; Jamie L. Roos et al.
Source: check_circle
Crossref

Constitutive activity of an atypical chemokine receptor revealed by inverse agonistic nanobodies

2024-11-04 | Preprint
Contributors: Claudia V. Perez Almeria; Omolade Otun; Roman Schlimgen; Thomas D. Lamme; Caitrin Crudden; Noureldine Youssef; Lejla Musli; Shawn Jenjak; Vladimir Bobkov; Julia Drube et al.
Source: check_circle
Crossref

Data from Competing engagement of β-arrestin isoforms balances IGF1R/p53 signaling and controls melanoma cell chemotherapeutic responsiveness

2024-09-16 | Preprint
Contributors: Sonia Cismas; Sylvya Pasca; Caitrin Crudden; Iara Troccoli Drakensjo; Naida Suleymanova; Simin Zhang; Benjamin Gebhard; Dawei Song; Shiyong Neo; Takashi Shibano et al.
Source: check_circle
Crossref

Supplementary Figure 1 from Competing engagement of β-arrestin isoforms balances IGF1R/p53 signaling and controls melanoma cell chemotherapeutic responsiveness

2024-09-16 | Preprint
Contributors: Sonia Cismas; Sylvya Pasca; Caitrin Crudden; Iara Troccoli Drakensjo; Naida Suleymanova; Simin Zhang; Benjamin Gebhard; Dawei Song; Shiyong Neo; Takashi Shibano et al.
Source: check_circle
Crossref

Supplementary Figure 1 from Competing engagement of β-arrestin isoforms balances IGF1R/p53 signaling and controls melanoma cell chemotherapeutic responsiveness

2024-09-16 | Preprint
Contributors: Sonia Cismas; Sylvya Pasca; Caitrin Crudden; Iara Troccoli Drakensjo; Naida Suleymanova; Simin Zhang; Benjamin Gebhard; Dawei Song; Shiyong Neo; Takashi Shibano et al.
Source: check_circle
Crossref

Supplementary Figure 2 from Competing engagement of β-arrestin isoforms balances IGF1R/p53 signaling and controls melanoma cell chemotherapeutic responsiveness

2024-09-16 | Preprint
Contributors: Sonia Cismas; Sylvya Pasca; Caitrin Crudden; Iara Troccoli Drakensjo; Naida Suleymanova; Simin Zhang; Benjamin Gebhard; Dawei Song; Shiyong Neo; Takashi Shibano et al.
Source: check_circle
Crossref

Supplementary Figure 2 from Competing engagement of β-arrestin isoforms balances IGF1R/p53 signaling and controls melanoma cell chemotherapeutic responsiveness

2024-09-16 | Preprint
Contributors: Sonia Cismas; Sylvya Pasca; Caitrin Crudden; Iara Troccoli Drakensjo; Naida Suleymanova; Simin Zhang; Benjamin Gebhard; Dawei Song; Shiyong Neo; Takashi Shibano et al.
Source: check_circle
Crossref

Supplementary Figure 3 from Competing engagement of β-arrestin isoforms balances IGF1R/p53 signaling and controls melanoma cell chemotherapeutic responsiveness

2024-09-16 | Preprint
Contributors: Sonia Cismas; Sylvya Pasca; Caitrin Crudden; Iara Troccoli Drakensjo; Naida Suleymanova; Simin Zhang; Benjamin Gebhard; Dawei Song; Shiyong Neo; Takashi Shibano et al.
Source: check_circle
Crossref

Supplementary Figure 3 from Competing engagement of β-arrestin isoforms balances IGF1R/p53 signaling and controls melanoma cell chemotherapeutic responsiveness

2024-09-16 | Preprint
Contributors: Sonia Cismas; Sylvya Pasca; Caitrin Crudden; Iara Troccoli Drakensjo; Naida Suleymanova; Simin Zhang; Benjamin Gebhard; Dawei Song; Shiyong Neo; Takashi Shibano et al.
Source: check_circle
Crossref

Supplementary Figure 4 from Competing engagement of β-arrestin isoforms balances IGF1R/p53 signaling and controls melanoma cell chemotherapeutic responsiveness

2024-09-16 | Preprint
Contributors: Sonia Cismas; Sylvya Pasca; Caitrin Crudden; Iara Troccoli Drakensjo; Naida Suleymanova; Simin Zhang; Benjamin Gebhard; Dawei Song; Shiyong Neo; Takashi Shibano et al.
Source: check_circle
Crossref

Supplementary Figure 4 from Competing engagement of β-arrestin isoforms balances IGF1R/p53 signaling and controls melanoma cell chemotherapeutic responsiveness

2024-09-16 | Preprint
Contributors: Sonia Cismas; Sylvya Pasca; Caitrin Crudden; Iara Troccoli Drakensjo; Naida Suleymanova; Simin Zhang; Benjamin Gebhard; Dawei Song; Shiyong Neo; Takashi Shibano et al.
Source: check_circle
Crossref

Supplementary Figure 5 from Competing engagement of β-arrestin isoforms balances IGF1R/p53 signaling and controls melanoma cell chemotherapeutic responsiveness

2024-09-16 | Preprint
Contributors: Sonia Cismas; Sylvya Pasca; Caitrin Crudden; Iara Troccoli Drakensjo; Naida Suleymanova; Simin Zhang; Benjamin Gebhard; Dawei Song; Shiyong Neo; Takashi Shibano et al.
Source: check_circle
Crossref

Supplementary Figure 5 from Competing engagement of β-arrestin isoforms balances IGF1R/p53 signaling and controls melanoma cell chemotherapeutic responsiveness

2024-09-16 | Preprint
Contributors: Sonia Cismas; Sylvya Pasca; Caitrin Crudden; Iara Troccoli Drakensjo; Naida Suleymanova; Simin Zhang; Benjamin Gebhard; Dawei Song; Shiyong Neo; Takashi Shibano et al.
Source: check_circle
Crossref

Supplementary Figure 6 from Competing engagement of β-arrestin isoforms balances IGF1R/p53 signaling and controls melanoma cell chemotherapeutic responsiveness

2024-09-16 | Preprint
Contributors: Sonia Cismas; Sylvya Pasca; Caitrin Crudden; Iara Troccoli Drakensjo; Naida Suleymanova; Simin Zhang; Benjamin Gebhard; Dawei Song; Shiyong Neo; Takashi Shibano et al.
Source: check_circle
Crossref

Supplementary Figure 6 from Competing engagement of β-arrestin isoforms balances IGF1R/p53 signaling and controls melanoma cell chemotherapeutic responsiveness

2024-09-16 | Preprint
Contributors: Sonia Cismas; Sylvya Pasca; Caitrin Crudden; Iara Troccoli Drakensjo; Naida Suleymanova; Simin Zhang; Benjamin Gebhard; Dawei Song; Shiyong Neo; Takashi Shibano et al.
Source: check_circle
Crossref

Supplementary Figure 7 from Competing engagement of β-arrestin isoforms balances IGF1R/p53 signaling and controls melanoma cell chemotherapeutic responsiveness

2024-09-16 | Preprint
Contributors: Sonia Cismas; Sylvya Pasca; Caitrin Crudden; Iara Troccoli Drakensjo; Naida Suleymanova; Simin Zhang; Benjamin Gebhard; Dawei Song; Shiyong Neo; Takashi Shibano et al.
Source: check_circle
Crossref

Supplementary Figure 7 from Competing engagement of β-arrestin isoforms balances IGF1R/p53 signaling and controls melanoma cell chemotherapeutic responsiveness

2024-09-16 | Preprint
Contributors: Sonia Cismas; Sylvya Pasca; Caitrin Crudden; Iara Troccoli Drakensjo; Naida Suleymanova; Simin Zhang; Benjamin Gebhard; Dawei Song; Shiyong Neo; Takashi Shibano et al.
Source: check_circle
Crossref

Supplementary Figure 8 from Competing engagement of β-arrestin isoforms balances IGF1R/p53 signaling and controls melanoma cell chemotherapeutic responsiveness

2024-09-16 | Preprint
Contributors: Sonia Cismas; Sylvya Pasca; Caitrin Crudden; Iara Troccoli Drakensjo; Naida Suleymanova; Simin Zhang; Benjamin Gebhard; Dawei Song; Shiyong Neo; Takashi Shibano et al.
Source: check_circle
Crossref

Supplementary Figure 8 from Competing engagement of β-arrestin isoforms balances IGF1R/p53 signaling and controls melanoma cell chemotherapeutic responsiveness

2024-09-16 | Preprint
Contributors: Sonia Cismas; Sylvya Pasca; Caitrin Crudden; Iara Troccoli Drakensjo; Naida Suleymanova; Simin Zhang; Benjamin Gebhard; Dawei Song; Shiyong Neo; Takashi Shibano et al.
Source: check_circle
Crossref

Table S1 from Competing engagement of β-arrestin isoforms balances IGF1R/p53 signaling and controls melanoma cell chemotherapeutic responsiveness

2024-09-16 | Preprint
Contributors: Sonia Cismas; Sylvya Pasca; Caitrin Crudden; Iara Troccoli Drakensjo; Naida Suleymanova; Simin Zhang; Benjamin Gebhard; Dawei Song; Shiyong Neo; Takashi Shibano et al.
Source: check_circle
Crossref

Table S1 from Competing engagement of β-arrestin isoforms balances IGF1R/p53 signaling and controls melanoma cell chemotherapeutic responsiveness

2024-09-16 | Preprint
Contributors: Sonia Cismas; Sylvya Pasca; Caitrin Crudden; Iara Troccoli Drakensjo; Naida Suleymanova; Simin Zhang; Benjamin Gebhard; Dawei Song; Shiyong Neo; Takashi Shibano et al.
Source: check_circle
Crossref

Table S2 from Competing engagement of β-arrestin isoforms balances IGF1R/p53 signaling and controls melanoma cell chemotherapeutic responsiveness

2024-09-16 | Preprint
Contributors: Sonia Cismas; Sylvya Pasca; Caitrin Crudden; Iara Troccoli Drakensjo; Naida Suleymanova; Simin Zhang; Benjamin Gebhard; Dawei Song; Shiyong Neo; Takashi Shibano et al.
Source: check_circle
Crossref

Table S2 from Competing engagement of β-arrestin isoforms balances IGF1R/p53 signaling and controls melanoma cell chemotherapeutic responsiveness

2024-09-16 | Preprint
Contributors: Sonia Cismas; Sylvya Pasca; Caitrin Crudden; Iara Troccoli Drakensjo; Naida Suleymanova; Simin Zhang; Benjamin Gebhard; Dawei Song; Shiyong Neo; Takashi Shibano et al.
Source: check_circle
Crossref

G protein-coupled receptors

Extracellular Vesicles and Circulating Nucleic Acids
2024-05-22 | Journal article | Author
SOURCE-WORK-ID:

d61eb6b4-b957-4837-8a69-0fc0a72f567e

EID:

2-s2.0-85198823354

Contributors: Lotte Di Niro; Amber C. Linders; Thomas Glynn; D. Michiel Pegtel; Marco Siderius; Caitrin Crudden; Martine Smit
Source: check_circle
Vrije Universiteit Amsterdam

Competing Engagement of β-arrestin Isoforms Balances IGF1R/p53 Signaling and Controls Melanoma Cell Chemotherapeutic Responsiveness

Molecular Cancer Research
2023-12-01 | Journal article | Author
SOURCE-WORK-ID:

7bd37799-bab1-4e9f-9eb9-1338976f3ca5

Contributors: Sonia Cismas; Sylvya Pasca; Caitrin Crudden; Iara Trocoli Drakensjo; Naida Suleymanova; Simin Zhang; Benjamin Gebhard; Dawei Song; Shiyong Neo; Takashi Shibano et al.
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University of Amsterdam - PURE
grade
Preferred source (of 3)‎

Exosomal release of the virus-encoded chemokine receptor US28 contributes to chemokine scavenging

iScience
2023-08-18 | Journal article | Author
SOURCE-WORK-ID:

1d89a4fd-98dd-4e55-b302-a444563898b3

Contributors: Maarten P Bebelman; Irfan M Setiawan; Nick D Bergkamp; Jeffrey R van Senten; Caitrin Crudden; Jan Paul M Bebelman; Frederik J Verweij; Guillaume van Niel; Marco Siderius; D Michiel Pegtel et al.
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University of Amsterdam - PURE
grade
Preferred source (of 2)‎

Correction

Oncogene
2023-03 | Journal article | Author
SOURCE-WORK-ID:

baf2eabd-478c-46ff-8afe-b146e78dc033

Contributors: Dawei Song; Sonia Cismas; Caitrin Crudden; Eric Trocme; Claire Worrall; Naida Suleymanova; Tingting Lin; Huiyuan Zheng; Stefan Seregard; Ada Girnita et al.
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University of Amsterdam - PURE

Luminescence-based screening for extracellular vesicle release modulators reveals a role for PI4KIIIβ in exosome biogenesis upon lysosome inhibition

2023-02-23 | Preprint
Contributors: Maarten P. Bebelman; Caitrin Crudden; Bart Snieder; Evangelia Thanou; Catharina J.M. Langedijk; Margarida Viola; Steven Eleonora; Urszula Baginska; Olaf Cotugno; Jan Paul M. Bebelman et al.
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Crossref

IGF-1R is a molecular determinant for response to p53 reactivation therapy in conjunctival melanoma

Oncogene
2022-01 | Journal article | Author
SOURCE-WORK-ID:

07e0209e-5f98-4940-9a0c-a77f427b98f3

Contributors: Dawei Song; Sonia Cismas; Caitrin Crudden; Eric Trocme; Claire Worrall; Naida Suleymanova; Tingting Lin; Huiyuan Zheng; Stefan Seregard; Ada Girnita et al.
Source: check_circle
University of Amsterdam - PURE
grade
Preferred source (of 2)‎

The forces driving cancer extracellular vesicle secretion

Neoplasia
2021-01 | Journal article
Part of ISSN: 1476-5586
Source: Self-asserted source
Caitrin Crudden

Inhibition of G Protein-Coupled Receptor Kinase 2 Promotes Unbiased Downregulation of IGF1 Receptor and Restrains Malignant Cell Growth

Cancer Research
2021-01-15 | Journal article | Author
SOURCE-WORK-ID:

9284c52c-e8f2-43b2-a380-5bb3b0300fbf

Contributors: Caitrin Crudden; Takashi Shibano; Dawei Song; Mihnea P Dragomir; Sonia Cismas; Julianna Serly; Daniela Nedelcu; Enrique Fuentes-Mattei; Andrei Tica; George A Calin et al.
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University of Amsterdam - PURE
grade
Preferred source (of 2)‎

The tale of a tail: The secret behind IGF-1R’s oncogenic power

Science Signaling
2020 | Journal article
EID:

2-s2.0-85089363043

Part of ISBN:

19379145 19450877

Contributors: Crudden, C.; Girnita, L.
Source: Self-asserted source
Caitrin Crudden via Scopus - Elsevier

The Convergence of Extracellular Vesicle and GPCR Biology.

Trends in pharmacological sciences
2020-07-22 | Journal article
Source: Self-asserted source
Caitrin Crudden
grade
Preferred source (of 3)‎

The tale of a tail: The secret behind IGF-1R’s oncogenic power

Science Signaling
2020-05-26 | Journal article
Contributors: Caitrin Crudden; Leonard Girnita
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Crossref
grade
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Below the Surface: IGF-1R Therapeutic Targeting and Its Endocytic Journey

Cells
2019-10-09 | Journal article
Contributors: Caitrin Crudden; Dawei Song; Sonia Cismas; Eric Trocmé; Sylvya Pasca; George A. Calin; Ada Girnita; Leonard Girnita
Source: check_circle
Crossref
grade
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Blurring Boundaries: Receptor Tyrosine Kinases as functional G Protein-Coupled Receptors.

International review of cell and molecular biology
2018 | Journal article
Contributors: Crudden C; Shibano T; Song D; Suleymanova N; Girnita A; Girnita L
Source: Self-asserted source
Caitrin Crudden via Europe PubMed Central
grade
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Genome-Wide Screen for MicroRNAs Reveals a Role for miR-203 in Melanoma Metastasis

Journal of Investigative Dermatology
2018-04 | Journal article | Author
SOURCE-WORK-ID:

edf0a984-ef80-49dd-8d98-7e3f6e324f70

Contributors: Warangkana Lohcharoenkal; Kunal Das Mahapatra; Lorenzo Pasquali; Caitrin Crudden; Lara Kular; Yeliz Z Akkaya Ulum; Lingyun Zhang; Ning Xu Landén; Leonard Girnita; Maja Jagodic et al.
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University of Amsterdam - PURE
grade
Preferred source (of 5)‎

Functional antagonism of β-arrestin isoforms balance IGF-1R expression and signalling with distinct cancer-related biological outcomes

Oncogene
2017-10-12 | Journal article | Author
SOURCE-WORK-ID:

c6acb180-fa39-48df-95b6-432eb66717db

EID:

2-s2.0-85030854058

Contributors: N. Suleymanova; Caitrin Crudden; T. Shibano; C. Worrall; I. Oprea; A. Tica; G. A. Calin; A. Girnita; L. Girnita
Source: check_circle
University of Amsterdam - PURE
grade
Preferred source (of 5)‎

Enhanced response of melanoma cells to MEK inhibitors following unbiased IGF-1R down-regulation

Oncotarget
2017-10-10 | Journal article | Author
SOURCE-WORK-ID:

a0afeeb6-3bb2-4459-8783-2df5e14e891c

Contributors: Naida Suleymanova; Caitrin Crudden; Claire Worrall; Anica Dricu; Ada Girnita; Leonard Girnita
Source: check_circle
University of Amsterdam - PURE
grade
Preferred source (of 5)‎

Unbalancing p53/Mdm2/IGF-1R axis by Mdm2 activation restrains the IGF-1-dependent invasive phenotype of skin melanoma

Oncogene
2017-06-08 | Journal article | Author
SOURCE-WORK-ID:

4194b49e-621d-46c5-a855-41ee289cfc98

EID:

2-s2.0-85009782258

Contributors: C. Worrall; N. Suleymanova; Caitrin Crudden; I. Trocoli Drakensjö; E. Candrea; D. Nedelcu; S. I. Takahashi; L. Girnita; A. Girnita
Source: check_circle
University of Amsterdam - PURE
grade
Preferred source (of 5)‎

Chapter Seven - When Phosphorylation Encounters Ubiquitination

Ubiquitination and Transmembrane Signaling
2016 | Book chapter | Author
SOURCE-WORK-ID:

032812bc-fde9-44a4-9ab5-81cd3457dd2c

EID:

2-s2.0-84964587209

Part of ISBN: 9780128093863
Contributors: L. Girnita; S. I. Takahashi; Caitrin Crudden; T. Fukushima; C. Worrall; H. Furuta; H. Yoshihara; F. Hakuno; A. Girnita
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University of Amsterdam - PURE
grade
Preferred source (of 5)‎

Differential Regulation of IGF-1 and Insulin Signaling by GRKs

G Protein-Coupled Receptor Kinases
2016 | Book chapter | Author
SOURCE-WORK-ID:

b036875c-9d3f-4d08-946a-93cc00b07644

EID:

2-s2.0-85100434941

Contributors: Leonard Girnita; Ada Girnita; Caitrin Crudden
Source: check_circle
University of Amsterdam - PURE

Targeting the IGF-1R: The Tale of the Tortoise and the Hare.

2015 | Journal article
Contributors: Crudden C; Girnita A; Girnita L
Source: Self-asserted source
Caitrin Crudden via Europe PubMed Central
grade
Preferred source (of 3)‎

The dichotomy of the Insulin-like growth factor 1 receptor: RTK and GPCR: friend or foe for cancer treatment?

2015-02 | Journal article
Contributors: Crudden C; Ilic M; Suleymanova N; Worrall C; Girnita A; Girnita L
Source: Self-asserted source
Caitrin Crudden via Europe PubMed Central
grade
Preferred source (of 4)‎

Peer review (16 reviews for 5 publications/grants)

Review activity for Cancers. (2)
Review activity for Cells. (10)
Review activity for Clinical and experimental immunology (1)
Review activity for Journal of extracellular vesicles. (2)
Review activity for Oncogenesis. (1)