Personal information

Other IDs

SciProfiles: 2669886

Countries

Singapore

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Employment (6)

Institute of Sustainability for Chemicals, Energy and Environment: Singapore, SG

2022-04-01 to present | Director (Chemical Biotechnology and Biocatalysis)
Employment
Source: Self-asserted source
Yee Hwee Lim

Institute of Chemical and Engineering Sciences: Singapore, SG

2021-08-01 to 2022-03-31 | Covering Head of Division (Functional Molecules & Polymers)
Employment
Source: Self-asserted source
Yee Hwee Lim

Institute of Chemical and Engineering Sciences: Singapore, SG

2021-04-01 to 2022-03-31 | Senior Scientist (Functional Molecules & Polymers)
Employment
Source: Self-asserted source
Yee Hwee Lim

Institute of Chemical and Engineering Sciences: Singapore, SG

2020-04-01 to 2021-03-31 | Scientist (Functional Molecules & Polymers)
Employment
Source: Self-asserted source
Yee Hwee Lim

Institute of Chemical and Engineering Sciences: Singapore, SG

2010-08-16 to 2020-03-31 | Scientist (Organic Chemistry)
Employment
Source: Self-asserted source
Yee Hwee Lim

Nanyang Technological University: Singapore, SG

2013-07-01 to 2018-06-30 | Adjunct Assistant Professor (Lee Kong Chian School of Medicine)
Employment
Source: Self-asserted source
Yee Hwee Lim

Education and qualifications (3)

University of Bristol: Bristol, GB

2001-10 to 2014-06 | BSc (Hons) First Class in Chemistry
Education
Source: Self-asserted source
Yee Hwee Lim

University of Oxford: Oxford, GB

2005-06-25 to 2010-07-06 | D.Phil (Biochemistry) (Chemistry)
Education
Source: Self-asserted source
Yee Hwee Lim

The Scripps Research Institute: La Jolla, California, US

2005-06-25 to 2010-07-06 | Ph.D. (Organic Chemistry)
Education
Source: Self-asserted source
Yee Hwee Lim

Professional activities (1)

Agency for Science, Technology and Research: Singapore, SG

2021-09-01 to 2023-08-31 | Editorial Board Member (A*STAR Research Publications)
Service
Source: Self-asserted source
Yee Hwee Lim

Funding (7)

An integrative approach to build a microbial alkaloid production platform for biotechnology

2018-08 to 2023-07 | Grant
NRF Competitive Research Programme (CRP) (Singapore, SG)
GRANT_NUMBER:

NRF-CRP19-2017-05
Source: Self-asserted source
Yee Hwee Lim

Develop efficient computational/experimental workflow to increase enzyme evolution speed and create new oxidation enzyme panels

2018-04 to 2019-04 | Grant
A*STAR SERC Strategic Fund (Singapore, SG)
GRANT_NUMBER:

A1718g0092
Source: Self-asserted source
Yee Hwee Lim

Activating Cryptic Biosynthetic Gene Clusters in Native Streptomyces Hosts for Natural Product Discovery

2015-03 to 2018-11 | Grant
National Research Foundation (Singapore, SG)
GRANT_NUMBER:

NRF2013-THE001-094
Source: Self-asserted source
Yee Hwee Lim

Advancement of 11C Radiolabeling and Microfluidic Technologies for PET Imaging

2015-02 to 2018-08 | Grant
National Medical Research Council (Singapore, SG)
GRANT_NUMBER:

CBRG14may036
Source: Self-asserted source
Yee Hwee Lim

Development of a fluorinase screening kit through coevolution of enzyme and substrates

2013-08 to 2016-10 | Grant
GSK-EBD (Singapore, SG)
Source: Self-asserted source
Yee Hwee Lim

Enabling technologies to advance radiochemistry for molecular imaging

2012-07 to 2016-01 | Grant
A*STAR Joint Council Organization (Singapore, SG)
GRANT_NUMBER:

JCO 1230400020
Source: Self-asserted source
Yee Hwee Lim

Rapid Synthesis of any 18F-Aromatic Substrates via the Diels–Alder/retro-Diels–Alder Reactions

2012-04 to 2013-08 | Grant
A*STAR Joint Council Organization (Singapore, SG)
GRANT_NUMBER:

12302EG013
Source: Self-asserted source
Yee Hwee Lim

Works (45)

Application of Cas12j for <i>Streptomyces</i> Editing

Biomolecules
2024-04 | Journal article | Author
DOI: 10.3390/biom14040486
Contributors: Lee Ling Tan; Elena Heng; Chung Yan Leong; Veronica Ng; Lay Kien Yang; Deborah Chwee San Seow; Lokanand Koduru; Yoganathan Kanagasundaram; Siew Bee Ng; GuangRong Peh et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

The Engineering, Expression, and Immobilization of Epimerases for <i>D</i>-allulose Production

International Journal of Molecular Sciences
2023-08 | Journal article | Author
DOI: 10.3390/ijms241612703
Contributors: Jin Hao Tan; Anqi Chen; Jiawu Bi; Yee Hwee Lim; Fong Tian Wong; Dave Siak-Wei Ow
Source: check_circle
Multidisciplinary Digital Publishing Institute

Further Characterization of Fungal Halogenase RadH and Its Homologs

Biomolecules
2023-07 | Journal article | Author
DOI: 10.3390/biom13071081
Contributors: GuangRong Peh; Gregory A. Gunawan; Terence Tay; Elaine Tiong; Lee Ling Tan; Shimin Jiang; Yi Ling Goh; Suming Ye; Joel Wen Han Wong; Christopher J. Brown et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

Structural investigation of Fe(III)-salen complexes as “turn-on” fluorogenic probes for selective detection of pyrophosphate ions

Dyes and Pigments
2022-11 | Journal article
DOI: 10.1016/j.dyepig.2022.110708
Part of ISSN: 0143-7208
Contributors: Eunice Y.-L. Hui; Dillon W.P. Tay; Jean-Alexandre Richard; Zuzana Pohancenikova; Kevin Renault; Anthony Romieu; Yee Hwee Lim
Source: Self-asserted source
Yee Hwee Lim via Crossref Metadata Search

A Mild and Regioselective Route to Fluoroalkyl Aromatic Compounds via Directed Cycloaddition Reactions

The Journal of Organic Chemistry
2022-07-08 | Journal article
DOI: 10.1021/acs.joc.2c00800
Part of ISSN: 0022-3263
Contributors: David L. Cousins; Yee Hwee Lim; Joseph P. A. Harrity
Source: Self-asserted source
Yee Hwee Lim via Crossref Metadata Search

Pyrimidin‐6‐yl Trifluoroborate Salts as Versatile Templates for Heterocycle Synthesis

Angewandte Chemie
2021-03 | Journal article
DOI: 10.1002/ange.202101297
Part of ISSN: 0044-8249
Contributors: David L. Cousins; Prisca Fricero; Kenji P. M. Kopf; Elliot J. McColl; Werngard Czechtizky; Yee Hwee Lim; Joseph P. A. Harrity
Source: Self-asserted source
Yee Hwee Lim via Crossref Metadata Search
grade
Preferred source (of 3)‎

Direct Deoxydehydration of Cyclic <i>trans</i> ‐Diol Substrates: An Experimental and Computational Study of the Reaction Mechanism of Vanadium(V)‐based Catalysis**

ChemSusChem
2021-02-09 | Journal article
DOI: 10.1002/cssc.202002594
Part of ISSN: 1864-5631
Contributors: Ebru Aksanoglu; Yee Hwee Lim; Richard A. Bryce
Source: Self-asserted source
Yee Hwee Lim via Crossref Metadata Search

Chemistry, Enzymology and Applications of Fluorinase

Frontiers of Organofluorine Chemistry
2020 | Other
DOI: 10.1142/9781786347336_0012
Contributors: Yee Hwee Lim; Ee Lui Ang
Source: Self-asserted source
Yee Hwee Lim via Crossref Metadata Search

Biosynthetic engineering of the antifungal, anti-MRSA auroramycin

Microbial Cell Factories
2020-01-06 | Journal article
DOI: 10.1186/s12934-019-1274-y
Part of ISSN: 1475-2859
Contributors: Wan Lin Yeo; Elena Heng; Lee Ling Tan; Yi Wee Lim; Kuan Chieh Ching; De-Juin Tsai; Yi Wun Jhang; Tsai-Ling Lauderdale; Kak-Shan Shia; Huimin Zhao et al.
Source: Self-asserted source
Yee Hwee Lim via Crossref Metadata Search
grade
Preferred source (of 3)‎

Correction: Chemogenomic profiling in yeast reveals antifungal mode-of-action of polyene macrolactam auroramycin

PLOS ONE
2019-08-08 | Journal article
DOI: 10.1371/journal.pone.0221074
Part of ISSN: 1932-6203
Contributors: Jin Huei Wong; Mohammad Alfatah; Kiat Whye Kong; Shawn Hoon; Wan Lin Yeo; Kuan Chieh Ching; Corinna Jie Hui Goh; Mingzi M. Zhang; Yee Hwee Lim; Fong Tian Wong et al.
Source: Self-asserted source
Yee Hwee Lim via Crossref Metadata Search

Effect of microchannel junction angle on two-phase liquid-gas Taylor flow

Chemical Engineering Science
2019-07 | Journal article
DOI: 10.1016/j.ces.2019.03.044
Part of ISSN: 0009-2509
Contributors: An Eng Lim; Chun Yee Lim; Yee Cheong Lam; Yee Hwee Lim
Source: Self-asserted source
Yee Hwee Lim via Crossref Metadata Search

Chemogenomic profiling in yeast reveals antifungal mode-of-action of polyene macrolactam auroramycin

PLOS ONE
2019-06-10 | Journal article
DOI: 10.1371/journal.pone.0218189
Part of ISSN: 1932-6203
Contributors: Jin Huei Wong; Mohammad Alfatah; Kiat Whye Kong; Shawn Hoon; Wan Lin Yeo; Kuan Chieh Ching; Corinna Jie Hui Goh; Mingzi M. Zhang; Yee Hwee Lim; Fong Tian Wong et al.
Source: Self-asserted source
Yee Hwee Lim via Crossref Metadata Search

Auroramycin: A Potent Antibiotic from Streptomyces roseosporus by CRISPR-Cas9 Activation

ChemBioChem
2018-06 | Journal article
DOI: 10.1002/cbic.201800266
Part of ISSN: 1439-4227
Contributors: Yee Hwee Lim; Fong Tian Wong; Wan Lin Yeo; Kuan Chieh Ching; Yi Wee Lim; Elena Heng; Shuwen Chen; De-Juin Tsai; Tsai-Ling Lauderdale; Kak-Shan Shia et al.
Source: Self-asserted source
Yee Hwee Lim via Crossref Metadata Search

One-Pot Palladium-Catalyzed Cross-Coupling Treble of Borylation, the Suzuki Reaction and Amination

Advanced Synthesis & Catalysis
2017 | Journal article
Source: Self-asserted source
Yee Hwee Lim

Probing the molecular determinants of fluorinase specificity

Chemical Communications
2017 | Journal article
Source: Self-asserted source
Yee Hwee Lim

Empirical and Computational Insights into N-Arylation Reactions Catalyzed by Palladium meta-Terarylphosphine Catalyst

ChemPlusChem
2017-04 | Journal article
DOI: 10.1002/cplu.201700042
Part of ISSN: 2192-6506
Contributors: Fui Fong Yong; Adrian M. Mak; Wenqin Wu; Michael B. Sullivan; Edward G. Robins; Charles W. Johannes; Howard Jong; Yee Hwee Lim
Source: Self-asserted source
Yee Hwee Lim via Crossref Metadata Search

CRISPR–Cas9 strategy for activation of silent Streptomyces biosynthetic gene clusters

Nature Chemical Biology
2017-04-10 | Journal article
DOI: 10.1038/nchembio.2341
Part of ISSN: 1552-4450
Contributors: Mingzi M Zhang; Fong Tian Wong; Yajie Wang; Shangwen Luo; Yee Hwee Lim; Elena Heng; Wan Lin Yeo; Ryan E Cobb; Behnam Enghiad; Ee Lui Ang et al.
Source: Self-asserted source
Yee Hwee Lim via Crossref Metadata Search

Decarboxylative/Sonogashira-type cross-coupling using PdCl 2 (Cy* Phine) 2

RSC Advances
2016 | Journal article
Source: Self-asserted source
Yee Hwee Lim

Mechanistic Insights and Implications of Dearomative Rearrangement in Copper-Free Sonogashira Cross-Coupling Catalyzed by Pd-Cy* Phine

Organometallics
2016 | Journal article
Source: Self-asserted source
Yee Hwee Lim

Directed Evolution of a Fluorinase for Improved Fluorination Efficiency with a Non-native Substrate

Angewandte Chemie International Edition
2016-10 | Journal article
DOI: 10.1002/anie.201606722
Contributors: Huihua Sun; Wan Lin Yeo; Yee Hwee Lim; Xinying Chew; Derek John Smith; Bo Xue; Kok Ping Chan; Robert C. Robinson; Edward G. Robins; Huimin Zhao et al.
Source: Self-asserted source
Yee Hwee Lim via Crossref Metadata Search

Palladium precatalysts containing meta-terarylphosphine ligands for expedient copper-free Sonogashira cross-coupling reactions

Catalysis Science & Technology
2015 | Journal article
Source: Self-asserted source
Yee Hwee Lim

Palladium-meta-Terarylphosphine Catalyst for the Mizoroki--Heck Reaction of (Hetero) Aryl Bromides and Functional Olefins

The Journal of organic chemistry
2015 | Journal article
Source: Self-asserted source
Yee Hwee Lim

A Versatile and Efficient Palladium--meta-Terarylphosphine Catalyst for the Copper-Free Sonogashira Coupling of (Hetero-) Aryl Chlorides and Alkynes

European Journal of Organic Chemistry
2014 | Journal article
Source: Self-asserted source
Yee Hwee Lim

Facile synthesis of enol ethers via Zn (OTf) 2-mediated formal alkyne hydration-Smiles rearrangement

RSC Advances
2014 | Journal article
Source: Self-asserted source
Yee Hwee Lim

Phosphorus-containing catalysts

2014-08 | Patent
Source: Self-asserted source
Yee Hwee Lim

Direct conversion of indoles to 3, 3-difluoro-2-oxindoles via electrophilic fluorination

Organic letters
2012 | Journal article
Source: Self-asserted source
Yee Hwee Lim

Metal-Free Oxidative Fluorination of Phenols with [ 18 F]Fluoride

Angewandte Chemie International Edition
2012-05 | Journal article
DOI: 10.1002/anie.201201502
Contributors: Zhanghua Gao; Yee Hwee Lim; Matthew Tredwell; Lei Li; Stefan Verhoog; Matthew Hopkinson; Wojciech Kaluza; Thomas Lee Collier; Jan Passchier; Mickael Huiban et al.
Source: Self-asserted source
Yee Hwee Lim via Crossref Metadata Search

Fluorine Radiolabelling Process

2011-07 | Patent
Source: Self-asserted source
Yee Hwee Lim

Fluorine Radiolabelling Process

2011-07 | Patent
Source: Self-asserted source
Yee Hwee Lim

Fluorine Radiolabelling Process

2011-07 | Patent
Source: Self-asserted source
Yee Hwee Lim

Synthesis of an Advanced Maoecrystal V Core Structure

Chemistry - A European Journal
2011-04 | Journal article
DOI: 10.1002/chem.201100232
Contributors: Lin Dong; Lujiang Deng; Yee Hwee Lim; Gulice Y. C. Leung; David Y.-K. Chen
Source: Self-asserted source
Yee Hwee Lim via Crossref Metadata Search

Total sysntheses of bisanthraquinones through cascade reactions 18F-radiochemistry to advance cancer imaging

2010 | Dissertation or Thesis
Source: Self-asserted source
Yee Hwee Lim

Origins of Regioselectivity of Diels- Alder Reactions for the Synthesis of Bisanthraquinone Antibiotic BE-43472B

The Journal of organic chemistry
2009 | Journal article
Source: Self-asserted source
Yee Hwee Lim

Total Synthesis and Biological Evaluation of (+)- and (−)-Bisanthraquinone Antibiotic BE-43472B and Related Compounds

Journal of the American Chemical Society
2009-10 | Journal article
DOI: 10.1021/ja9073694
Contributors: K. C. Nicolaou; Jochen Becker; Yee Hwee Lim; Alexandre Lemire; Thomas Neubauer; Ana Montero
Source: Self-asserted source
Yee Hwee Lim via Crossref Metadata Search

Cover Picture: Total Synthesis and Absolute Configuration of the Bisanthraquinone Antibiotic BE-43472B (Angew. Chem. Int. Ed. 19/2009)

Angewandte Chemie International Edition
2009-04 | Journal article
DOI: 10.1002/anie.200990095
Contributors: K. C. Nicolaou; Yee Hwee Lim; Jochen Becker
Source: Self-asserted source
Yee Hwee Lim via Crossref Metadata Search

Total Synthesis and Absolute Configuration of the Bisanthraquinone Antibiotic BE-43472B

Angewandte Chemie International Edition
2009-04 | Journal article
DOI: 10.1002/anie.200900058
Contributors: K. C. Nicolaou; Yee Hwee Lim; Jochen Becker
Source: Self-asserted source
Yee Hwee Lim via Crossref Metadata Search

Total Syntheses of 2,2‘- epi -Cytoskyrin A, Rugulosin, and the Alleged Structure of Rugulin

Journal of the American Chemical Society
2007-04 | Journal article
DOI: 10.1021/ja0685708
Contributors: K. C. Nicolaou; Yee Hwee Lim; Jared L. Piper; Charles D. Papageorgiou
Source: Self-asserted source
Yee Hwee Lim via Crossref Metadata Search

Benzothiophene Derivatives: Preparation and Pharmaceutical Applications

2006-09 | Patent
Source: Self-asserted source
Yee Hwee Lim

Total Synthesis of (+)-Rugulosin and (+)-2,2′-epi-Cytoskyrin A through Cascade Reactions

Angewandte Chemie International Edition
2005 | Journal article
DOI: 10.1002/anie.200503678
Contributors: K. C. Nicolaou; Yee Hwee Lim; Charles D. Papageorgiou; Jared L. Piper
Source: Self-asserted source
Yee Hwee Lim via Crossref Metadata Search

A Spirobicyclo[3.1.0] Terpene from the Investigation of Sesquiter-pene Synthases from Lactarius deliciosus

Other
DOI: 10.26434/chemrxiv-2022-15mnl
Contributors: Choon Boon Cheong; Guangrong Peh; Yifeng Wei; Rehka T; Ee Lui Ang; Huimin Zhao; Congqiang Zhang; Yee Hwee Lim
Source: Self-asserted source
Yee Hwee Lim via Crossref Metadata Search

Application of Cas12j for <i>Streptomyces</i> editing and cluster activation

Other
DOI: 10.1101/2021.10.28.465406
Contributors: Lee Ling Tan; Elena Heng; Nadiah Zulkarnain; Chung Yan Leong; Veronica Ng; Lay Kien Yang; Deborah Chwee San Seow; Guangrong Peh; Yee Hwee Lim; Koduru Lokanand et al.
Source: Self-asserted source
Yee Hwee Lim via Crossref Metadata Search

Characterization of Cas proteins for CRISPR-Cas editing in streptomycetes

Other
DOI: 10.1101/526996
Contributors: Wan Lin Yeo; Elena Heng; Lee Ling Tan; Yi Wee Lim; Yee Hwee Lim; Shawn Hoon; Huimin Zhao; Mingzi M Zhang; Fong T. Wong
Source: Self-asserted source
Yee Hwee Lim via Crossref Metadata Search

Direct Deoxydehydration of Cyclic Trans-Diol Substrates: An Experimental and Computational Study of the Reaction Mechanism of vanadium(V)-Based Catalysis

Other
DOI: 10.26434/chemrxiv.13140428.v1
Contributors: Ebru Aksanoglu; Yee Hwee Lim; Richard Bryce
Source: Self-asserted source
Yee Hwee Lim via Crossref Metadata Search

Structural investigation of Fe(III)-salen complexes as "turn-on" fluorogenic probes for selective detection of pyrophosphate ions

Other
DOI: 10.26434/chemrxiv-2022-xqlqc
Contributors: Eunice Y.-L. HUI; Dillon W. P. TAY; Jean-Alexandre RICHARD; Zuzana POHANCENIKOVA; Kévin RENAULT; Anthony ROMIEU; Yee Hwee LIM
Source: Self-asserted source
Yee Hwee Lim via Crossref Metadata Search

Training old dogs to do new tricks: A general multi-pronged activation approach for natural product discovery in Actinomycetes

Other
DOI: 10.21203/rs.3.rs-2055033/v1
Contributors: Dillon Tay; Lee Ling Tan; Elena Heng; Nadiah Zulkarnain; Kuan Chieh Ching; Mario Wibowo; Elaine Chin; Zann Tan; Chung Yan Leong; Veronica Ng et al.
Source: Self-asserted source
Yee Hwee Lim via Crossref Metadata Search

Peer review (4 reviews for 3 publications/grants)

Review activity for ChemistrySelect (2)
Review activity for Journal of organic chemistry. (1)
Review activity for Organic letters. (1)
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