Joachim Griesenbeck (0000-0002-7817-6095)

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since 2016 Associate Professor at the NWFIII at the University of Regensburg, Lehrstuhl Biochemie III
since 2010 Permanent academic staff member (principal investigator) at the University of Regensburg (Germany), Lehrstuhl Biochemie III
2006 - 2010 Habilitation in Biochemistry at the NWFIII at the University of Regensburg (Germany)
2004 - 2010 Group Leader at the University of Regensburg (Germany), Lehrstuhl Biochemie III
2003 - 2004 Life Science Research Associate at Stanford University (U.S.A.), Department of Structural Biology, Laboratory of Prof. Dr. Roger D. Kornberg
1998 - 2003 Postdoctoral Researcher at Stanford University (U.S.A.), Department of Structural Biology, Laboratory of Prof. Dr. Roger D. Kornberg
1994 - 1998 Ph.D. Thesis at the Free University of Berlin (Germany), Institut für Biochemie, Laboratory of Prof. Dr. Dr. Manfred Schweiger

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Institut für Biochemie, Genetik und Mikrobiologie, Universität Regensburg: Regensburg, Bavaria, DE

2004-09-01 to present | Associate Professor (Biochemie III)

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Joachim Griesenbeck

https://orcid.org/0000-0002-7817-6095

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Institut für Biochemie, Genetik und Mikrobiologie, Universität Regensburg: Regensburg, Bavaria, DE

Works (50 of 55)

Features of yeast RNA polymerase I with special consideration of the lobe binding subunits

Synthesis of the ribosomal RNA precursor in human cells: mechanisms, factors and regulation

Impact of the yeast S0/uS2-cluster ribosomal protein rpS21/eS21 on rRNA folding and the architecture of small ribosomal subunit precursors

Impact of the yeast S0/uS2-cluster ribosomal protein rpS21/eS21 on rRNA folding and the architecture of small ribosomal subunit precursors

RNA polymerase I (Pol I) lobe-binding subunit Rpa12.2 promotes RNA cleavage and proofreading

Analysis of subunit folding contribution of three yeast large ribosomal subunit proteins required for stabilisation and processing of intermediate nuclear rRNA precursors

Analysis of subunit folding contribution of three yeast large ribosomal subunit proteins required for stabilisation and processing of intermediate nuclear rRNA precursors

Effects of polyploidy on the coordination of gene expression between organellar and nuclear genomes in Leucanthemum Mill. (Compositae, Anthemideae)

The C-terminal region of Net1 is an activator of RNA polymerase I transcription with conserved features from yeast to human

ALY RNA-Binding Proteins Are Required for Nucleocytosolic mRNA Transport and Modulate Plant Growth and Development

Analysis of In Vivo Chromatin and Protein Interactions of Arabidopsis Transcript Elongation Factors.

Structural transitions during large ribosomal subunit maturation analyzed by tethered nuclease structure probing in S. cerevisiae.

Structure and Function of RNA Polymerases and the Transcription Machineries.

The Composition of the Arabidopsis RNA Polymerase II Transcript Elongation Complex Reveals the Interplay between Elongation and mRNA Processing Factors

Analysis of S. cerevisiae RNA Polymerase I Transcription In Vitro.

Structure of the initiation-competent RNA polymerase I and its implication for transcription.

Prenatal Exposure to Nitrosatable Drugs, Dietary Intake of Nitrites, and Preterm Birth.

Chromatin Endogenous Cleavage (ChEC) as a Method to Quantify Protein Interaction with Genomic DNA in Saccharomyces cerevisiae.

Chromatin structure analysis of single gene molecules by psoralen cross-linking and electron microscopy.

Studies on the Coordination of Ribosomal Protein Assembly Events Involved in Processing and Stabilization of Yeast Early Large Ribosomal Subunit Precursors.

Purification of specific chromatin domains from single-copy gene loci in Saccharomyces cerevisiae.

Binding of the termination factor Nsi1 to its cognate DNA site is sufficient to terminate RNA polymerase I transcription in vitro and to induce termination in vivo.

Compositional and structural analysis of selected chromosomal domains from Saccharomyces cerevisiae.

UV light-induced DNA lesions cause dissociation of yeast RNA polymerases-I and establishment of a specialized chromatin structure at rRNA genes.

Chromatin states at ribosomal DNA loci.

RNA polymerase I termination: Where is the end?

Studies on the assembly characteristics of large subunit ribosomal proteins in S. cerevisae.

Rrp5p, Noc1p and Noc2p form a protein module which is part of early large ribosomal subunit precursors in S. cerevisiae.

Chromatin endogenous cleavage and psoralen crosslinking assays to analyze rRNA gene chromatin in vivo.

Interrelationships between yeast ribosomal protein assembly events and transient ribosome biogenesis factors interactions in early pre-ribosomes.

Local tertiary structure probing of ribonucleoprotein particles by nuclease fusion proteins.

The Reb1-homologue Ydr026c/Nsi1 is required for efficient RNA polymerase I termination in yeast.

Selective removal of promoter nucleosomes by the RSC chromatin-remodeling complex.

Establishment and maintenance of alternative chromatin states at a multicopy gene locus.

Occlusion of regulatory sequences by promoter nucleosomes in vivo.

Reduction in ribosomal protein synthesis is sufficient to explain major effects on ribosome production after short-term TOR inactivation in Saccharomyces cerevisiae.

TOR-dependent reduction in the expression level of Rrn3p lowers the activity of the yeast RNA Pol I machinery, but does not account for the strong inhibition of rRNA production.

Alternative chromatin structures of the 35S rRNA genes in Saccharomyces cerevisiae provide a molecular basis for the selective recruitment of RNA polymerases I and II.

Actively transcribed rRNA genes in S. cerevisiae are organized in a specialized chromatin associated with the high-mobility group protein Hmo1 and are largely devoid of histone molecules.

Nucleosome retention and the stochastic nature of promoter chromatin remodeling for transcription.

Site specific phosphorylation of yeast RNA polymerase I.

Structural basis of eukaryotic gene transcription.

Purification of defined chromosomal domains.

Removal of promoter nucleosomes by disassembly rather than sliding in vivo.

Affinity purification of specific chromatin segments from chromosomal loci in yeast.

Nucleosomes unfold completely at a transcriptionally active promoter.

A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3.

A novel human DNA-binding protein with sequence similarity to a subfamily of redox proteins which is able to repress RNA-polymerase-III-driven transcription of the Alu-family retroposons in vitro.

Stimulation of the catalytic activity of poly(ADP-ribosyl) transferase by transcription factor Yin Yang 1.

Regulation of RNA polymerase II-dependent transcription by poly(ADP-ribosyl)ation of transcription factors.

Peer review (2 reviews for 2 publications/grants)