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Scopus Author ID: 55769881800

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Employment (2)

University of North Carolina at Chapel Hill: Chapel Hill, NC, US

2020-07-01 to present | Assistant Professor (Genetics)
Employment
Source: Self-asserted source
Laura Raffield

University of North Carolina: Chapel Hill, NC, US

2015-07 to 2020-06-30 | Postdoctoral Fellow (Genetics)
Employment
Source: Self-asserted source
Laura Raffield

Education and qualifications (2)

Wake Forest School of Medicine: Winston-Salem, NC, US

2011-08 to 2015-06 | PhD (Molecular Genetics and Genomics)
Qualification
Source: Self-asserted source
Laura Raffield

University of North Carolina: Chapel Hill, NC, US

2007-08 to 2011-05 | BS (Biology)
Qualification
Source: Self-asserted source
Laura Raffield

Works (50 of 130)

Items per page:
Page 1 of 3

Characterization of the phenotypic consequences of the Duffy-null genotype

Blood Advances
2025-03-25 | Journal article
DOI: 10.1182/bloodadvances.2024014399
Contributors: Micah R. Hysong; Megan M. Shuey; Jennifer E. Huffman; Paul Auer; Alexander Reiner; Laura M. Raffield
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Crossref

Cross-Ancestry Comparison of Aptamer and Antibody Proteomics Measures

2025-02-13 | Preprint
DOI: 10.21203/rs.3.rs-5968391/v1
Contributors: Laura Raffield; Jayna Nicholas; Daniel Katz; Usman Tahir; Catherine Debban; Francois Aguet; Tom Blackwell; Russell Bowler; Kelsy Broadaway; Jingsha Chen et al.
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Crossref

Variational Autoencoder-based Model Improves Polygenic Prediction in Blood Cell Traits

2025-01-18 | Preprint
DOI: 10.1101/2025.01.13.632820
Contributors: Xiaoqi Li; Minxing Pang; Jia Wen; Laura Y. Zhou; Laura M. Raffield; Haibo Zhou; Huaxiu Yao; Can Chen; Quan Sun; Yun Li
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Crossref

Epigenome-wide association study meta-analysis of BMI in African American Adults

2025-01-16 | Preprint
DOI: 10.1101/2025.01.15.25320607
Contributors: Kendra Ferrier; Mariaelisa Graff; Iain R. Konigsberg; Maggie Stanislawski; Heather M. Highland; Laura M. Raffield; April P. Carson; Eric Boerwinkle; Jill M. Norris; Chris R. Gignoux et al.
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Crossref

Whole-genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles

Blood
2024-11-21 | Journal article
DOI: 10.1182/blood.2023022596
Contributors: Jennifer E. Huffman; Jayna Nicholas; Julie Hahn; Adam S. Heath; Laura M. Raffield; Lisa R. Yanek; Jennifer A. Brody; Florian Thibord; Laura Almasy; Traci M. Bartz et al.
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Crossref

EndoPRS: Incorporating Endophenotype Information to Improve Polygenic Risk Scores for Clinical Endpoints

2024-05-24 | Preprint
DOI: 10.1101/2024.05.23.24307839
Contributors: Elena V. Kharitonova; Quan Sun; Frank Ockerman; Brian Chen; Laura Y. Zhou; Hongyuan Cao; Rasika A. Mathias; Paul L. Auer; Carole Ober; Laura M. Raffield et al.
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Crossref

A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels

Blood
2024-05-02 | Journal article
DOI: 10.1182/blood.2023021452
Contributors: Paul S. de Vries; Paula Reventun; Michael R. Brown; Adam S. Heath; Jennifer E. Huffman; Ngoc-Quynh Le; Allison Bebo; Jennifer A. Brody; Gerard Temprano-Sagrera; Laura M. Raffield et al.
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Crossref

Association analysis of mitochondrial DNA heteroplasmic variants: methods and application

2024-01-13 | Preprint
DOI: 10.1101/2024.01.12.24301233
Contributors: Xianbang Sun; Katia Bulekova; Jian Yang; Meng Lai; Achilleas N. Pitsillides; Xue Liu; Yuankai Zhang; Xiuqing Guo; Qian Yong; Laura M. Raffield et al.
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Crossref

Branched chain amino acids harbor distinct and often opposing effects on health and disease

Communications Medicine
2023-11-28 | Journal article
DOI: 10.1038/s43856-023-00382-x
Contributors: Christy L. Avery; Annie Green Howard; Harold H. Lee; Carolina G. Downie; Moa P. Lee; Sarah H. Koenigsberg; Anna F. Ballou; Michael H. Preuss; Laura M. Raffield; Rina A. Yarosh et al.
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Crossref

Association Between Whole Blood–Derived Mitochondrial DNA Copy Number, Low‐Density Lipoprotein Cholesterol, and Cardiovascular Disease Risk

Journal of the American Heart Association
2023-10-17 | Journal article
DOI: 10.1161/JAHA.122.029090
Contributors: Xue Liu; Xianbang Sun; Yuankai Zhang; Wenqing Jiang; Meng Lai; Kerri L. Wiggins; Laura M. Raffield; Lawrence F. Bielak; Wei Zhao; Achilleas Pitsillides et al.
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Crossref

Gene Expression and Splicing QTL Analysis of Blood Cells in African American Participants from the Jackson Heart Study

2023-04-29 | Preprint
DOI: 10.1101/2023.04.26.538455
Contributors: Jia Wen; Quan Sun; Le Huang; Lingbo Zhou; Margaret F. Doyle; Lynette Ekunwe; Nels C. Olson; Alexander P. Reiner; Yun Li; Laura M. Raffield
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Crossref

Circulating Soluble CD163, Associations With Cardiovascular Outcomes and Mortality, and Identification of Genetic Variants in Older Individuals: The Cardiovascular Health Study

Journal of the American Heart Association
2022-11 | Journal article
DOI: 10.1161/JAHA.121.024374
Contributors: Peter Durda; Laura M. Raffield; Ethan M. Lange; Nels C. Olson; Nancy Swords Jenny; Mary Cushman; Pia Deichgraeber; Niels Grarup; Anna Jonsson; Torben Hansen et al.
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The association between mitochondrial DNA copy number, low-density lipoprotein cholesterol, and cardiovascular disease risk

2022-10-25 | Preprint
DOI: 10.1101/2022.10.23.22281418
Contributors: Xue Liu; Xianbang Sun; Yuankai Zhang; Wenqing Jiang; Lai Meng; Kerri L. Wiggins; Laura M. Raffield; Lawrence F. Bielak; Wei Zhao; Achilleas Pitsillides et al.
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Crossref

Non-linear machine learning models incorporating SNPs and PRS improve polygenic prediction in diverse human populations

Communications Biology
2022-08-22 | Journal article
DOI: 10.1038/s42003-022-03812-z
Contributors: Michael Elgart; Genevieve Lyons; Santiago Romero-Brufau; Nuzulul Kurniansyah; Jennifer A. Brody; Xiuqing Guo; Henry J. Lin; Laura Raffield; Yan Gao; Han Chen et al.
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Crossref

Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program

Communications Biology
2022-07-28 | Journal article
DOI: 10.1038/s42003-022-03702-4
Contributors: Daniel DiCorpo; Sheila M. Gaynor; Emily M. Russell; Kenneth E. Westerman; Laura M. Raffield; Timothy D. Majarian; Peitao Wu; Chloé Sarnowski; Heather M. Highland; Anne Jackson et al.
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Crossref

Clonal Hematopoiesis Is Associated With Higher Risk of Stroke

Stroke
2022-03 | Journal article
DOI: 10.1161/STROKEAHA.121.037388
Contributors: Romit Bhattacharya; Seyedeh M. Zekavat; Jeffrey Haessler; Myriam Fornage; Laura Raffield; Md Mesbah Uddin; Alexander G. Bick; Abhishek Niroula; Bing Yu; Christopher Gibson et al.
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Crossref

Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study

Diabetologia
2022-03 | Journal article
DOI: 10.1007/s00125-021-05635-9
Contributors: Carolina G. Downie; Sofia F. Dimos; Stephanie A. Bien; Yao Hu; Burcu F. Darst; Linda M. Polfus; Yujie Wang; Genevieve L. Wojcik; Ran Tao; Laura M. Raffield et al.
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Crossref

Whole-Genome Sequencing Association Analyses of Stroke and Its Subtypes in Ancestrally Diverse Populations From Trans-Omics for Precision Medicine Project

Stroke
2022-03 | Journal article
DOI: 10.1161/STROKEAHA.120.031792
Contributors: Yao Hu; Jeffrey W. Haessler; Regina Manansala; Kerri L. Wiggins; Arden Moscati; Alexa Beiser; Nancy L. Heard-Costa; Chloe Sarnowski; Laura M. Raffield; Jaeyoon Chung et al.
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Crossref

Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed

Cell Genomics
2022-01 | Journal article
DOI: 10.1016/j.xgen.2021.100084
Contributors: Margaret A. Taub; Matthew P. Conomos; Rebecca Keener; Kruthika R. Iyer; Joshua S. Weinstock; Lisa R. Yanek; John Lane; Tyne W. Miller-Fleming; Jennifer A. Brody; Laura M. Raffield et al.
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Crossref

Super interactive promoters provide insight into cell type-specific regulatory networks in blood lineage cell types

PLOS Genetics
2022-01-31 | Journal article
DOI: 10.1371/journal.pgen.1009984
Contributors: Jia Wen; Mingyao Li; Taylor M. Lagler; Quan Sun; Yuchen Yang; Jiawen Chen; Yuriko Harigaya; Vijay G. Sankaran; Ming Hu; Alexander P. Reiner et al.
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Crossref

DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function

Clinical Epigenetics
2021-12 | Journal article
DOI: 10.1186/s13148-021-01082-w
Contributors: Pamela R. Matías-García; Cavin K. Ward-Caviness; Laura M. Raffield; Xu Gao; Yan Zhang; Rory Wilson; Xīn Gào; Jana Nano; Andrew Bostom; Elena Colicino et al.
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Crossref

Soluble Urokinase Plasminogen Activator Receptor: Genetic Variation and Cardiovascular Disease Risk in Black Adults

Circulation: Genomic and Precision Medicine
2021-12 | Journal article
DOI: 10.1161/CIRCGEN.121.003421
Contributors: Nels C. Olson; Laura M. Raffield; Anne H. Moxley; Tyne W. Miller-Fleming; Paul L. Auer; Nora Franceschini; Debby Ngo; Timothy A. Thornton; Ethan M. Lange; Yun Li et al.
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Crossref

Obesity Duration, Severity, and Distribution Trajectories and Cardiovascular Disease Risk in the Atherosclerosis Risk in Communities Study

Journal of the American Heart Association
2021-12-21 | Journal article
DOI: 10.1161/JAHA.121.019946
Contributors: Laura M. Raffield; Annie Green Howard; Misa Graff; Dan‐Yu Lin; Susan Cheng; Ellen Demerath; Chiadi Ndumele; Priya Palta; Casey M. Rebholz; Sara Seidelmann et al.
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Crossref

Whole genome sequence analysis of platelet traits in the NHLBI trans-omics for precision medicine initiative.

Human molecular genetics
2021-09 | Journal article
DOI: 10.1093/hmg/ddab252
PMID: 34553764
Contributors: Little A; Hu Y; Sun Q; Jain D; Broome J; Chen MH; Thibord F; McHugh C; Surendran P; Blackwell TW et al.
Source: Self-asserted source
Laura Raffield via Europe PubMed Central

Analyses of biomarker traits in diverse UK biobank participants identify associations missed by European-centric analysis strategies.

Journal of human genetics
2021-08 | Journal article
DOI: 10.1038/s10038-021-00968-0
PMID: 34376796
Contributors: Sun Q; Graff M; Rowland B; Wen J; Huang L; Miller-Fleming TW; Haessler J; Preuss MH; Chai JF; Lee MP et al.
Source: Self-asserted source
Laura Raffield via Europe PubMed Central

Genetic underpinnings of regional adiposity distribution in African Americans: Assessments from the Jackson Heart Study.

PloS one
2021-08 | Journal article
DOI: 10.1371/journal.pone.0255609
PMID: 34347846
PMC: PMC8336790
Contributors: Anwar MY; Raffield LM; Lange LA; Correa A; Taylor KC
Source: Self-asserted source
Laura Raffield via Europe PubMed Central

Multiethnic Genome-Wide Association Study of Subclinical Atherosclerosis in Individuals With Type 2 Diabetes

Circulation: Genomic and Precision Medicine
2021-08 | Journal article
DOI: 10.1161/CIRCGEN.120.003258
Contributors: Yingchang Lu; Latchezar Dimitrov; Shyh-Huei Chen; Lawrence F. Bielak; Joshua C. Bis; Mary F. Feitosa; Lingyi Lu; Maryam Kavousi; Laura M. Raffield; Albert V. Smith et al.
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Crossref

Transcriptome-wide association study in UK Biobank Europeans identifies associations with blood cell traits

2021-08 | Preprint
DOI: 10.1101/2021.08.03.453690
PPR: PPR379602
Contributors: Rowland B; Venkatesh S; Tardaguila M; Wen J; Rosen JD; Tapia AL; Sun Q; Graff M; Vuckovic D; Lettre G et al.
Source: Self-asserted source
Laura Raffield via Europe PubMed Central

CUE: CpG impUtation ensemble for DNA methylation levels across the human methylation450 (HM450) and EPIC (HM850) BeadChip platforms

Epigenetics
2021-08-03 | Journal article
DOI: 10.1080/15592294.2020.1827716
Contributors: Gang Li; Laura Raffield; Mark Logue; Mark W. Miller; Hudson P. Santos, Jr; T. Michael O’Shea; Rebecca C. Fry; Yun Li
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Crossref

Presence and transmission of mitochondrial heteroplasmic mutations in human populations of European and African ancestry.

Mitochondrion
2021-07 | Journal article
DOI: 10.1016/j.mito.2021.07.004
PMID: 34303007
Contributors: Liu C; Fetterman JL; Qian Y; Sun X; Blackwell TW; Pitsillides A; Cade BE; Wang H; Raffield LM; Lange LA et al.
Source: Self-asserted source
Laura Raffield via Europe PubMed Central

Supplemental Association of Clonal Hematopoiesis With Incident Heart Failure.

Journal of the American College of Cardiology
2021-07 | Journal article
DOI: 10.1016/j.jacc.2021.04.085
PMID: 34210413
Contributors: Yu B; Roberts MB; Raffield LM; Zekavat SM; Nguyen NQH; Biggs ML; Brown MR; Griffin G; Desai P; Correa A et al.
Source: Self-asserted source
Laura Raffield via Europe PubMed Central

Transcriptome-Wide Association Study of Blood Cell Traits in African Ancestry and Hispanic/Latino Populations.

Genes
2021-07 | Journal article
DOI: 10.3390/genes12071049
PMID: 34356065
PMC: PMC8307403
Contributors: Wen J; Xie M; Rowland B; Rosen JD; Sun Q; Chen J; Tapia AL; Qian H; Kowalski MH; Shan Y et al.
Source: Self-asserted source
Laura Raffield via Europe PubMed Central

Polygenic Risk Prediction using Gradient Boosted Trees Captures Non-Linear Genetic Effects and Allele Interactions in Complex Phenotypes

2021-07-16 | Other
DOI: 10.1101/2021.07.09.21260288
Contributors: Michael Elgart; Genevieve Lyons; Santiago Romero-Brufau; Nuzulul Kurniansyah; Jennifer A. Brody; Xiuqing Guo; Henry J Lin; Laura Raffield; Yan Gao; Han Chen et al.
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Crossref

Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging.

Genome biology
2021-06 | Journal article
DOI: 10.1186/s13059-021-02398-9
PMID: 34187551
PMC: PMC8243879
Contributors: McCartney DL; Min JL; Richmond RC; Lu AT; Sobczyk MK; Davies G; Broer L; Guo X; Jeong A; Jung J et al.
Source: Self-asserted source
Laura Raffield via Europe PubMed Central

Large trans-ethnic meta-analysis identifies AKR1C4 as a novel gene associated with age at menarche.

Human reproduction (Oxford, England)
2021-06 | Journal article
DOI: 10.1093/humrep/deab086
PMID: 34021356
Contributors: Sarnowski C; Cousminer DL; Franceschini N; Raffield LM; Jia G; Fernández-Rhodes L; Grant SFA; Hakonarson H; Lange LA; Long J et al.
Source: Self-asserted source
Laura Raffield via Europe PubMed Central

Multi-ethnic genome-wide association analyses of white blood cell and platelet traits in the Population Architecture using Genomics and Epidemiology (PAGE) study.

BMC genomics
2021-06 | Journal article
DOI: 10.1186/s12864-021-07745-5
PMID: 34107879
PMC: PMC8191001
Contributors: Hu Y; Bien SA; Nishimura KK; Haessler J; Hodonsky CJ; Baldassari AR; Highland HM; Wang Z; Preuss M; Sitlani CM et al.
Source: Self-asserted source
Laura Raffield via Europe PubMed Central

Soluble CD14 Levels in the Jackson Heart Study: Associations With Cardiovascular Disease Risk and Genetic Variants

Arteriosclerosis, Thrombosis, and Vascular Biology
2021-06 | Journal article
DOI: 10.1161/ATVBAHA.121.316035
Contributors: Maggie A. Stanislawski; Leslie A. Lange; Laura M. Raffield; Neil A. Zakai; Mariah Meyer; Kendra Ferrier; Mindy D. Szeto; Colton Leavitt; Jonathan A. Shortt; Timothy A. Thornton et al.
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Crossref

Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program.

American journal of human genetics
2021-06 | Journal article
DOI: 10.1016/j.ajhg.2021.04.015
PMID: 34087167
PMC: PMC8206380
Contributors: Hu Y; Stilp AM; McHugh CP; Rao S; Jain D; Zheng X; Lane J; Méric de Bellefon S; Raffield LM; Chen MH et al.
Source: Self-asserted source
Laura Raffield via Europe PubMed Central

Assay-related Differences in SuPAR Levels: Implications for Measurement and Data Interpretation

2021-06-28 | Other
DOI: 10.1101/2021.06.23.21259148
Contributors: Salim S. Hayek; Laura M. Raffield; Yan Gao; Gunnar Engstrom; Arshed A. Quyyumi; Alexander P. Reiner; Jochen Reiser
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Crossref

Clonal hematopoiesis associated with epigenetic aging and clinical outcomes.

Aging cell
2021-05 | Journal article
DOI: 10.1111/acel.13366
PMID: 34050697
PMC: PMC8208788
Contributors: Nachun D; Lu AT; Bick AG; Natarajan P; Weinstock J; Szeto MD; Kathiresan S; Abecasis G; Taylor KD; Guo X et al.
Source: Self-asserted source
Laura Raffield via Europe PubMed Central

FGL1 as a modulator of plasma D-dimer levels: Exome-wide marker analysis of plasma tPA, PAI-1, and D-dimer.

Journal of thrombosis and haemostasis : JTH
2021-05 | Journal article
DOI: 10.1111/jth.15345
PMID: 33876560
Contributors: Thibord F; Song C; Pattee J; Rodriguez BAT; Chen MH; O'Donnell CJ; Kleber ME; Delgado GE; Guo X; Yao J et al.
Source: Self-asserted source
Laura Raffield via Europe PubMed Central

The trans-ancestral genomic architecture of glycemic traits.

Nature genetics
2021-05 | Journal article
DOI: 10.1038/s41588-021-00852-9
PMID: 34059833
PMC: PMC7610958
Contributors: Chen J; Spracklen CN; Marenne G; Varshney A; Corbin LJ; Luan J; Willems SM; Wu Y; Zhang X; Horikoshi M et al.
Source: Self-asserted source
Laura Raffield via Europe PubMed Central

A System for Phenotype Harmonization in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program.

American journal of epidemiology
2021-04 | Journal article
DOI: 10.1093/aje/kwab115
PMID: 33861317
Contributors: Stilp AM; Emery LS; Broome JG; Buth EJ; Khan AT; Laurie CA; Wang FF; Wong Q; Chen D; D'Augustine CM et al.
Source: Self-asserted source
Laura Raffield via Europe PubMed Central

Development and Validation of Machine Learning-Based Race-Specific Models to Predict 10-Year Risk of Heart Failure: A Multicohort Analysis.

Circulation
2021-04 | Journal article
DOI: 10.1161/circulationaha.120.053134
PMID: 33845593
Contributors: Segar MW; Jaeger BC; Patel KV; Nambi V; Ndumele CE; Correa A; Butler J; Chandra A; Ayers C; Rao S et al.
Source: Self-asserted source
Laura Raffield via Europe PubMed Central

Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci.

Genome medicine
2021-04 | Journal article
DOI: 10.1186/s13073-021-00877-z
PMID: 33931109
PMC: PMC8088054
Contributors: Breeze CE; Batorsky A; Lee MK; Szeto MD; Xu X; McCartney DL; Jiang R; Patki A; Kramer HJ; Eales JM et al.
Source: Self-asserted source
Laura Raffield via Europe PubMed Central

Super interactive promoters provide insight into cell type-specific regulatory networks in blood lineage cell types

2021-03-16 | Preprint
DOI: 10.1101/2021.03.15.435494
Contributors: Taylor M. Lagler; Yuchen Yang; Yuriko Harigaya; Vijay G. Sankaran; Ming Hu; Alexander P. Reiner; Laura M. Raffield; Jia Wen; Yun Li
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Crossref

A large-scale transcriptome-wide association study (TWAS) of ten blood cell phenotypes reveals complexities of TWAS fine-mapping

2021-02 | Preprint
DOI: 10.1101/2021.02.23.432444
PPR: PPR287912
Contributors: Tapia AL; Rowland BT; Rosen JD; Preuss M; Young K; Graff M; Choquet H; Couper DJ; Buyske S; Bien SA et al.
Source: Self-asserted source
Laura Raffield via Europe PubMed Central

From GWAS Variant to Function: a Study of ~148,000 Variants for Blood Cell Traits

2021-02 | Preprint
DOI: 10.1101/2021.02.16.431409
PPR: PPR284323
Contributors: Sun Q; Crowley CA; Huang L; Wen J; Chen J; Bao EL; Auer PL; Lettre G; Reiner AP; Sankaran VG et al.
Source: Self-asserted source
Laura Raffield via Europe PubMed Central

Malaria is a cause of iron deficiency in African children.

Nature medicine
2021-02 | Journal article
DOI: 10.1038/s41591-021-01238-4
PMID: 33619371
PMC: PMC7610676
Contributors: Muriuki JM; Mentzer AJ; Mitchell R; Webb EL; Etyang AO; Kyobutungi C; Morovat A; Kimita W; Ndungu FM; Macharia AW et al.
Source: Self-asserted source
Laura Raffield via Europe PubMed Central

Genetic analysis of mitochondrial DNA copy number and associated traits identifies loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation, and reveals a causal association of mitochondrial function with mortality

2021-01 | Preprint
DOI: 10.1101/2021.01.25.428086
PPR: PPR274983
Contributors: Longchamps R; Yang S; Castellani C; Shi W; Lane J; Grove M; Bartz T; Sarnowski C; Burrows K; Guyatt A et al.
Source: Self-asserted source
Laura Raffield via Europe PubMed Central
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Peer review (6 reviews for 3 publications/grants)

Review activity for Genome medicine. (1)
Review activity for Nature communications (3)
Review activity for Nature genetics. (2)
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