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Employment (5)

Illumina AI Labs: Foster City, California, US

2022-02 to present | Group Leader and Staff Bioinformatics Scientist
Employment
Source: Self-asserted source
Jacob Ulirsch

Patch Biosciences: New York City, New York, US

2020-11 to 2022-01 | Computational Biologist
Employment
Source: Self-asserted source
Jacob Ulirsch

Broad Institute: Cambridge, Massachusetts, US

2013 to 2017 | Computational Biologist
Employment
Source: Self-asserted source
Jacob Ulirsch

Boston Children's Hospital: Boston, MA, US

2013 to 2017 | Computational Biologist (Hematology/Oncology)
Employment
Source: Self-asserted source
Jacob Ulirsch

University of North Carolina School of Medicine: Chapel Hill, NC, US

2011 to 2013 | Data Analyst (Anesthesiology)
Employment
Source: Self-asserted source
Jacob Ulirsch

Education and qualifications (2)

Harvard University: Cambridge, MA, US

2017 to 2022 | PhD (Genetics & Genomics)
Education
Source: Self-asserted source
Jacob Ulirsch

University of North Carolina at Chapel Hill: Chapel Hill, NC, US

2007 to 2011 | BS (Mathematics)
Education
Source: Self-asserted source
Jacob Ulirsch

Works (50 of 60)

Items per page:
Page 1 of 2

Improving fine-mapping by modeling infinitesimal effects

Nature Genetics
2024-01 | Journal article
DOI: 10.1038/s41588-023-01597-3
Contributors: Ran Cui; Roy A. Elzur; Masahiro Kanai; Jacob C. Ulirsch; Omer Weissbrod; Mark J. Daly; Benjamin M. Neale; Zhou Fan; Hilary K. Finucane
Source: check_circle
Crossref

Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases

Nature Genetics
2023-08 | Journal article
DOI: 10.1038/s41588-023-01443-6
Contributors: Elle M. Weeks; Jacob C. Ulirsch; Nathan Y. Cheng; Brian L. Trippe; Rebecca S. Fine; Jenkai Miao; Tejal A. Patwardhan; Masahiro Kanai; Joseph Nasser; Charles P. Fulco et al.
Source: check_circle
Crossref

Rare penetrant mutations confer severe risk of common diseases

Science
2023-06-02 | Journal article
DOI: 10.1126/science.abo1131
Contributors: Petko P. Fiziev; Jeremy McRae; Jacob C. Ulirsch; Jacqueline S. Dron; Tobias Hamp; Yanshen Yang; Pierrick Wainschtein; Zijian Ni; Joshua G. Schraiber; Hong Gao et al.
Source: check_circle
Crossref

Improving fine-mapping by modeling infinitesimal effects

2022-10-24 | Preprint
DOI: 10.1101/2022.10.21.513123
Contributors: Ran Cui; Roy A Elzur; Masahiro Kanai; Jacob C Ulirsch; Omer Weissbrod; Mark J Daly; Benjamin M Neale; Zhou Fan; Hilary K Finucane
Source: check_circle
Crossref

A cross-disorder dosage sensitivity map of the human genome

Cell
2022-08 | Journal article
DOI: 10.1016/j.cell.2022.06.036
Contributors: Ryan L. Collins; Joseph T. Glessner; Eleonora Porcu; Maarja Lepamets; Rhonda Brandon; Christopher Lauricella; Lide Han; Theodore Morley; Lisa-Marie Niestroj; Jacob Ulirsch et al.
Source: check_circle
Crossref

Author Correction: Direct characterization of cis-regulatory elements and functional dissection of complex genetic associations using HCR–FlowFISH

Nature Genetics
2021-10-08 | Journal article
DOI: 10.1038/s41588-021-00943-7
Contributors: Steven K. Reilly; Sager J. Gosai; Alan Gutierrez; Ava Mackay-Smith; Jacob C. Ulirsch; Masahiro Kanai; Kousuke Mouri; Daniel Berenzy; Susan Kales; Gina M. Butler et al.
Source: check_circle
Crossref

Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation

Nature Communications
2021-09-02 | Journal article
DOI: 10.1038/s41467-021-25514-6
Contributors: Shubham Khetan; Susan Kales; Romy Kursawe; Alexandria Jillette; Jacob C. Ulirsch; Steven K. Reilly; Duygu Ucar; Ryan Tewhey; Michael L. Stitzel
Source: check_circle
Crossref

Direct characterization of cis-regulatory elements and functional dissection of complex genetic associations using HCR–FlowFISH

Nature Genetics
2021-08-29 | Journal article
DOI: 10.1038/s41588-021-00900-4
Contributors: Steven K. Reilly; Sager J. Gosai; Alan Gutierrez; Ava Mackay-Smith; Jacob C. Ulirsch; Masahiro Kanai; Kousuke Mouri; Daniel Berenzy; Susan Kales; Gina M. Butler et al.
Source: check_circle
Crossref

Leveraging supervised learning for functionally informed fine-mapping of cis-eQTLs identifies an additional 20,913 putative causal eQTLs

Nature Communications
2021-06-07 | Journal article
DOI: 10.1038/s41467-021-23134-8
Contributors: Qingbo S. Wang; David R. Kelley; Jacob Ulirsch; Masahiro Kanai; Shuvom Sadhuka; Ran Cui; Carlos Albors; Nathan Cheng; Yukinori Okada; Koichi Matsuda et al.
Source: check_circle
Crossref

Genome-wide enhancer maps link risk variants to disease genes

Nature
2021-05-13 | Journal article
DOI: 10.1038/s41586-021-03446-x
Contributors: Joseph Nasser; Drew T. Bergman; Charles P. Fulco; Philine Guckelberger; Benjamin R. Doughty; Tejal A. Patwardhan; Thouis R. Jones; Tung H. Nguyen; Jacob C. Ulirsch; Fritz Lekschas et al.
Source: check_circle
Crossref

Tractor uses local ancestry to enable the inclusion of admixed individuals in GWAS and to boost power

Nature Genetics
2021-02 | Journal article
DOI: 10.1038/s41588-020-00766-y
Contributors: Elizabeth G. Atkinson; Adam X. Maihofer; Masahiro Kanai; Alicia R. Martin; Konrad J. Karczewski; Marcos L. Santoro; Jacob C. Ulirsch; Yoichiro Kamatani; Yukinori Okada; Hilary K. Finucane et al.
Source: check_circle
Crossref

Genome-wide functional screen of 3’UTR variants uncovers causal variants for human disease and evolution

2021-01-13 | Preprint
DOI: 10.1101/2021.01.13.424697
Contributors: Dustin Griesemer; James R Xue; Steven K Reilly; Jacob C Ulirsch; Kalki Kukreja; Joe Davis; Masahiro Kanai; David K Yang; Stephen B Montgomery; Carl D Novina et al.
Source: check_circle
Crossref

Functionally informed fine-mapping and polygenic localization of complex trait heritability

Nature Genetics
2020-12-16 | Journal article
DOI: 10.1038/s41588-020-00735-5
Contributors: Omer Weissbrod; Farhad Hormozdiari; Christian Benner; Ran Cui; Jacob Ulirsch; Steven Gazal; Armin P. Schoech; Bryce van de Geijn; Yakir Reshef; Carla Márquez-Luna et al.
Source: check_circle
Crossref

Tractor: A framework allowing for improved inclusion of admixed individuals in large-scale association studies

2020-05-19 | Preprint
DOI: 10.1101/2020.05.17.100727
Contributors: Elizabeth G. Atkinson; Adam X. Maihofer; Masahiro Kanai; Alicia R. Martin; Konrad J. Karczewski; Marcos L. Santoro; Jacob C. Ulirsch; Yoichiro Kamatani; Yukinori Okada; Hilary K. Finucane et al.
Source: check_circle
Crossref

HCR-FlowFISH: A flexible CRISPR screening method to identify cis-regulatory elements and their target genes

2020-05-12 | Preprint
DOI: 10.1101/2020.05.11.078675
Contributors: SK Reilly; SJ Gosai; A Gutierrez; JC Ulirsch; M Kanai; D Berenzy; S Kales; GB Butler; A Gladden-Young; HK Finucane et al.
Source: check_circle
Crossref

Prioritizing disease and trait causal variants at the TNFAIP3 locus using functional and genomic features

Nature Communications
2020-03-06 | Journal article
DOI: 10.1038/s41467-020-15022-4
Contributors: John P. Ray; Carl G. de Boer; Charles P. Fulco; Caleb A. Lareau; Masahiro Kanai; Jacob C. Ulirsch; Ryan Tewhey; Leif S. Ludwig; Steven K. Reilly; Drew T. Bergman et al.
Source: check_circle
Crossref

Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation

Nature Genetics
2020-02 | Journal article
DOI: 10.1038/s41588-019-0568-7
Contributors: Anindita Basak; Mathias Munschauer; Caleb A. Lareau; Kara E. Montbleau; Jacob C. Ulirsch; Christina R. Hartigan; Monica Schenone; John Lian; Yaomei Wang; Yumin Huang et al.
Source: check_circle
Crossref

Functionally-informed fine-mapping and polygenic localization of complex trait heritability

2019-10-17 | Other
DOI: 10.1101/807792
Contributors: Omer Weissbrod; Farhad Hormozdiari; Christian Benner; Ran Cui; Jacob Ulirsch; Steven Gazal; Armin P. Schoech; Bryce van de Geijn; Yakir Reshef; Carla Márquez-Luna et al.
Source: check_circle
Crossref

Transcriptional States and Chromatin Accessibility Underlying Human Erythropoiesis.

Cell reports
2019-06 | Journal article
DOI: 10.1016/j.celrep.2019.05.046
PMID: 31189107
Contributors: Ludwig LS; Lareau CA; Bao EL; Nandakumar SK; Muus C; Ulirsch JC; Chowdhary K; Buenrostro JD; Mohandas N; An X et al.
Source: Self-asserted source
Jacob Ulirsch via Europe PubMed Central

Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis.

eLife
2019-05 | Journal article
DOI: 10.7554/eLife.44080
PMID: 31070582
PMC: PMC6534380
Contributors: Nandakumar SK; McFarland SK; Mateyka LM; Lareau CA; Ulirsch JC; Ludwig LS; Agarwal G; Engreitz JM; Przychodzen B; McConkey M et al.
Source: Self-asserted source
Jacob Ulirsch via Europe PubMed Central

HRI coordinates translation necessary for protein homeostasis and mitochondrial function in erythropoiesis.

eLife
2019-04 | Journal article
DOI: 10.7554/eLife.46976
PMID: 31033440
PMC: PMC6533081
Contributors: Zhang S; Macias-Garcia A; Ulirsch JC; Velazquez J; Butty VL; Levine SS; Sankaran VG; Chen JJ
Source: Self-asserted source
Jacob Ulirsch via Europe PubMed Central

Interrogation of human hematopoiesis at single-cell and single-variant resolution

Nature Genetics
2019-04-11 | Journal article
DOI: 10.1038/s41588-019-0362-6
Contributors: Jacob C. Ulirsch; Caleb A. Lareau; Erik L. Bao; Leif S. Ludwig; Michael H. Guo; Christian Benner; Ansuman T. Satpathy; Vinay K. Kartha; Rany M. Salem; Joel N. Hirschhorn et al.
Source: check_circle
Crossref

Impaired human hematopoiesis due to a cryptic intronic GATA1 splicing mutation.

The Journal of experimental medicine
2019-03 | Journal article
DOI: 10.1084/jem.20181625
PMID: 30914438
Contributors: Abdulhay NJ; Fiorini C; Verboon JM; Ludwig LS; Ulirsch JC; Zieger B; Lareau CA; Mi X; Roy A; Obeng EA et al.
Source: Self-asserted source
Jacob Ulirsch via Europe PubMed Central

Lineage Tracing in Humans Enabled by Mitochondrial Mutations and Single-Cell Genomics.

Cell
2019-02 | Journal article
DOI: 10.1016/j.cell.2019.01.022
PMID: 30827679
Contributors: Ludwig LS; Lareau CA; Ulirsch JC; Christian E; Muus C; Li LH; Pelka K; Ge W; Oren Y; Brack A et al.
Source: Self-asserted source
Jacob Ulirsch via Europe PubMed Central

Genetic predisposition to mosaic Y chromosome loss in blood is associated with genomic instability in other tissues and susceptibility to non-haematological cancers

2019-01 | Other
DOI: 10.1101/514026
OTHER-ID:

PPR66679
Contributors: Thompson D; Genovese G; Halvardson J; Ulirsch J; Wright D; Terao C; Davidsson O; Day F; Sulem P; Jiang Y et al.
Source: Self-asserted source
Jacob Ulirsch via Europe PubMed Central

Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis

2018-12 | Other
DOI: 10.1101/500579
OTHER-ID:

PPR65543
Contributors: Nandakumar SK; McFarland SK; Mateyka LM; Lareau CA; Ulirsch JC; Ludwig LS; Agarwal G; Engreitz JM; Przychodzen B; McConkey M et al.
Source: Self-asserted source
Jacob Ulirsch via Europe PubMed Central

The Genetic Landscape of Diamond-Blackfan Anemia.

American journal of human genetics
2018-11 | Journal article
DOI: 10.1016/j.ajhg.2018.10.027
PMID: 30503522
Contributors: Ulirsch JC; Verboon JM; Kazerounian S; Guo MH; Yuan D; Ludwig LS; Handsaker RE; Abdulhay NJ; Fiorini C; Genovese G et al.
Source: Self-asserted source
Jacob Ulirsch via Europe PubMed Central

Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk.

Nature genetics
2018-09 | Journal article
DOI: 10.1038/s41588-018-0196-7
PMID: 30177862
Contributors: Reshef YA; Finucane HK; Kelley DR; Gusev A; Kotliar D; Ulirsch JC; Hormozdiari F; Nasser J; O'Connor L; van de Geijn B et al.
Source: Self-asserted source
Jacob Ulirsch via Europe PubMed Central

Iron and Heme Coordinate Erythropoiesis through HRI-Mediated Regulation of Protein Translation and Gene Expression

2018-09 | Other
DOI: 10.1101/408054
OTHER-ID:

PPR54772
Contributors: Zhang S; Macias-Garcia A; Ulirsch JC; Velazquez J; Butty VL; Levine SS; Sankaran VG; Chen J
Source: Self-asserted source
Jacob Ulirsch via Europe PubMed Central

The NORAD lncRNA assembles a topoisomerase complex critical for genome stability.

Nature
2018-08 | Journal article
DOI: 10.1038/s41586-018-0453-z
PMID: 30150775
Contributors: Munschauer M; Nguyen CT; Sirokman K; Hartigan CR; Hogstrom L; Engreitz JM; Ulirsch JC; Fulco CP; Subramanian V; Chen J et al.
Source: Self-asserted source
Jacob Ulirsch via Europe PubMed Central

The Genetic Landscape of Diamond-Blackfan Anemia

2018-07 | Other
DOI: 10.1101/365890
OTHER-ID:

PPR44988
Contributors: Ulirsch JC; Verboon JM; Kazerounian S; Guo MH; Yuan D; Ludwig LS; Handsaker RE; Abdulhay NJ; Fiorini C; Genovese G et al.
Source: Self-asserted source
Jacob Ulirsch via Europe PubMed Central

Common α-globin variants modify hematologic and other clinical phenotypes in sickle cell trait and disease.

PLoS genetics
2018-03 | Journal article
DOI: 10.1371/journal.pgen.1007293
PMID: 29590102
PMC: PMC5891078
Contributors: Raffield LM; Ulirsch JC; Naik RP; Lessard S; Handsaker RE; Jain D; Kang HM; Pankratz N; Auer PL; Bao EL et al.
Source: Self-asserted source
Jacob Ulirsch via Europe PubMed Central

Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis.

Cell
2018-03 | Journal article
DOI: 10.1016/j.cell.2018.02.036
PMID: 29551269
Contributors: Khajuria RK; Munschauer M; Ulirsch JC; Fiorini C; Ludwig LS; McFarland SK; Abdulhay NJ; Specht H; Keshishian H; Mani DR et al.
Source: Self-asserted source
Jacob Ulirsch via Europe PubMed Central

Interrogation of human hematopoiesis at single-cell and single-variant resolution

2018-01 | Other
DOI: 10.1101/255224
OTHER-ID:

PPR19396
Contributors: Lareau CA; Ulirsch JC; Bao EL; Ludwig LS; Guo MH; Benner C; Satpathy AT; Salem R; Hirschhorn JN; Finucane HK et al.
Source: Self-asserted source
Jacob Ulirsch via Europe PubMed Central

Whole-exome sequencing identifies an α-globin cluster triplication resulting in increased clinical severity of β-thalassemia.

Cold Spring Harbor molecular case studies
2017-11 | Journal article
DOI: 10.1101/mcs.a001941
PMID: 28667000
PMC: PMC5701307
Contributors: Steinberg-Shemer O; Ulirsch JC; Noy-Lotan S; Krasnov T; Attias D; Dgany O; Laor R; Sankaran VG; Tamary H
Source: Self-asserted source
Jacob Ulirsch via Europe PubMed Central

Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk

2017-10 | Other
DOI: 10.1101/204685
OTHER-ID:

PPR13420
Contributors: Reshef YA; Finucane HK; Kelley DR; Gusev A; Kotliar D; Ulirsch JC; Hormozdiari F; Nasser J; O'Connor L; van de Geijn B et al.
Source: Self-asserted source
Jacob Ulirsch via Europe PubMed Central

Developmentally-faithful and effective human erythropoiesis in immunodeficient and Kit mutant mice.

American journal of hematology
2017-07 | Journal article
DOI: 10.1002/ajh.24805
PMID: 28568895
PMC: PMC5546987
Contributors: Fiorini C; Abdulhay NJ; McFarland SK; Munschauer M; Ulirsch JC; Chiarle R; Sankaran VG
Source: Self-asserted source
Jacob Ulirsch via Europe PubMed Central

Confounding in ex vivo models of Diamond-Blackfan anemia.

Blood
2017-06 | Journal article
DOI: 10.1182/blood-2017-05-783191
PMID: 28615220
PMC: PMC5580274
Contributors: Ulirsch JC; Lareau C; Ludwig LS; Mohandas N; Nathan DG; Sankaran VG
Source: Self-asserted source
Jacob Ulirsch via Europe PubMed Central

Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation.

Cell
2017-03 | Journal article
DOI: 10.1016/j.cell.2017.02.026
PMID: 28283061
PMC: PMC5376096
Contributors: Kim AR; Ulirsch JC; Wilmes S; Unal E; Moraga I; Karakukcu M; Yuan D; Kazerounian S; Abdulhay NJ; King DS et al.
Source: Self-asserted source
Jacob Ulirsch via Europe PubMed Central

Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms.

Proceedings of the National Academy of Sciences of the United States of America
2016-12 | Journal article
DOI: 10.1073/pnas.1619052114
PMID: 28031487
PMC: PMC5255587
Contributors: Guo MH; Nandakumar SK; Ulirsch JC; Zekavat SM; Buenrostro JD; Natarajan P; Salem RM; Chiarle R; Mitt M; Kals M et al.
Source: Self-asserted source
Jacob Ulirsch via Europe PubMed Central

A novel pathogenic mutation in RPL11 identified in a patient diagnosed with diamond Blackfan anemia as a young adult.

Blood cells, molecules & diseases
2016-08 | Journal article
DOI: 10.1016/j.bcmd.2016.08.001
PMID: 27667165
Contributors: Narla A; Yuan D; Kazerounian S; LaVasseur C; Ulirsch JC; Narla J; Glader B; Sankaran VG; Gazda H
Source: Self-asserted source
Jacob Ulirsch via Europe PubMed Central

Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms

2016-08 | Other
DOI: 10.1101/067934
OTHER-ID:

PPR29511
Contributors: Guo M; Nandakumar SK; Ulirsch JC; Zekavat SM; Buenrostro JD; Natarajan P; Salem R; Chiarle R; Mitt M; Kals M et al.
Source: Self-asserted source
Jacob Ulirsch via Europe PubMed Central

Exome sequencing results in successful diagnosis and treatment of a severe congenital anemia.

Cold Spring Harbor molecular case studies
2016-07 | Journal article
DOI: 10.1101/mcs.a000885
PMID: 27551681
PMC: PMC4990811
Contributors: Lacy JN; Ulirsch JC; Grace RF; Towne MC; Hale J; Mohandas N; Lux SE; Agrawal PB; Sankaran VG
Source: Self-asserted source
Jacob Ulirsch via Europe PubMed Central

Systematic Functional Dissection of Common Genetic Variation Affecting Red Blood Cell Traits.

Cell
2016-06 | Journal article
DOI: 10.1016/j.cell.2016.04.048
PMID: 27259154
PMC: PMC4893171
Contributors: Ulirsch JC; Nandakumar SK; Wang L; Giani FC; Zhang X; Rogov P; Melnikov A; McDonel P; Do R; Mikkelsen TS et al.
Source: Self-asserted source
Jacob Ulirsch via Europe PubMed Central

Insight into GATA1 transcriptional activity through interrogation of cis elements disrupted in human erythroid disorders.

Proceedings of the National Academy of Sciences of the United States of America
2016-04 | Journal article
DOI: 10.1073/pnas.1521754113
PMID: 27044088
PMC: PMC4843446
Contributors: Wakabayashi A; Ulirsch JC; Ludwig LS; Fiorini C; Yasuda M; Choudhuri A; McDonel P; Zon LI; Sankaran VG
Source: Self-asserted source
Jacob Ulirsch via Europe PubMed Central

Advances in understanding erythropoiesis: evolving perspectives.

British journal of haematology
2016-02 | Journal article
DOI: 10.1111/bjh.13938
PMID: 26846448
PMC: PMC4833665
Contributors: Nandakumar SK; Ulirsch JC; Sankaran VG
Source: Self-asserted source
Jacob Ulirsch via Europe PubMed Central

Association of Epidemiologic Factors and Genetic Variants Influencing Hypothalamic-Pituitary-Adrenocortical Axis Function With Postconcussive Symptoms After Minor Motor Vehicle Collision.

Psychosomatic medicine
2016-01 | Journal article
DOI: 10.1097/PSY.0000000000000253
PMID: 26588823
PMC: PMC4696893
Contributors: Auvergne L; Bortsov AV; Ulirsch JC; Peak DA; Jones JS; Swor RA; Domeier RM; Lee DC; Rathlev NK; Hendry PL et al.
Source: Self-asserted source
Jacob Ulirsch via Europe PubMed Central

Targeted Application of Human Genetic Variation Can Improve Red Blood Cell Production from Stem Cells.

Cell stem cell
2015-10 | Journal article
DOI: 10.1016/j.stem.2015.09.015
PMID: 26607381
PMC: PMC4707983
Contributors: Giani FC; Fiorini C; Wakabayashi A; Ludwig LS; Salem RM; Jobaliya CD; Regan SN; Ulirsch JC; Liang G; Steinberg-Shemer O et al.
Source: Self-asserted source
Jacob Ulirsch via Europe PubMed Central

BCL11A deletions result in fetal hemoglobin persistence and neurodevelopmental alterations.

The Journal of clinical investigation
2015-05 | Journal article
DOI: 10.1172/JCI81163
PMID: 25938782
PMC: PMC4497765
Contributors: Basak A; Hancarova M; Ulirsch JC; Balci TB; Trkova M; Pelisek M; Vlckova M; Muzikova K; Cermak J; Trka J et al.
Source: Self-asserted source
Jacob Ulirsch via Europe PubMed Central

Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells.

The Journal of clinical investigation
2015-05 | Journal article
DOI: 10.1172/JCI77670
PMID: 25961454
PMC: PMC4497743
Contributors: Noh JY; Gandre-Babbe S; Wang Y; Hayes V; Yao Y; Gadue P; Sullivan SK; Chou ST; Machlus KR; Italiano JE et al.
Source: Self-asserted source
Jacob Ulirsch via Europe PubMed Central
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