Personal information

Websites & social links

https://www2.mrc-lmb.cam.ac.uk/group-leaders/a-to-g/gerry-crossan/

Countries

United Kingdom

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Employment (1)

MRC Laboratory of Molecular Biology: Cambridge, Cambridgeshire, GB

2015-08-01 to 2024-04-26
Employment
Source: Self-asserted source
Gerry Crossan

Education and qualifications (1)

University of Cambridge: Cambridge, Cambridgeshire, GB

2008-10-01 to 2014-01-25
Education
Source: Self-asserted source
Gerry Crossan

Works (21)

p53 regulates diverse tissue-specific outcomes to endogenous DNA damage in mice

Nature Communications
2024-03-21 | Journal article
DOI: 10.1038/s41467-024-46844-1
Contributors: Ross J. Hill; Nazareno Bona; Job Smink; Hannah K. Webb; Alastair Crisp; Juan I. Garaycoechea; Gerry P. Crossan
Source: check_circle
Crossref

Fanconi anemia DNA crosslink repair factors protect against LINE-1 retrotransposition during mouse development

Nature Structural & Molecular Biology
2023-10 | Journal article
DOI: 10.1038/s41594-023-01067-8
Contributors: Nazareno Bona; Gerry P. Crossan
Source: check_circle
Crossref

Primordial germ cell DNA demethylation and development require DNA translesion synthesis.

2023-07-06 | Preprint
DOI: 10.21203/rs.3.rs-3005183/v1
Contributors: Gerry Crossan; Pranay Shah; Ross Hill; Stephen Clark; Camille Dion; Abdulkadir Abakir; Mark Arends; Harry Leitch; Wolf Reik
Source: check_circle
Crossref

Primordial germ cell DNA demethylation and development require DNA translesion synthesis

2023-07-05 | Preprint
DOI: 10.1101/2023.07.05.547775
Contributors: Pranay Shah; Ross Hill; Stephen Clark; Camille Dion; Abdulkadir Abakir; Mark Arends; Harry Leitch; Wolf Reik; Gerry Crossan
Source: check_circle
Crossref

GCNA is a histone binding protein required for spermatogonial stem cell maintenance

Nucleic Acids Research
2023-06-09 | Journal article
DOI: 10.1093/nar/gkad168
Contributors: Jonathan Ribeiro; Gerry P Crossan
Source: check_circle
Crossref

GCNA is a histone binding protein required for spermatogonial stem cell maintenance

2022-02-22 | Preprint
DOI: 10.1101/2022.02.21.481287
Contributors: Jonathan Ribeiro; Gerry P. Crossan
Source: check_circle
Crossref

DNA cross-link repair safeguards genomic stability during premeiotic germ cell development

Nature Genetics
2019-08 | Journal article
DOI: 10.1038/s41588-019-0471-2
Contributors: Ross J. Hill; Gerry P. Crossan
Source: check_circle
Crossref

Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells.

Nature
2018-01 | Journal article
DOI: 10.1038/nature25154
PMID: 29323295
PMC: PMC6047743
Contributors: Garaycoechea JI; Crossan GP; Langevin F; Mulderrig L; Louzada S; Yang F; Guilbaud G; Park N; Roerink S; Nik-Zainal S et al.
Source: Self-asserted source
Gerry Crossan via Europe PubMed Central

Metformin: treating the cause of Fanconi anemia?

Blood
2016-12 | Journal article
DOI: 10.1182/blood-2016-11-748129
PMID: 27979864
PMC: PMC5305048
Contributors: Crossan GP
Source: Self-asserted source
Gerry Crossan via Europe PubMed Central
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Preferred source (of 2)‎

Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen.

2015-10 | Journal article
DOI: 10.1016/j.molcel.2015.08.020
PMID: 26412304
PMC: PMC4595711
Contributors: Pontel LB; Rosado IV; Burgos-Barragan G; Garaycoechea JI; Yu R; Arends MJ; Chandrasekaran G; Broecker V; Wei W; Liu L et al.
Source: Self-asserted source
Gerry Crossan via Europe PubMed Central

Do mutational dynamics in stem cells explain the origin of common cancers?

2015-02 | Journal article
DOI: 10.1016/j.stem.2015.01.009
PMID: 25658366
Contributors: Crossan GP; Garaycoechea JI; Patel KJ
Source: Self-asserted source
Gerry Crossan via Europe PubMed Central

Maternal aldehyde elimination during pregnancy preserves the fetal genome.

2014-09 | Journal article
DOI: 10.1016/j.molcel.2014.07.010
PMID: 25155611
PMC: PMC4175174
Contributors: Oberbeck N; Langevin F; King G; de Wind N; Crossan GP; Patel KJ
Source: Self-asserted source
Gerry Crossan via Europe PubMed Central

Mouse SLX4 is a tumor suppressor that stimulates the activity of the nuclease XPF-ERCC1 in DNA crosslink repair.

2014-05 | Journal article
DOI: 10.1016/j.molcel.2014.03.014
PMID: 24726326
PMC: PMC4017094
Contributors: Hodskinson MR; Silhan J; Crossan GP; Garaycoechea JI; Mukherjee S; Johnson CM; Schärer OD; Patel KJ
Source: Self-asserted source
Gerry Crossan via Europe PubMed Central

[Aldehydes and Fanconi anaemia: the enemy within].

2013-04 | Journal article
DOI: 10.1051/medsci/2013294009
PMID: 23621931
Contributors: Langevin FP; Garaycoechea JI; Crossan GP; Patel KJ
Source: Self-asserted source
Gerry Crossan via Europe PubMed Central

Analysis of the novel fanconi anemia gene SLX4/FANCP in familial breast cancer cases.

2013-01 | Journal article
DOI: 10.1002/humu.22206
PMID: 22911665
Contributors: Bakker JL; van Mil SE; Crossan G; Sabbaghian N; De Leeneer K; Poppe B; Adank M; Gille H; Verheul H; Meijers-Heijboer H et al.
Source: Self-asserted source
Gerry Crossan via Europe PubMed Central

Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function.

2012-09 | Journal article
DOI: 10.1038/nature11368
PMID: 22922648
Contributors: Garaycoechea JI; Crossan GP; Langevin F; Daly M; Arends MJ; Patel KJ
Source: Self-asserted source
Gerry Crossan via Europe PubMed Central

The Fanconi anaemia pathway orchestrates incisions at sites of crosslinked DNA.

2012-01 | Journal article
DOI: 10.1002/path.3002
PMID: 21956823
Contributors: Crossan GP; Patel KJ
Source: Self-asserted source
Gerry Crossan via Europe PubMed Central

"Ring-fencing" BRCA1 tumor suppressor activity.

2011-12 | Journal article
DOI: 10.1016/j.ccr.2011.11.019
PMID: 22172717
Contributors: Patel KJ; Crossan GP; Hodskinson MR
Source: Self-asserted source
Gerry Crossan via Europe PubMed Central

Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway.

2011-11 | Journal article
DOI: 10.1038/nsmb.2173
PMID: 22081012
Contributors: Rosado IV; Langevin F; Crossan GP; Takata M; Patel KJ
Source: Self-asserted source
Gerry Crossan via Europe PubMed Central

Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice.

2011-07 | Journal article
DOI: 10.1038/nature10192
PMID: 21734703
Contributors: Langevin F; Crossan GP; Rosado IV; Arends MJ; Patel KJ
Source: Self-asserted source
Gerry Crossan via Europe PubMed Central

Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia.

2011-02 | Journal article
DOI: 10.1038/ng.752
PMID: 21240276
PMC: PMC3624090
Contributors: Crossan GP; van der Weyden L; Rosado IV; Langevin F; Gaillard PH; McIntyre RE; Sanger Mouse Genetics Project; Gallagher F; Kettunen MI; Lewis DY et al.
Source: Self-asserted source
Gerry Crossan via Europe PubMed Central

Peer review (1 review for 1 publication/grant)

Review activity for Nature communications (1)
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