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Cell Biology, Quantitative Biology, Cellular Growth, Cell Division
United Kingdom

Activities

Employment (3)

University of Edinburgh: Edinburgh, GB

2023 to present | Wellcome Trust CDA Fellow and Group Leader (Wellcome Centre for Cell Biology )
Employment
Source: Self-asserted source
Matthew P. Swaffer

Stanford University: CA, US

2017 to 2023 | Postdoctoral Fellow (Biology)
Employment
Source: Self-asserted source
Matthew P. Swaffer

The Francis Crick Institute: London, GB

2015 to 2016 | Research Associate (Nurse Laboratory)
Employment
Source: Self-asserted source
Matthew P. Swaffer

Education and qualifications (2)

University College London: London, GB

2011 to 2015 | PhD in Cell and Molecular Biology (The Francis Crick Institute)
Education
Source: Self-asserted source
Matthew P. Swaffer

University of Cambridge: Cambridge, GB

2008 to 2011 | BA in Natural Sciences (Queens' College)
Education
Source: Self-asserted source
Matthew P. Swaffer

Funding (1)

How does cell size influence cellular biosynthesis and function?

2023-02-01 to 2031-01-31 | Grant
Wellcome Trust (London, UK, GB)
GRANT_NUMBER:

225903/Z/22/Z

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WT Grant Tracker

Works (19)

Somatic polyploidy supports biosynthesis and tissue function by increasing transcriptional output

Journal of Cell Biology
2025-03-03 | Journal article
Contributors: Alexander T. Lessenger; Jan M. Skotheim; Mathew P. Swaffer; Jessica L. Feldman
Source: check_circle
Crossref

Intracellular diffusion in the cytoplasm increases with cell size in fission yeast

2024-09-23 | Preprint
Contributors: Catherine Tan; Michael C. Lanz; Matthew Swaffer; Jan Skotheim; Fred Chang
Source: check_circle
Crossref

RNA polymerase II dynamics and mRNA stability feedback scale mRNA amounts with cell size.

Cell
2023-11 | Journal article
Contributors: Swaffer MP; Marinov GK; Zheng H; Fuentes Valenzuela L; Tsui CY; Jones AW; Greenwood J; Kundaje A; Greenleaf WJ; Reyes-Lamothe R et al.
Source: Self-asserted source
Matthew P. Swaffer via Europe PubMed Central

Meeting report - Cell size and growth: from single cells to the tree of life.

Journal of cell science
2022-10 | Journal article
Contributors: Chatzitheodoridou D; D'Ario M; Jones I; Piñeros L; Serbanescu D; O'Donnell F; Cadart C; Swaffer MP
Source: Self-asserted source
Matthew P. Swaffer via Europe PubMed Central

Increasing cell size remodels the proteome and promotes senescence.

Molecular cell
2022-08 | Journal article
Contributors: Lanz MC; Zatulovskiy E; Swaffer MP; Zhang L; Ilerten I; Zhang S; You DS; Marinov G; McAlpine P; Elias JE et al.
Source: Self-asserted source
Matthew P. Swaffer via Europe PubMed Central

Eukaryotic Cell Size Control and Its Relation to Biosynthesis and Senescence.

Annual review of cell and developmental biology
2022-05 | Journal article
Contributors: Xie S; Swaffer M; Skotheim JM
Source: Self-asserted source
Matthew P. Swaffer via Europe PubMed Central

Transcriptional and chromatin-based partitioning mechanisms uncouple protein scaling from cell size.

Molecular cell
2021-11 | Journal article
Contributors: Swaffer MP; Kim J; Chandler-Brown D; Langhinrichs M; Marinov GK; Greenleaf WJ; Kundaje A; Schmoller KM; Skotheim JM
Source: Self-asserted source
Matthew P. Swaffer via Europe PubMed Central

G 1 cyclin–Cdk promotes cell cycle entry through localized phosphorylation of RNA polymerase II

Science
2021-10-15 | Journal article
Contributors: Mardo Kõivomägi; Matthew P. Swaffer; Jonathan J. Turner; Georgi Marinov; Jan M. Skotheim
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Crossref
grade
Preferred source (of 2)‎

RNA polymerase II dynamics and mRNA stability feedback scale mRNA in proportion to cell size

2021-09-20 | Preprint
Contributors: Matthew P. Swaffer; Georgi K. Marinov; Huan Zheng; Crystal Yee Tsui; Andrew W. Jones; Jessica Greenwood; Anshul Kundaje; William J. Greenleaf; Rodrigo Reyes-Lamothe; Jan M. Skotheim
Source: check_circle
Crossref

Localized phosphorylation of RNA Polymerase II by G1 cyclin-Cdk promotes cell cycle entry

2021-03 | Preprint
Contributors: Kõivomägi M; Swaffer MP; Turner JJ; Marinov G; Skotheim JM
Source: Self-asserted source
Matthew P. Swaffer via Europe PubMed Central

Substrate Phosphorylation Rates as an In Vivo Measurement of Kinase Activity.

Methods in molecular biology (Clifton, N.J.)
2021-01 | Journal article
Contributors: Swaffer MP
Source: Self-asserted source
Matthew P. Swaffer via Europe PubMed Central

Science during lockdown - from virtual seminars to sustainable online communities.

Journal of cell science
2020-08 | Journal article
Contributors: Bottanelli F; Cadot B; Campelo F; Curran S; Davidson PM; Dey G; Raote I; Straube A; Swaffer MP
Source: Self-asserted source
Matthew P. Swaffer via Europe PubMed Central

Transcriptional and chromatin-based partitioning mechanisms uncouple protein scaling from cell size

2020-08-28 | Preprint
Contributors: Matthew P. Swaffer; Devon Chandler-Brown; Jacob Kim; Maurice Langhinrichs; Georgi Marinov; William Greenleaf; Anshul Kundaje; Kurt M. Schmoller; Jan M. Skotheim
Source: check_circle
Crossref

Long-range single-molecule mapping of chromatin accessibility in eukaryotes.

Nature methods
2020-02 | Journal article
Contributors: Shipony Z; Marinov GK; Swaffer MP; Sinnott-Armstrong NA; Skotheim JM; Kundaje A; Greenleaf WJ
Source: Self-asserted source
Matthew P. Swaffer via Europe PubMed Central

The Hydrophobic Patch Directs Cyclin B to Centrosomes to Promote Global CDK Phosphorylation at Mitosis.

Current biology : CB
2020-02 | Journal article
Contributors: Basu S; Roberts EL; Jones AW; Swaffer MP; Snijders AP; Nurse P
Source: Self-asserted source
Matthew P. Swaffer via Europe PubMed Central

Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Cell reports
2018-07 | Journal article
Contributors: Swaffer MP; Jones AW; Flynn HR; Snijders AP; Nurse P
Source: Self-asserted source
Matthew P. Swaffer via Europe PubMed Central

CDK Substrate Phosphorylation and Ordering the Cell Cycle.

Cell
2016-12 | Journal article
Contributors: Swaffer MP; Jones AW; Flynn HR; Snijders AP; Nurse P
Source: Self-asserted source
Matthew P. Swaffer via Europe PubMed Central

An Imaging Flow Cytometry-based approach to analyse the fission yeast cell cycle in fixed cells.

Methods (San Diego, Calif.)
2015-05 | Journal article
Contributors: Patterson JO; Swaffer M; Filby A
Source: Self-asserted source
Matthew P. Swaffer via Europe PubMed Central

What determines cell size?

BMC biology
2012-12 | Journal article
Contributors: Marshall WF; Young KD; Swaffer M; Wood E; Nurse P; Kimura A; Frankel J; Wallingford J; Walbot V; Qu X et al.
Source: Self-asserted source
Matthew P. Swaffer via Europe PubMed Central

Peer review (1 review for 1 publication/grant)

Review activity for Current opinion in cell biology. (1)