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Employment (1)

University of Florida: Gainesville, FL, US

2020-08-01 to present | Assistant Professor (Pharmacology & Therapeutics)
Employment
Source: Self-asserted source
Mark Moehle

Education and qualifications (2)

Vanderbilt University: Nashville, TN, US

2015-07 to present | Postdoc (Pharmacology)
Education
Source: Self-asserted source
Mark Moehle

University of Alabama at Birmingham: Birmingham, AL, US

2010-07 to 2015-08 | PhD (Neurology)
Education
Source: Self-asserted source
Mark Moehle

Funding (3)

M4 muscarinic acetylcholine receptor signaling as a potent regulator of motor deficits

2019-04-01 to 2021-03-31 | Grant
National Institute of Neurological Disorders and Stroke (Bethesda, US)
URL: https://app.dimensions.ai/details/grant/grant.8388721
GRANT_NUMBER: K99NS110878
Source: Self-asserted source
Mark Moehle via DimensionsWizard

Role of Microglial LRRK2 in Inflammation

2012-09-28 to 2015-09-27 | Grant
National Institute of Neurological Disorders and Stroke (Bethesda, US)
URL: https://grants.uberresearch.com/100000065/F31NS081963/Role-of-Microglial-LRRK2-in-Inflammation
GRANT_NUMBER: 5F31NS081963-03
Source: Self-asserted source
Mark Moehle via DimensionsWizard

Role of Microglial LRRK2 in Inflammation

2012-09-28 to 2015-05-31 | Grant
National Institute of Neurological Disorders and Stroke (Bethesda, US)
URL: https://app.dimensions.ai/details/grant/grant.2368419
GRANT_NUMBER: F31NS081963
Source: Self-asserted source
Mark Moehle via DimensionsWizard

Works (21)

Aggregated A-synuclein leads to corticostriatal synaptic dysfunction

2025-01-30 | Preprint
DOI: 10.1101/2025.01.29.635597
Contributors: Charlotte F. Brzozowski; Harshita Challa; Nolwazi Z. Gcwensa; Dominic Hall; Douglas Nabert; Nicole Chambers; Ignacio Gallardo; Michael Millet; Laura Volpicelli-Daley; Mark S. Moehle
Source: check_circle
Crossref

GαolfRegulates Biochemical Signaling in Neurons Associated with Movement Control and Initiation

2024-04-05 | Preprint
DOI: 10.1101/2024.04.03.587766
Contributors: Michael Millett; Anika Heuberger; Elisabeth Martin Castosa; Allison Comite; Preston Wagner; Dominic Hall; Ignacio Gallardo; Nicole E Chambers; Lloyd Wagner; Mark S Moehle
Source: check_circle
Crossref

Mechanisms of GNAL Linked Dystonia

2023-10-02 | Data management plan
DOI: 10.48321/D18Q0P
Source: check_circle
California Digital Library DMP Tool

The muscarinic M4 acetylcholine receptor exacerbates symptoms of movement disorders

Biochemical Society Transactions
2023-04-26 | Journal article
DOI: 10.1042/BST20220525
Contributors: Nicole E. Chambers; Michael Millett, Jr; Mark S. Moehle
Source: check_circle
Crossref

Sub-type selective muscarinic acetylcholine receptors modulation for the treatment of parkinsonian tremor

2022-04-04 | Preprint
DOI: 10.1101/2022.04.04.487007
Contributors: Kinsey Bickham; C. Price Withers; Augusto Diedrich; Mark Stephen Moehle
Source: check_circle
Crossref

Discovery of the First Selective M4 Muscarinic Acetylcholine Receptor Antagonists with in Vivo Antiparkinsonian and Antidystonic Efficacy

ACS Pharmacology & Translational Science
2021-08-13 | Journal article
DOI: 10.1021/acsptsci.0c00162
Contributors: Mark S. Moehle; Aaron M. Bender; Jonathan W. Dickerson; Daniel J. Foster; Aidong Qi; Hyekyung P. Cho; Yuping Donsante; Weimin Peng; Zoey Bryant; Kaylee J. Stillwell et al.
Source: check_circle
Crossref

Activation of the mGlu1 metabotropic glutamate receptor has antipsychotic-like effects and is required for efficacy of M4 muscarinic receptor allosteric modulators

Molecular Psychiatry
2020-11 | Journal article
DOI: 10.1038/s41380-018-0206-2
Contributors: Samantha E. Yohn; Daniel J. Foster; Dan P. Covey; Mark S. Moehle; Jordan Galbraith; Pedro M. Garcia-Barrantes; Hyekyung P. Cho; Michael Bubser; Anna L. Blobaum; Max E. Joffe et al.
Source: check_circle
Crossref

Roles of the M4 acetylcholine receptor in the basal ganglia and the treatment of movement disorders

Movement Disorders
2019-08 | Journal article
DOI: 10.1002/mds.27740
Contributors: Mark S. Moehle; P. Jeffrey Conn
Source: check_circle
Crossref

Urinary LRRK2 phosphorylation predicts parkinsonian phenotypes in G2019S LRRK2 carriers

Neurology
2016-02-10 | Journal article
DOI: 10.1212/wnl.0000000000002436
Contributors: K. B. Fraser; M. S. Moehle; R. N. Alcalay; A. B. West; On behalf of the LRRK2 Cohort Consortium; LRRK2 Cohort Consortium
Source: Self-asserted source
Mark Moehle via Crossref Metadata Search

Allosteric activation of M 4 muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice

Proc Natl Acad Sci USA
2015-10 | Journal article
DOI: 10.1073/pnas.1512812112
Contributors: Tristano Pancani; Daniel J. Foster; Mark S. Moehle; Terry Jo Bichell; Emma Bradley; Thomas M. Bridges; Rebecca Klar; Mike Poslusney; Jerri M. Rook; J. Scott Daniels et al.
Source: Self-asserted source
Mark Moehle via Crossref Metadata Search

M1 and M2 immune activation in Parkinson’s Disease: Foe and ally?

Neuroscience
2015-08 | Journal article
DOI: 10.1016/j.neuroscience.2014.11.018
Contributors: M.S. Moehle; A.B. West
Source: Self-asserted source
Mark Moehle via Crossref Metadata Search

Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration

J. Biol. Chem.
2015-06 | Journal article
DOI: 10.1074/jbc.m115.660001
Contributors: João P. L. Daher; Hisham A. Abdelmotilib; Xianzhen Hu; Laura A. Volpicelli-Daley; Mark S. Moehle; Kyle B. Fraser; Elie Needle; Yi Chen; Stefanus J. Steyn; Paul Galatsis et al.
Source: Self-asserted source
Mark Moehle via Crossref Metadata Search

Leucine-rich repeat kinase 2 deficiency is protective in rhabdomyolysis-induced kidney injury

Human Molecular Genetics
2015-04 | Journal article
DOI: 10.1093/hmg/ddv147
Contributors: R. Boddu; T. D. Hull; S. Bolisetty; X. Hu; M. S. Moehle; J. P. L. Daher; A. I. Kamal; R. Joseph; J. F. George; A. Agarwal et al.
Source: Self-asserted source
Mark Moehle via Crossref Metadata Search

The G2019S LRRK2 mutation increases myeloid cell chemotactic responses and enhances LRRK2 binding to actin-regulatory proteins

Hum. Mol. Genet.
2015-04 | Journal article
DOI: 10.1093/hmg/ddv157
Contributors: Mark S. Moehle; João Paulo Lima Daher; Travis D. Hull; Ravindra Boddu; Hisham A. Abdelmotilib; James Mobley; George T. Kannarkat; Malú G. Tansey; Andrew B. West
Source: Self-asserted source
Mark Moehle via Crossref Metadata Search

Unique Functional and Structural Properties of the LRRK2 Protein ATP-binding Pocket

Journal of Biological Chemistry
2014-09 | Journal article
DOI: 10.1074/jbc.m114.602318
Contributors: Z. Liu; R. A. Galemmo; K. B. Fraser; M. S. Moehle; S. Sen; L. A. Volpicelli-Daley; L. J. DeLucas; L. J. Ross; J. Valiyaveettil; O. Moukha-Chafiq et al.
Source: Self-asserted source
Mark Moehle via Crossref Metadata Search

Abrogation of  -synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats

Proceedings of the National Academy of Sciences
2014-06-09 | Journal article
DOI: 10.1073/pnas.1403215111
Contributors: J. P. L. Daher; L. A. Volpicelli-Daley; J. P. Blackburn; M. S. Moehle; A. B. West
Source: Self-asserted source
Mark Moehle via Crossref Metadata Search

Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents

J. Comp. Neurol.
2014-06-02 | Journal article
DOI: 10.1002/cne.23612
Contributors: Andrew B. West; Rita M. Cowell; João P.L. Daher; Mark S. Moehle; Kelly M. Hinkle; Heather L. Melrose; David G. Standaert; Laura A. Volpicelli-Daley
Source: Self-asserted source
Mark Moehle via Crossref Metadata Search

Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents

J. Comp. Neurol.
2014-04 | Journal article
DOI: 10.1002/cne.23583
Contributors: Andrew B. West; Rita M. Cowell; João P.L. Daher; Mark S. Moehle; Kelly M. Hinkle; Heather L. Melrose; David G. Standaert; Laura A. Volpicelli-Daley
Source: Self-asserted source
Mark Moehle via Crossref Metadata Search

LRRK2 secretion in exosomes is regulated by 14-3-3

Human Molecular Genetics
2013-07 | Journal article
DOI: 10.1093/hmg/ddt346
Contributors: K. B. Fraser; M. S. Moehle; J. P. L. Daher; P. J. Webber; J. Y. Williams; C. A. Stewart; T. A. Yacoubian; R. M. Cowell; T. Dokland; T. Ye et al.
Source: Self-asserted source
Mark Moehle via Crossref Metadata Search

Regional differences in expression of β-tubulin isoforms in schizophrenia

Schizophrenia Research
2012-03 | Journal article
DOI: 10.1016/j.schres.2011.12.010
Contributors: Mark S. Moehle; Richard F. Luduena; Vahram Haroutunian; James H. Meador-Woodruff; Robert E. McCullumsmith
Source: Self-asserted source
Mark Moehle via Crossref Metadata Search

LRRK2 Inhibition Attenuates Microglial Inflammatory Responses

Journal of Neuroscience
2012-02-01 | Journal article
DOI: 10.1523/jneurosci.5601-11.2012
Contributors: M. S. Moehle; P. J. Webber; T. Tse; N. Sukar; D. G. Standaert; T. M. DeSilva; R. M. Cowell; A. B. West
Source: Self-asserted source
Mark Moehle via Crossref Metadata Search

Peer review (2 reviews for 2 publications/grants)

Review activity for ACS chemical neuroscience. (1)
Review activity for Life sciences. (1)
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