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Keywords

single-cell genomics, hematopoiesis, molecular biology, computational biology, bioinformatics, big data, transcriptomics, molecular genetics

Countries

Sweden

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Employment (1)

Lund Stem Cell Center: Lund, SE

2017-08 to present (DMH)
Employment
Source: Self-asserted source
Parashar Dhapola

Education and qualifications (1)

Lund University: Lund, SE

2018-08-01 to 2022-12-01 | PhD (Faculty of Medicine )
Education
Source: Self-asserted source
Parashar Dhapola

Works (30)

Single cell multi-omics analysis of chronic myeloid leukemia links cellular heterogeneity to therapy response

2024-04-05 | Preprint
DOI: 10.7554/eLife.92074
Contributors: Rebecca Warfvinge; Linda Geironson Ulfsson; Parashar Dhapola; Fatemeh Safi; Mikael N.E. Sommarin; Shamit Soneji; Henrik Hjorth-Hansen; Satu Mustjoki; Johan Richter; Ram Krishna Thakur et al.
Source: check_circle
Crossref

Single cell multi-omics analysis of chronic myeloid leukemia links cellular heterogeneity to therapy response

2024-04-05 | Preprint
DOI: 10.7554/eLife.92074.2
Contributors: Rebecca Warfvinge; Linda Geironson Ulfsson; Parashar Dhapola; Fatemeh Safi; Mikael N.E. Sommarin; Shamit Soneji; Henrik Hjorth-Hansen; Satu Mustjoki; Johan Richter; Ram Krishna Thakur et al.
Source: check_circle
Crossref

Tracking early mammalian organogenesis – prediction and validation of differentiation trajectories at whole organism scale

Development
2024-02-01 | Journal article
DOI: 10.1242/dev.201867
Contributors: Ivan Imaz-Rosshandler; Christina Rode; Carolina Guibentif; Luke T. G. Harland; Mai-Linh N. Ton; Parashar Dhapola; Daniel Keitley; Ricard Argelaguet; Fernando J. Calero-Nieto; Jennifer Nichols et al.
Source: check_circle
Crossref

Single cell multi-omics analysis of chronic myeloid leukemia links cellular heterogeneity to therapy response

2023-11-30 | Preprint
DOI: 10.7554/eLife.92074.1
Contributors: Rebecca Warfvinge; Linda Geironson Ulfsson; Parashar Dhapola; Fatemeh Safi; Mikael N.E. Sommarin; Shamit Soneji; Henrik Hjorth-Hansen; Satu Mustjoki; Johan Richter; Ram Krishna Thakur et al.
Source: check_circle
Crossref

Single-cell multiomics of human fetal hematopoiesis define a developmental-specific population and a fetal signature

Blood Advances
2023-09-26 | Journal article
DOI: 10.1182/bloodadvances.2023009808
Contributors: Mikael N. E. Sommarin; Rasmus Olofzon; Sara Palo; Parashar Dhapola; Shamit Soneji; Göran Karlsson; Charlotta Böiers
Source: check_circle
Crossref

CD9 marks myeloid/MegE-biased human hematopoiesis

2023-09-07 | Preprint
DOI: 10.1101/2023.09.06.556527
Contributors: Fatemeh Safi; Parashar Dhapola; Mikael N.E. Sommarin; Göran Karlsson
Source: check_circle
Crossref

Single cell multi-omics analysis of chronic myeloid leukemia links cellular heterogeneity to therapy response

2023-08-18 | Preprint
DOI: 10.1101/2023.08.16.553504
Contributors: Rebecca Warfvinge; Linda Geironson Ulfsson; Parashar Dhapola; Fatemeh Safi; Mikael N.E. Sommarin; Shamit Soneji; Henrik Hjorth-Hansen; Satu Mustjoki; Johan Richter; Ram Krishna Thakur et al.
Source: check_circle
Crossref

Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age.

Cell reports
2023-03-23 | Journal article | Formal analysis
DOI: 10.1016/j.celrep.2023.112304
PMID: 36961818
Contributors: Anna Konturek-Ciesla; Parashar Dhapola; Zhang Q; Säwén P; Wan H; Karlsson G; Bryder D
Source: Self-asserted source
Parashar Dhapola

Tracking Early Mammalian Organogenesis – Prediction and Validation of Differentiation Trajectories at Whole Organism Scale

2023-03-18 | Preprint
DOI: 10.1101/2023.03.17.532833
Contributors: Ivan Imaz-Rosshandler; Christina Rode; Carolina Guibentif; Mai-Linh N. Ton; Parashar Dhapola; Daniel Keitley; Ricard Argelaguet; Fernando J. Calero-Nieto; Jennifer Nichols; John C. Marioni et al.
Source: check_circle
Crossref

Identification of phenotypically, functionally, and anatomically distinct stromal niche populations in human bone marrow based on single-cell RNA sequencing

eLife
2023-03-06 | Journal article | Formal analysis
DOI: 10.7554/elife.81656
Part of ISSN: 2050-084X
Contributors: Hongzhe Li; Sandro Bräunig; Parashar Dhapola; Göran Karlsson; Stefan Lang; Stefan Scheding
Source: Self-asserted source
Parashar Dhapola

In vitro clonal multilineage differentiation of distinct murine hematopoietic progenitor populations.

STAR protocols
2023-01-10 | Journal article | Formal analysis
DOI: 10.1016/j.xpro.2022.101965
PMID: 36633951
PMC: PMC9843257
Contributors: Fatemeh Safi; Parashar Dhapola; Erlandsson E; Ulfsson LG; Ariana S. Calderón; Charlotta Böiers; Karlsson G
Source: Self-asserted source
Parashar Dhapola

Scarf enables a highly memory-efficient analysis of large-scale single-cell genomics data

Nature Communications
2022-08-08 | Journal article
DOI: 10.1038/s41467-022-32097-3
Contributors: Parashar Dhapola; Johan Rodhe; Rasmus Olofzon; Thomas Bonald; Eva Erlandsson; Shamit Soneji; Göran Karlsson
Source: check_circle
Crossref

Concurrent stem- and lineage-affiliated chromatin programs precede hematopoietic lineage restriction.

Cell reports
2022-05-01 | Journal article | Formal analysis, Conceptualization
DOI: 10.1016/j.celrep.2022.110798
PMID: 35545037
Contributors: Safi F; Parashar Dhapola; Warsi S; Sommarin M; Erlandsson E; Ungerbäck J; Warfvinge R; Sitnicka E; Bryder D; Charlotta Böiers et al.
Source: Self-asserted source
Parashar Dhapola

Genome-wide association study on 13 167 individuals identifies regulators of blood CD34+cell levels.

Blood
2022-03-01 | Journal article | Author
DOI: 10.1182/blood.2021013220
PMID: 35007327
Contributors: Lopez de Lapuente Portilla A; Ludvig Ekdahl; Cafaro C; Ali Z; Miharada N; Thorleifsson G; Kristijonas Zemaitis; Lamarca Arrizabalaga A; Malte Thodberg; Pertesi M et al.
Source: Self-asserted source
Parashar Dhapola

A Combined Immunophenotypic And Transcriptional Single-Cell Map Of First Trimester Human Fetal Liver Hematopoiesis

2021-12-29 | Preprint
DOI: 10.1101/2021.12.29.474425
Contributors: Mikael N.E. Sommarin; Rasmus Olofzon; Sara Palo; Parashar Dhapola; Göran Karlsson; Charlotta Böiers
Source: check_circle
Crossref

CellexalVR: A virtual reality platform to visualize and analyze single-cell omics data

iScience
2021-11 | Journal article
DOI: 10.1016/j.isci.2021.103251
Contributors: Oscar Legetth; Johan Rodhe; Stefan Lang; Parashar Dhapola; Mattias Wallergård; Shamit Soneji
Source: check_circle
Crossref

Scarf: A toolkit for memory efficient analysis of large-scale single-cell genomics data

Biorxiv
2021-05-03 | Preprint
DOI: 10.1101/2021.05.02.441899
Source: Self-asserted source
Parashar Dhapola
grade
Preferred source (of 2)‎

Single-Cell Multiomics Reveals Distinct Cell States at the Top of the Human Hematopoietic Hierarchy

Biorxiv
2021-04-02 | Preprint
DOI: 10.1101/2021.04.01.437998
Source: Self-asserted source
Parashar Dhapola

Genome-wide association study on 13,167 individuals identifies regulators of hematopoietic stem and progenitor cell levels in human blood

Biorxiv
2021-04-01 | Preprint
DOI: 10.1101/2021.03.31.437808
Source: Self-asserted source
Parashar Dhapola

Nabo – a framework to define leukemia-initiating cells and differentiation in single-cell RNA-sequencing data

Biorxiv
2020-10-02 | Preprint
DOI: 10.1101/2020.09.30.321216
Source: Self-asserted source
Parashar Dhapola

Loss of Cxcr5 alters neuroblast proliferation and migration in the aged brain.

Stem cells (Dayton, Ohio)
2020-05-29 | Journal article
DOI: 10.1002/stem.3207
PMID: 32469107
Source: Self-asserted source
Parashar Dhapola

Concurrent stem- and lineage-affiliated chromatin programs precede hematopoietic lineage restriction

Biorxiv
2020-05-01 | Preprint
DOI: 10.1101/2020.04.29.069062
Source: Self-asserted source
Parashar Dhapola

BLM Potentiates c-Jun Degradation and Alters Its Function as an Oncogenic Transcription Factor.

Cell reports
2018-07-01 | Journal article
DOI: 10.1016/j.celrep.2018.06.101
PMID: 30044990
Source: Self-asserted source
Parashar Dhapola

CellexalVR: A virtual reality platform to visualise and analyse single-cell data

Biorxiv
2018-05-24 | Preprint
DOI: 10.1101/329102
Source: Self-asserted source
Parashar Dhapola

Novel internal regulators and candidate miRNAs within miR-379/miR-656 miRNA cluster can alter cellular phenotype of human glioblastoma.

Scientific reports
2018-05-16 | Journal article
DOI: 10.1038/s41598-018-26000-8
PMID: 29769662
PMC: PMC5955984
Source: Self-asserted source
Parashar Dhapola

Transcription regulation of CDKN1A (p21/CIP1/WAF1) by TRF2 is epigenetically controlled through the REST repressor complex.

Scientific reports
2017-09-14 | Journal article
DOI: 10.1038/s41598-017-11177-1
PMID: 28912501
PMC: PMC5599563
Source: Self-asserted source
Parashar Dhapola

ATF3 negatively regulates cellular antiviral signaling and autophagy in the absence of type I interferons.

Scientific reports
2017-08-18 | Journal article
DOI: 10.1038/s41598-017-08584-9
PMID: 28821775
PMC: PMC5562757
Source: Self-asserted source
Parashar Dhapola

Epigenetic suppression of human telomerase (<i>hTERT</i>) is mediated by the metastasis suppressor NME2 in a G-quadruplex-dependent fashion.

The Journal of biological chemistry
2017-07-17 | Journal article
DOI: 10.1074/jbc.m117.792077
PMID: 28717007
PMC: PMC5602382
Source: Self-asserted source
Parashar Dhapola
grade
Preferred source (of 2)‎

QuadBase2: web server for multiplexed guanine quadruplex mining and visualization.

Nucleic acids research
2016-05-16 | Journal article
DOI: 10.1093/nar/gkw425
PMID: 27185890
PMC: PMC4987949
Source: Self-asserted source
Parashar Dhapola

BreCAN-DB: a repository cum browser of personalized DNA breakpoint profiles of cancer genomes.

Nucleic acids research
2015-11-19 | Journal article
DOI: 10.1093/nar/gkv1264
PMID: 26586806
PMC: PMC4702892
Source: Self-asserted source
Parashar Dhapola

Peer review (1 review for 1 publication/grant)

Review activity for PloS one. (1)
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