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National Cheng Kung University: Tainan, TW

2017-08-01 to present | Professor (Department of Biochemistry and Molecular Biology)
Employment
Source: Self-asserted source
Chang-Shi Chen

Works (39)

PRMT-7/PRMT7 activates HLH-30/TFEB to guard plasma membrane integrity compromised by bacterial pore-forming toxins

Autophagy
2024-06-02 | Journal article
DOI: 10.1080/15548627.2024.2306655
Contributors: Hui-Chen Hsieh; I-Hsiang Huang; Shao-Wen Chang; Po-Lin Chen; Yu-Cheng Su; Shuying Wang; Wei-Jiun Tsai; Ping-Hung Chen; Raffi V. Aroian; Chang-Shi Chen
Source: check_circle
Crossref

Haemolysin Ahh1 secreted from Aeromonas dhakensis activates the NLRP3 inflammasome in macrophages and mediates severe soft tissue infection

International Immunopharmacology
2024-02 | Journal article
DOI: 10.1016/j.intimp.2023.111478
Contributors: Yu-Cheng Su; Ching-Chun Wang; Yi-Wei Chen; Sin-Tian Wang; Cing-Ying Shu; Pei-Jane Tsai; Wen-Chien Ko; Chang-Shi Chen; Po-Lin Chen
Source: check_circle
Crossref

Host CDK-1 and formin mediate microvillar effacement induced by enterohemorrhagic Escherichia coli

Nature Communications
2021-12 | Journal article
DOI: 10.1038/s41467-020-20355-1
Part of ISSN: 2041-1723
Source: Self-asserted source
Chang-Shi Chen

OmpR coordinates the expression of virulence factors of Enterohemorrhagic Escherichia coli in the alimentary tract of Caenorhabditis elegans

Molecular Microbiology
2021-07 | Journal article
DOI: 10.1111/mmi.14698
Contributors: Sin‐Tian Wang; Cheng‐Ju Kuo; Chih‐Wen Huang; Tzer‐Min Lee; Jenn‐Wei Chen; Chang‐Shi Chen
Source: check_circle
Crossref

The conserved regulator of autophagy and innate immunity hlh-30/TFEB mediates tolerance of enterohemorrhagic Escherichia coli in Caenorhabditis elegans.

Genetics
2021-03-01 | Journal article
DOI: 10.1093/genetics/iyaa052
PMID: 33683370
Source: Self-asserted source
Chang-Shi Chen

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).

Autophagy
2021-02-08 | Journal article
DOI: 10.1080/15548627.2020.1797280
PMID: 33634751
Source: Self-asserted source
Chang-Shi Chen

Iron Acquisition of Urinary Tract Infection <i>Escherichia coli</i> Involves Pathogenicity in <i>Caenorhabditis elegans</i>.

Microorganisms
2021-02-02 | Journal article
DOI: 10.3390/microorganisms9020310
PMID: 33540892
Source: Self-asserted source
Chang-Shi Chen

Effects of electrotactic exercise and antioxidant EUK-134 on oxidative stress relief in Caenorhabditis elegans.

PloS one
2021-01-20 | Journal article
DOI: 10.1371/journal.pone.0245474
PMID: 33471830
PMC: PMC7817057
Source: Self-asserted source
Chang-Shi Chen

The role of the bacterial protease Prc in the uropathogenesis of extraintestinal pathogenic Escherichia coli

Journal of Biomedical Science
2020-12 | Journal article
DOI: 10.1186/s12929-019-0605-y
Part of ISSN: 1423-0127
Source: Self-asserted source
Chang-Shi Chen

IGLR-2, a Leucine-Rich Repeat Domain Containing Protein, Is Required for the Host Defense in Caenorhabditis elegans

Frontiers in Immunology
2020-11-30 | Journal article
DOI: 10.3389/fimmu.2020.561337
Part of ISSN: 1664-3224
Source: Self-asserted source
Chang-Shi Chen

UvrY is required for the full virulence of Aeromonas dhakensis

Virulence
2020-01-01 | Journal article
DOI: 10.1080/21505594.2020.1768339
Part of ISSN: 2150-5594
Part of ISSN: 2150-5608
Source: Self-asserted source
Chang-Shi Chen

Worms on a Chip

Bioanalysis
2019 | Book chapter
DOI: 10.1007/978-981-13-6229-3_6
Part of ISBN: 9789811362286
Part of ISBN: 9789811362293
Part of ISSN: 2364-1118
Part of ISSN: 2364-1126
Source: Self-asserted source
Chang-Shi Chen

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Database
2019-01-01 | Journal article
DOI: 10.1093/database/baz085
Part of ISSN: 1758-0463
Source: Self-asserted source
Chang-Shi Chen

Evaluating Virulence and Pathogenesis of <em>Aeromonas</em> Infection in a <em>Caenorhabditis elegans</em> Model

Journal of Visualized Experiments
2018-12-20 | Journal article
DOI: 10.3791/58768
Part of ISSN: 1940-087X
Source: Self-asserted source
Chang-Shi Chen

Rationally designed divalent caffeic amides inhibit amyloid-β fibrillization, induce fibril dissociation, and ameliorate cytotoxicity

European Journal of Medicinal Chemistry
2018-10 | Journal article
DOI: 10.1016/j.ejmech.2018.08.084
Part of ISSN: 0223-5234
Source: Self-asserted source
Chang-Shi Chen

RIOK-1 Is a Suppressor of the p38 MAPK Innate Immune Pathway in Caenorhabditis elegans

Frontiers in Immunology
2018-04-17 | Journal article
DOI: 10.3389/fimmu.2018.00774
Part of ISSN: 1664-3224
Source: Self-asserted source
Chang-Shi Chen

Detection of Enterohemorrhagic <em>Escherichia Coli</em> Colonization in Murine Host by Non-invasive <em>In Vivo</em> Bioluminescence System

Journal of Visualized Experiments
2018-04-09 | Journal article
DOI: 10.3791/56169
Part of ISSN: 1940-087X
Source: Self-asserted source
Chang-Shi Chen

A multi-omic analysis reveals the role of fumarate in regulating the virulence of enterohemorrhagic Escherichia coli

Cell Death & Disease
2018-03-07 | Journal article
DOI: 10.1038/s41419-018-0423-2
Contributors: Cheng-Ju Kuo; Sin-Tian Wang; Chia-Mei Lin; Hao-Chieh Chiu; Cheng-Rung Huang; Der-Yen Lee; Geen-Dong Chang; Ting-Chen Chou; Jenn-Wei Chen; Chang-Shi Chen
Source: check_circle
Crossref

A Disease Model of Muscle Necrosis Caused by Aeromonas dhakensis Infection in Caenorhabditis elegans

Frontiers in Microbiology
2017 | Journal article
DOI: 10.3389/fmicb.2016.02058
WOSUID:

WOS:000391152800001
Contributors: Chen, Po-Lin; Chen, Yi-Wei; Ou, Chun-Chun; Lee, Tzer-Min; Wu, Chi-Jung; Ko, Wen-Chien; Chen, Chang-Shi
Source: Self-asserted source
Chang-Shi Chen via ResearcherID

HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C-elegans

Autophagy
2017 | Journal article
DOI: 10.1080/15548627.2016.1256933
WOSUID:

WOS:000395125200012
Contributors: Chen, Huan-Da; Kao, Cheng-Yuan; Liu, Bang-Yu; Huang, Shin-Whei; Kuo, Cheng-Ju; Ruan, Jhen-Wei; Lin, Yen-Hung; Huang, Cheng-Rung; Chen, Yu-Hung; Wang, Horng-Dar et al.
Source: Self-asserted source
Chang-Shi Chen via ResearcherID

Neuroprotective Effects of Betulin in Pharmacological and Transgenic Caenorhabditis elegans Models of Parkinson’s Disease

Cell Transplantation
2017-12 | Journal article
DOI: 10.1177/0963689717738785
Part of ISSN: 0963-6897
Part of ISSN: 1555-3892
Source: Self-asserted source
Chang-Shi Chen

Design and Synthesis of Malonamide Derivatives as Antibiotics against Methicillin-Resistant Staphylococcus aureus

Molecules
2017-12-22 | Journal article
DOI: 10.3390/molecules23010027
Part of ISSN: 1420-3049
Source: Self-asserted source
Chang-Shi Chen

Exercise in an electrotactic flow chamber ameliorates age-related degeneration in Caenorhabditis elegans

Scientific Reports
2016 | Journal article
DOI: 10.1038/srep28064
WOSUID:

WOS:000378079000001
Contributors: Chuang, Han-Sheng; Kuo, Wan-Jung; Lee, Chia-Lin; Chu, I-Hua; Chen, Chang-Shi
Source: Self-asserted source
Chang-Shi Chen via ResearcherID

In vitro and in vivo activity of a novel sorafenib derivative SC5005 against MRSA

Journal of Antimicrobial Chemotherapy
2016 | Journal article
DOI: 10.1093/jac/dkv367
WOSUID:

WOS:000372427600024
Contributors: Chang, Han-Chu; Huang, Yu-Ting; Chen, Chang-Shi; Chen, Yi-Wei; Huang, Yu-Tsung; Su, Jung-Chen; Teng, Lee-Jeng; Shiau, Chung-Wai; Chiu, Hao-Chieh
Source: Self-asserted source
Chang-Shi Chen via ResearcherID

Mutation of the Enterohemorrhagic Escherichia coli Core LPS Biosynthesis Enzyme RfaD Confers Hypersusceptibility to Host Intestinal Innate Immunity In vivo

Frontiers in Cellular and Infection Microbiology
2016 | Journal article
DOI: 10.3389/fcimb.2016.00082
WOSUID:

WOS:000381368500001
Contributors: Kuo, Cheng-Ju; Chen, Jenn-Wei; Chiu, Hao-Chieh; Teng, Ching-Hao; Hsu, Tai-I; Lu, Pei-Jung; Syu, Wan-Jr; Wang, Sin-Tian; Chou, Ting-Chen; Chen, Chang-Shi
Source: Self-asserted source
Chang-Shi Chen via ResearcherID

Aeromonas stool isolates from individuals with or without diarrhea in southern Taiwan: Predominance of Aeromonas veronii

Journal of Microbiology Immunology and Infection
2015 | Journal article
DOI: 10.1016/j.jmii.2014.08.007
WOSUID:

WOS:000366534400006
Contributors: Chen, Po-Lin; Tsai, Pei-Jane; Chen, Chang-Shi; Lu, Ying-Chuan; Chen, Hung-Mo; Lee, Nan-Yao; Lee, Ching-Chi; Li, Chia-Wen; Li, Ming-Chi; Wu, Chi-Jung et al.
Source: Self-asserted source
Chang-Shi Chen via ResearcherID

Loss of DNase II function in the gonad is associated with a higher expression of antimicrobial genes in Caenorhabditis elegans

Biochemical Journal
2015 | Journal article
DOI: 10.1042/BJ20150563
WOSUID:

WOS:000361054300012
Contributors: Yu, Hsiang; Lai, Huey-Jen; Lin, Tai-Wei; Chen, Chang-Shi; Lo, Szecheng J.
Source: Self-asserted source
Chang-Shi Chen via ResearcherID

A comparative study of clinical Aeromonas dhakensis and Aeromonas hydrophila isolates in southern Taiwan: A. dhakensis is more predominant and virulent

Clinical Microbiology and Infection
2014 | Journal article
DOI: 10.1111/1469-0691.12456
WOSUID:

WOS:000340199000004
Contributors: Chen, P-L; Wu, C-J; Chen, C-S; Tsai, P-J; Tang, H-J; Ko, W-C
Source: Self-asserted source
Chang-Shi Chen via ResearcherID

Acetylcorynoline attenuates dopaminergic neuron degeneration and alpha-synuclein aggregation in animal models of Parkinson's disease

Neuropharmacology
2014 | Journal article
DOI: 10.1016/j.neuropharm.2013.08.007
WOSUID:

WOS:000337214400012
Contributors: Fu, Ru-Huei; Wang, Yu-Chi; Chen, Chang-Shi; Tsai, Rong-Tzong; Liu, Shih-Ping; Chang, Wen-Lin; Lin, Hsin-Lien; Lu, Chia-Hui; Wei, Jing-Rong; Wang, Zih-Wan et al.
Source: Self-asserted source
Chang-Shi Chen via ResearcherID

MicroRNA-18a is elevated in prostate cancer and promotes tumorigenesis through suppressing STK4 in vitro and in vivo

Oncogenesis
2014 | Journal article
DOI: 10.1038/oncsis.2014.12
WOSUID:

WOS:000348443800003
Contributors: Hsu, T-I; Hsu, C-H; Lee, K-H; Lin, J-T; Chen, C-S; Chang, K-C; Su, C-Y J.; Hsiao, M.; Lu, P-J
Source: Self-asserted source
Chang-Shi Chen via ResearcherID

n-Butylidenephthalide Protects against Dopaminergic Neuron Degeneration and alpha-Synuclein Accumulation in Caenorhabditis elegans Models of Parkinson's Disease

Plos One
2014 | Journal article
DOI: 10.1371/journal.pone.0085305
WOSUID:

WOS:000329862500236
Contributors: Fu, Ru-Huei; Harn, Horng-Jyh; Liu, Shih-Ping; Chen, Chang-Shi; Chang, Wen-Lin; Chen, Yue-Mi; Huang, Jing-En; Li, Rong-Jhu; Tsai, Sung-Yu; Hung, Huey-Shan et al.
Source: Self-asserted source
Chang-Shi Chen via ResearcherID

Virulence Diversity among Bacteremic Aeromonas Isolates: Ex Vivo, Animal, and Clinical Evidences

Plos One
2014 | Journal article
DOI: 10.1371/journal.pone.0111213
WOSUID:

WOS:000344402600031
Contributors: Chen, Po-Lin; Wu, Chi-Jung; Tsai, Pei-Jane; Tang, Hung-Jen; Chuang, Yin-Ching; Lee, Nan-Yao; Lee, Ching-Chi; Li, Chia-Wen; Li, Ming-Chi; Chen, Chi-Chung et al.
Source: Self-asserted source
Chang-Shi Chen via ResearcherID

Enterohaemorrhagic Escherichia coli O157:H7 Shiga-like toxin 1 is required for full pathogenicity and activation of the p38 mitogen-activated protein kinase pathway in Caenorhabditis elegans

Cellular Microbiology
2013 | Journal article
DOI: 10.1111/cmi.12030
WOSUID:

WOS:000314586600008
Contributors: Chou, T-C.; Chiu, H-C.; Kuo, C-J.; Wu, C-M.; Syu, W-J.; Chiu, W-T.; Chen, C-S.
Source: Self-asserted source
Chang-Shi Chen via ResearcherID

Immobilization of the nematode caenorhabditis elegans with addressable light-induced heat knockdown (ALINK)

Lab on a Chip
2013 | Journal article
DOI: 10.1039/c3lc50454a
WOSUID:

WOS:000321220000017
Contributors: Chuang, Han-Sheng; Chen, Hsiang-Yu; Chen, Chang-Shi; Chiu, Wen-Tai
Source: Self-asserted source
Chang-Shi Chen via ResearcherID

SESN-1 is a positive regulator of lifespan in Caenorhabditis elegans

Experimental Gerontology
2013 | Journal article
DOI: 10.1016/j.exger.2012.12.011
WOSUID:

WOS:000315683800010
Contributors: Yang, Ya-Luen; Loh, Kah-Sin; Liou, Bang-Yu; Chu, I-Hua; Kuo, Cheng-Ju; Chen, Huan-Da; Chen, Chang-Shi
Source: Self-asserted source
Chang-Shi Chen via ResearcherID

Genome Sequence of a Novel Human Pathogen, Aeromonas aquariorum

Journal of Bacteriology
2012 | Journal article
DOI: 10.1128/JB.00621-12
WOSUID:

WOS:000306634300036
Contributors: Wu, Chi-Jung; Wang, Hsuan-Chen; Chen, Chang-Shi; Shu, Hung-Yu; Kao, Ai-Wen; Chen, Po-Lin; Ko, Wen-Chien
Source: Self-asserted source
Chang-Shi Chen via ResearcherID

WWP-1 Is a Novel Modulator of the DAF-2 Insulin-Like Signaling Network Involved in Pore-Forming Toxin Cellular Defenses in Caenorhabditis elegans

PLOS ONE
2010 | Journal article
DOI: ARTN e9494 DOI 10.1371/journal.pone.0009494
WOSUID:

ISI:000275063300010
Contributors: Chen, CS; Bellier, A; Kao, CY; Yang, YL; Chen, HD; Los, FCO; Aroian, RV
Source: Self-asserted source
Chang-Shi Chen via ResearcherID

Hypoxia and the Hypoxic Response Pathway Protect against Pore-Forming Toxins in C. elegans

PLOS PATHOGENS
2009 | Journal article
DOI: ARTN e1000689 DOI 10.1371/journal.ppat.1000689
WOSUID:

ISI:000274227000013
Contributors: Bellier, A; Chen, CS; Kao, CY; Cinar, HN; Aroian, RV
Source: Self-asserted source
Chang-Shi Chen via ResearcherID

Expression of Cry5B protein from Bacillus thuringiensis in plant roots confers resistance to root-knot nematode

BIOLOGICAL CONTROL
2008 | Journal article
DOI: 10.1016/j.biocontrol.2008.06.007
WOSUID:

WOS:000259711500015
Contributors: LI, XQ; TAN, A; VOEGTLINE, M; et al.
Source: Self-asserted source
Chang-Shi Chen via ResearcherID
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