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Keywords

GPCR

Countries

China

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Employment (1)

Sichuan University: Chengdu, Sichuan, CN

2021-09-01 to present | Doctorate degree ( State Key Laboratory of Biotherapy and Cancer Center)
Employment
Source: Self-asserted source
Chang Zhao

Education and qualifications (2)

Sichuan University: Chengdu, Sichuan, CN

2021-09-01 to present | Doctorate degree ( State Key Laboratory of Biotherapy and Cancer Center)
Education
Source: Self-asserted source
Chang Zhao

Sichuan University: Chengdu, CN

2017-09-14 to 2020-06-30 | Masters degree ( State Key Laboratory of Biotherapy and Cancer Center)
Education
Source: Self-asserted source
Chang Zhao

Works (12)

Cryo-EM structure of small-molecule agonist bound delta opioid receptor-Gi complex enables discovery of biased compound

Nature Communications
2024-09-27 | Journal article
DOI: 10.1038/s41467-024-52601-1
Contributors: Lin Cheng; Zhuang Miao; Sicen Liu; Zhe Li; Hong Fu; Chanjuan Xu; Shilong Hu; Chang Zhao; Yuxuan Liu; Tiantian Zhao et al.
Source: check_circle
Crossref

Structure-based identification of a G protein–biased allosteric modulator of cannabinoid receptor CB1

Proceedings of the National Academy of Sciences
2024-06-11 | Journal article
DOI: 10.1073/pnas.2321532121
Contributors: Siyuan Shen; Chao Wu; Guifeng Lin; Xin Yang; Yangli Zhou; Chang Zhao; Zhuang Miao; Xiaowen Tian; Kexin Wang; Zhiqian Yang et al.
Source: check_circle
Crossref

Ligand recognition and G-protein coupling of trace amine receptor TAAR1

Nature
2023-12-21 | Journal article
DOI: 10.1038/s41586-023-06804-z
Contributors: Zheng Xu; Lulu Guo; Jingjing Yu; Siyuan Shen; Chao Wu; Weifeng Zhang; Chang Zhao; Yue Deng; Xiaowen Tian; Yuying Feng et al.
Source: check_circle
Crossref

Cryo-EM structures of human GPR34 enable the identification of selective antagonists

Proceedings of the National Academy of Sciences
2023-09-26 | Journal article
DOI: 10.1073/pnas.2308435120
Contributors: Anjie Xia; Xihao Yong; Changbin Zhang; Guifeng Lin; Guowen Jia; Chang Zhao; Xin Wang; Yize Hao; Yifei Wang; Pei Zhou et al.
Source: check_circle
Crossref

Orthosteric ligand selectivity and allosteric probe dependence at Hydroxycarboxylic acid receptor HCAR2

Signal Transduction and Targeted Therapy
2023-09-25 | Journal article
DOI: 10.1038/s41392-023-01625-y
Part of ISSN: 2059-3635
Contributors: Lin Cheng; Suyue Sun; Heli Wang; Chang Zhao; Xiaowen Tian; Ying Liu; Ping Fu; Zhenhua Shao; renjie chai; Wei Yan
Source: Self-asserted source
Chang Zhao

Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation

Molecular Cell
2023-09-07 | Journal article
DOI: 10.1016/j.molcel.2023.07.030
Part of ISSN: 1097-2765
Contributors: Chang Zhao; Heli Wang; Ying Liu; Lin Cheng; Bo Wang; Xiaowen Tian; Hong Fu; Chao Wu; Ziyan Li; Chenglong Shen et al.
Source: Self-asserted source
Chang Zhao

Prospect of acromegaly therapy: molecular mechanism of clinical drugs octreotide and paltusotine

Nature Communications
2023-02-21 | Journal article
DOI: 10.1038/s41467-023-36673-z
Contributors: Jie Zhao; Hong Fu; Jingjing Yu; Weiqi Hong; Xiaowen Tian; Jieyu Qi; Suyue Sun; Chang Zhao; Chao Wu; Zheng Xu et al.
Source: check_circle
Crossref

Mechanism of activation and biased signaling in complement receptor C5aR1

Cell Research
2023-02-17 | Journal article
DOI: 10.1038/s41422-023-00779-2
Contributors: Yuying Feng; Chang Zhao; Yue Deng; Heli Wang; Liang Ma; Sicen Liu; Xiaowen Tian; Bo Wang; Yan Bin; Peipei Chen et al.
Source: check_circle
Crossref

Allosteric modulation of G protein-coupled receptor signaling

Frontiers in Endocrinology
2023-02-16 | Journal article
DOI: 10.3389/fendo.2023.1137604
Part of ISSN: 1664-2392
Contributors: Siyuan Shen; Chang Zhao; Chao Wu; Suyue Sun; Ziyan Li; Wei Yan; Zhenhua Shao
Source: Self-asserted source
Chang Zhao

Conformational remodeling enhances activity of lanthipeptide zinc-metallopeptidases

Nature Chemical Biology
2022-07 | Journal article
DOI: 10.1038/s41589-022-01018-2
Contributors: Chang Zhao; Wangjian Sheng; Ying Wang; Jie Zheng; Xiangqian Xie; Yong Liang; Wanqing Wei; Rui Bao; Huan Wang
Source: check_circle
Crossref

Structural insights into sphingosine-1-phosphate recognition and ligand selectivity of S1PR3–Gi signaling complexes

Cell Research
2022-02 | Journal article
DOI: 10.1038/s41422-021-00567-w
Part of ISSN: 1001-0602
Part of ISSN: 1748-7838
Source: Self-asserted source
Chang Zhao

Structural and biochemical studies of the glycosyltransferase Bs-YjiC from Bacillus subtilis

International Journal of Biological Macromolecules
2021-01 | Journal article
DOI: 10.1016/j.ijbiomac.2020.10.238
Part of ISSN: 0141-8130
Source: Self-asserted source
Chang Zhao
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