Personal information

Other IDs

Scopus Author ID: 6507561928
Loop profile: 87144

Keywords

Type 1 Diabetes, Autoimmunity, Immune tolerance, Dendritic cells, Stromal cells, Beta cell antigens, T cells

Countries

United States

Biography

Dr. Remi Creusot is an Associate Professor in the Department of Medicine and Principal Investigator at the Columbia Center for Translational Immunology and the Naomi Berrie Diabetes Center. Dr. Creusot received his PhD in Immunology from University College London. He subsequently trained at Stanford University, in the Department of Medicine, Division of Immunology and Rheumatology. Dr. Creusot joined Columbia University in 2012 and his research interests revolve around the pathogenesis and immunotherapy of Type 1 diabetes. His group studies how several processes that contribute to the maintenance of immune tolerance are impaired, and works on several new therapeutic strategies aimed at restoring immune tolerance and blocking autoimmunity.

Activities

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Employment (6)

Irving Medical Center, Columbia University: NY, NY, US

2022-07-01 to present | Associate Professor of Medical Sciences (Medicine)
Employment
Source: Self-asserted source
Remi Creusot

Columbia University Irving Medical Center: New York, NY, US

2012-11-05 to 2022-06-30 | Assistant Professor of Medical Sciences (Medicine)
Employment
Source: Self-asserted source
Remi Creusot

Stanford University: Stanford, CA, US

2012-06 to 2012-10 | Instructor (Medicine)
Employment
Source: Self-asserted source
Remi Creusot

Stanford University: Stanford, CA, US

2007-08 to 2012-05 | Research Associate (Medicine)
Employment
Source: Self-asserted source
Remi Creusot

Stanford University: Stanford, CA, US

2003-01 to 2007-07 | Postdoctoral (Medicine)
Employment
Source: Self-asserted source
Remi Creusot

University College London: London, London, GB

1999-03 to 2001-02 | Research Assistant (Immunology)
Employment
Source: Self-asserted source
Remi Creusot

Education and qualifications (3)

University College London: London, London, GB

1999-03 to 2002-12 | PhD (Immunology)
Education
Source: Self-asserted source
Remi Creusot

Universite Henri Poincare Nancy I : Vandoeuvre-les-Nancy, Lorraine, FR

1997-09 to 1998-09 | MS (Microbiology)
Education
Source: Self-asserted source
Remi Creusot

Universite Henri Poincare Nancy I: Vandoeuvre-les-Nancy, Lorraine, FR

1992-09 to 1996-09 | BS (Biochemistry)
Education
Source: Self-asserted source
Remi Creusot

Works (38)

Soluble antigen arrays improve the efficacy and safety of peptide-based tolerogenic immunotherapy

2023-05-07 | Preprint
DOI: 10.1101/2023.05.05.539161
Contributors: Rebuma Firdessa-Fite; Stephanie N. Johnson; Martin A. Leon; Joshua O. Sestak; Cory Berkland; Remi J. Creusot
Source: check_circle
Crossref

Endotope mRNA vaccine

2023-02-03 | Data management plan
DOI: 10.48321/D15G8C
Source: check_circle
California Digital Library DMP Tool

Epitope-based precision immunotherapy of Type 1 diabetes

Human Vaccines & Immunotherapeutics
2023-01-02 | Journal article
DOI: 10.1080/21645515.2022.2154098
Contributors: Rebuma Firdessa Fite; Camillo Bechi Genzano; Roberto Mallone; Remi J. Creusot
Source: check_circle
Crossref

Pharmacological conversion of gut epithelial cells into insulin-producing cells lowers glycemia in diabetic animals

Journal of Clinical Investigation
2022-12-15 | Journal article
DOI: 10.1172/JCI162720
Contributors: Wen Du; Junqiang Wang; Taiyi Kuo; Liheng Wang; Wendy M. McKimpson; Jinsook Son; Hitoshi Watanabe; Takumi Kitamoto; Yunkyoung Lee; Remi J. Creusot et al.
Source: check_circle
Crossref

Preclinical evaluation of a precision medicine approach to DNA vaccination in type 1 diabetes

Proceedings of the National Academy of Sciences
2022-04-12 | Journal article
DOI: 10.1073/pnas.2110987119
Contributors: Jorge Postigo-Fernandez; Rebuma Firdessa-Fite; Rémi J. Creusot
Source: check_circle
Crossref

Orchestrating multiplexity in polychromatic science through OMIPs: A decade‐old resource to empower biomedical research

Cytometry Part A
2021-09 | Journal article
DOI: 10.1002/cyto.a.24471
Contributors: Wei Wang; Remi J. Creusot
Source: check_circle
Crossref

Preclinical evaluation of a precision medicine approach to DNA vaccination in Type 1 diabetes

2021-06-02 | Other
DOI: 10.1101/2021.06.02.446808
Contributors: Jorge Postigo-Fernandez; Rémi J. Creusot
Source: check_circle
Crossref

Soluble Antigen Arrays Efficiently Deliver Peptides and Arrest Spontaneous Autoimmune Diabetes

Diabetes
2021-06-01 | Journal article
DOI: 10.2337/db20-0845
Contributors: Rebuma Firdessa-Fite; Stephanie N. Johnson; Martin A. Leon; Mohsen Khosravi-Maharlooei; Rocky L. Baker; Joshua O. Sestak; Cory Berkland; Remi J. Creusot
Source: check_circle
Crossref

Humanized Mice Reveal New Insights Into the Thymic Selection of Human Autoreactive CD8 <sup>+</sup> T Cells

Frontiers in immunology
2019 | Journal article
DOI: 10.3389/fimmu.2019.00063
EID:

2-s2.0-85061853222
Contributors: Li, Y.; Teteloshvili, N.; Tan, S.; Rao, S.; Han, A.; Yang, Y.-G.; Creusot, R.J.
Source: Self-asserted source
Remi Creusot via Scopus - Elsevier

A multi-epitope DNA vaccine enables a broad engagement of diabetogenic T cells for tolerance in Type 1 diabetes

Journal of Autoimmunity
2019-03 | Journal article
DOI: 10.1016/j.jaut.2018.11.003
Contributors: Jorge Postigo-Fernandez; Rémi J. Creusot
Source: check_circle
Crossref
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Preferred source (of 2)‎

PPAR? deacetylation dissociates thiazolidinedione's metabolic benefits from its adverse effects

Journal of Clinical Investigation
2018 | Journal article
DOI: 10.1172/JCI98709
EID:

2-s2.0-85048301397
Contributors: Kraakman, M.J.; Liu, Q.; Postigo-Fernandez, J.; Ji, R.; Kon, N.; Larrea, D.; Namwanje, M.; Fan, L.; Chan, M.; Area-Gomez, E. et al.
Source: Self-asserted source
Remi Creusot via Scopus - Elsevier

Altered Function of Antigen-Presenting Cells in Type 1 Diabetes: A Challenge for Antigen-Specific Immunotherapy?

Diabetes
2018-08-01 | Journal article
DOI: 10.2337/db17-1564
Contributors: Rémi J. Creusot; Jorge Postigo-Fernandez; Nato Teteloshvili
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Efficient Presentation of Multiple Endogenous Epitopes to Both CD4<sup>+</sup>and CD8<sup>+</sup>Diabetogenic T Cells for Tolerance

Molecular Therapy - Methods and Clinical Development
2017 | Journal article
DOI: 10.1016/j.omtm.2016.12.002
EID:

2-s2.0-85015388472
Contributors: Dastagir, S.R.; Postigo-Fernandez, J.; Xu, C.; Stoeckle, J.H.; Firdessa-Fite, R.; Creusot, R.J.
Source: Self-asserted source
Remi Creusot via Scopus - Elsevier

Concise Review: Cell-Based Therapies and Other Non-Traditional Approaches for Type 1 Diabetes

Stem Cells
2016 | Journal article
DOI: 10.1002/stem.2290
EID:

2-s2.0-84958259403
Contributors: Creusot, R.J.; Battaglia, M.; Roncarolo, M.-G.; Fathman, C.G.
Source: Self-asserted source
Remi Creusot via Scopus - Elsevier

Inflammation and hyperglycemia mediate Deaf1 splicing in the pancreatic lymph nodes via distinct pathways during type 1 diabetes

Diabetes
2015 | Journal article
DOI: 10.2337/db14-0803
EID:

2-s2.0-84921906050
Contributors: Yip, L.; Fuhlbrigge, R.; Taylor, C.; Creusot, R.J.; Nishikawa-Matsumura, T.; Whiting, C.C.; Schartner, J.M.; Akter, R.; Von Herrath, M.; Fathman, C.G.
Source: Self-asserted source
Remi Creusot via Scopus - Elsevier

Toward beta cell replacement for diabetes

EMBO Journal
2015 | Journal article
DOI: 10.15252/embj.201490685
EID:

2-s2.0-84926246629
Contributors: Johannesson, B.; Sui, L.; Freytes, D.O.; Creusot, R.J.; Egli, D.
Source: Self-asserted source
Remi Creusot via Scopus - Elsevier

It's time to bring dendritic cell therapy to type 1 diabetes

Diabetes
2014 | Journal article
DOI: 10.2337/db13-0886
EID:

2-s2.0-84891762344
Contributors: Creusot, R.J.; Giannoukakis, N.; Trucco, M.; Clare-Salzler, M.J.; Fathman, C.G.
Source: Self-asserted source
Remi Creusot via Scopus - Elsevier

Initiating type i diabetes: New suspects in the lineup

Nature Medicine
2013 | Journal article
DOI: 10.1038/nm.3044
EID:

2-s2.0-84872059933
Contributors: Creusot, R.J.
Source: Self-asserted source
Remi Creusot via Scopus - Elsevier

Reduced DEAF1 function during type 1 diabetes inhibits translation in lymph node stromal cells by suppressing Eif4g3

Journal of Molecular Cell Biology
2013 | Journal article
DOI: 10.1093/jmcb/mjs052
EID:

2-s2.0-84875692817
Contributors: Yip, L.; Creusot, R.J.; Pager, C.T.; Sarnow, P.; Fathman, C.G.
Source: Self-asserted source
Remi Creusot via Scopus - Elsevier

Superkines: Cytokines displaying better targeted functions,Superkines, des cytokines aux fonctions mieux ciblées

Medecine/Sciences
2013 | Journal article
DOI: 10.1051/medsci/2013294004
EID:

2-s2.0-84876916111
Contributors: Creusot, R.J.; Moraga, I.
Source: Self-asserted source
Remi Creusot via Scopus - Elsevier

Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines

Nature Chemical Biology
2012 | Journal article
DOI: 10.1038/nchembio.1096
EID:

2-s2.0-84870308987
Contributors: Junttila, I.S.; Creusot, R.J.; Moraga, I.; Bates, D.L.; Wong, M.T.; Alonso, M.N.; Suhoski, M.M.; Lupardus, P.; Meier-Schellersheim, M.; Engleman, E.G. et al.
Source: Self-asserted source
Remi Creusot via Scopus - Elsevier

NF-κB in DCs: It takes effort to be immature

Nature Medicine
2011 | Journal article
DOI: 10.1038/nm.2586
EID:

2-s2.0-84856080086
Contributors: Creusot, R.J.
Source: Self-asserted source
Remi Creusot via Scopus - Elsevier

A short pulse of IL-4 delivered by dcs electroporated with modified mRNA can both prevent and treat autoimmune diabetes in NOD mice

Molecular Therapy
2010 | Journal article
DOI: 10.1038/mt.2010.146
EID:

2-s2.0-78650912749
Contributors: Creusot, R.J.; Chang, P.; Healey, D.G.; Tcherepanova, I.Y.; Nicolette, C.A.; Fathman, C.G.
Source: Self-asserted source
Remi Creusot via Scopus - Elsevier

Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetes

Nature Immunology
2009 | Journal article
DOI: 10.1038/ni.1773
EID:

2-s2.0-69049109653
Contributors: Yip, L.; Su, L.; Sheng, D.; Chang, P.; Atkinson, M.; Czesak, M.; Albert, P.R.; Collier, A.-R.; Turley, S.J.; Fathman, G.C. et al.
Source: Self-asserted source
Remi Creusot via Scopus - Elsevier

Glycogen synthase kinase 3β missplicing contributes to leukemia stem cell generation

Proceedings of the National Academy of Sciences of the United States of America
2009 | Journal article
DOI: 10.1073/pnas.0900189106
EID:

2-s2.0-62649139996
Contributors: Abrahamsson, A.E.; Geron, I.; Gotlib, J.; Dao, K.-H.T.; Barroga, C.F.; Newton, I.G.; Giles, F.J.; Durocher, J.; Creusot, R.S.; Karimi, M. et al.
Source: Self-asserted source
Remi Creusot via Scopus - Elsevier

Lymphoid tissue-specific homing of bone marrow-derived dendritic cells

Blood
2009 | Journal article
DOI: 10.1182/blood-2009-02-204321
EID:

2-s2.0-69249202402
Contributors: Creusot, R.J.; Yaghoubi, S.S.; Chang, P.; Chia, J.; Contag, C.H.; Gambhir, S.S.; Fathman, C.G.
Source: Self-asserted source
Remi Creusot via Scopus - Elsevier

Tissue- and age-specific changes in gene expression during disease induction and progression in NOD mice

Clinical Immunology
2008 | Journal article
DOI: 10.1016/j.clim.2008.07.028
EID:

2-s2.0-53749099191
Contributors: Kodama, K.; Butte, A.J.; Creusot, R.J.; Su, L.; Sheng, D.; Hartnett, M.; Iwai, H.; Soares, L.R.; Fathman, C.G.
Source: Self-asserted source
Remi Creusot via Scopus - Elsevier

Tissue-targeted therapy of autoimmune diabetes using dendritic cells transduced to express IL-4 in NOD mice

Clinical Immunology
2008 | Journal article
DOI: 10.1016/j.clim.2007.12.009
EID:

2-s2.0-41549150638
Contributors: Creusot, R.J.; Yaghoubi, S.S.; Kodama, K.; Dang, D.N.; Dang, V.H.; Breckpot, K.; Thielemans, K.; Gambhir, S.S.; Fathman, C.G.
Source: Self-asserted source
Remi Creusot via Scopus - Elsevier

TSG-6 protein expression in the pancreatic islets of NOD mice

Journal of Molecular Histology
2008 | Journal article
DOI: 10.1007/s10735-008-9199-5
EID:

2-s2.0-56349171695
Contributors: Kvezereli, M.; Michie, S.A.; Yu, T.; Creusot, R.J.; Fontaine, M.J.
Source: Self-asserted source
Remi Creusot via Scopus - Elsevier

Multimodality imaging of T-cell hybridoma trafficking in collagen-induced arthritic mice: Image-based estimation of the number of cells accumulating in mouse paws

Journal of Biomedical Optics
2007 | Journal article
DOI: 10.1117/1.2821415
EID:

2-s2.0-37549025341
Contributors: Yaghoubi, S.S.; Creusot, R.J.; Ray, P.; Fathman, C.G.; Gambhir, S.S.
Source: Self-asserted source
Remi Creusot via Scopus - Elsevier

IFN-γ gene expression is controlled by the architectural transcription factor HMGA1

International Immunology
2005 | Journal article
DOI: 10.1093/intimm/dxh209
EID:

2-s2.0-20144376842
Contributors: Chau, K.-Y.; Keane-Myers, A.M.; Fedele, M.; Ikeda, Y.; Creusot, R.J.; Menozzi, L.; Cousins, D.J.; Manfioletti, G.; Feigenbaum, L.; Fusco, A. et al.
Source: Self-asserted source
Remi Creusot via Scopus - Elsevier

Gene therapy for type 1 diabetes: A novel approach for targeted treatment of autoimmunity

Journal of Clinical Investigation
2004 | Journal article
DOI: 10.1172/JCI23168
EID:

2-s2.0-9644275456
Contributors: Creusot, R.J.; Fathman, C.G.
Source: Self-asserted source
Remi Creusot via Scopus - Elsevier

How DCs control cross-regulation between lymphocytes

Trends in Immunology
2004 | Journal article
DOI: 10.1016/j.it.2004.01.005
EID:

2-s2.0-1342281659
Contributors: Creusot, R.J.; Mitchison, N.A.
Source: Self-asserted source
Remi Creusot via Scopus - Elsevier

Murine CD4<sup>+</sup>CD25<sup>+</sup> regulatory T cells fail to undergo chromatin remodeling across the proximal promoter region of the IL-2 gene

Journal of Immunology
2004 | Journal article
DOI: 10.4049/jimmunol.173.8.4994
EID:

2-s2.0-6344231287
Contributors: Su, L.; Creusot, R.J.; Gallo, E.M.; Chan, S.M.; Utz, P.J.; Fathman, C.G.; Ermann, J.
Source: Self-asserted source
Remi Creusot via Scopus - Elsevier

Instruction of naive CD4<sup>+</sup> T cells by polarized CD4<sup>+</sup> T cells within dendritic cell clusters

European Journal of Immunology
2003 | Journal article
DOI: 10.1002/eji.200323811
EID:

2-s2.0-0038496773
Contributors: Creusot, R.J.; Biswas, J.S.; Thomsen, L.L.; Tite, J.P.; Mitchison, N.A.; Chain, B.M.
Source: Self-asserted source
Remi Creusot via Scopus - Elsevier

Local cooperation dominates over competition between CD4<sup>+</sup> T cells of different antigen/MHC specificity

Journal of Immunology
2003 | Journal article
DOI: 10.4049/jimmunol.171.1.240
EID:

2-s2.0-0037530603
Contributors: Creusot, R.J.; Thomsen, L.L.; Tite, J.P.; Chain, B.M.
Source: Self-asserted source
Remi Creusot via Scopus - Elsevier

The immunological synapse

Molecular Immunology
2002 | Journal article
DOI: 10.1016/S0161-5890(02)00028-7
EID:

2-s2.0-0036247367
Contributors: Creusot, R.J.; Mitchison, N.A.; Terazzini, N.M.
Source: Self-asserted source
Remi Creusot via Scopus - Elsevier

Early commitment of adoptively transferred CD4<sup>+</sup> T cells following particle-mediated DNA vaccination: Implications for the study of immunomodulation

Vaccine
2001 | Journal article
DOI: 10.1016/S0264-410X(00)00405-9
EID:

2-s2.0-0035825590
Contributors: Creusot, R.J.; Thomsen, L.L.; Van Wely, C.A.; Topley, P.; Tite, J.P.; Chain, B.M.
Source: Self-asserted source
Remi Creusot via Scopus - Elsevier

Peer review (6 reviews for 6 publications/grants)

Review activity for ACS applied bio materials. (1)
Review activity for ACS nano. (1)
Review activity for JoVE. (1)
Review activity for Molecular therapy (1)
Review activity for Molecular therapy. (1)
Review activity for Nature communications (1)
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