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Marconett Lab Website

Keywords

Lung cancer, Epigenomics

Countries

United States

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Employment (4)

City of Hope: Duarte, CA, US

2024-01-08 to present | Associate Professor (Integrated Translational Sciences)
Employment
Source: Self-asserted source
Crystal Marconett

University of Southern California Norris Comprehensive Cancer Center: Los Angeles, CA, US

2022-07-01 to 2024-01-05 | Associate Professor (Translational Genomics)
Employment
Source: Self-asserted source
Crystal Marconett

University of Southern California: Los Angeles, CA, US

2015-06-01 to 2022-06-30 | Assistant Professor of Research (Surgery, Biochemistry and Molecular Biology)
Employment
Source: Self-asserted source
Crystal Marconett

University of Southern California: Los Angeles, CA, US

2009-12 to 2015-05 | Postdoctoral Scholar (Biochemistry and Molecular Biology)
Employment
Source: Self-asserted source
Crystal Marconett

Education and qualifications (2)

University of California Berkeley: Berkeley, CA, US

2005-07 to 2009-12 | PhD (Molecular and Cell Biology)
Education
Source: Self-asserted source
Crystal Marconett

University of California Santa Cruz: Santa Cruz, CA, US

2001-09 to 2005-03 | B.S. (Molecular, Cell and Developmental Biology)
Education
Source: Self-asserted source
Crystal Marconett

Professional activities (3)

American Thoracic Society: New York, New York, US

2022-09-01 to present (Full Member)
Membership
Source: Self-asserted source
Crystal Marconett

RNA Society: Bethesda, Maryland, US

2018-01-01 to present | Full Member
Membership
Source: Self-asserted source
Crystal Marconett

American Association For Cancer Research: Philadelphia, Pennsylvania, US

2017-01-01 to present | Active Member
Membership
Source: Self-asserted source
Crystal Marconett

Funding (4)

Elucidating the Cellular Origins of lung adenocarcinoma

2023-07-11 to 2028-06-30 | Grant
National Cancer Institute (Bethesda, US)
URL: https://app.dimensions.ai/details/grant/grant.13553455
GRANT_NUMBER: R01CA262258
Source: Self-asserted source
Crystal Marconett via DimensionsWizard

The Therapeutic Role of lncRNA-Mediated DNA Repair in Lung Cancer

2021-05-15 to 2023-05-14 | Grant
Congressionally Directed Medical Research Programs (Frederick, US)
URL: https://app.dimensions.ai/details/grant/grant.9632980
GRANT_NUMBER:

W81XWH-21-1-0231
Source: Self-asserted source
Crystal Marconett via DimensionsWizard

The therapeutic role of lncRNA- mediated DNA repair in lung cancer

2021-01-01 to 2024-12-31 | Grant
American Cancer Society (Atlanta, US)
DOI: 10.53354/ACS.RSG-20-135-01-RMC.pc.gr.142471
GRANT_NUMBER:

RSG-20-135-01-RMC
Source: check_circle
American Cancer Society - ProposalCentral

Indole control of breast cancer through downregulation of ER

2007-07-01 to 2009-06-30 | Grant
California Breast Cancer Research Program (CA, US)
URL: https://app.dimensions.ai/details/grant/grant.5029753
GRANT_NUMBER:

13GB-0162
Source: Self-asserted source
Crystal Marconett via DimensionsWizard

Works (42)

Alveolar type I cells can give rise to KRAS-induced lung adenocarcinoma.

Cell reports
2023-11-22 | Journal article
DOI: 10.1016/j.celrep.2023.113286
PMID: 37995179
Contributors: Yang M; Shen H; Flodby P; Koss MD; Bassiouni R; Liu Y; Jashashvili T; Neely A; Ogbolu E; Castillo J et al.
Source: Self-asserted source
Crystal Marconett

CLOCK'ing differences in DNA methylation signatures to understand the molecular etiology of lung cancer.

Translational lung cancer research
2023-04-10 | Journal article
DOI: 10.21037/tlcr-23-65
PMID: 37425400
PMC: PMC10326774
Contributors: Neely AM; Yang M; Marconett CN
Source: Self-asserted source
Crystal Marconett

PEACOCK: a machine learning approach to assess the validity of cell type-specific enhancer-gene regulatory relationships.

NPJ systems biology and applications
2023-04-03 | Journal article
DOI: 10.1038/s41540-023-00270-z
PMID: 37012250
PMC: PMC10070356
Contributors: Mills C; Marconett CN; Lewinger JP; Huaiyu Mi
Source: Self-asserted source
Crystal Marconett

FOXO1 Couples KGF and PI-3K/AKT Signaling to NKX2.1-Regulated Differentiation of Alveolar Epithelial Cells

Cells
2022-03 | Journal article | Author
DOI: 10.3390/cells11071122
Contributors: Qian Zhong; Yixin Liu; Michele Ramos Correa; Crystal Marconett; Parviz Minoo; Changgong Li; David K. Ann; Beiyun Zhou; Zea Borok
Source: check_circle
Multidisciplinary Digital Publishing Institute

Development of human alveolar epithelial cell models to study distal lung biology and disease.

iScience
2022-01-15 | Journal article
DOI: 10.1016/j.isci.2022.103780
PMID: 35169685
PMC: PMC8829779
Contributors: Tran E; Shi T; Li X; Chowdhury AY; Jiang D; Liu Y; Wang H; Yan C; Wallace WD; Lu R et al.
Source: Self-asserted source
Crystal Marconett

The Sulfotransferase SULT1C2 Is Epigenetically Activated and Transcriptionally Induced by Tobacco Exposure and Is Associated with Patient Outcome in Lung Adenocarcinoma.

International journal of environmental research and public health
2021-12-31 | Journal article
DOI: 10.3390/ijerph19010416
PMID: 35010676
PMC: PMC8744592
Contributors: Johnson C; Mullen DJ; Selamat SA; Campan M; Ite Offringa; Crystal Marconett
Source: Self-asserted source
Crystal Marconett

Comprehensive epigenomic profiling of human alveolar epithelial differentiation identifies key epigenetic states and transcription factor co-regulatory networks for maintenance of distal lung identity.

BMC genomics
2021-12-18 | Journal article | Author
DOI: 10.1186/s12864-021-08152-6
PMID: 34922464
PMC: PMC8684104
Contributors: Zhou B; Stueve TR; Mihalakakos EA; Miao L; Mullen D; Wang Y; Liu Y; Luo J; Tran E; Siegmund KD et al.
Source: Self-asserted source
Crystal Marconett

Beyond the transcription factor: the under-studied role of epigenomics in lung differentiation.

Epigenomics
2021-10-19 | Journal article | Author
DOI: 10.2217/epi-2021-0348
PMID: 34664989
Contributors: Laurence St. Pierre; Crystal Marconett
Source: Self-asserted source
Crystal Marconett
grade
Preferred source (of 2)‎

The evolutionarily conserved long non-coding RNA LINC00261 drives neuroendocrine prostate cancer proliferation and metastasis via distinct nuclear and cytoplasmic mechanisms.

Molecular oncology
2021-04-26 | Journal article
DOI: 10.1002/1878-0261.12954
PMID: 33793068
PMC: PMC8253100
Contributors: Rebecca Mather; Parolia A; Sandra E. Carson; Venalainen E; David Roig-Carles; Jaber M; Chu SC; Alborelli I; Wu R; Lin D et al.
Source: Self-asserted source
Crystal Marconett

PEREGRINE: A genome-wide prediction of enhancer to gene relationships supported by experimental evidence.

PloS one
2020-12-15 | Journal article
DOI: 10.1371/journal.pone.0243791
PMID: 33320871
PMC: PMC7737992
Contributors: Caitlin Mills; Anushya Muruganujan; Dustin Ebert; Crystal Marconett; Juan Pablo Lewinger; Paul D. Thomas; Huaiyu Mi
Source: Self-asserted source
Crystal Marconett

Integrated Single-Cell RNA-Sequencing Analysis of Aquaporin 5-Expressing Mouse Lung Epithelial Cells Identifies GPRC5A as a Novel Validated Type I Cell Surface Marker.

Cells
2020-11-11 | Journal article
DOI: 10.3390/cells9112460
PMID: 33187367
PMC: PMC7697677
Contributors: Horie M; Alessandra Castaldi; Sunohara M; Wang H; Ji Y; Liu Y; Li F; Wilkinson TA; Hung L; Shen H et al.
Source: Self-asserted source
Crystal Marconett

TENET 2.0: Identification of key transcriptional regulators and enhancers in lung adenocarcinoma.

PLoS genetics
2020-09-14 | Journal article | Author
DOI: 10.1371/journal.pgen.1009023
PMID: 32925947
PMC: PMC7515200
Contributors: Daniel Mullen; Yan C; Kang DS; Beiyun Zhou; Zea Borok; Crystal Marconett; Peggy Farnham; Ite Offringa; Suhn K. Rhie
Source: Self-asserted source
Crystal Marconett

Genome-wide integration of microRNA and transcriptomic profiles of differentiating human alveolar epithelial cells.

American journal of physiology. Lung cellular and molecular physiology
2020-05-20 | Journal article
DOI: 10.1152/ajplung.00519.2019
PMID: 32432919
PMC: PMC7468844
Contributors: Castaldi A; Horie M; Rieger ME; Dubourd M; Sunohara M; Pandit K; Zhou B; Ite Offringa; Crystal Marconett; Zea Borok
Source: Self-asserted source
Crystal Marconett

Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women.

Genomics
2019-07-12 | Journal article
DOI: 10.1016/j.ygeno.2019.07.008
PMID: 31306748
PMC: PMC6954985
Contributors: Crystal Marconett; Wong JYY; Zhang H; Hsiung CA; Shiraishi K; Yu K; Keitaro Matsuo; Wong MP; Hong YC; Wang J et al.
Source: Self-asserted source
Crystal Marconett

LINC00261 Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response.

Cancer research
2019-02-22 | Journal article
DOI: 10.1158/0008-5472.can-18-2034
PMID: 30796052
PMC: PMC6571057
Contributors: Shahabi S; Kumaran V; Castillo J; Cong Z; Nandagopal G; Mullen DJ; Alvarado A; Correa MR; Saizan A; Goel R et al.
Source: Self-asserted source
Crystal Marconett

CLDN18.1 attenuates malignancy and related signaling pathways of lung adenocarcinoma in vivo and in vitro.

International journal of cancer
2018-10-16 | Journal article
DOI: 10.1002/ijc.31734
PMID: 30325015
PMC: PMC6263834
Contributors: jiao luo; Chimge NO; Zhou B; Flodby P; Castaldi A; Firth AL; Liu Y; Wang H; Yang C; Crystal Marconett et al.
Source: Self-asserted source
Crystal Marconett

Positional integration of lung adenocarcinoma susceptibility loci with primary human alveolar epithelial cell epigenomes.

Epigenomics
2018-09-13 | Journal article
DOI: 10.2217/epi-2018-0003
PMID: 30212242
PMC: PMC6391636
Contributors: Yang C; Stueve TR; Yan C; Suhn K. Rhie; Mullen DJ; Luo J; Zhou B; Borok Z; Crystal Marconett; Offringa IA
Source: Self-asserted source
Crystal Marconett

Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis.

The Journal of clinical investigation
2018-02-05 | Journal article
DOI: 10.1172/jci90429
PMID: 29400695
PMC: PMC5824875
Contributors: Zhou B; Per Flodby; Luo J; Castillo DR; Liu Y; Fa-Xing Yu; McConnell A; Varghese B; Li G; Chimge NO et al.
Source: Self-asserted source
Crystal Marconett

Epigenome-wide analysis of DNA methylation in lung tissue shows concordance with blood studies and identifies tobacco smoke-inducible enhancers.

Human molecular genetics
2017-08-01 | Journal article
DOI: 10.1093/hmg/ddx188
PMID: 28854564
PMC: PMC5886283
Contributors: Stueve TR; Wen-Qing Li; Shi J; Crystal Marconett; Zhang T; Yang C; Mullen D; Yan C; Wheeler W; Hua X et al.
Source: Self-asserted source
Crystal Marconett

Intersecting transcriptomic profiling technologies and long non-coding RNA function in lung adenocarcinoma: discovery, mechanisms, and therapeutic applications.

Oncotarget
2017-06-09 | Journal article
DOI: 10.18632/oncotarget.18432
PMID: 29113413
PMC: PMC5655308
Contributors: Castillo J; Stueve TR; Crystal Marconett
Source: Self-asserted source
Crystal Marconett

Cross-Species Transcriptome Profiling Identifies New Alveolar Epithelial Type I Cell-Specific Genes.

American journal of respiratory cell and molecular biology
2017-03-01 | Journal article | Author
DOI: 10.1165/rcmb.2016-0071oc
PMID: 27749084
PMC: PMC5359537
Contributors: Crystal Marconett; Beiyun Zhou; Sunohara M; Pouldar TM; Wang H; Liu Y; Rieger ME; Tran E; Flodby P; Siegmund KD et al.
Source: Self-asserted source
Crystal Marconett

Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations.

Human molecular genetics
2017-01-01 | Journal article
DOI: 10.1093/hmg/ddw414
PMID: 28025329
PMC: PMC5856088
Contributors: Crystal Marconett; Seow WJ; Keitaro Matsuo; Hsiung CA; Shiraishi K; Song M; Kim HN; Wong MP; Hong YC; Hosgood HD 3rd et al.
Source: Self-asserted source
Crystal Marconett

Somatic Genomics and Clinical Features of Lung Adenocarcinoma: A Retrospective Study.

PLoS medicine
2016-12-06 | Journal article
DOI: 10.1371/journal.pmed.1002162
PMID: 27923066
PMC: PMC5140047
Contributors: Shi J; Hua X; Zhu B; SARANGAN RAVICHANDRAN; Wang M; Cu Nguyen; Seth Brodie; Alessandro Palleschi; marco alloisio; Marco Alloisio et al.
Source: Self-asserted source
Crystal Marconett

Pleiotropic Analysis of Lung Cancer and Blood Triglycerides.

Journal of the National Cancer Institute
2016-08-26 | Journal article
DOI: 10.1093/jnci/djw167
PMID: 27565901
PMC: PMC5241892
Contributors: Verena Zuber; Crystal Marconett; Shi J; Hua X; Wheeler W; Yang C; Song L; Dale AM; Marina Laplana; Angela Risch et al.
Source: Self-asserted source
Crystal Marconett

The 78-kD Glucose-Regulated Protein Regulates Endoplasmic Reticulum Homeostasis and Distal Epithelial Cell Survival during Lung Development.

American journal of respiratory cell and molecular biology
2016-07-01 | Journal article | Author
DOI: 10.1165/rcmb.2015-0327oc
PMID: 26816051
PMC: PMC4942208
Contributors: Flodby P; Li C; Liu Y; Wang H; Crystal Marconett; Laird-Offringa IA; Minoo P; Amy Lee; Zhou B
Source: Self-asserted source
Crystal Marconett
grade
Preferred source (of 2)‎

The importance of detailed epigenomic profiling of different cell types within organs.

Epigenomics
2016-06-15 | Journal article
DOI: 10.2217/epi-2016-0005
PMID: 27305639
PMC: PMC5066118
Contributors: Stueve TR; Crystal Marconett; Zhou B; Borok Z; Laird-Offringa IA
Source: Self-asserted source
Crystal Marconett

Functional lung adenocarcinoma risk SNPs identified through positional integration with human alveolar epithelial cell epigenomes

Journal of Thoracic Oncology
2016-02 | Journal article
DOI: 10.1016/j.jtho.2015.12.076
Contributors: Chenchen Yang; Theresa Ryan Stueve; Crystal Nicole Marconett; Suhn Kyong Rhie; Jiao Luo; Beiyun Zhou; Zea Borok; Ite A. Laird-Offringa
Source: Self-asserted source
Crystal Marconett via Crossref Metadata Search

Combinations of differentiation markers distinguish subpopulations of alveolar epithelial cells in adult lung

Am J Physiol Lung Cell Mol Physiol
2015-11-06 | Journal article
DOI: 10.1152/ajplung.00337.2015
Contributors: Janice M. Liebler; Crystal N. Marconett; Nicholas Juul; Hongjun Wang; Yixin Liu; Per Flodby; Ite A. Laird-Offringa; Parviz Minoo; Beiyun Zhou
Source: Self-asserted source
Crystal Marconett via Crossref Metadata Search

Transcriptomic profiling of primary alveolar epithelial cell differentiation in human and rat

Genomics Data
2014 | Journal article
DOI: 10.1016/j.gdata.2014.05.011
Contributors: Crystal N. Marconett; Beiyun Zhou; Kimberly D. Siegmund; Zea Borok; Ite A. Laird-Offringa
Source: Self-asserted source
Crystal Marconett via Crossref Metadata Search

Abstract 287: Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue

Cancer Res
2014-09 | Journal article
DOI: 10.1158/1538-7445.am2014-287
Contributors: Jianxin Shi; Crystal Marconett; Jubao Duan; Paula Hyland; Peng Li; Zhaoming Wang; William Wheeler; Mihaela Campan; Jing Huang; Weiyin Zhou et al.
Source: Self-asserted source
Crystal Marconett via Crossref Metadata Search

Claudin 4 knockout mice: normal physiological phenotype with increased susceptibility to lung injury

AJP: Lung Cellular and Molecular Physiology
2014-08-08 | Journal article
DOI: 10.1152/ajplung.00077.2014
Contributors: H. Kage; P. Flodby; D. Gao; Y. H. Kim; C. N. Marconett; L. DeMaio; K.-J. Kim; E. D. Crandall; Z. Borok
Source: Self-asserted source
Crystal Marconett via Crossref Metadata Search

Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis

Am J Respir Cell Mol Biol
2014-03-03 | Journal article
DOI: 10.1165/rcmb.2013-0353oc
Contributors: Guanglei Li; Per Flodby; Jiao Luo; Hidenori Kage; Arnold Sipos; Danping Gao; Yanbin Ji; LaMonta L Beard; Crystal N Marconett; Lucas DeMaio et al.
Source: Self-asserted source
Crystal Marconett via Crossref Metadata Search

Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue

Nat Comms
2014-02 | Journal article
DOI: 10.1038/ncomms4365
Contributors: Jianxin Shi; Crystal N. Marconett; Jubao Duan; Paula L. Hyland; Peng Li; Zhaoming Wang; William Wheeler; Beiyun Zhou; Mihaela Campan; Diane S. Lee et al.
Source: Self-asserted source
Crystal Marconett via Crossref Metadata Search

CDKN2A/p16 Inactivation Mechanisms and Their Relationship to Smoke Exposure and Molecular Features in Non–Small-Cell Lung Cancer

Journal of Thoracic Oncology
2013-11 | Journal article
DOI: 10.1097/jto.0b013e3182a46c0c
Contributors: Kit W. Tam; Wei Zhang; Junichi Soh; Victor Stastny; Min Chen; Han Sun; Kelsie Thu; Jonathan J. Rios; Chenchen Yang; Crystal N. Marconett et al.
Source: Self-asserted source
Crystal Marconett via Crossref Metadata Search

Integrated Transcriptomic and Epigenomic Analysis of Primary Human Lung Epithelial Cell Differentiation

PLoS Genet
2013-06 | Journal article
DOI: 10.1371/journal.pgen.1003513
Contributors: Crystal N. Marconett; Beiyun Zhou; Megan E. Rieger; Suhaida A. Selamat; Mickael Dubourd; Xiaohui Fang; Sean K. Lynch; Theresa Ryan Stueve; Kimberly D. Siegmund; Benjamin P. Berman et al.
Source: Self-asserted source
Crystal Marconett via Crossref Metadata Search

Indole-3-Carbinol disrupts Estrogen Receptor-alpha dependent expression of Insulin-like Growth Factor-1 Receptor and Insulin Receptor Substrate-1 and proliferation of human breast cancer cells

Molecular and Cellular Endocrinology
2012-11 | Journal article
DOI: 10.1016/j.mce.2012.07.008
Contributors: Crystal N. Marconett; Ankur K. Singhal; Shyam N. Sundar; Gary L. Firestone
Source: Self-asserted source
Crystal Marconett via Crossref Metadata Search

Indole-3-carbinol downregulation of telomerase gene expression requires the inhibition of estrogen receptor-alpha and Sp1 transcription factor interactions within the hTERT promoter and mediates the G1 cell cycle arrest of human breast cancer cells

Carcinogenesis
2011-06 | Journal article
DOI: 10.1093/carcin/bgr116
Contributors: C. N. Marconett; S. N. Sundar; M. Tseng; A. S. Tin; K. Q. Tran; K. M. Mahuron; L. F. Bjeldanes; G. L. Firestone
Source: Self-asserted source
Crystal Marconett via Crossref Metadata Search

HDAC3 And GATA-6/p300 Coordinately Regulate Type I Cell-Specific Aquaporin-5 (Aqp5) Gene Expression During Alveolar Epithelial Cell (AEC) Transdifferentiation

C27. GENETIC PROGRAMS DRIVING LUNG DEVELOPMENT AND REGENERATION
2011-05 | Conference paper
DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4217
Contributors: Beiyun Zhou; Yixin Liu; Crystal Marconett; David K. Ann; Per Flodby; Parviz Minoo; Michael Kahn; Edward D. Crandall; Ite A Laird-Offringa; Zea Borok
Source: Self-asserted source
Crystal Marconett via Crossref Metadata Search

1-Benzyl-indole-3-carbinol is a novel indole-3-carbinol derivative with significantly enhanced potency of anti-proliferative and anti-estrogenic properties in human breast cancer cells

Chemico-Biological Interactions
2010-08 | Journal article
DOI: 10.1016/j.cbi.2010.05.015
Contributors: Hanh H. Nguyen; Sergey N. Lavrenov; Shyam N. Sundar; David H.H. Nguyen; Min Tseng; Crystal N. Marconett; Jenny Kung; Richard E. Staub; Maria N. Preobrazhenskaya; Leonard F. Bjeldanes et al.
Source: Self-asserted source
Crystal Marconett via Crossref Metadata Search

BZL101, a phytochemical extract from the Scutellaria barbata plant, disrupts proliferation of human breast and prostate cancer cells through distinct mechanisms dependent on the cancer cell phenotype

Cancer Biology & Therapy
2010-08 | Journal article
DOI: 10.4161/cbt.10.4.12424
Contributors: Crystal N. Marconett; Travis J. Morgenstern; Adrianna K. San Roman; Shyam N. Sundar; Ankur K. Singhal; Gary L. Firestone
Source: Self-asserted source
Crystal Marconett via Crossref Metadata Search

Indole-3-Carbinol Triggers Aryl Hydrocarbon Receptor-dependent Estrogen Receptor (ER)  Protein Degradation in Breast Cancer Cells Disrupting an ER -GATA3 Transcriptional Cross-Regulatory Loop

Molecular Biology of the Cell
2010-02-03 | Journal article
DOI: 10.1091/mbc.e09-08-0689
Contributors: C. N. Marconett; S. N. Sundar; K. M. Poindexter; T. R. Stueve; L. F. Bjeldanes; G. L. Firestone
Source: Self-asserted source
Crystal Marconett via Crossref Metadata Search

Artemisinin selectively decreases functional levels of estrogen receptor-alpha and ablates estrogen-induced proliferation in human breast cancer cells

Carcinogenesis
2008-08 | Journal article
DOI: 10.1093/carcin/bgn214
Contributors: S. N. Sundar; C. N. Marconett; V. B. Doan; J. A. Willoughby; G. L. Firestone
Source: Self-asserted source
Crystal Marconett via Crossref Metadata Search
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