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Trillion Base Pair Project

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Loop profile: 1091284

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United Kingdom

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Employment (2)

Prozomix (United Kingdom): Haltwhistle, GB

2018-06-01 to present | Technical Director (Research and Development)
Employment
Source: Self-asserted source
James Finnigan

Newcastle University: Newcastle upon Tyne, Newcastle upon Tyne, GB

2012-07-23 to 2013-06-29 | Placement Student - Research Scientist (Musculoskeletal Research Group)
Employment
Source: Self-asserted source
James Finnigan

Education and qualifications (2)

Northumbria University: Newcastle upon Tyne, GB

2014-10-01 to 2018-05-31 | Doctor of Philosophy
Education
Source: Self-asserted source
James Finnigan

University of Huddersfield: Huddersfield, Kirklees, GB

2010-09-20 to 2014-07-09 | Medical Genetics BSc (Applied Sciences)
Education
Source: Self-asserted source
James Finnigan

Works (19)

A method for the systematic selection of enzyme panel candidates by solving the maximum diversity problem

Biosystems
2024-02 | Journal article
DOI: 10.1016/j.biosystems.2023.105105
Contributors: Christian Atallah; Katherine James; Zhen Ou; James Skelton; David Markham; Matt S. Burridge; James Finnigan; Simon Charnock; Anil Wipat
Source: check_circle
Crossref

Chemoenzymatic Cascades for the Enantioselective Synthesis of β‐Hydroxysulfides Bearing a Stereocentre at the C−O or C−S Bond by Ketoreductases

Angewandte Chemie
2022-08 | Journal article
DOI: 10.1002/ange.202202363
Contributors: Fei Zhao; Kate Lauder; Siyu Liu; James D. Finnigan; Simon B. R. Charnock; Simon J. Charnock; Daniele Castagnolo
Source: check_circle
Crossref

Automatic Diverse Subset Selection From Enzyme Families by Solving the Maximum Diversity Problem

2022-08-15 | Conference paper
DOI: 10.1109/CIBCB55180.2022.9863021
Contributors: Christian Atallah; Katherine James; Zhen Ou; James Skelton; David Markham; James Finnigan; Simon Charnock; Anil Wipat
Source: check_circle
Crossref

Chemoenzymatic Cascades for the Enantioselective Synthesis of β‐Hydroxysulfides Bearing a Stereocentre at C− O or C − S Bonds by Ketoreductases (KREDs)

Angewandte Chemie International Edition
2022-05-16 | Journal article
DOI: 10.1002/anie.202202363
Part of ISSN: 1433-7851
Part of ISSN: 1521-3773
Source: Self-asserted source
James Finnigan
grade
Preferred source (of 2)‎

Multifunctional biocatalyst for conjugate reduction and reductive amination

Nature
2022-04-07 | Journal article
DOI: 10.1038/s41586-022-04458-x
Contributors: Thomas W. Thorpe; James R. Marshall; Vanessa Harawa; Rebecca E. Ruscoe; Anibal Cuetos; James D. Finnigan; Antonio Angelastro; Rachel S. Heath; Fabio Parmeggiani; Simon J. Charnock et al.
Source: check_circle
Crossref

A coupled ketoreductase-diaphorase assay for the detection of polyethylene terephthalate-hydrolyzing activity.

ChemSusChem
2022-03 | Journal article
DOI: 10.1002/cssc.202102750
PMID: 35315974
Contributors: Gimeno-Pérez M; Finnigan J; Echeverria C; Charnock SJ; Hidalgo A; Mate DM
Source: Self-asserted source
James Finnigan via Europe PubMed Central
grade
Preferred source (of 2)‎

An Engineered Cytidine Deaminase for Biocatalytic Production of a Key Intermediate of the Covid-19 Antiviral Molnupiravir.

Journal of the American Chemical Society
2022-02 | Journal article
DOI: 10.1021/jacs.1c11048
PMID: 35224970
PMC: PMC8915250
Contributors: Burke AJ; Birmingham WR; Zhuo Y; Thorpe TW; Zucoloto da Costa B; Crawshaw R; Rowles I; Finnigan JD; Young C; Holgate GM et al.
Source: Self-asserted source
James Finnigan via Europe PubMed Central

An Efficient Synthesis of the Bicyclic Darunavir Side Chain Using Chemoenzymatic Catalysis

Organic Process Research & Development
2022-02-18 | Journal article
DOI: 10.1021/acs.oprd.2c00017
Part of ISSN: 1083-6160
Part of ISSN: 1520-586X
Source: Self-asserted source
James Finnigan

Synthesis of Pharmaceutically Relevant 2‐Aminotetralin and 3‐Aminochroman Derivatives via Enzymatic Reductive Amination

Angewandte Chemie
2021-11-08 | Journal article
DOI: 10.1002/ange.202110321
Contributors: Joan Citoler; Vanessa Harawa; James R. Marshall; Han Bevinakatti; James D. Finnigan; Simon J. Charnock; Nicholas J. Turner
Source: check_circle
Crossref
grade
Preferred source (of 3)‎

Discovery of a multi-functional biocatalyst for asymmetric conjugate reduction-reductive amination

2021-07 | Preprint
DOI: 10.21203/rs.3.rs-640129/v1
PPR: PPR368650
Contributors: Turner N; Thorpe T; Marshall J; Harawa V; Ruscoe R; Cuetos A; Finnigan J; Angelastro A; Parmeggiani F; Charnock S et al.
Source: Self-asserted source
James Finnigan via Europe PubMed Central

A Biocatalytic Approach to a Key Intermediate for the Synthesis of the COVID-19 Experimental Drug Molnupiravir

2021-02 | Preprint
DOI: 10.26434/chemrxiv.13721692.v1
PPR: PPR311210
Contributors: Burke A; Birmingham W; Zhuo Y; Costa BZd; Crawshaw R; Thorpe T; Rowles I; Finnigan J; Charnock SJ; Lovelock S et al.
Source: Self-asserted source
James Finnigan via Europe PubMed Central

Screening and characterization of a diverse panel of metagenomic imine reductases for biocatalytic reductive amination

Nature Chemistry
2021-02 | Journal article
DOI: 10.1038/s41557-020-00606-w
Contributors: James R. Marshall; Peiyuan Yao; Sarah L. Montgomery; James D. Finnigan; Thomas W. Thorpe; Ryan B. Palmer; Juan Mangas-Sanchez; Richard A. M. Duncan; Rachel S. Heath; Kirsty M. Graham et al.
Source: check_circle
Crossref

Cytochromes P450 (P450s): A review of the class system with a focus on prokaryotic P450s.

Advances in protein chemistry and structural biology
2020-09 | Journal article
DOI: 10.1016/bs.apcsb.2020.06.005
PMID: 32951814
Contributors: Finnigan JD; Young C; Cook DJ; Charnock SJ; Black GW
Source: Self-asserted source
James Finnigan via Europe PubMed Central

Enantioselective Synthesis of α‐Thiocarboxylic Acids by Nitrilase Biocatalysed Dynamic Kinetic Resolution of α‐Thionitriles

Chemistry – A European Journal
2020-08-17 | Journal article
DOI: 10.1002/chem.202001108
Contributors: Kate Lauder; Silvia Anselmi; James D. Finnigan; Yuyin Qi; Simon J. Charnock; Daniele Castagnolo
Source: check_circle
Crossref

Chemoenzymatic synthesis of substituted azepanes by sequential biocatalytic reduction and organolithium-mediated rearrangement.

Journal of the American Chemical Society
2018-12 | Journal article
DOI: 10.1021/jacs.8b11891
PMID: 30521324
Contributors: Zawodny W; Marshall JR; Finnigan JD; Turner NJ; Clayden J; Montgomery SL
Source: Self-asserted source
James Finnigan via Europe PubMed Central

nanoDSF as screening tool for enzyme libraries and biotechnology development.

The FEBS journal
2018-11 | Journal article
DOI: 10.1111/febs.14696
PMID: 30414312
Contributors: Magnusson AO; Szekrenyi A; Joosten HJ; Finnigan J; Charnock S; Fessner WD
Source: Self-asserted source
James Finnigan via Europe PubMed Central

Cytochromes P450: History, Classes, Catalytic Mechanism, and Industrial Application.

Advances in protein chemistry and structural biology
2016-08 | Journal article
DOI: 10.1016/bs.apcsb.2016.07.003
PMID: 27567486
Contributors: Cook DJ; Finnigan JD; Cook K; Black GW; Charnock SJ
Source: Self-asserted source
James Finnigan via Europe PubMed Central

Serum amyloid A induces interleukin-6 in dermal fibroblasts via Toll-like receptor 2, interleukin-1 receptor-associated kinase 4 and nuclear factor-κB.

2014-11 | Journal article
DOI:

10.1111/imm.12260

PMID:

24476318
Contributors: O'Reilly S; Cant R; Ciechomska M; Finnigan J; Oakley F; Hambleton S; van Laar JM
Source: Self-asserted source
James Finnigan via Europe PubMed Central

Role of toll-like receptors in systemic sclerosis.

2013 | Journal article
DOI:

10.1017/erm.2013.10

PMID:

23985302
Contributors: Ciechomska M; Cant R; Finnigan J; van Laar JM; O'Reilly S
Source: Self-asserted source
James Finnigan via Europe PubMed Central
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