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Works (8)

Stearoyl-CoA desaturase inhibition is toxic to acute myeloid leukemia displaying high levels of the de novo fatty acid biosynthesis and desaturation

Leukemia
2024-11 | Journal article
DOI: 10.1038/s41375-024-02390-9
Contributors: Vilma Dembitz; Hannah Lawson; Richard Burt; Sirisha Natani; Céline Philippe; Sophie C. James; Samantha Atkinson; Jozef Durko; Lydia M. Wang; Joana Campos et al.
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Pivotal role of the endoplasmic reticulum stress-related XBP1s/miR-22/SIRT1 axis in acute myeloid leukemia apoptosis and response to chemotherapy

Leukemia
2024-08 | Journal article
DOI: 10.1038/s41375-024-02321-8
Contributors: Céline Philippe; Manon Jaud; Kelly Féral; Alexandre Gay; Loïc Van Den Berghe; Manon Farce; Marina Bousquet; Stéphane Pyronnet; Laurent Mazzolini; Kevin Rouault-Pierre et al.
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The E592K variant of SF3B1 creates unique RNA missplicing and associates with high-risk MDS without ring sideroblasts

Blood Advances
2024-08-13 | Journal article
DOI: 10.1182/bloodadvances.2023011260
Contributors: In Young Choi; Jonathan P. Ling; Jian Zhang; Eric Helmenstine; Wencke Walter; Panagiotis Tsakiroglou; Riley E. Bergman; Céline Philippe; James L. Manley; Kevin Rouault-Pierre et al.
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Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death

Nature Communications
2023-04-14 | Journal article
DOI: 10.1038/s41467-023-37652-0
Contributors: Keith Woodley; Laura S. Dillingh; George Giotopoulos; Pedro Madrigal; Kevin M. Rattigan; Céline Philippe; Vilma Dembitz; Aoife M. S. Magee; Ryan Asby; Louie N. van de Lagemaat et al.
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The E592K variant of SF3B1 creates unique RNA missplicing and associates with high-risk MDS without ring sideroblasts

2023-04-14 | Preprint
DOI: 10.21203/rs.3.rs-2802265/v1
Contributors: In Young Choi; Jonathan P. Ling; Jian Zhang; Eric Helmenstine; Wencke Walter; Riley E. Bergman; Céline Philippe; James L. Manley; Kevin Rouault-Pierre; Bing Li et al.
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Vitamin B5 and succinyl-CoA improve ineffective erythropoiesis in SF3B1 -mutated myelodysplasia

Science Translational Medicine
2023-03 | Journal article
DOI: 10.1126/scitranslmed.abn5135
Contributors: Syed A. Mian; Céline Philippe; Eleni Maniati; Pantelitsa Protopapa; Tiffany Bergot; Marion Piganeau; Travis Nemkov; Doriana Di Bella; Valle Morales; Andrew J. Finch et al.
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Germline ERCC excision repair 6 like 2 (ERCC6L2) mutations lead to impaired erythropoiesis and reshaping of the bone marrow microenvironment

British Journal of Haematology
2022-12 | Journal article
DOI: 10.1111/bjh.18466
Contributors: Hannah Armes; Findlay Bewicke‐Copley; Ana Rio‐Machin; Doriana Di Bella; Céline Philippe; Anna Wozniak; Hemanth Tummala; Jun Wang; Teresa Ezponda; Felipe Prosper et al.
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The transcription factor DDIT3 is a potential driver of dyserythropoiesis in myelodysplastic syndromes

Nature Communications
2022-12-09 | Journal article
DOI: 10.1038/s41467-022-35192-7
Contributors: Nerea Berastegui; Marina Ainciburu; Juan P. Romero; Paula Garcia-Olloqui; Ana Alfonso-Pierola; Céline Philippe; Amaia Vilas-Zornoza; Patxi San Martin-Uriz; Raquel Ruiz-Hernández; Ander Abarrategi et al.
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