Personal information

Danger signals, P2X7R, Macrophages, Inflammation, Inflammasome, Deubiquitinases, Interleukin-1, caspase-1, ASC
United Kingdom

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Employment (1)

The University of Manchester: Manchester, GB

Employment
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University of Manchester - PURE

Works (50 of 65)

Items per page:
Page 1 of 2

Very Early-Onset IBD-Associated IL-18opathy Treated with an Anti-IL-18 Antibody

Journal of Clinical Medicine
2024-10-11 | Journal article
Contributors: Anthea Guha; Rodrigo Diaz-Pino; Andrew Fagbemi; Stephen M. Hughes; Robert F. Wynn; Gloria Lopez-Castejon; Peter D. Arkwright
Source: check_circle
Crossref
grade
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Proximity labelling of pro-interleukin-1α reveals evolutionary conserved nuclear interactions

Nature Communications
2024-08-08 | Journal article
Contributors: Rose Wellens; Victor S. Tapia; Paula I. Seoane; Hayley Bennett; Antony Adamson; Graham Coutts; Jack Rivers-Auty; Martin Lowe; Jack P. Green; Gloria Lopez-Castejon et al.
Source: check_circle
Crossref
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Pyroptosis leads to loss of centrosomal integrity in macrophages

Cell Death Discovery
2024-08-08 | Journal article
Contributors: Siyi Bai; Fatima Martin-Sanchez; David Brough; Gloria Lopez-Castejon
Source: check_circle
Crossref
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Type I interferon regulates interleukin-1beta and IL-18 production and secretion in human macrophages.

Life Science Alliance
2024-06-01 | Journal article | Author
SOURCE-WORK-ID:

d3bf253a-44f1-4adc-a1f7-1f0dde965a6a

EID:

2-s2.0-85188920072

Contributors: Rodrigo Diaz Pino; Gillian Rice; Diego San Felipe Riba; Tamar Pepanashvili; Paul Kasher; Tracy Briggs; Gloria Lopez-Castejon
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University of Manchester - PURE
grade
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Pyroptosis leads to loss of centrosomal integrity in macrophages

2023-11-22 | Preprint
Contributors: Siyi Bai; Fatima Martin-Sanchez; David Brough; Gloria Lopez-Castejon
Source: check_circle
Crossref

Method to Measure Ubiquitination of NLRs

NLR Proteins
2023-08-15 | Book chapter | Author
SOURCE-WORK-ID:

ec60bcc1-f095-4d51-acff-ebb464ce2a47

EID:

2-s2.0-85168064758

Part of ISBN: 978-1-0716-3350-2
Part of ISBN: 978-1-0716-3349-6
Part of ISBN: 978-1-0716-3352-6
Contributors: Jonathan Worboys; Pablo Palazón-Riquelme; Gloria Lopez-Castejon
Source: check_circle
University of Manchester - PURE

Disruptions in endocytic traffic contribute to the activation of the NLRP3 inflammasome

Science Signaling
2023-02-21 | Journal article | Author
SOURCE-WORK-ID:

c4e67e60-891d-40dd-8c78-67aaed08d51f

EID:

2-s2.0-85148679254

Contributors: Bali Lee; Christopher Hoyle; Rose Wellens; Jack Green; Fatima Martin-Sanchez; Daniel M. Williams; Billie J Matchett; Paula I. Seoane; Hayley Bennett; Antony D. Adamson et al.
Source: check_circle
University of Manchester - PURE

NLRP3 inflammasome triggers interleukin-37 release from human monocytes

European journal of immunology
2022-04-16 | Journal article | Author
SOURCE-WORK-ID:

35354c50-6e8b-491e-a6b1-ff0a091e5c84

Contributors: Anna Gritsenko; Rodrigo Díaz Pino; Gloria Lopez-Castejon
Source: check_circle
University of Manchester - PURE
grade
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Internalization of the Membrane Attack Complex Triggers NLRP3 Inflammasome Activation and IL-1β Secretion in Human Macrophages

Frontiers in Immunology
2021-09-28 | Journal article | Author
SOURCE-WORK-ID:

f8f22f92-fbfe-4a7c-9589-1254ffdf4afb

EID:

2-s2.0-85117147452

Contributors: Ines Diaz-del-Olmo; Jonathan Worboys; Fatima Martin-Sanchez; Anna Gritsenko; Ashley R. Ambrose; Gillian M. Tannahill; Eva-Maria Nichols; Gloria Lopez-Castejon; Daniel Davis
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University of Manchester - PURE

NLRP3 activation in response to disrupted endocytic traffic

bioRxiv
2021-09-16 | Journal article | Author
SOURCE-WORK-ID:

5ba2e05b-bf65-4aa6-8bc9-f70e6ed6ddd1

Contributors: Bali Lee; Christopher Hoyle; Jack Green; Rose Wellens; Fatima Martín-Sánchez; Daniel Williams; Paula Seoane Denicola; Hayley Bennett; Antony D. Adamson; Gloria Lopez-Castejon et al.
Source: check_circle
University of Manchester - PURE

NLRP3 at the crossroads between immune/inflammatory responses and enteric neuroplastic remodeling in a mouse model of diet-induced obesity.

British journal of pharmacology
2021-05-17 | Journal article
Source: Self-asserted source
Gloria Lopez-Castejon

Response to correspondence on "Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles

Genome Biology
2021-04-07 | Journal article | Author
SOURCE-WORK-ID:

ac3325d8-6f01-429d-a649-fe2f4f1cba23

EID:

2-s2.0-85103904816

Contributors: Channabasavaiah B Gurumurthy; Aidan R O'Brien; Rolen M Quadros; John Adams; Pilar Alcaide; Shinya Ayabe; Johnathan Ballard; Surinder K Batra; Marie-Claude Beauchamp; Kathleen A Becker et al.
Source: check_circle
University of Manchester - PURE

Pro-IL-1 beta Is an Early Prognostic Indicator of Severe Donor Lung Injury During Ex Vivo Lung Perfusion

Transplantation
2021-04-01 | Journal article | Author
SOURCE-WORK-ID:

8cbfe008-4985-44b7-890e-0d6214c0148c

EID:

2-s2.0-85103607577

WOSUID:

000639593000021

Contributors: Triin Major; Alexandra L Ball; John Stone; Rebecca J Edge; Gloria Lopez-Castejon; Trygve Sjöberg; Anders Andreasson; Stig Steen; Andrew J Fisher; James E Fildes
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University of Manchester - PURE
grade
Preferred source (of 2)‎

The NLRP3-inflammasome as a sensor of organelle dysfunction.

The Journal of cell biology
2020-12 | Journal article
Contributors: Seoane PI; Lee B; Hoyle C; Yu S; Lopez-Castejon G; Lowe M; Brough D
Source: Self-asserted source
Gloria Lopez-Castejon via Europe PubMed Central

Bafilomycin A1 enhances NLRP3 inflammasome activation in human monocytes independent of lysosomal acidification

The FEBS Journal
2020-11-03 | Journal article | Author
SOURCE-WORK-ID:

e30a3d35-1c23-4f32-acab-48f919b65619

EID:

2-s2.0-85096752788

Contributors: SHI YU; Jack Green; Rose Wellens; Gloria Lopez-Castejon; David Brough
Source: check_circle
University of Manchester - PURE
grade
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Mechanisms of NLRP3 priming in inflammaging and age related diseases

Cytokine & Growth Factor Reviews
2020-10 | Journal article
Contributors: Anna Gritsenko; Jack P. Green; David Brough; Gloria Lopez-Castejon
Source: check_circle
Crossref

Priming is dispensable for NLRP3 inflammasome activation in human monocytes in vitro

Frontiers in Immunology
2020-09-30 | Journal article | Author
SOURCE-WORK-ID:

265c008c-3d65-427d-addc-aea0cd9a5746

EID:

2-s2.0-85092749103

Contributors: Anna Gritsenko; Shi Yu; Fatima Martín-Sánchez; Inés Díaz Del Olmo; Eva-Maria Nichols; Daniel Davis; David Brough; Gloria Lopez-Castejon
Source: check_circle
University of Manchester - PURE
grade
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Prodromal Intestinal Events in Alzheimer's Disease (AD): Colonic Dysmotility and Inflammation Are Associated with Enteric AD-Related Protein Deposition.

International journal of molecular sciences
2020-05 | Journal article
Contributors: Pellegrini C; Daniele S; Antonioli L; Benvenuti L; D'Antongiovanni V; Piccarducci R; Pietrobono D; Citi V; Piragine E; Flori L et al.
Source: Self-asserted source
Gloria Lopez-Castejon via Europe PubMed Central

Priming is dispensable for NLRP3 inflammasome activation in human monocytes

2020-01-30 | Preprint
Contributors: Anna Gritsenko; Shi Yu; Fatima Martin-Sanchez; Ines Diaz del Olmo; Eva-Maria Nichols; Daniel M. Davis; David Brough; Gloria Lopez-Castejon
Source: check_circle
Crossref

Control of the inflammasome by the ubiquitin system

The FEBS Journal
2019-11-02 | Journal article | Author
SOURCE-WORK-ID:

b8f82947-0bc8-4a95-b69a-3d14311ca4da

EID:

2-s2.0-85075213212

Contributors: Gloria Lopez-Castejon
Source: check_circle
University of Manchester - PURE
grade
Preferred source (of 2)‎

Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation.

Genome biology
2019-08-26 | Journal article
Source: Self-asserted source
Gloria Lopez-Castejon
grade
Preferred source (of 2)‎

The three cytokines IL-1β, IL-18, and IL-1α share related but distinct secretory routes.

The Journal of biological chemistry
2019-04-02 | Journal article
Source: Self-asserted source
Gloria Lopez-Castejon
grade
Preferred source (of 2)‎

The inflammasomes, immune guardians at defence barriers

Immunology
2018 | Journal article
Source: Self-asserted source
Gloria Lopez-Castejon

Pathophysiology of NSAID-associated intestinal lesions in the rat

Frontiers in Pharmacology
2018-11-29 | Journal article | Author
SOURCE-WORK-ID:

6c8d38fe-6e5d-4615-be0b-6919ea33b73a

EID:

2-s2.0-85057798738

Contributors: Rocchina Colucci; Carolina Pellegrini; Matteo Fornai; Erika Tirotta; Luca Antonioli; Cecilia Renzulli; Emilia Ghelardi; Elena Piccoli; Daniela Gentile; Laura Benvenuti et al.
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University of Manchester - PURE
grade
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USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation

EMBO reports
2018-10 | Journal article | Author
SOURCE-WORK-ID:

9a18293a-2cd3-4401-8af7-cbb25a02567e

EID:

2-s2.0-85053370062

Contributors: Pablo Palazón-Riquelme; Jonathan Worboys; Jack Green; Ana Valera; Fatima Martín-Sánchez; Carolina Pellegrini; David Brough; Gloria Lopez-Castejon
Source: check_circle
University of Manchester - PURE
grade
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Chloride regulates dynamic NLRP3-dependent ASC oligomerisation and inflammasome priming

Proceedings of the National Academy of Sciences
2018-10-02 | Journal article | Author
SOURCE-WORK-ID:

d0ca5c41-8be2-4555-a5be-c1b6559d736e

EID:

2-s2.0-85054377201

Contributors: Jack Green; SHI YU; Fátima Martín-Sánchez; Pablo Pelegrin; Gloria Lopez-Castejon; Catherine Lawrence; David Brough
Source: check_circle
University of Manchester - PURE
grade
Preferred source (of 2)‎

Canonical and Non-Canonical Activation of NLRP3 Inflammasome at the Crossroad between Immune Tolerance and Intestinal Inflammation

Frontiers in immunology
2017 | Journal article
Source: Self-asserted source
Gloria Lopez-Castejon
grade
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Development of an Acrylate Derivative Targeting the NLRP3 Inflammasome for the Treatment of Inflammatory Bowel Disease

Journal of medicinal chemistry
2017 | Journal article
Source: Self-asserted source
Gloria Lopez-Castejon
grade
Preferred source (of 2)‎

P2X7 Receptor Dependent Tuning of Gut Epithelial Responses to Infection

Immunology and cell biology
2017-02 | Journal article | Author
SOURCE-WORK-ID:

7c501e42-4909-4600-9662-fcb8cd85eab9

EID:

2-s2.0-84988654504

Contributors: Szu-Wei Huang; Catherine Walker; Joanne Pennock; Kathryn Else; Werner Muller; Michael Daniels; Carolina Pellegrini; David Brough; Gloria Lopez-Castejon; Sheena Cruickshank
Source: check_circle
University of Manchester - PURE
grade
Preferred source (of 2)‎

Functional Reconstruction of NLRs in HEK293 Cells.

2016 | Journal article
Contributors: Compan V; López-Castejón G
Source: Self-asserted source
Gloria Lopez-Castejon via Europe PubMed Central

Functional Reconstruction of NLRs in HEK293 Cells.

NLR proteins : methods and protocols
2016 | Book chapter | Author
SOURCE-WORK-ID:

1351e61a-9613-4adf-b52f-92b06da5a9be

EID:

2-s2.0-84990217423

Part of ISBN: 978-1-4939-3566-6
Part of ISBN: 978-1-4939-3564-2
Contributors: Vincent Compan; Gloria Lopez-Castejon
Source: check_circle
University of Manchester - PURE

Method to Measure Ubiquitination of NLRs.

2016 | Journal article
Contributors: Palazón-Riquelme P; López-Castejón G
Source: Self-asserted source
Gloria Lopez-Castejon via Europe PubMed Central

Method to Measure Ubiquitination of NLRs.

NLR proteins : methods and protocols
2016 | Book chapter | Author
SOURCE-WORK-ID:

02950ffb-9b7b-4f39-b8ff-582495f41117

EID:

2-s2.0-84990208199

Part of ISBN: 978-1-4939-3566-6
Part of ISBN: 978-1-4939-3564-2
Contributors: Pablo Palazón; Gloria Lopez-Castejon
Source: check_circle
University of Manchester - PURE

Deubiquitinases: Novel Therapeutic Targets in Immune Surveillance?

Mediators of Inflammation
2016-07-04 | Journal article | Author
SOURCE-WORK-ID:

b4ee533b-191a-4c94-a36d-af0f069923ad

EID:

2-s2.0-84984820649

Contributors: Gloria Lopez-Castejon; Mariola J Edelmann
Source: check_circle
University of Manchester - PURE
grade
Preferred source (of 2)‎

Apoptosis-associated speck-like protein containing a CARD forms specks but does not activate caspase-1 in the absence of NLRP3 during macrophage swelling.

Journal of Immunology
2015-02-01 | Journal article | Author
SOURCE-WORK-ID:

f5a66373-6a73-46aa-8c7d-2ec4f0fe5ba0

EID:

2-s2.0-84921456203

Contributors: Vincent Compan; Fátima Martín-Sánchez; Alberto Baroja-Mazo; Gloria Lopez-Castejon; Ana I Gomez; Alexei Verkhratsky; David Brough; Pablo Pelegrín
Source: check_circle
University of Manchester - PURE
grade
Preferred source (of 2)‎

Zinc depletion regulates the processing and secretion of IL-1β.

CELL DEATH & DISEASE
2014 | Journal article | Author
SOURCE-WORK-ID:

53942f60-f62f-4432-97fa-531a931304dc

EID:

2-s2.0-84957547650

Contributors: Pedro Mendes; H. Summersgill; H. England; Gloria Lopez-Castejon; Catherine Lawrence; N. M. Luheshi; J. Pahle; P. Mendes; David Brough
Source: check_circle
University of Manchester - PURE
grade
Preferred source (of 2)‎

Dendritic cell IL-1α and IL-1β are polyubiquitinated and degraded by the proteasome.

Journal of Biological Chemistry
2014-12-19 | Journal article | Author
SOURCE-WORK-ID:

c5e81878-f8ba-40e1-aa9d-91aaeeead31b

EID:

2-s2.0-84919385996

Contributors: Joseph Ainscough; G. Frank Gerberick; Maryam Zahedi-Nejad; Gloria Lopez-Castejon; David Brough; Ian Kimber; Rebecca Dearman
Source: check_circle
University of Manchester - PURE
grade
Preferred source (of 2)‎

Microglia and macrophages differentially modulate cell death after brain injury caused by oxygen-glucose deprivation in organotypic brain slices

GLIA
2013 | Journal article | Author
SOURCE-WORK-ID:

e88c3626-25b9-4423-9209-a1a8e8944959

EID:

2-s2.0-84883196455

Contributors: Sylvie Girard; David Brough; Gloria Lopez-Castejon; James Giles; Nancy Rothwell; Stuart Allan
Source: check_circle
University of Manchester - PURE
grade
Preferred source (of 2)‎

Regulation of NLRP3 activation by the ubiquitin system

Inflammasome
2013-12 | Journal article | Author
SOURCE-WORK-ID:

ef25d613-d934-4218-a434-5ed313f30975

Contributors: Gloria Lopez-Castejon
Source: check_circle
University of Manchester - PURE

Acidosis Drives Damage-associated Molecular Pattern (DAMP)-induced Interleukin-1 Secretion via a Caspase-1-independent Pathway

Journal of Biological Chemistry
2013-10-18 | Journal article | Author
SOURCE-WORK-ID:

597bde38-0fa0-47af-ab66-aa02d32b4d65

EID:

2-s2.0-84886928516

Contributors: M. E. Edye; Gloria Lopez-Castejon; Stuart Allan; David Brough
Source: check_circle
University of Manchester - PURE
grade
Preferred source (of 2)‎

Regulation of NLRP3 activation by the ubiquitin system

Inflammasome
2013-10-09 | Journal article
OTHER-ID:

DOI: 10.2478/infl-2013-0003

Source: Self-asserted source
Gloria Lopez-Castejon

Response to Boyle et al

Immunity
2013-03-21 | Journal article | Author
SOURCE-WORK-ID:

acec5cee-72a5-43c5-83a8-b42e14b8ce1a

EID:

2-s2.0-84875522599

Contributors: Diego Angosto; Gloria Lopez-Castejon; Victoriano Mulero; Pablo Pelegrín
Source: check_circle
University of Manchester - PURE
grade
Preferred source (of 2)‎

Deubiquitinases regulate the activity of caspase-1 and interleukin-1β secretion via assembly of the inflammasome

Journal of Biological Chemistry
2013-01-25 | Journal article | Author
SOURCE-WORK-ID:

8124f03f-3a9f-48af-8e72-dfffc52585f3

EID:

2-s2.0-84873834109

Contributors: Gloria Lopez-Castejon; Nadia M. Luheshi; Vincent Compan; Stephen High; Roger Whitehead; Sabine Flitsch; Aleksandr Kirov; Igor Prudovsky; Eileithyia Swanton; David Brough
Source: check_circle
University of Manchester - PURE
grade
Preferred source (of 2)‎

NLRP3-inflammasome activating DAMPs stimulate an inflammatory response in glia in the absence of priming which contributes to brain inflammation after injury

Frontiers in Immunology
2012 | Journal article | Author
SOURCE-WORK-ID:

2082b5d0-abf4-4eb8-85e9-6e81983a560d

EID:

2-s2.0-84874280618

Contributors: Catherine Diane Savage; Gloria Lopez-Castejon; Adam Denes; David Brough
Source: check_circle
University of Manchester - PURE
grade
Preferred source (of 2)‎

Evolution of inflammasome functions in vertebrates: Inflammasome and caspase-1 trigger fish macrophage cell death but are dispensable for the processing of IL-1β

Innate Immunity
2012-12 | Journal article | Author
SOURCE-WORK-ID:

68503ae8-ebbe-4aea-95ea-f9647f97a779

EID:

2-s2.0-84864868585

Contributors: Diego Angosto; Gloria Lopez-Castejon; Azucena López-Muñoz; María P. Sepulcre; Marta Arizcun; José Meseguer; Victoriano Mulero
Source: check_circle
University of Manchester - PURE
grade
Preferred source (of 2)‎

Cell Volume Regulation Modulates NLRP3 Inflammasome Activation

Immunity
2012-09-21 | Journal article | Author
SOURCE-WORK-ID:

f6839519-f336-4e82-986d-e6baba424997

EID:

2-s2.0-84866512376

Contributors: Vincent Compan; Alberto Baroja-Mazo; Gloria Lopez-Castejon; Ana I. Gomez; Carlos M. Martínez; Diego Angosto; María T. Montero; Antonio S. Herranz; Eulalia Bazán; Diana Reimers et al.
Source: check_circle
University of Manchester - PURE
grade
Preferred source (of 2)‎

Caspase-1: Is IL-1 just the tip of the ICEberg?

Cell Death and Disease
2012-07 | Journal article | Author
SOURCE-WORK-ID:

ce5d48a6-ab66-4c6c-8359-6f81c47b96c3

EID:

2-s2.0-84864883030

Contributors: A. Denes; Gloria Lopez-Castejon; David Brough
Source: check_circle
University of Manchester - PURE
grade
Preferred source (of 2)‎

Current status of inflammasome blockers as anti-inflammatory drugs

Expert Opinion on Investigational Drugs
2012-07 | Journal article | Author
SOURCE-WORK-ID:

eb15c193-4640-4ecd-8f55-4a108fb234c3

EID:

2-s2.0-84862301337

Contributors: Gloria Lopez-Castejon; Pablo Pelegrín
Source: check_circle
University of Manchester - PURE
grade
Preferred source (of 2)‎

Inhibition of calpain blocks the phagosomal escape of listeria monocytogenes

PLoS ONE
2012-04-26 | Journal article | Author
SOURCE-WORK-ID:

8b65e786-2541-432b-b64e-1076d631b0e9

EID:

2-s2.0-84860370817

Contributors: Gloria Lopez-Castejon; David Corbett; Marie Goldrick; Ian Roberts; David Brough
Source: check_circle
University of Manchester - PURE
grade
Preferred source (of 2)‎

Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages

European journal of immunology
2012-03 | Journal article | Author
SOURCE-WORK-ID:

31891514-f3e3-4ef2-997f-81158fa2c2a4

EID:

2-s2.0-84859515412

Contributors: Nadia M. Luheshi; James A. Giles; Gloria Lopez-Castejon; David Brough
Source: check_circle
University of Manchester - PURE
grade
Preferred source (of 2)‎
Items per page:
Page 1 of 2

Peer review (7 reviews for 5 publications/grants)

Review activity for Cell communication and signaling. (1)
Review activity for Cell reports. (3)
Review activity for Communications biology. (1)
Review activity for Nature communications (1)
Review activity for Thorax (1)