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Loop profile: 958333
SciProfiles: 542145

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Employment (1)

Brody School of Medicine at East Carolina University: Greenville, NC, US

2003-07 to present | Professor and Graduate Director (Biochemistry and Molecular Biology)
Employment
Source: Self-asserted source
Brett Keiper

Education and qualifications (3)

Brandeis University: Waltham, US

1985-08 to 1991-01 | PhD (Biochemistry)
Education
Source: Self-asserted source
Brett Keiper

Juniata College: Huntingdon, US

1981-09 to 1985-02 | Bachelor of Science (Chemistry)
Education
Source: Self-asserted source
Brett Keiper

Philipps-Universität Marburg: Marburg, DE

1983-09 to 1984-07 | Year exchange (Biochemie)
Education
Source: Self-asserted source
Brett Keiper

Funding (5)

Regulatory Mechanism for Cellular Dedifferentiation in C. elegans Germline

2022-02-01 to 2025-01-31 | Grant
Directorate for Biological Sciences (Alexandria, US)
URL: https://app.dimensions.ai/details/grant/grant.9967323
GRANT_NUMBER: 2132286
Source: Self-asserted source
Brett Keiper via DimensionsWizard

MCA: Post-Nuclear Granules Traffic mRNAs through Helicases and Initiation Factors to Set Their Translational Fates

2021-08-01 to 2024-07-31 | Grant
Directorate for Biological Sciences (Alexandria, US)
URL: https://app.dimensions.ai/details/grant/grant.9730441
GRANT_NUMBER: 2119959
Source: Self-asserted source
Brett Keiper via DimensionsWizard

mRNA selection by eIF4E isoforms and their sequestering factors.

2017-08-01 to 2020-07-31 | Grant
Directorate for Biological Sciences (Arlington, US)
URL: https://app.dimensions.ai/details/grant/grant.6936850
GRANT_NUMBER: 1714264
Source: Self-asserted source
Brett Keiper via DimensionsWizard

Translational Control of Growth and Apoptosis in C. Elegans Development by Initiation Factor Isoforms

2009-04-01 to 2014-03-31 | Grant
Directorate for Biological Sciences (Arlington, US)
URL: https://app.dimensions.ai/details/grant/grant.2997150
GRANT_NUMBER: 0842475
Source: Self-asserted source
Brett Keiper via DimensionsWizard

Function of Tissue-specific eIF4E isoforms in Caenorhabditis elegans

2004-01-15 to 2008-12-31 | Grant
Directorate for Biological Sciences (Arlington, US)
URL: https://app.dimensions.ai/details/grant/grant.3040071
GRANT_NUMBER: 0321017
Source: Self-asserted source
Brett Keiper via DimensionsWizard

Works (29)

Two germ granule eIF4E isoforms reside in different mRNPs to hand offC elegansmRNAs from translational repression to activation

2024-05-26 | Preprint
DOI: 10.1101/2024.05.24.595216
Contributors: Gita Gajjar; Hayden P. Huggins; Eun Suk Kim; Weihua Huang; Frederic X. Bonnet; Dustin L. Updike; Brett D. Keiper
Source: check_circle
Crossref

GLH-1/Vasa represses neuropeptide expression and drives spermiogenesis in the C. elegans germline.

Developmental biology
2022-10-21 | Journal article
DOI: 10.1016/j.ydbio.2022.10.003
PMID: 36273621
PMC: PMC9677334
Contributors: Rochester JD; Min H; Gajjar GA; Sharp CS; Maki NJ; Rollins JA; Keiper BD; Graber JH; Dustin Updike
Source: Self-asserted source
Brett Keiper

Regulation of Germ Cell mRNPs by eIF4E:4EIP Complexes: Multiple Mechanisms, One Goal.

Frontiers in cell and developmental biology
2020-07-07 | Journal article
DOI: 10.3389/fcell.2020.00562
PMID: 32733883
PMC: PMC7358283
Contributors: Huggins HP; Keiper BD
Source: Self-asserted source
Brett Keiper

Distinct roles of two eIF4E isoforms in the germline of Caenorhabditis elegans

Journal of Cell Science
2020-03-15 | Journal article
DOI: 10.1242/jcs.237990
Contributors: Hayden P. Huggins; Jacob S. Subash; Hamilton Stoffel; Melissa A. Henderson; Jenna L. Hoffman; David S. Buckner; Madhu S. Sengupta; Peter R. Boag; Myon-Hee Lee; Brett D. Keiper
Source: check_circle
Crossref

Cap-Independent mRNA Translation in Germ Cells.

International Journal of Molecular Sciences
2019-01-05 | Journal article
DOI: 10.3390/ijms20010173
PMID: 30621249
PMC: PMC6337596
Source: Self-asserted source
Brett Keiper

Subunits of the DNA polymerase alpha-primase complex promote Notch-mediated proliferation with discrete and shared functions in C. elegans germline.

The FEBS journal
2018-05-28 | Journal article
DOI: 10.1111/febs.14512
PMID: 29775245
PMC: PMC6105403
Source: Self-asserted source
Brett Keiper

Poly(A)-binding proteins are required for microRNA-mediated silencing and to promote target deadenylation in C. elegans.

Nucleic acids research
2016-04-19 | Journal article
DOI: 10.1093/nar/gkw276
PMID: 27095199
PMC: PMC4937315
Source: Self-asserted source
Brett Keiper

A systematic mRNA control mechanism for germline stem cell homeostasis and cell fate specification.

BMB Reports
2016-02-01 | Journal article
DOI: 10.5483/BMBRep.2016.49.2.135
PMID: 26303971
PMC: PMC4915122
Source: Self-asserted source
Brett Keiper

Spatial and temporal translational control of germ cell mRNAs mediated by the eIF4E isoform IFE-1.

Journal of Cell Science
2015-11-05 | Journal article
DOI: 10.1242/jcs.172684
PMID: 26542024
Source: Self-asserted source
Brett Keiper

Positive mRNA Translational Control in Germ Cells by Initiation Factor Selectivity.

BioMed Research International
2015-08-19 | Journal article
DOI: 10.1155/2015/327963
PMID: 26357652
PMC: PMC4556832
Source: Self-asserted source
Brett Keiper

Mammalian target of rapamycin complex 1 (mTORC1) Is required for mouse spermatogonial differentiation in vivo.

Developmental Biology
2015-08-05 | Journal article
DOI: 10.1016/j.ydbio.2015.08.004
PMID: 26254600
PMC: PMC4641790
Source: Self-asserted source
Brett Keiper

Retinoic acid regulates Kit translation during spermatogonial differentiation in the mouse.

Developmental Biology
2014-11-04 | Journal article
DOI: 10.1016/j.ydbio.2014.10.020
PMID: 25446031
PMC: PMC4268412
Source: Self-asserted source
Brett Keiper

Induction of cap-independent BiP (hsp-3) and Bcl-2 (ced-9) translation in response to eIF4G (IFG-1) depletion in C. elegans.

Translation (Austin, Tex.)
2014-04-29 | Journal article
DOI: 10.4161/trla.28935
PMID: 26779406
PMC: PMC4705828
Source: Self-asserted source
Brett Keiper

Translational activation of developmental messenger RNAs during neonatal mouse testis development.

Biology of Reproduction
2013-09-19 | Journal article
DOI: 10.1095/biolreprod.113.109819
PMID: 23926285
PMC: PMC4094195
Source: Self-asserted source
Brett Keiper

Cap-independent translation promotes C. elegans germ cell apoptosis through Apaf-1/CED-4 in a caspase-dependent mechanism.

PloS One
2011-09-01 | Journal article
DOI: 10.1371/journal.pone.0024444
PMID: 21909434
PMC: PMC3164730
Source: Self-asserted source
Brett Keiper

A C. elegans eIF4E-family member upregulates translation at elevated temperatures of mRNAs encoding MSH-5 and other meiotic crossover proteins.

Journal of Cell Science
2010-06-08 | Journal article
DOI: 10.1242/jcs.063107
PMID: 20530576
PMC: PMC2886744
Source: Self-asserted source
Brett Keiper

A germline-specific isoform of eIF4E (IFE-1) is required for efficient translation of stored mRNAs and maturation of both oocytes and sperm.

Journal of Cell Science
2009-04-21 | Journal article
DOI: 10.1242/jcs.046771
PMID: 19383718
PMC: PMC2680099
Source: Self-asserted source
Brett Keiper

Depletion of the cap-associated isoform of translation factor eIF4G induces germline apoptosis in C. elegans.

Cell Death and Differentiation
2008-05-02 | Journal article
DOI: 10.1038/cdd.2008.46
PMID: 18451872
Source: Self-asserted source
Brett Keiper

Translation of a small subset of Caenorhabditis elegans mRNAs is dependent on a specific eukaryotic translation initiation factor 4E isoform.

Molecular and Cellular Biology
2005-01-01 | Journal article
DOI: 10.1128/MCB.25.1.100-113.2005
PMID: 15601834
PMC: PMC538781
Source: Self-asserted source
Brett Keiper

Discrimination between mono- and trimethylated cap structures by two isoforms of Caenorhabditis elegans eIF4E.

The EMBO Journal
2002-09-01 | Journal article
DOI: 10.1093/emboj/cdf473
PMID: 12198170
PMC: PMC126203
Source: Self-asserted source
Brett Keiper

An isoform of eIF4E is a component of germ granules and is required for spermatogenesis in C. elegans.

Development (Cambridge, England)
2001-10-01 | Journal article
PMID: 11641215
PMC: PMC2430591
Source: Self-asserted source
Brett Keiper

Functional characterization of five eIF4E isoforms in Caenorhabditis elegans.

The Journal of Biological Chemistry
2000-04-01 | Journal article
DOI: 10.1074/jbc.275.14.10590
PMID: 10744754
Source: Self-asserted source
Brett Keiper

Translational recruitment of Xenopus maternal mRNAs in response to poly(A) elongation requires initiation factor eIF4G-1.

Developmental Biology
1999-02-01 | Journal article
DOI: 10.1006/dbio.1998.9131
PMID: 9918691
Source: Self-asserted source
Brett Keiper

Cleavage of Poly(A)-binding protein by coxsackievirus 2A protease in vitro and in vivo: another mechanism for host protein synthesis shutoff?

Journal of Virology
1999-01-01 | Journal article
PMID: 9847377
PMC: PMC103878
Source: Self-asserted source
Brett Keiper

Protein synthesis initiation factor 4G.

The International Journal of Biochemistry & Cell Biology
1999-01-01 | Journal article
DOI: 10.1016/s1357-2725(98)00130-7
PMID: 10216942
Source: Self-asserted source
Brett Keiper

Cap-independent translation initiation in Xenopus oocytes.

Nucleic Acids Research
1997-01-01 | Journal article
DOI: 10.1093/nar/25.2.395
PMID: 9016570
PMC: PMC146431
Source: Self-asserted source
Brett Keiper

Phosphorylation of eukaryotic protein synthesis initiation factor 4E at Ser-209.

The Journal of Biological Chemistry
1995-06-01 | Journal article
DOI: 10.1074/jbc.270.24.14597
PMID: 7782323
Source: Self-asserted source
Brett Keiper

Saccharomyces cerevisiae cdc15 mutants arrested at a late stage in anaphase are rescued by Xenopus cDNAs encoding N-ras or a protein with beta-transducin repeats.

Molecular and Cellular Biology
1993-08-01 | Journal article
DOI: 10.1128/mcb.13.8.4953
PMID: 8393141
PMC: PMC360138
Source: Self-asserted source
Brett Keiper

Nucleotide sequence and 40 S subunit assembly of Xenopus laevis ribosomal protein S22.

The Journal of Biological Chemistry
1990-11-01 | Journal article
PMID: 2246230
Source: Self-asserted source
Brett Keiper

Peer review (3 reviews for 3 publications/grants)

Review activity for Cell reports. (1)
Review activity for Current biology. (1)
Review activity for Environmental toxicology and pharmacology. (1)
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