Personal information

Activities

Employment (3)

University of Massachusetts Boston: Boston, MA, US

2015-05-03 to present | Associate Professor (Center for Personalized Cancer Therapy)
Employment
Source: Self-asserted source
Changmeng Cai

Beth Israel Deaconess Medical Center: Boston, MA, US

2015-04-01 to 2015-05-02 | Assistant Professor (Medicine)
Employment
Source: Self-asserted source
Changmeng Cai

Beth Israel Deaconess Medical Center: Boston, MA, US

2010 to 2015 | Instructor (Medicine)
Employment
Source: Self-asserted source
Changmeng Cai

Education and qualifications (3)

University of Toledo: Toledo, OH, US

2002 to 2007 | Ph.D. (Biological Sciences)
Education
Source: Self-asserted source
Changmeng Cai

University of Toledo: Toledo, OH, US

2000 to 2002 | M.S. (Bioengineering)
Education
Source: Self-asserted source
Changmeng Cai

Tsinghua University: Beijing, Beijing, CN

1995 to 2000 | B.S. (Biomedical Engineering)
Education
Source: Self-asserted source
Changmeng Cai

Funding (6)

Study the Mechanism of Retinoblastoma Protein Mediated Androgen Receptor Transcriptional Repression Activity on DNA Replication

2017-09-25 to 2022-08-31 | Grant
National Cancer Institute (Rockville, US)
GRANT_NUMBER: R01CA211350
Source: Self-asserted source
Changmeng Cai via DimensionsWizard

Combination Therapy With Testosterone and Statins to Inhibit Tumor Cell Proliferation in Castration-Resistant Prostate Cancer

Source: Self-asserted source
Changmeng Cai via DimensionsWizard

Molecular basis of androgen receptor mediated gene transcriptional repression

Source: Self-asserted source
Changmeng Cai via DimensionsWizard

Molecular basis of androgen receptor mediated gene transcriptional repression

Source: Self-asserted source
Changmeng Cai via DimensionsWizard

AR Regulation of TMPRSS2:ERG in Castration-Resistant Prostate Cancer

2009-02-01 to 2011-02-28 | Grant
Congressionally Directed Medical Research Programs (Fort Detrick, US)
GRANT_NUMBER:

W81XWH0910159

Source: Self-asserted source
Changmeng Cai via DimensionsWizard
grade
Preferred source (of 2)‎

Targeting Lysine-Specific Demethylase 1 to Prevent Androgen Receptor Reactivation in Castration-Resistant Prostate Cancer

Source: Self-asserted source
Changmeng Cai via DimensionsWizard

Works (50 of 55)

Items per page:
Page 1 of 2

Voluntary Exercise Attenuates Tumor Growth in a Preclinical Model of Castration-Resistant Prostate Cancer

2024-10-18 | Preprint
Contributors: Nicolas Berger; Benjamin Kugler; Dong Han; Muqing Li; Paul Nguyen; Meaghan Anderson; Songqi Zhang; Changmeng Cai; Kai Zou
Source: check_circle
Crossref

Demethylation of EHMT1/GLP Protein Reprograms Its Transcriptional Activity and Promotes Prostate Cancer Progression.

Cancer research communications
2023-08-31 | Journal article | Author
Contributors: Anna Besschetnova; WANTING HAN; Mingyu Liu; Yanfei Gao; Muqing Li; Zifeng Wang; Maryam Labaf; Susan Patalano; Kavita Venkataramani; Rachel Muriph et al.
Source: Self-asserted source
Changmeng Cai

SETD7 functions as a transcription repressor in prostate cancer via methylating FOXA1.

Proceedings of the National Academy of Sciences of the United States of America
2023-08-07 | Journal article | Author
Contributors: Zifeng Wang; Petricca J; Liu M; Songqi Zhang; Chen S; Muqing Li; Anna Besschetnova; Patalano S; Venkataramani K; Kellee Siegfried et al.
Source: Self-asserted source
Changmeng Cai

LSD1 Inhibition Disrupts Super-Enhancer-Driven Oncogenic Transcriptional Programs in Castration-Resistant Prostate Cancer.

Cancer research
2023-05-01 | Journal article | Author
Contributors: Muqing Li; Mingyu Liu; WANTING HAN; Zifeng Wang; Dong Han; Susan Patalano; Jill A. Macoska; Steven Balk; housheng hansen he; Eva Corey et al.
Source: Self-asserted source
Changmeng Cai

Increased <i>AR</i> expression in castration-resistant prostate cancer rapidly induces AR signaling reprogramming with the collaboration of EZH2.

Frontiers in oncology
2022-11-03 | Journal article
Contributors: Labaf M; Li M; Ting L; Karno B; Songqi Zhang; Gao S; Patalano S; Macoska JA; Zarringhalam K; Han D et al.
Source: Self-asserted source
Changmeng Cai

Exploiting the tumor-suppressive activity of the androgen receptor by CDK4/6 inhibition in castration-resistant prostate cancer.

Molecular therapy : the journal of the American Society of Gene Therapy
2022-02-02 | Journal article
Contributors: Han W; Mingyu Liu; Han D; Toure AA; Li M; Anna Besschetnova; Wang Z; Patalano S; Jill A. Macoska; Lam HM et al.
Source: Self-asserted source
Changmeng Cai

RB1 loss in castration-resistant prostate cancer confers vulnerability to LSD1 inhibition.

Oncogene
2022-01-03 | Journal article | Author
Contributors: WANTING HAN; Liu M; Dong Han; Li M; Toure AA; Wang Z; Anna Besschetnova; Patalano S; Jill A. Macoska; Shuai Gao et al.
Source: Self-asserted source
Changmeng Cai

Inhibition of EZH2 transactivation function sensitizes solid tumors to genotoxic stress.

Proceedings of the National Academy of Sciences of the United States of America
2022-01-01 | Journal article | Author
Contributors: Liao Y; Chen CH; Xiao T; Bárbara de la Peña Avalos; Eloise Dray; Changmeng Cai; Shuai Gao; Shah N; Zhao Zhang; Feit A et al.
Source: Self-asserted source
Changmeng Cai
grade
Preferred source (of 2)‎

Susceptibility-Associated Genetic Variation in <i>NEDD9</i> Contributes to Prostate Cancer Initiation and Progression.

Cancer research
2021-02-25 | Journal article
Contributors: Dong Han; Jude Owiredu; Healy BM; Li M; Maryam Labaf; Jocelyn Steinfeld; Patalano S; Gao S; Liu M; Jill A. Macoska et al.
Source: Self-asserted source
Changmeng Cai

Pioneer of prostate cancer: past, present and the future of FOXA1.

Protein & cell
2020-09-18 | Journal article | Author
Contributors: Mona Teng; Stanley Zhou; Changmeng Cai; Mathieu Lupien; housheng hansen he
Source: Self-asserted source
Changmeng Cai
grade
Preferred source (of 2)‎

Chromatin binding of FOXA1 is promoted by LSD1-mediated demethylation in prostate cancer.

Nature genetics
2020-08-31 | Journal article | Author
Contributors: Shuai Gao; Chen S; Han D; Zifeng Wang; Li M; WANTING HAN; Anna Besschetnova; Liu M; Zhou F; Barrett D et al.
Source: Self-asserted source
Changmeng Cai

A Novel Mechanism to Induce BRCAness in Cancer Cells.

Cancer research
2020-07-01 | Journal article
Contributors: Cai C
Source: Self-asserted source
Changmeng Cai

ZBTB7A Mediates the Transcriptional Repression Activity of the Androgen Receptor in Prostate Cancer.

Cancer research
2019-08-23 | Journal article
Contributors: Han D; Sujun Chen; WANTING HAN; Shuai Gao; Jude Owiredu; Li M; Balk SP; He HH; Cai C
Source: Self-asserted source
Changmeng Cai

LSD1 Activates PI3K/AKT Signaling Through Regulating p85 Expression in Prostate Cancer Cells.

Frontiers in oncology
2019-08-02 | Journal article
Contributors: Zifeng Wang; Shuai Gao; Han D; Han W; Li M; Cai C
Source: Self-asserted source
Changmeng Cai

Forkhead domain mutations in FOXA1 drive prostate cancer progression.

Cell research
2019-07-19 | Journal article | Author
Contributors: Shuai Gao; Sujun Chen; Han D; Barrett D; WANTING HAN; Ahmed M; Patalano S; Macoska JA; He HH; Changmeng Cai
Source: Self-asserted source
Changmeng Cai
grade
Preferred source (of 2)‎

TMPRSS2-ERG activates NO-cGMP signaling in prostate cancer cells

Oncogene
2019-05 | Journal article
Contributors: Feng Zhou; Shuai Gao; Dong Han; Wanting Han; Sujun Chen; Susan Patalano; Jill A. Macoska; Housheng Hansen He; Changmeng Cai
Source: check_circle
Crossref

BMX-mediated regulation of multiple tyrosine kinases contributes to castration resistance in prostate cancer

Cancer Research
2018 | Journal article
EID:

2-s2.0-85053196018

Contributors: Chen, S.; Cai, C.; Sowalsky, A.G.; Ye, H.; Ma, F.; Yuan, X.; Simon, N.I.; Gray, N.S.; Balk, S.P.
Source: Self-asserted source
Changmeng Cai via Scopus - Elsevier

Reactivation of androgen receptor-regulated lipid biosynthesis drives the progression of castration-resistant prostate cancer

Oncogene
2018 | Journal article
EID:

2-s2.0-85041543259

Contributors: Han, W.; Gao, S.; Barrett, D.; Ahmed, M.; Han, D.; MacOska, J.A.; He, H.H.; Cai, C.
Source: Self-asserted source
Changmeng Cai via Scopus - Elsevier

A novel nonsense mutation in androgen receptor confers resistance to CYP17 inhibitor treatment in prostate cancer

Oncotarget
2017 | Journal article
EID:

2-s2.0-85010754799

Contributors: Han, D.; Gao, S.; Valencia, K.; Owiredu, J.; Han, W.; Waal, E.; Macoska, J.A.; Cai, C.
Source: Self-asserted source
Changmeng Cai via Scopus - Elsevier

Exploiting AR-regulated drug transport to induce sensitivity to the survivin inhibitor YM155

Molecular Cancer Research
2017 | Journal article
EID:

2-s2.0-85017031724

Contributors: Nyquist, M.D.; Corella, A.; Burns, J.; Coleman, I.; Gao, S.; Tharakan, R.; Riggan, L.; Cai, C.; Corey, E.; Nelson, P.S. et al.
Source: Self-asserted source
Changmeng Cai via Scopus - Elsevier

LSD1-mediated epigenetic reprogramming drives CENPE expression and prostate cancer progression

Cancer Research
2017 | Journal article
EID:

2-s2.0-85031410519

Contributors: Liang, Y.; Ahmed, M.; Guo, H.; Soares, F.; Hua, J.T.; Gao, S.; Lu, C.; Poon, C.; Han, W.; Langstein, J. et al.
Source: Self-asserted source
Changmeng Cai via Scopus - Elsevier

Positive feedback loop mediated by protein phosphatase 1? mobilization of P-TEFb and basal CDK1 drives androgen receptor in prostate cancer

Nucleic Acids Research
2017 | Journal article
EID:

2-s2.0-85019128272

Contributors: Liu, X.; Gao, Y.; Ye, H.; Gerrin, S.; Ma, F.; Wu, Y.; Zhang, T.; Russo, J.; Cai, C.; Yuan, X. et al.
Source: Self-asserted source
Changmeng Cai via Scopus - Elsevier

Androgen Receptor Tumor Suppressor Function Is Mediated by Recruitment of Retinoblastoma Protein

Cell Reports
2016 | Journal article
EID:

2-s2.0-84994882450

Contributors: Gao, S.; Gao, Y.; He, H.H.; Han, D.; Han, W.; Avery, A.; Macoska, J.A.; Liu, X.; Chen, S.; Ma, F. et al.
Source: Self-asserted source
Changmeng Cai via Scopus - Elsevier

ErbB2 signaling increases androgen receptor expression in abiraterone-resistant prostate cancer

Clinical Cancer Research
2016 | Journal article
EID:

2-s2.0-84978484277

Contributors: Gao, S.; Ye, H.; Gerrin, S.; Wang, H.; Sharma, A.; Chen, S.; Patnaik, A.; Sowalsky, A.G.; Voznesensky, O.; Han, W. et al.
Source: Self-asserted source
Changmeng Cai via Scopus - Elsevier

Protein phosphatase 1 suppresses androgen receptor ubiquitylation and degradation

Oncotarget
2016 | Journal article
EID:

2-s2.0-84957700698

Contributors: Liu, X.; Han, W.; Gulla, S.; Simon, N.I.; Gao, Y.; Cai, C.; Yang, H.; Zhang, X.; Liu, J.; Balk, S.P. et al.
Source: Self-asserted source
Changmeng Cai via Scopus - Elsevier

SOX9 drives WNT pathway activation in prostate cancer

Journal of Clinical Investigation
2016 | Journal article
EID:

2-s2.0-84988535650

Contributors: Ma, F.; Ye, H.; He, H.H.; Gerrin, S.J.; Chen, S.; Tanenbaum, B.A.; Cai, C.; Sowalsky, A.G.; He, L.; Wang, H. et al.
Source: Self-asserted source
Changmeng Cai via Scopus - Elsevier

Abiraterone treatment in castration-resistant prostate cancer selects for progesterone responsive mutant androgen receptors

Clinical Cancer Research
2015 | Journal article
EID:

2-s2.0-84927655173

Contributors: Chen, E.J.; Sowalsky, A.G.; Gao, S.; Cai, C.; Voznesensky, O.; Schaefer, R.; Loda, M.; True, L.D.; Ye, H.; Troncoso, P. et al.
Source: Self-asserted source
Changmeng Cai via Scopus - Elsevier

PLZF, a tumor suppressor genetically lost in metastatic castration-resistant prostate cancer, is a mediator of resistance to androgen deprivation therapy

Cancer Research
2015 | Journal article
EID:

2-s2.0-84930215434

Contributors: Hsieh, C.-L.; Botta, G.; Gao, S.; Li, T.; Van Allen, E.M.; Treacy, D.J.; Cai, C.; He, H.H.; Sweeney, C.J.; Brown, M. et al.
Source: Self-asserted source
Changmeng Cai via Scopus - Elsevier

Androgen receptor functions in castration-resistant prostate cancer and mechanisms of resistance to new agents targeting the androgen axis

Oncogene
2014 | Journal article
EID:

2-s2.0-84901827161

Contributors: Yuan, X.; Cai, C.; Chen, S.; Chen, S.; Yu, Z.; Balk, S.P.
Source: Self-asserted source
Changmeng Cai via Scopus - Elsevier

Galeterone prevents androgen receptor binding to chromatin and enhances degradation of mutant androgen receptor

Clinical Cancer Research
2014 | Journal article
EID:

2-s2.0-84905436109

Contributors: Yu, Z.; Cai, C.; Gao, S.; Simon, N.I.; Shen, H.C.; Balk, S.P.
Source: Self-asserted source
Changmeng Cai via Scopus - Elsevier

Lysine-Specific Demethylase 1 Has Dual Functions as a Major Regulator of Androgen Receptor Transcriptional Activity

Cell Reports
2014 | Journal article
EID:

2-s2.0-84915775734

Contributors: Cai, C.; He, H.H.; Gao, S.; Chen, S.; Yu, Z.; Gao, Y.; Chen, S.; Chen, M.W.; Zhang, J.; Ahmed, M. et al.
Source: Self-asserted source
Changmeng Cai via Scopus - Elsevier

Rapid induction of androgen receptor splice variants by androgen deprivation in prostate cancer

Clinical Cancer Research
2014 | Journal article
EID:

2-s2.0-84896536370

Contributors: Yu, Z.; Chen, S.; Sowalsky, A.G.; Voznesensky, O.S.; Mostaghel, E.A.; Nelson, P.S.; Cai, C.; Balk, S.P.
Source: Self-asserted source
Changmeng Cai via Scopus - Elsevier

Androgen receptor epigenetics

Translational Andrology and Urology
2013 | Journal article
EID:

2-s2.0-84901240570

Contributors: Cai, C.; Yuan, X.; Balk, S.P.
Source: Self-asserted source
Changmeng Cai via Scopus - Elsevier

Discovery of a selective irreversible BMX inhibitor for prostate cancer

ACS Chemical Biology
2013 | Journal article
EID:

2-s2.0-84880532700

Contributors: Liu, F.; Zhang, X.; Weisberg, E.; Chen, S.; Hur, W.; Wu, H.; Zhao, Z.; Wang, W.; Mao, M.; Cai, C. et al.
Source: Self-asserted source
Changmeng Cai via Scopus - Elsevier

ERG induces androgen receptor-mediated regulation of SOX9 in prostate cancer

Journal of Clinical Investigation
2013 | Journal article
EID:

2-s2.0-84874598190

Contributors: Cai, C.; Wang, H.; He, H.H.; Chen, S.; He, L.; Ma, F.; Mucci, L.; Wang, Q.; Fiore, C.; Sowalsky, A.G. et al.
Source: Self-asserted source
Changmeng Cai via Scopus - Elsevier

Tyrosine kinase BMX phosphorylates phosphotyrosine-primed motif mediating the activation of multiple receptor tyrosine kinases

Science Signaling
2013 | Journal article
EID:

2-s2.0-84878675830

Contributors: Chen, S.; Jiang, X.; Gewinner, C.A.; Asara, J.M.; Simon, N.I.; Cai, C.; Cantley, L.C.; Balk, S.P.
Source: Self-asserted source
Changmeng Cai via Scopus - Elsevier

Androgen receptor enhances p27 degradation in prostate cancer cells through rapid and selective TORC2 activation

Journal of Biological Chemistry
2012 | Journal article
EID:

2-s2.0-84862926298

Contributors: Fang, Z.; Zhang, T.; Dizeyi, N.; Chen, S.; Wang, H.; Swanson, K.D.; Cai, C.; Balk, S.P.; Yuan, X.
Source: Self-asserted source
Changmeng Cai via Scopus - Elsevier

Androgen receptor serine 81 phosphorylation mediates chromatin binding and transcriptional activation

Journal of Biological Chemistry
2012 | Journal article
EID:

2-s2.0-84863245741

Contributors: Chen, S.; Gulla, S.; Cai, C.; Balk, S.P.
Source: Self-asserted source
Changmeng Cai via Scopus - Elsevier

EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent

Science
2012 | Journal article
EID:

2-s2.0-84871052080

Contributors: Xu, K.; Wu, Z.J.; Groner, A.C.; He, H.H.; Cai, C.; Lis, R.T.; Wu, X.; Stack, E.C.; Loda, M.; Liu, T. et al.
Source: Self-asserted source
Changmeng Cai via Scopus - Elsevier

In silico discovery of androgen receptor antagonists with activity in castration resistant prostate cancer

Molecular Endocrinology
2012 | Journal article
EID:

2-s2.0-84868089097

Contributors: Shen, H.C.; Shanmugasundaram, K.; Simon, N.I.; Cai, C.; Wang, H.; Chen, S.; Balk, S.P.; Rigby, A.C.
Source: Self-asserted source
Changmeng Cai via Scopus - Elsevier

Soluble guanylyl cyclase α1 and p53 cytoplasmic sequestration and down regulation in prostate cancer

Molecular Endocrinology
2012 | Journal article
EID:

2-s2.0-84856280676

Contributors: Cai, C.; Hsieh, C.-L.; Gao, S.; Kannan, A.; Bhansali, M.; Govardhan, K.; Dutta, R.; Shemshedini, L.
Source: Self-asserted source
Changmeng Cai via Scopus - Elsevier

Androgen Receptor Gene Expression in Prostate Cancer Is Directly Suppressed by the Androgen Receptor Through Recruitment of Lysine-Specific Demethylase 1

Cancer Cell
2011 | Journal article
EID:

2-s2.0-80054761058

Contributors: Cai, C.; He, H.; Chen, S.; Coleman, I.; Wang, H.; Fang, Z.; Chen, S.; Nelson, P.; Liu, X.S.; Brown, M. et al.
Source: Self-asserted source
Changmeng Cai via Scopus - Elsevier

Intratumoral androgen biosynthesis in prostate cancer pathogenesis and response to therapy

Endocrine-Related Cancer
2011 | Journal article
EID:

2-s2.0-80053940699

Contributors: Cai, C.; Balk, S.P.
Source: Self-asserted source
Changmeng Cai via Scopus - Elsevier

Intratumoral De Novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors

Cancer Research
2011 | Journal article
EID:

2-s2.0-80054021222

Contributors: Cai, C.; Chen, S.; Ng, P.; Bubley, G.J.; Nelson, P.S.; Mostaghel, E.A.; Marck, B.; Matsumoto, A.M.; Simon, N.I.; Wang, H. et al.
Source: Self-asserted source
Changmeng Cai via Scopus - Elsevier

Androgen receptor expression in prostate cancer cells is suppressed by activation of epidermal growth factor receptor and ErbB2

Cancer Research
2009 | Journal article
EID:

2-s2.0-67449158993

Contributors: Cai, C.; Portnoy, D.C.; Wang, H.; Jiang, X.; Chen, S.; Balk, S.P.
Source: Self-asserted source
Changmeng Cai via Scopus - Elsevier

Reactivation of androgen receptor-regulated TMPRSS2:ERG gene expression in castration-resistant prostate cancer

Cancer Research
2009 | Journal article
EID:

2-s2.0-68049131467

Contributors: Cai, C.; Wang, H.; Xu, Y.; Chen, S.; Balk, S.P.
Source: Self-asserted source
Changmeng Cai via Scopus - Elsevier

Expression of a hyperactive androgen receptor leads to androgen-independent growth of prostate cancer cells

Journal of Molecular Endocrinology
2008 | Journal article
EID:

2-s2.0-48949087166

Contributors: Hsieh, C.-L.; Cai, C.; Giwa, A.; Bivins, A.; Chen, S.-Y.; Sabry, D.; Govardhan, K.; Shemshedini, L.
Source: Self-asserted source
Changmeng Cai via Scopus - Elsevier

Androgen induces expression of the multidrug resistance protein gene MRP4 in prostate cancer cells

Prostate Cancer and Prostatic Diseases
2007 | Journal article
EID:

2-s2.0-33847642501

Contributors: Cai, C.; Omwancha, J.; Hsieh, C.-L.; Shemshedini, L.
Source: Self-asserted source
Changmeng Cai via Scopus - Elsevier

Androgen regulation of soluble guanylyl cyclaseα1 mediates prostate cancer cell proliferation

Oncogene
2007 | Journal article
EID:

2-s2.0-33947164005

Contributors: Cai, C.; Chen, S.-Y.; Zheng, Z.; Omwancha, J.; Lin, M.-F.; Balk, S.P.; Shemshedini, L.
Source: Self-asserted source
Changmeng Cai via Scopus - Elsevier

c-Jun has multiple enhancing activities in the novel cross talk between the androgen receptor and Ets variant gene 1 in prostate cancer

Molecular Cancer Research
2007 | Journal article
EID:

2-s2.0-34547116209

Contributors: Cai, C.; Hsieh, C.-L.; Shemshedini, L.
Source: Self-asserted source
Changmeng Cai via Scopus - Elsevier
Items per page:
Page 1 of 2

Peer review (12 reviews for 9 publications/grants)

Review activity for Cancer letters. (1)
Review activity for Cell reports. (4)
Review activity for Molecular cell. (1)
Review activity for Nature communications (1)
Review activity for Nature genetics. (1)
Review activity for Nature structural & molecular biology. (1)
Review activity for Oncogene. (1)
Review activity for Pharmacological research. (1)
Review activity for Signal transduction and targeted therapy. (1)