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Employment (4)

University of California Irvine & Polgenix Inc.: Irvine, California, US

2018-10-01 to present | Specialist (Ophthalomology)
Employment
Source: Self-asserted source
ZHIQIAN DONG

Case Western Reserve University & Polgenix, Inc.: Cleveland, Ohio, US

2007-02-01 to 2018-09-22 | Scientist (Pharmacology)
Employment
Source: Self-asserted source
ZHIQIAN DONG

Case Western Reserve University: Cleveland, OH, US

2005-07-01 to 2007-07-01 | Research Associate (Institute of Pathology)
Employment
Source: Self-asserted source
ZHIQIAN DONG

Rockefellor University and Weill Medical College of Cornell Univeristy: New York, NY, US

2003-07-15 to 2005-07-01 | Postdoctoral Fellow
Employment
Source: Self-asserted source
ZHIQIAN DONG

Education and qualifications (2)

Chinese University of Hong Kong: New Territories, HK

1999-07-01 to 2003-07-01 | PhD (Anatomical and Cellular Pathology)
Education
Source: Self-asserted source
ZHIQIAN DONG

Chongqing Medical University: Chongqing, Chongqing, CN

1980-09-01 to 1985-07-20 | MD (Medicine)
Education
Source: Self-asserted source
ZHIQIAN DONG

Works (43)

Restoring retinal polyunsaturated fatty acid balance and retina function by targeting ceramide in AdipoR1-deficient mice.

The Journal of biological chemistry
2024-04-16 | Journal article
DOI: 10.1016/j.jbc.2024.107291
PMID: 38636661
Contributors: Lewandowski D; Gao F; Imanishi S; Tworak A; Bassetto M; Dong Z; Antonio Pinto; Tabaka M; Kiser PD; Imanishi Y et al.
Source: Self-asserted source
ZHIQIAN DONG

Distinct mouse models of Stargardt disease display differences in pharmacological targeting of ceramides and inflammatory responses.

Proceedings of the National Academy of Sciences of the United States of America
2023-12-08 | Journal article | Author
DOI: 10.1073/pnas.2314698120
PMID: 38064509
Contributors: Zachary Engfer; Dominik Lewandowski; ZHIQIAN DONG; Palczewska G; Zhang J; Katarzyna Kordecka; Jagoda Płaczkiewicz; Damian Panas; Andrzej T Foik; Tabaka M et al.
Source: Self-asserted source
ZHIQIAN DONG

Rapid RGR-dependent visual pigment recycling is mediated by the RPE and specialized Müller glia.

Cell reports
2023-08-15 | Journal article
DOI: 10.1016/j.celrep.2023.112982
PMID: 37585292
PMC: PMC10530494
Contributors: Aleksander Tworak; Kolesnikov AV; John Hong; Choi EH; Luu JC; Palczewska G; Dong Z; Lewandowski D; Brooks MJ; Laura Campello et al.
Source: Self-asserted source
ZHIQIAN DONG

Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via phosphodiesterase inhibition.

Proceedings of the National Academy of Sciences of the United States of America
2023-05-01 | Journal article | Author
DOI: 10.1073/pnas.2221045120
PMID: 37126699
PMC: PMC10175720
Contributors: Jennings C. Luu; Saadane A; Henri Leinonen; Elliot Choi; Gao F; Dominik Lewandowski; Halabi M; Sander CL; Arum Wu; Wang JM et al.
Source: Self-asserted source
ZHIQIAN DONG

In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration

Nature Communications
2022-04-05 | Journal article
DOI: 10.1038/s41467-022-29490-3
Part of ISSN: 2041-1723
Contributors: Elliot H. Choi; Susie Suh; Andrzej T Foik; Henri Leinonen; Gregory A. Newby; Xin D. Gao; Samagya Banskota; Thanh Hoang; Samuel Du; Zhiqian Dong et al.
Source: Self-asserted source
ZHIQIAN DONG

Inhibition of ceramide accumulation in AdipoR1-/- mice increases photoreceptor survival and improves vision.

JCI insight
2022-02-22 | Journal article
DOI: 10.1172/jci.insight.156301
PMID: 35015730
PMC: PMC8876453
Contributors: Dominik Lewandowski; Andrzej T Foik; Smidak R; Choi EH; Zhang J; Hoang T; Aleksander Tworak; Suh S; Henri Leinonen; Dong Z et al.
Source: Self-asserted source
ZHIQIAN DONG

Nano-scale resolution of native retinal rod disk membranes reveals differences in lipid composition

Journal of Cell Biology
2021-08-02 | Journal article
DOI: 10.1083/jcb.202101063
Part of ISSN: 0021-9525
Part of ISSN: 1540-8140
Contributors: Christopher Sander; Avery Sears; Antonio Pinto; Elliot H. Choi; Shirin Kahremany; Fangyuan Gao; David Salom; Hui Jin; Els Pardon; Susie Suh et al.
Source: Self-asserted source
ZHIQIAN DONG

An inducible Cre mouse for studying roles of the RPE in retinal physiology and disease

JCI Insight
2021-05-10 | Journal article | Author
DOI: 10.1172/jci.insight.146604
Part of ISSN: 2379-3708
Contributors: Elliot H. Choi; Susie Suh; David E. Einstein; Henri Leinonen; ZHIQIAN DONG; Sriganesh Ramachandra Rao; Steven Fliesler; Seth Blackshaw; Minzhong Yu; Neal S. Peachey et al.
Source: Self-asserted source
ZHIQIAN DONG

Peptide Derivatives of Retinylamine Prevent Retinal Degeneration with Minimal Side Effects on Vision in Mice

Bioconjugate Chemistry
2021-03-17 | Journal article
DOI: 10.1021/acs.bioconjchem.1c00043
Part of ISSN: 1043-1802
Part of ISSN: 1520-4812
Contributors: Guanping Yu; Song-Qi Gao; Zhiqian Dong; Li Sheng; Da Sun; Ning Zhang; Jianye Zhang; Seunghee Margeivicus; Pingfu Fu; Marcin Golczak et al.
Source: Self-asserted source
ZHIQIAN DONG

Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing.

Nature biomedical engineering
2020-10-19 | Journal article
DOI: 10.1038/s41551-020-00632-6
PMID: 33077938
PMC: PMC7885272
Contributors: Susie Suh; Choi EH; Henri Leinonen; Andrzej T Foik; Gregory A. Newby; Wei-Hsi Yeh; Dong Z; Philip D. Kiser; David C. Lyon; David Liu et al.
Source: Self-asserted source
ZHIQIAN DONG

Noninvasive two-photon optical biopsy of retinal fluorophores

Proceedings of the National Academy of Sciences
2020-09-08 | Journal article
DOI: 10.1073/pnas.2007527117
Part of ISSN: 0027-8424
Part of ISSN: 1091-6490
Source: Self-asserted source
ZHIQIAN DONG

Epigenetic hallmarks of age-related macular degeneration are recapitulated in a photosensitive mouse model.

Human molecular genetics
2020-08-01 | Journal article
DOI: 10.1093/hmg/ddaa158
PMID: 32691052
Source: Self-asserted source
ZHIQIAN DONG

The selective estrogen receptor modulator raloxifene mitigates the effect of all-trans-retinal toxicity in photoreceptor degeneration.

The Journal of biological chemistry
2019-05-09 | Journal article
DOI: 10.1074/jbc.ra119.008697
PMID: 31073029
PMC: PMC6579480
Source: Self-asserted source
ZHIQIAN DONG

Conditional deletion of Des1 in the mouse retina does not impair the visual cycle in cones.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2019-01-15 | Journal article
DOI: 10.1096/fj.201802493r
PMID: 30645148
PMC: PMC6436658
Source: Self-asserted source
ZHIQIAN DONG

Two-photon imaging of the mammalian retina with ultrafast pulsing laser.

JCI insight
2018-09-06 | Journal article
DOI: 10.1172/jci.insight.121555
PMID: 30185665
PMC: PMC6171813
Source: Self-asserted source
ZHIQIAN DONG

Protective Effect of a Locked Retinal Chromophore Analog against Light-Induced Retinal Degeneration.

Molecular pharmacology
2018-07-17 | Journal article
DOI: 10.1124/mol.118.112581
PMID: 30018116
PMC: PMC6108575
Source: Self-asserted source
ZHIQIAN DONG

Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65.

Human molecular genetics
2018-07-01 | Journal article
DOI: 10.1093/hmg/ddy128
PMID: 29659842
PMC: PMC6005012
Source: Self-asserted source
ZHIQIAN DONG

A Combination of G Protein-Coupled Receptor Modulators Protects Photoreceptors from Degeneration.

The Journal of pharmacology and experimental therapeutics
2017-11-21 | Journal article
DOI: 10.1124/jpet.117.245167
PMID: 29162627
PMC: PMC5771314
Source: Self-asserted source
ZHIQIAN DONG

Dephosphorylation by protein phosphatase 2A regulates visual pigment regeneration and the dark adaptation of mammalian photoreceptors.

Proceedings of the National Academy of Sciences of the United States of America
2017-10-23 | Journal article
DOI: 10.1073/pnas.1712405114
PMID: 29078372
PMC: PMC5692576
Source: Self-asserted source
ZHIQIAN DONG

Characterization of physiochemical properties of caveolin-1 from normal and prion-infected human brains.

Oncotarget
2017-07-21 | Journal article
DOI: 10.18632/oncotarget.19431
PMID: 28903310
PMC: PMC5589549
Source: Self-asserted source
ZHIQIAN DONG

MicroRNA-processing Enzymes Are Essential for Survival and Function of Mature Retinal Pigmented Epithelial Cells in Mice.

The Journal of biological chemistry
2017-01-19 | Journal article
DOI: 10.1074/jbc.m116.770024
PMID: 28104803
PMC: PMC5336169
Source: Self-asserted source
ZHIQIAN DONG

Receptor MER Tyrosine Kinase Proto-oncogene (MERTK) Is Not Required for Transfer of Bis-retinoids to the Retinal Pigmented Epithelium.

The Journal of biological chemistry
2016-11-14 | Journal article
DOI: 10.1074/jbc.m116.764563
PMID: 27875314
PMC: PMC5207201
Source: Self-asserted source
ZHIQIAN DONG

Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration.

Science signaling
2016-07-26 | Journal article
DOI: 10.1126/scisignal.aag0245
PMID: 27460988
PMC: PMC4972460
Source: Self-asserted source
ZHIQIAN DONG

Serum levels of lipid metabolites in age-related macular degeneration.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2015-07-17 | Journal article
DOI: 10.1096/fj.15-275289
PMID: 26187344
PMC: PMC4608905
Source: Self-asserted source
ZHIQIAN DONG

Molecular pharmacodynamics of emixustat in protection against retinal degeneration.

The Journal of clinical investigation
2015-06-15 | Journal article
DOI: 10.1172/jci80950
PMID: 26075817
PMC: PMC4563688
Source: Self-asserted source
ZHIQIAN DONG

Expansion of first-in-class drug candidates that sequester toxic all-trans-retinal and prevent light-induced retinal degeneration.

Molecular pharmacology
2014-12-23 | Journal article
DOI: 10.1124/mol.114.096560
PMID: 25538117
PMC: PMC4352584
Source: Self-asserted source
ZHIQIAN DONG

Noninvasive two-photon microscopy imaging of mouse retina and retinal pigment epithelium through the pupil of the eye.

Nature medicine
2014-06-22 | Journal article
DOI: 10.1038/nm.3590
PMID: 24952647
PMC: PMC4087080
Source: Self-asserted source
ZHIQIAN DONG

Two-photon microscopy reveals early rod photoreceptor cell damage in light-exposed mutant mice.

Proceedings of the National Academy of Sciences of the United States of America
2014-03-24 | Journal article
DOI: 10.1073/pnas.1317986111
PMID: 24706832
PMC: PMC3986171
Source: Self-asserted source
ZHIQIAN DONG

Systems pharmacology identifies drug targets for Stargardt disease-associated retinal degeneration.

The Journal of clinical investigation
2013-11-15 | Journal article
DOI: 10.1172/jci69076
PMID: 24231350
PMC: PMC3859412
Source: Self-asserted source
ZHIQIAN DONG

Protease-sensitive prions with 144-bp insertion mutations.

Aging
2013-03-01 | Journal article
DOI: 10.18632/aging.100543
PMID: 23515139
PMC: PMC3629288
Source: Self-asserted source
ZHIQIAN DONG

QLT091001, a 9-cis-retinal analog, is well-tolerated by retinas of mice with impaired visual cycles.

Investigative ophthalmology & visual science
2013-01-17 | Journal article
DOI: 10.1167/iovs.12-11152
PMID: 23249702
PMC: PMC4686220
Source: Self-asserted source
ZHIQIAN DONG

Effect of caloric intake on Western-style diet-induced intestinal tumors in a mouse model for hereditary colon cancer.

Nutrition and cancer
2012-03-22 | Journal article
DOI: 10.1080/01635581.2012.660672
PMID: 22439692
Source: Self-asserted source
ZHIQIAN DONG

Post-translational modifications of the serotonin type 4 receptor heterologously expressed in mouse rod cells.

Biochemistry
2011-12-20 | Journal article
DOI: 10.1021/bi201707v
PMID: 22145929
PMC: PMC3268512
Source: Self-asserted source
ZHIQIAN DONG

Failure to detect the presence of prions in the uterine and gestational tissues from a Gravida with Creutzfeldt-Jakob disease.

The American journal of pathology
2009-04-06 | Journal article
DOI: 10.2353/ajpath.2009.081045
PMID: 19349373
PMC: PMC2671249
Source: Self-asserted source
ZHIQIAN DONG

Heterologous expression and purification of the serotonin type 4 receptor from transgenic mouse retina.

Biochemistry
2008-12-01 | Journal article
DOI: 10.1021/bi8018527
PMID: 19053287
Source: Self-asserted source
ZHIQIAN DONG

A novel human disease with abnormal prion protein sensitive to protease.

Annals of neurology
2008-06-01 | Journal article
DOI: 10.1002/ana.21420
PMID: 18571782
PMC: PMC2767200
Source: Self-asserted source
ZHIQIAN DONG

Accessibility of a critical prion protein region involved in strain recognition and its implications for the early detection of prions.

Cellular and molecular life sciences : CMLS
2008-02-01 | Journal article
DOI: 10.1007/s00018-007-7478-z
PMID: 18193391
PMC: PMC7079802
Source: Self-asserted source
ZHIQIAN DONG

Insoluble aggregates and protease-resistant conformers of prion protein in uninfected human brains.

The Journal of biological chemistry
2006-09-20 | Journal article
DOI: 10.1074/jbc.m602238200
PMID: 16987816
Source: Self-asserted source
ZHIQIAN DONG

Chronic wasting disease of elk and deer and Creutzfeldt-Jakob disease: comparative analysis of the scrapie prion protein.

The Journal of biological chemistry
2005-12-07 | Journal article
DOI: 10.1074/jbc.m509052200
PMID: 16338930
PMC: PMC4484765
Source: Self-asserted source
ZHIQIAN DONG

Creutzfeldt-Jakob disease (CJD) with a mutation at codon 148 of prion protein gene: relationship with sporadic CJD.

The American journal of pathology
2005-12-01 | Journal article
DOI: 10.1016/s0002-9440(10)61254-0
PMID: 16314483
PMC: PMC1613192
Source: Self-asserted source
ZHIQIAN DONG

Identification of two contiguous minimally deleted regions on chromosome 1p36.31-p36.32 in oligodendroglial tumours.

British journal of cancer
2004-09-01 | Journal article
DOI: 10.1038/sj.bjc.6602093
PMID: 15475940
PMC: PMC2747719
Source: Self-asserted source
ZHIQIAN DONG

Mutation analysis of DMBT1 in glioblastoma, medulloblastoma and oligodendroglial tumors.

International journal of cancer
2003-05-01 | Journal article
DOI: 10.1002/ijc.11019
PMID: 12672033
Source: Self-asserted source
ZHIQIAN DONG

Clonality of oligoastrocytomas.

Human pathology
2002-05-01 | Journal article
DOI: 10.1053/hupa.2002.124784
PMID: 12094379
Source: Self-asserted source
ZHIQIAN DONG
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